Pharmacology and Physiology of Human Adrenergic Receptor polymorphisms

Annual Review of Pharmacology and Toxicology - Tập 43 Số 1 - Trang 381-411 - 2003
Kersten M. Small1, Dennis W. McGraw1, Stephen B. Liggett1
1Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267

Tóm tắt

Adrenergic receptors are expressed on virtually every cell type in the body and are the receptors for epinephrine and norepinephrine within the sympathetic nervous system. They serve critical roles in maintaining homeostasis in normal physiologic settings as well as pathologic states. These receptors are also targets for therapeutically administered agonists and antagonists. Recent studies have shown that at least seven adrenergic receptor subtypes display variation in amino acid sequence in the human population due to common genetic polymorphisms. Variations in potential regulatory domains in noncoding sequence are also present. Here, we review the consequences of these polymorphisms in terms of signaling, human physiology and disease, and response to therapy.

Từ khóa


Tài liệu tham khảo

Hoffman BB. 2001.Catecholamines, sympathomimetic drugs, and adrenergic receptor antagonists.InThe Pharmacological Basis of Therapeutics, ed. JG Hardman, LE Limbird, 10:215–68. New York: McGraw-Hill

Goldstein DS, Eisenhofer G, McCarty R, eds. 1998.Catecholamines: Bridging Basic Science with Clinical Medicine, pp. 1–1084. San Diego: Academic

10.1016/S0076-6879(02)43152-7

10.1016/S0014-5793(02)02564-4

10.1016/S0165-6147(00)01758-2

10.1002/(SICI)1098-1004(1999)14:3<271::AID-HUMU14>3.3.CO;2-H

10.1007/s001090000080

Suzuki T, 1992, Mol. Pharmacol., 41, 542

10.1097/00005344-200202000-00001

10.1074/jbc.274.18.12670

10.1002/1098-1004(200012)16:6<534::AID-HUMU24>3.0.CO;2-X

10.1073/pnas.100127897

10.1038/46040

10.1006/jmcc.2000.1123

10.1073/pnas.96.12.7059

10.1161/01.CIR.101.5.558

10.1006/jmcc.1999.0947

10.1016/S0140-6736(99)00549-8

10.1086/339621

10.1067/mhj.2002.125325

10.1056/NEJMoa020803

10.1161/01.CIR.104.2.187

10.1172/JCI12774

10.1097/00008571-200104000-00003

10.1042/CS20000145

10.1165/ajrcmb/8.3.334

10.1164/ajrccm.158.3.9801035

10.1021/bi00198a006

10.1165/ajrcmb.13.1.7598936

10.1164/ajrccm.162.6.9909046

10.1097/00008571-200003000-00007

Green SA, 1993, J. Biol. Chem., 268, 23116, 10.1016/S0021-9258(19)49434-9

10.1073/pnas.93.19.10483

10.1073/pnas.97.19.10483

10.1172/JCI117838

10.1136/thx.50.4.353

10.1016/S0140-6736(95)91994-5

10.1016/S0091-6749(97)70234-3

10.1016/S0140-6736(97)03211-X

10.1172/JCI119874

Hancox RJ, 1998, Eur. Respir. J., 11, 589, 10.1183/09031936.98.11030589

10.1046/j.1365-2222.1998.00245.x

10.1164/ajrccm.158.6.9804126

10.1016/S0009-9236(99)70071-8

10.1007/s004390050947

10.3109/02770909909087295

10.1164/ajrccm.161.2.9902072

10.1111/j.1365-2222.1993.tb00267.x

10.1164/ajrccm.162.1.9907092

10.1046/j.1365-2222.2000.00929.x

10.1164/ajrccm.162.2.9910108

10.1136/thorax.55.9.762

10.1164/ajrccm.163.6.2001101

10.1164/ajrccm.162.4.9912103

10.1046/j.1365-2222.1999.00571.x

10.1016/S1081-1206(10)62697-X

10.1056/NEJM200202143460718

10.1056/NEJMoa010819

10.1056/NEJM199801083380210

10.1038/85411

10.1046/j.1523-1755.1998.00926.x

10.1161/01.HYP.33.6.1425

10.1161/01.HYP.30.4.773

10.1046/j.1365-2796.2000.00721.x

10.1161/01.CIR.101.25.2877

10.1097/00004872-200018020-00006

10.1067/mcp.2000.106293

10.1161/01.HYP.36.3.371

10.1067/mhj.2000.101781

10.1073/pnas.98.4.1607

10.1172/JCI4059

10.1161/01.RES.86.8.834

10.1161/01.CIR.103.8.1048

10.1046/j.1365-2796.1999.00495.x

10.1172/JCI119854

10.1046/j.1365-2796.1999.0437e.x

10.1016/S0140-6736(99)00251-2

10.1016/S0140-6736(05)77192-0

10.1007/s001250051120

10.1038/sj.ijo.0801168

10.1038/sj.ijo.0801063

10.1038/sj.ijo.0801180

10.1046/j.1365-2796.2000.00669.x

10.1056/NEJM199508103330605

Liggett SB, 1992, Mol. Pharmacol., 42, 634

10.1210/en.137.6.2638

10.2337/diabetes.48.1.203

10.1093/hmg/1.5.349-a

10.1097/00008571-199910000-00012

Buscher R, 1999, J. Pharmacol. Exp. Ther., 291, 793

10.1111/j.1476-5381.1996.tb15552.x

10.1016/S0304-3940(99)01000-9

10.1159/000026674

10.1007/s007020170065

10.1074/jbc.M004550200

10.1111/j.1399-0004.1997.tb02436.x

Bono M, 1996, Gene Geogr., 10, 151

10.1093/nar/16.18.9070

10.1097/00004872-199209000-00015

10.1126/science.273.5276.801

10.1161/01.HYP.23.1_Suppl.I203

10.1097/00001756-199805110-00006

10.1016/S0165-1781(99)00124-9

10.1016/S0920-9964(00)00127-4

10.1530/eje.0.1440291

10.1016/0895-7061(95)00024-J

10.1161/01.HYP.27.6.1210

10.1002/j.1550-8528.1995.tb00145.x

10.1093/ndt/14.11.2657

10.1074/jbc.M008118200

10.1021/bi00037a036

10.1074/jbc.270.9.4681

10.1016/S0895-7061(99)00070-9

10.1016/S0735-1097(01)01201-3

10.1126/science.273.5276.803

10.1210/jc.84.7.2429

10.1038/sj.ijo.0801798

10.2337/diabetes.50.1.91

10.1074/jbc.M000796200