When words are painful: Unraveling the mechanisms of the nocebo effect

Amanzio, 1999, Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific sub-systems, J Neurosci, 19, 484, 10.1523/JNEUROSCI.19-01-00484.1999 Amanzio, 2001, Response variability to analgesics: a role for non-specific activation of endogenous opioids, Pain, 90, 205, 10.1016/S0304-3959(00)00486-3 Andre, 2005, Involvement of cholecystokininergic systems in anxiety-induced hyperalgesia in male rats: behavioral and biochemical studies, J Neurosci, 25, 7896, 10.1523/JNEUROSCI.0743-05.2005 Baber, 1989, The role of CCK caerulein, and CCK antagonists in nociception, Pain, 39, 307, 10.1016/0304-3959(89)90045-6 Barsky, 2002, Nonspecific medication side effects and the nocebo phenomenon, JAMA, 287, 622, 10.1001/jama.287.5.622 Beinfeld, 1983, Cholecystokinin in the central nervous system: a minireview, Neuropeptides, 3, 411, 10.1016/0143-4179(83)90032-X Benedetti, 1995, Potentiation of placebo analgesia by proglumide, Lancet, 346, 1231, 10.1016/S0140-6736(95)92938-X Benedetti, 1996, The opposite effects of the opiate antagonist naloxone and the cholecystokinin antagonist proglumide on placebo analgesia, Pain, 64, 535, 10.1016/0304-3959(95)00179-4 Benedetti, 1997, Cholecystokinin type-A and type-B receptors and their modulation of opioid analgesia, News Physiol Sci, 12, 263 Benedetti, 1997, The neurobiology of placebo analgesia: from endogenous opioids to cholecystokinin, Progr Neurobiol, 52, 109, 10.1016/S0301-0082(97)00006-3 Benedetti, 2006, The biochemical and neuroendocrine bases of the hyperalgesic nocebo effect, J Neurosci, 26, 12014, 10.1523/JNEUROSCI.2947-06.2006 Benedetti, 1997, Blockade of nocebo hyperalgesia by the cholecystokinin antagonist proglumide, Pain, 71, 135, 10.1016/S0304-3959(97)03346-0 Benedetti, 1999, Somatotopic activation of opioid systems by target-directed expectations of analgesia, J Neurosci, 19, 3639, 10.1523/JNEUROSCI.19-09-03639.1999 Benedetti, 2004, Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus, Nat Neurosci, 7, 587, 10.1038/nn1250 Benedetti, 2004, Placebo-induced analgesia: methodology, neurobiology, clinical use, and ethics, Rev Analg, 7, 129, 10.3727/000000003783992955 Benedetti, 2003, Open versus hidden medical treatments: the patient’s knowledge about a therapy affects the therapy outcome Benedetti, 2003, Conscious expectation and unconscious conditioning in analgesic, motor and hormonal placebo/nocebo responses, J Neurosci, 23, 4315, 10.1523/JNEUROSCI.23-10-04315.2003 Benedetti, 2005, Neurobiological mechanisms of the placebo effect, J Neurosci, 25, 10390, 10.1523/JNEUROSCI.3458-05.2005 Chiodo, 1983, Proglumide: selective antagonism of excitatory effects of cholecystokinin in the central nervous system, Science, 219, 1449, 10.1126/science.6828873 Chua, 1999, A functional anatomy of anticipatory anxiety, Neuroimage, 9, 563, 10.1006/nimg.1999.0407 Colloca, 2004, Overt versus covert treatment for pain, anxiety, and Parkinson’s disease, Lancet Neurol, 3, 679, 10.1016/S1474-4422(04)00908-1 Colloca, 2005, Placebos and painkillers: is mind as really as matter?, Nat Rev Neurosci, 6, 545, 10.1038/nrn1705 Crawley, 1994, Biological actions of cholecystokinin, Peptides, 15, 731, 10.1016/0196-9781(94)90104-X Dannecker, 2003, An examination of the relationships among recalled, expected, and actual intensity and unpleasantness of delayed onset muscle pain, J Pain, 4, 74, 10.1054/jpai.2003.7 de la Fuente-Fernandez, 2001, Expectation and dopamine release: mechanism of the placebo effect in Parkinson’s disease, Science, 293, 1164, 10.1126/science.1060937 Dourish, 1988, Enhancement of morphine analgesia and prevention of morphine tolerance in the rat by the cholecystokinin antagonist L-364,718, Eur J Pharmacol, 147, 469, 10.1016/0014-2999(88)90183-5 Dworkin, 1983, Cognitive reversal of expected nitrous oxide analgesia for acute pain, Anesth Analg, 62, 1073, 10.1213/00000539-198312000-00005 Finniss, 2005, Mechanisms of the placebo response and their impact on clinical trials and clinical practice, Pain, 114, 3, 10.1016/j.pain.2004.12.012 Flaten, 1999, Drug-related information generates placebo and nocebo responses that modify the drug response, Psychosom Med, 61, 250, 10.1097/00006842-199903000-00018 