The K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation

Nature - Tập 397 Số 6716 - Trang 251-255 - 1999
Claudio Rivera1, Juha Voipio1, John A. Payne2, Eva Ruusuvuori1, Hannele Lahtinen1, Karri Lämsä1, Ulla Pirvola3, Märt Saarma3, Kai Kaila1
1Department of Biosciences, Division of Animal Physiology,
2Department of Human Physiology, University of California School of Medicine, Davis, 95616, California, USA
3Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Helsinki , FIN-00014, Finland

Tóm tắt

Từ khóa


Tài liệu tham khảo

Kaila, K. Ionic basis of GABAAreceptor channel function in the nervous system. Prog. Neurobiol. 42, 489– 537 (1994).

Ben-Ari, Y., Cherubini, E., Corradetti, R. & Gaiarsa, J. L. Giant synaptic potentials in immature rat CA3 hippocampal neurones. J. Physiol. (Lond.) 416, 303–325 (1989).

Cherubini, E., Gaiarsa, J. L. & Ben-Ari, Y. GABA: an excitatory transmitter in early postnatal life. Trends Neurosci. 14, 515– 519 (1991).

Serafini, R., Valeyev, A. Y., Barker, J. L. & Poulter, M. O. Depolarizing GABA-activated Cl− channels in embryonic rat spinal and olfactory bulb cells. J. Physiol. (Lond.) 488, 371–386 (1995).

Yuste, R. & Katz, L. Control of postsynaptic Ca2+ influx in developing neocortex by excitatory and inhibitory neurotransmitters. Neuron 6, 333–344 (1991).

LoTurco, J., Owens, D., Heath, M., Davis, M. & Kriegstein, A. GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis. Neuron 15, 1287 –1298 (1995).

Payne, J. A., Stevenson, J. & Donaldson, L. Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronal-specific isoform. J. Biol. Chem. 271, 16245–16252 (1996).

Gillen, C., Brill, S., Payne, J. A. & Forbush, B. II Molecular cloning and functional expression of the K-Cl cotransporter from rabbit, rat, and human. A new member of the cation-chloride cotransporter family. J. Biol. Chem. 271, 16237–16244 (1993).

Payne, J. A. Functional characterization of the neuronal-specific K-Cl cotransporter KCC2: Implications for [K+]0regulation. Am. J. Physiol. 42, C1516–C1525 (1997).

Misgeld, U., Deisz, R. A., Dodt, H. U. & Lux, H. D. The role of chloride transport in postsynaptic inhibition of hippocampal neurons. Science 232, 1413–1415 (1986).

Thompson, S. M. & Gähwiler, B. H. Activity-dependent disinhibition. II. Effect of extracellular potassium, furosemide, and membrane potential on E cl - in hippocampal CA3 neurons. J. Neurophysiol. 61, 512–523 (1989).

Deschenes, M., Feltz, P. & Lamour, Y. Amodel for an estimate in vivo of the ionic basis of presynaptic inhibition: an intracellular analysis of the GABA-induced depolarization in rat dorsal root ganglia. Brain Res. 118, 486–493 (1976).

Bayer, S. A. & Altman, J. Directions in neurogenetic gradients and patterns of anatomical connections in the telencephalon. Prog. Neurobiol. 29, 57–106 ( 1987).

Rivera, C., Wegelius, K., Reeben, M., Saarma, M. & Kaila, K. Developmental regulation of K-Cl cotransporter (KCC2 and KCC1) mRNA in early postnatal rat hippocampus. Soc. Neurosci. Abstr. 23, 26.7 (1997).

Clayton, G. H., Owens, G. C., Wolff, J. S. & Smith, R. L. Ontogeny of cation-Cl cotransporter expression in rat neocortex. Brain Res. Dev. Brain Res. 109, 281– 292 (1998).

Stoppini, L., Buchs, P. A. & Muller, D. Asimple method for organotypic cultures of nervous tissue. J. Neurosci. Methods 37, 173– 182 (1991).

Bevensee, M. O. & Boron, W. F. in pH and Brain Function(eds Kaila, K. & Ransom, B.) 211–231 (Wiley, New York, (1998)).

Kaila, K., Voipio, J., Paalasmaa, P., Pasternack, M. & Deisz, R. A. The role of bicarbonate in GABA Areceptor-mediated IPSPs of rat neocortical neurons. J. Physiol. (Lond.) 464, 273–289 ( 1993).

Clayton, G. H., Staley, K. J., Wilcox, C. L., Owens, G. C. & Smith, R. L. Developmental expression of CLC-2 in the rat nervous system. Brain Res. Dev. Brain Res. 108, 307–318 (1998).

Zhang, L., Spiegelman, I. & Carlen, P. Development of GABA-mediated chloride-dependent inhibition in CA1 pyramidal neurones of immature rat hippocampal slices. J. Physiol. (Lond.) 444, 25–49 (1991).

Sutor, B. & Luhmann, H. Development of exitatory and inhibitory postsynaptic potentials in the rat neocortex. Perspectives Dev. Neurobiol. 2, 409–419 ( 1994).

Wu, W. L., Ziskind-Conhaim, L. & Sweet, M. A. Early development of glycine and GABA mediated synapses in rat spinal cord. J. Neurosci. 12, 3935 –3945 (1992).

van den Pol, A. N., Obrietan, K. & Chen, G. Exitatory action of GABA after neuronal trauma. J. Neurosci. 16, 4283–4292 (1996).

Chomczynski, P. & Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chlorophorm extraction. Anal. Biochem. 162, 156–159 (1987).

Pasternack, M., Smirnov, S. & Kaila, K. Proton modulation of functionally distinct GABAAreceptors in acutely isolated pyramidal neurons of rat hippocampus. Neuropharmacology 35, 1279–1288 ( 1996).

Moshnyakov, M., Arumäe, U. & Saarma, M. mRNAs for one two or three members of trk receptor family are expressed in single rat trigeminal ganglion neurons. Mol. Brain Res. 43, 141–148 ( 1996).

Bengström, M. & Paulin, L. Synthesis and purification of thio-oligonucleotides. Nucleic Acids Symp. Ser. 24, 288 (1991).

Pirvola, U. et al. Brain-derived neurotrophic factor and neurotrophin 3 mRNAs in the peripheral target fields of developing inner ear ganglia. Proc. Natl Acad. Sci. USA 89, 9915–9919 (1992).