The light and the dark sides of Interleukin-10 in immune-mediated diseases and cancer.
Tài liệu tham khảo
Moore, 2001, Interleukin-10 and the interleukin-10 receptor, Annu. Rev. Immunol., 19, 683, 10.1146/annurev.immunol.19.1.683
Sabat, 2010, Biology of interleukin-10, Cytokine Growth Factor Rev., 21, 331, 10.1016/j.cytogfr.2010.09.002
Groux, 1997, A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis, Nature, 389, 737, 10.1038/39614
Haringer, 2009, Identification and characterization of IL-10/IFN-gamma-producing effector-like T cells with regulatory function in human blood, J. Exp. Med., 206, 1009, 10.1084/jem.20082238
Sanjabi, 2009, Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity, Curr. Opin. Pharmacol., 9, 447, 10.1016/j.coph.2009.04.008
Kuhn, 1993, Interleukin-10-deficient mice develop chronic enterocolitis, Cell, 75, 263, 10.1016/0092-8674(93)80068-P
Sellon, 1998, Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice, Infect. Immun., 66, 5224, 10.1128/IAI.66.11.5224-5231.1998
Glocker, 2011, IL-10 and IL-10 receptor defects in humans, Ann. N.Y. Acad. Sci., 1246, 102, 10.1111/j.1749-6632.2011.06339.x
Zigmond, 2014, Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis, Immunity, 40, 720, 10.1016/j.immuni.2014.03.012
Shouval, 2014, Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function, Immunity, 40, 706, 10.1016/j.immuni.2014.03.011
Huber, 2011, Th17 cells express interleukin-10 receptor and are controlled by Foxp3 and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner, Immunity, 34, 554, 10.1016/j.immuni.2011.01.020
Kamanaka, 2011, Memory/effector (CD45RB(lo)) CD4 T cells are controlled directly by IL-10 and cause IL-22-dependent intestinal pathology, J. Exp. Med., 208, 1027, 10.1084/jem.20102149
Kullberg, 2003, Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope, Proc. Natl. Acad. Sci. U. S. A., 100, 15830, 10.1073/pnas.2534546100
Yang, 2014, Focused specificity of intestinal TH17 cells towards commensal bacterial antigens, Nature, 510, 152, 10.1038/nature13279
Esplugues, 2011, Control of TH17 cells occurs in the small intestine, Nature, 475, 514, 10.1038/nature10228
Chaudhry, 2011, Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation, Immunity, 34, 566, 10.1016/j.immuni.2011.03.018
Davidson, 1996, T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice, J. Exp. Med., 184, 241, 10.1084/jem.184.1.241
Miyara, 2011, Human FoxP3(+)CD4(+) regulatory T cells: their knowns and unknowns, Immunol. Cell Biol., 89, 346, 10.1038/icb.2010.137
Rubtsov, 2008, Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces, Immunity, 28, 546, 10.1016/j.immuni.2008.02.017
Asseman, 1999, An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation, J. Exp. Med., 190, 995, 10.1084/jem.190.7.995
Gagliani, 2013, Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells, Nat. Med., 10.1038/nm.3179
Facciotti, 2016, IL-10-producing forkhead box protein 3-negative regulatory T cells inhibit B-cell responses and are involved in systemic lupus erythematosus, J. Allergy Clin. Immunol., 137, 318, 10.1016/j.jaci.2015.06.044
Geginat, 2014, Plasticity of human CD4 T cell subsets, Front. Immunol., 5, 630, 10.3389/fimmu.2014.00630
Jeon, 2012, Probiotic Bifidobacterium breve induces IL-10-producing Tr1 cells in the colon, PLoS Pathog., 8, e1002714, 10.1371/journal.ppat.1002714
Desreumaux, 2012, Safety and efficacy of antigen-specific regulatory T-cell therapy for patients with refractory Crohn’s disease, Gastroenterology, 143, 1207, 10.1053/j.gastro.2012.07.116
Gambineri, 2003, Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis, Curr. Opin. Rheumatol., 15, 430, 10.1097/00002281-200307000-00010
Moes, 2010, Reduced expression of FOXP3 and regulatory T-cell function in severe forms of early-onset autoimmune enteropathy, Gastroenterology, 139, 770, 10.1053/j.gastro.2010.06.006