Frith, 1997, Brain mechanisms associated with top-down processes in perception, Philos Trans R Soc Lond B Biol Sci, 352, 1221, 10.1098/rstb.1997.0104 Gall, 1987, Co-localization of enkephalin and cholecystokinin in discrete areas of rat brain, Brain Res, 403, 403, 10.1016/0006-8993(87)90085-0 Gibbins, 1987, Pathway-specific patterns of the co-existence of substance P, calcitonin gene-related peptide, cholecystokinin and dynorphin in neurons of the dorsal root ganglia of the guinea-pig, Cell Tissue Res, 248, 417, 10.1007/BF00218210 Grevert, 1983, Partial antagonism of placebo analgesia by naloxone, Pain, 16, 129, 10.1016/0304-3959(83)90203-8 Hahn RA (1985) A sociocultural model of illness and healing. In: L. White, Tursky, B., Schwartz, G.E. (eds.), Placebo: Theory, Research, and Mechanisms, Guilford, New York, pp. 332–350. Hahn, 1997, The nocebo phenomenon: concept, evidence, and implications for public health, Prev Med, 26, 607, 10.1006/pmed.1996.0124 Harro, 1990, Anxiogenic-like action of caerulein, a CCK-8 receptor agonist, in the mouse: influence of acute and subchronic diazepam treatment, Naunyn Schmiedebergs Arch Pharmacol, 341, 62 Harro, 1991, Evidence that CCK-B receptors mediate the regulation of exploratory behaviour in the rat, Eur J Pharmacol, 193, 379, 10.1016/0014-2999(91)90156-K Hebb, 2005, Cholecystokinin and endogenous opioid peptides: interactive influence on pain, cognition, and emotion, Prog Neuropsychopharmacol Biol Psychiatry, 29, 1225, 10.1016/j.pnpbp.2005.08.008 Heinricher, 2001, Circuitry underlying antiopioid actions of cholecystokinin within the rostral ventromedial medulla, J Neurophysiol, 85, 280, 10.1152/jn.2001.85.1.280 Heinricher, 2004, Neural basis for the hyperalgesic action of cholecystokinin in the rostral ventromedial medulla, J Neurophysiol, 92, 1982, 10.1152/jn.00411.2004 Hoffman, 2005, Pain and the placebo: what we have learned, Perspect Biol Med, 48, 248, 10.1353/pbm.2005.0054 Hsieh, 1999, Anticipatory coping of pain expressed in the human anterior cingulated cortex: a positron emission tomography study, Neurosci Lett, 262, 61, 10.1016/S0304-3940(99)00060-9 Kantor, 1966, Oral analgesic studies: pentazocine hydrochloride, codeine, aspirin, and placebo and their influence on response to placebo, Clin Pharmacol Ther, 7, 447, 10.1002/cpt196674447 Keltner, 2006, Isolating the modulatory effect of expectation on pain transmission: a functional magnetic resonance imaging study, J Neurosci, 26, 4437, 10.1523/JNEUROSCI.4463-05.2006 Kennedy, 1961, The nocebo reaction, Med Exp Int J Exp Med, 95, 203 Kissel, 1964 Koyama, 1998, Nociceptive neurons in the macaque anterior cingulated activate during anticipation of pain, Neuroreport, 9, 2663, 10.1097/00001756-199808030-00044 Koyama, 2005, The subjective experience of pain: where expectations become reality, Proc Natl Acad Sci U S A, 102, 12950, 10.1073/pnas.0408576102 Laska, 1973, Anticipation of analgesia, Headache, 13, 1, 10.1111/j.1526-4610.1973.hed1301001.x Lavigne, 1989, Proglumide potentiates morphine analgesia for acute postsurgical pain, Clin Pharmacol Ther, 45, 666, 10.1038/clpt.1989.88 Leuchter, 2002, Changes in brain function of depressed subjects during treatment with placebo, Am J Psychiatry, 159, 122, 10.1176/appi.ajp.159.1.122 Levine, 1978, The mechanism of placebo analgesia, Lancet, 2, 654, 10.1016/S0140-6736(78)92762-9 Levine, 1981, Analgesic responses to morphine and placebo in individuals with postoperative pain, Pain, 10, 379, 10.1016/0304-3959(81)90099-3 Lorenz, 2005, Cortical correlates of false expectations during pain intensity judgments: a possible manifestation of placebo/nocebo cognitions, Brain Behav Immun, 19, 283, 10.1016/j.bbi.2005.03.010 Maldonado, 1993, Association of the peptidase inhibitor RB 101 and CCK-B antagonist strongly enhances antinociceptive responses, Neuroreport, 4, 947, 10.1097/00001756-199307000-00028 Mayberg, 2002, The functional neuroanatomy of the placebo effect, Am J Psychiatry, 159, 728, 10.1176/appi.ajp.159.5.728 Mercado, 2006, Expectation and the placebo effect in Parkinson’s disease patients with subthalamic nucleus deep brain stimulation, Mov Disord, 21, 1457, 10.1002/mds.20935 Mesulam, 1998, From sensation to cognition, Brain, 121, 1013, 