The role of innate mediators in inflammatory response

Bathon, 2000, A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis., New Eng. J. Med., 343, 1586, 10.1056/NEJM200011303432201 Bondeson, 1999, Defining therapeutic targets by using adenovirus: blocking NF-kappaB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators, Proc. Natl. Acad. Sci. U.S.A., 96, 5668, 10.1073/pnas.96.10.5668 Dinarello, 1999, Interleukin-18, Methods, 19, 121, 10.1006/meth.1999.0837 Ghayur, 1997, Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production, Nature, 386, 619, 10.1038/386619a0 Giri, 1995, Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor, EMBO J, 14, 3654, 10.1002/j.1460-2075.1995.tb00035.x Grabstein, 1994, Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor, Science, 264, 965, 10.1126/science.8178155 Gracie, 1999, A proinflammatory role for IL-18 in rheumatoid arthritis, J. Clin. Invest., 104, 1393, 10.1172/JCI7317 Joosten, 2000, An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis, J. Immunol., 165, 6553, 10.4049/jimmunol.165.11.6553 Kanakaraj, 1999, Defective Interleukin (IL)-18-mediated natural killer and T helper cell Type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice, J. Exp. Med., 189, 1129, 10.1084/jem.189.7.1129 Leung, 2001, A role for IL-18 in neutrophil activation, J. Immunol., 31, 2979 Lipsky, 2000, Infliximab and methotrexate in the treatment of rheumatoid arthritis, New Eng. J. Med., 343, 1594, 10.1056/NEJM200011303432202 Lodolce, 1998, IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation, Immunity, 9, 669, 10.1016/S1074-7613(00)80664-0 McInnes, 1996, The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis, Nat. Med., 2, 175, 10.1038/nm0296-175 McInnes, 2000, Interleukin 18: a pleiotropic participant in chronic inflammation, Immunol. Today, 21, 312, 10.1016/S0167-5699(00)01648-0 McInnes, 1998, A role for IL-15 in rheumatoid arthritis?, Nat. Med., 4, 643, 10.1038/nm0698-643b McInnes, 1997, Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis, Nat. Med., 3, 189, 10.1038/nm0297-189 McInnes, 1998, Interleukin 15: a proinflammatory role in rheumatoid arthritis synovitis, Immunol. Today, 19, 75, 10.1016/S0167-5699(97)01205-X Oppenheimer-Marks, 1998, Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells in vitro and in the SCID mouse–human rheumatoid arthritis model in vivo, J. Clin. Invest., 101, 1261, 10.1172/JCI1986 Plater-Zyberk, 2001, Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis, J. Clin. Invest., 108, 1825, 10.1172/JCI200112097 Rezzonico, 2000, Engagement of CD11b and CD11c beta2 integrin by antibodies or soluble CD23 induces IL-1beta production on primary human monocytes through mitogen-activated protein kinase-dependent pathways, Blood, 95, 3868, 10.1182/blood.V95.12.3868.012k43_3868_3877 Ribbens, 2000, CD40–CD40 ligand (CD154) engagement is required but may not be sufficient for human T helper 1 cell induction of interleukin-2- or interleukin-15-driven, contact-dependent, interleukin-1beta production by monocytes, Immunology, 99, 279, 10.1046/j.1365-2567.2000.00948.x Ruchatz, 1998, Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology, J. Immunol., 160, 5654, 10.4049/jimmunol.160.11.5654 Thurkow, 1997, Increased expression of IL-15 in the synovium of patients with rheumatoid arthritis compared with patients with Yersinia-induced arthritis and osteoarthritis, J. Pathol., 181, 444, 10.1002/(SICI)1096-9896(199704)181:4<444::AID-PATH778>3.0.CO;2-O Vey, 1996, Expression and cleavage of tumor necrosis factor-alpha and tumor necrosis factor receptors by human monocytic cell lines upon direct contact with stimulated T cells, Eur. J. Immunol., 26, 2404, 10.1002/eji.1830261021 Waldmann, 1999, The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens, Ann. Rev. Immunol., 17, 19, 10.1146/annurev.immunol.17.1.19 Wei, 2001, Reduced incidence and severity of collagen-induced arthritis in mice lacking IL-18, J. Immunol., 166, 517, 10.4049/jimmunol.166.1.517