Passerini, 2011, Functional type 1 regulatory T cells develop regardless of FOXP3 mutations in patients with IPEX syndrome, Eur. J. Immunol., 41, 1120, 10.1002/eji.201040909
Li, 2008, TGF-beta: a master of all T cell trades, Cell, 134, 392, 10.1016/j.cell.2008.07.025
Fahlen, 2005, T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells, J. Exp. Med., 201, 737, 10.1084/jem.20040685
Li, 2007, T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation, Immunity, 26, 579, 10.1016/j.immuni.2007.03.014
Sledzinska, 2013, TGF-beta signalling is required for CD4(+) T cell homeostasis but dispensable for regulatory T cell function, PLoS Biol., 11, e1001674, 10.1371/journal.pbio.1001674
Maynard, 2007, Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10, Nat. Immunol., 8, 931, 10.1038/ni1504
Yen, 2006, IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6, J. Clin. Invest., 116, 1310, 10.1172/JCI21404
Berg, 1996, Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses, J. Clin. Invest., 98, 1010, 10.1172/JCI118861
Ramesh, 2014, Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids, J. Exp. Med., 211, 89, 10.1084/jem.20130301
Heinemann, 2014, IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1, Nat. Commun., 5, 3770, 10.1038/ncomms4770
Astier, 2007, Abnormal Tr1 differentiation in multiple sclerosis, J. Neuroimmunol., 191, 70, 10.1016/j.jneuroim.2007.09.018
Rousset, 1992, Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes, Proc. Natl. Acad. Sci. U. S. A., 89, 1890, 10.1073/pnas.89.5.1890
Ma, 2005, Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells, J. Clin. Invest., 115, 1049, 10.1172/JCI200523139
Bryant, 2007, Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells, J. Immunol., 179, 8180, 10.4049/jimmunol.179.12.8180
Avery, 2008, STAT3 is required for IL-21-induced secretion of IgE from human naive B cells, Blood, 112, 1784, 10.1182/blood-2008-02-142745
Yoon, 2009, IL-21 and IL-10 have redundant roles but differential capacities at different stages of plasma cell generation from human germinal center B cells, J. Leukoc. Biol., 86, 1311, 10.1189/jlb.0409268
Apetoh, 2010, The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27, Nat. Immunol., 11, 854, 10.1038/ni.1912
Pot, 2009, Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells, J. Immunol., 183, 797, 10.4049/jimmunol.0901233
Kastirr, 2014, IL-21 is a central memory t cell-Associated cytokine that inhibits the generation of pathogenic th1/17 effector cells, J. Immunol., 10.4049/jimmunol.1400775
Spolski, 2009, Leonard WJ. IL-21 mediates suppressive effects via its induction of IL-10, J. Immunol., 182, 2859, 10.4049/jimmunol.0802978
Banchereau, 1994, The CD40 antigen and its ligand, Annu. Rev. Immunol., 12, 881, 10.1146/annurev.iy.12.040194.004313
Laman, 1996, Functions of CD40 and its ligand, gp39 (CD40L), Crit. Rev. Immunol., 16, 59, 10.1615/CritRevImmunol.v16.i1.40
Frentsch, 2005, Direct access to CD4+ T cells specific for defined antigens according to CD154 expression, Nat. Med., 11, 1118, 10.1038/nm1292
Rivino, 2010, CCR6 is expressed on an IL-10-producing, autoreactive memory T cell population with context-dependent regulatory function, J. Exp. Med., 207, 565, 10.1084/jem.20091021
Jin, 2004, Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis, J. Immunol., 173, 657, 10.4049/jimmunol.173.1.657
Okamura, 2015, TGF-beta3-expressing CD4+CD25(−)LAG3+ regulatory T cells control humoral immune responses, Nat. Commun., 6, 6329, 10.1038/ncomms7329
Kim, 2001, Subspecialization of CXCR5+ T cells: b helper activity is focused in a germinal center-localized subset of CXCR5+ T cells, J. Exp. Med., 193, 1373, 10.1084/jem.193.12.1373
Geginat, 2013, The CD4-centered universe of human T cell subsets, Semin. Immunol., 25, 252, 10.1016/j.smim.2013.10.012