10.1093/brain/121.6.1013 Mitchell, 1998, The contribution of the rostral ventromedial medulla to the antinociceptive effects of systemic morphine in restrained and unrestrained rats, Neuroscience, 87, 123, 10.1016/S0306-4522(98)00119-5 Noble, 1993, Modulation of opioid antinociception by CCK at the supraspinal level: evidence of regulatory mechanisms between CCK and enkephalin systems in the control pain, Br J Pharmacol, 109, 1064, 10.1111/j.1476-5381.1993.tb13730.x Noble, 1999, XXI. Structure, disribution, and functions of cholecystokinin receptors, Pharmacol Rev, 51, 745 Pacheco-Lopez, 2006, Expectations and associations that heal: immunomodulatory placebo effects and its neurobiology, Brain Behav Immun, 20, 430, 10.1016/j.bbi.2006.05.003 Pessoa, 2003, Neuroimaging studies of attention: from modulation of sensory processing to top-down control, J Neurosci, 23, 3990, 10.1523/JNEUROSCI.23-10-03990.2003 Petrovic, 2002, Placebo and opioid analgesia: imaging a shared neuronal network, Science, 295, 1737, 10.1126/science.1067176 Ploghaus, 1999, Dissociating pain from its anticipation in the human brain, Science, 284, 1979, 10.1126/science.284.5422.1979 Pollo, 2002, Expectation modulates the response to subthalamic nucleus stimulation in Parkinsonian patients, Neuroreport, 13, 1383, 10.1097/00001756-200208070-00006 Porro, 2002, Does anticipation of pain affect cortical nociceptive systems?, J Neurosci, 22, 3206, 10.1523/JNEUROSCI.22-08-03206.2002 Porro, 2003, Functional activity mapping of the mesial hemispheric wall during anticipation of pain, Neuroimage, 19, 1738, 10.1016/S1053-8119(03)00184-8 Price, 1985, Potentiation of systemic morphine analgesia in humans by proglumide, a cholecystokinin antagonist, Anesth Analg, 64, 801, 10.1213/00000539-198508000-00010 Price, 2000, Psychological and neural mechanisms of the affective dimension of pain, Science, 288, 1769, 10.1126/science.288.5472.1769 Price, 2001, Assessing placebo effects without placebo groups: an untapped possibility?, Pain, 90, 201, 10.1016/S0304-3959(01)00265-2 Price, 2006, Placebo analgesia is accompanied by large reductions in pain-related brain activity in irritable bowel syndrome patients, Pain, 127, 63 Sawamoto, 2000, Expectation of pain enhances responses to nonpainful somatosensory stimulation in the anterior cingulated cortex and parietal operculum/posterior insula: an event-related functional magnetic resonance imaging study, J Neurosci, 20, 7438, 10.1523/JNEUROSCI.20-19-07438.2000 Stengaard-Pedersen, 1981, Localization and opiate binding of enkephalin, CCK and ACTH/beta-endorphin in the rat central nervous system, Peptides, 2, 3, 10.1016/0196-9781(81)90050-4 Suberg, 1985, Behavioral and electrophysiological investigations of opiate/cholecystokinin interactions, Vol 9, 541 Valverde, 1994, Cholecystokinin B antagonists strongly potentiate antinociception mediated by endogenous enkephalins, J Pharmacol Exp Ther, 270, 77 Vanderhaeghen, 1975, New peptide in the vertebrate CNS reacting with antigastrin antibodies, Nature, 257, 604, 10.1038/257604a0 van Megen, 1994, On the significance of cholecystokinin receptors in panic disorder, Prog Neuropsychopharmacol Biol Psychiatry, 18, 1235, 10.1016/0278-5846(94)90090-6 Wager, 2004, Placebo-induced changes in FMRI in the anticipation and experience of pain, Science, 303, 1162, 10.1126/science.1093065 Watkins, 1985, Potentiation of morphine analgesia by the cholecystokinin antagonist proglumide, Brain Res, 327, 169, 10.1016/0006-8993(85)91511-2 Watkins, 1985, Cholecystokinin antagonists selectively potentiate analgesia induced by endogenous opiates, Brain Res, 327, 181, 10.1016/0006-8993(85)91512-4 Wiesenfeld-Hallin, 1990, PD134308, a selective antagonist of cholecystokinin type B receptor, enhances the analgesic effect of morphine and synergistically interacts with intrathecal galanin to depress spinal nociceptive reflexes, Proc Natl Acad Sci U S A, 87, 7105, 10.1073/pnas.87.18.7105 Xu, 1994, The CCK-B antagonist CI988 enhances the reflex-depressive effect of morphine in axotomized rats, Neuroreport, 5, 718, 10.1097/00001756-199402000-00015 Zubieta, 2005, Placebo effects mediated by endogenous opioid activity on μ-opioid receptors, J Neurosci, 25, 7754, 10.1523/JNEUROSCI.0439-05.2005