Crotty, 2011, Follicular helper CD4T cells (TFH), Annu. Rev. Immunol., 29, 621, 10.1146/annurev-immunol-031210-101400
Schoenbrunn, 2012, A converse 4-1BB and CD40 ligand expression pattern delineates activated regulatory T cells (Treg) and conventional T cells enabling direct isolation of alloantigen-reactive natural Foxp3+ Treg, J. Immunol., 189, 5985, 10.4049/jimmunol.1201090
Linterman, 2011, Foxp3+ follicular regulatory T cells control the germinal center response, Nat. Med., 17, 975, 10.1038/nm.2425
Peng, 2013, Role of interleukin-10 and interleukin-10 receptor in systemic lupus erythematosus, Clin. Rheumatol., 10.1007/s10067-013-2294-3
Gualtierotti, 2010, Updating on the pathogenesis of systemic lupus erythematosus, Autoimmun. Rev., 10, 3, 10.1016/j.autrev.2010.09.007
Pan, 2013, Decreased serum level of IL-21 in new-onset systemic lupus erythematosus patients, Rheumatol. Int., 33, 2337, 10.1007/s00296-013-2724-1
Llorente, 1995, Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus, J. Exp. Med., 181, 839, 10.1084/jem.181.3.839
Llorente, 2000, Clinical and biologic effects of anti-interleukin-10 monoclonal antibody administration in systemic lupus erythematosus, Arthritis Rheum., 43, 1790, 10.1002/1529-0131(200008)43:8<1790::AID-ANR15>3.0.CO;2-2
Ishida, 1994, Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice, J. Exp. Med., 179, 305, 10.1084/jem.179.1.305
Blanco, 2015, T follicular helper (Tfh) cells in lupus: activation and involvement in SLE pathogenesis, Eur. J. Immunol., 46, 281, 10.1002/eji.201545760
Linterman, 2009, Follicular helper T cells are required for systemic autoimmunity, J. Exp. Med., 206, 561, 10.1084/jem.20081886
Mitsdoerffer, 2010, Proinflammatory T helper type 17 cells are effective B-cell helpers, Proc. Natl. Acad. Sci. U. S. A., 107, 14292, 10.1073/pnas.1009234107
Hirota, 2013, Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses, Nat. Immunol., 14, 372, 10.1038/ni.2552
Steinfelder, 2011, Epigenetic modification of the human CCR6 gene is associated with stable CCR6 expression in T cells, Blood, 117, 2839, 10.1182/blood-2010-06-293027
Acosta-Rodriguez, 2007, Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells, Nat. Immunol., 8, 639, 10.1038/ni1467
Lim, 2007, Loss of IL-7 receptor alpha on CD4+ T cells defines terminally differentiated B cell-helping effector T cells in a B cell-rich lymphoid tissue, J. Immunol., 179, 7448, 10.4049/jimmunol.179.11.7448
Finke, 2009, Endogenous type I interferon inducers in autoimmune diseases, Autoimmunity, 42, 349, 10.1080/08916930902831829
Le Buanec, 2011, IFN-alpha and CD46 stimulation are associated with active lupus and skew natural T regulatory cell differentiation to type 1 regulatory T (Tr1) cells, Proc. Natl. Acad. Sci. U. S. A., 108, 18995, 10.1073/pnas.1113301108
Fuchs, 2009, CD46-induced human treg enhance B-cell responses, Eur. J. Immunol., 39, 3097, 10.1002/eji.200939392
Wu, 2008, Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells, J. Immunol., 181, 6038, 10.4049/jimmunol.181.9.6038
Mellor-Pita, 2009, Monocytes and T lymphocytes contribute to a predominance of interleukin 6 and interleukin 10 in systemic lupus erythematosus, Cytom. B Clin. Cytom., 76, 261, 10.1002/cyto.b.20468
Joo, 2012, Serum from patients with SLE instructs monocytes to promote IgG and IgA plasmablast differentiation, J. Exp. Med., 209, 1335, 10.1084/jem.20111644
Llorente, 1993, Spontaneous production of interleukin-10 by B lymphocytes and monocytes in systemic lupus erythematosus, Eur. Cytokine Netw., 4, 421
DiMartino, 2008, Insoluble immune complexes are most effective at triggering IL-10 production in human monocytes and synergize with TLR ligands and C5a, Clin. Immunol., 127, 56, 10.1016/j.clim.2007.11.014
Fillatreau, 2002, B cells regulate autoimmunity by provision of IL-10, Nat. Immunol., 3, 944, 10.1038/ni833
Blair, 2010, CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients, Immunity, 32, 129, 10.1016/j.immuni.2009.11.009
Heine, 2014, Autocrine IL-10 promotes human B-cell differentiation into IgM- or IgG-secreting plasmablasts, Eur. J. Immunol., 44, 1615, 10.1002/eji.201343822
Kyriakidis, 2014, A comprehensive review of autoantibodies in primary Sjogren’s syndrome: clinical phenotypes and regulatory mechanisms, J. autoimmun., 51, 67, 10.1016/j.jaut.2013.11.001
Chen, 1991, IL-10: a novel cytotoxic T cell differentiation factor, J Immunol., 147, 528, 10.4049/jimmunol.147.2.528
Groux, 1998, Inhibitory and stimulatory effects of IL-10 on human CD8+ T cells, J. Immunol., 160, 3188, 10.4049/jimmunol.160.7.3188
Mocellin, 2004, IL-10 stimulatory effects on human NK cells explored by gene profile analysis, Genes Immun., 5, 621, 10.1038/sj.gene.6364135
Emmerich, 2012, IL-10 directly activates and expands tumor-resident CD8(+) T cells without de novo infiltration from secondary lymphoid organs, Cancer Res., 72, 3570, 10.1158/0008-5472.CAN-12-0721
Balasa, 1998, IL-10 impacts autoimmune diabetes via a CD8+ T cell pathway circumventing the requirement for CD4+ T and B lymphocytes, J. Immunol., 161, 4420, 10.4049/jimmunol.161.8.4420
Mumm, 2011, IL-10 elicits IFNgamma-dependent tumor immune surveillance, Cancer Cell, 20, 781, 10.1016/j.ccr.2011.11.003
Neven, 2013, A Mendelian predisposition to B-cell lymphoma caused by IL-10R deficiency, Blood, 122, 3713, 10.1182/blood-2013-06-508267
Oft, 2013, No immunosurveillance in human IL-10R deficiency, Blood, 122, 3702, 10.1182/blood-2013-10-531657
Jankovic, 2007, Conventional T-bet(+) Foxp3(−) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection, J. Exp. Med., 204, 273, 10.1084/jem.20062175
Geginat, 2015, Immunity to pathogens taught by specialized human dendritic cell subsets, Front. Immunol., 6, 527, 10.3389/fimmu.2015.00527
Schoenberger, 1998, T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions, Nature, 393, 480, 10.1038/31002
Nizzoli, 2013, Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T cell responses, Blood, 10.1182/blood-2013-04-495424
Geginat, 2003, Proliferation and differentiation potential of human CD8+ memory T-cell subsets in response to antigen or homeostatic cytokines, Blood, 101, 4260, 10.1182/blood-2002-11-3577
Feau, 2011, Autocrine IL-2 is required for secondary population expansion of CD8(+) memory T cells, Nat. Immunol., 12, 908, 10.1038/ni.2079
Noelle, 1992, CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation, Immunol. Today, 13, 431, 10.1016/0167-5699(92)90068-I
Cui, 2011, An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells, Immunity, 35, 792, 10.1016/j.immuni.2011.09.017
Laidlaw, 2015, Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells, Nat. Immunol., 16, 871, 10.1038/ni.3224
Sato, 2011, Interleukin 10 in the tumor microenvironment: a target for anticancer immunotherapy, Immunol. Res., 51, 170, 10.1007/s12026-011-8262-6
Mannino, 2015, The paradoxical role of IL-10 in immunity and cancer, Cancer Lett., 367, 103, 10.1016/j.canlet.2015.07.009
Dennis, 2013, Current status of interleukin-10 and regulatory T-cells in cancer, Curr. Opin. Oncol., 25, 637, 10.1097/CCO.0000000000000006
Herbst, 1996, Frequent expression of interleukin-10 by Epstein-Barr virus-harboring tumor cells of Hodgkin’s disease, Blood, 87, 2918, 10.1182/blood.V87.7.2918.bloodjournal8772918
Huber, 2012, IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine, Nature, 491, 259, 10.1038/nature11535
Schreiber, 2000, Safety and efficacy of recombinant human interleukin 10 in chronic active Crohn’s disease: crohn's Disease IL-10Cooperative Study Group, Gastroenterology, 119, 1461, 10.1053/gast.2000.20196
