Endocrine Regulation of Male Fertility by the Skeleton

Cell - Tập 144 - Trang 796-809 - 2011
Franck Oury1, Grzegorz Sumara1, Olga Sumara1, Mathieu Ferron2, Haixin Chang3, Charles E. Smith4, Louis Hermo4, Susan Suarez3, Bryan L. Roth5, Patricia Ducy6, Gerard Karsenty1
1Department of Genetics and Development, Columbia University, New York, NY 10032 USA
2Department of Genetics and Development, Columbia University, New York, NY 10032, USA
3Department of Biomedical Sciences, Cornell University, T5-006 Veterinary Research Tower, Ithaca, NY 14853, USA
4Department of Anatomy and Cell Biology, McGill University, 3640 University Street, Montreal, Quebec, H3A 2B2, Canada
5Department of Pharmacology, Medicinal Chemistry and Natural Products and National Institute of Mental Health Psychoactive Drug Screening Program, Schools of Medicine and Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
6Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA

Tài liệu tham khảo

Basura, 2008, Ontogeny of serotonin and serotonin2A receptors in rat auditory cortex, Hear. Res., 244, 45, 10.1016/j.heares.2008.07.009 Bremner, 1994, Immunohistochemical localization of androgen receptors in the rat testis: evidence for stage-dependent expression and regulation by androgens, Endocrinology, 135, 1227, 10.1210/endo.135.3.8070367 Bridges, 2008, Generation of Cyp17iCre transgenic mice and their application to conditionally delete estrogen receptor alpha (Esr1) from the ovary and testis, Genesis, 46, 499, 10.1002/dvg.20428 Brinkworth, 1995, Identification of male germ cells undergoing apoptosis in adult rats, J. Reprod. Fertil., 105, 25, 10.1530/jrf.0.1050025 Dacquin, 2002, Mouse alpha1(I)-collagen promoter is the best known promoter to drive efficient Cre recombinase expression in osteoblast, Dev. Dyn., 224, 245, 10.1002/dvdy.10100 Dacquin, 2004, Knock-in of nuclear localised beta-galactosidase reveals that the tyrosine phosphatase Ptprv is specifically expressed in cells of the bone collar, Dev. Dyn., 229, 826, 10.1002/dvdy.20003 Dakhova, 2009, Dickkopf-like1 regulates postpubertal spermatocyte apoptosis and testosterone production, Endocrinology, 150, 404, 10.1210/en.2008-0673 De Gendt, 2004, A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis, Proc. Natl. Acad. Sci. USA, 101, 1327, 10.1073/pnas.0308114100 Ducy, 2000, Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass, Cell, 100, 197, 10.1016/S0092-8674(00)81558-5 Dufau, 2007, Gonadotropin-regulated testicular helicase (GRTH/DDX25): an essential regulator of spermatogenesis, Trends Endocrinol. Metab., 18, 314, 10.1016/j.tem.2007.09.001 Feldman, 2002, Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study, J. Clin. Endocrinol. Metab., 87, 589, 10.1210/jcem.87.2.8201 Ferron, 2008, Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice, Proc. Natl. Acad. Sci. USA, 105, 5266, 10.1073/pnas.0711119105 Ferron, 2010, Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism, Cell, 142, 296, 10.1016/j.cell.2010.06.003 Fukumoto, 2007, FGF23 is a hormone-regulating phosphate metabolism—unique biological characteristics of FGF23, Bone, 40, 1190, 10.1016/j.bone.2006.12.062 Fulzele, 2010, Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition, Cell, 142, 309, 10.1016/j.cell.2010.06.002 Gray, 1991, An examination of research design effects on the association of testosterone and male aging: results of a meta-analysis, J. Clin. Epidemiol., 44, 671, 10.1016/0895-4356(91)90028-8 Harada, 2003, Control of osteoblast function and regulation of bone mass, Nature, 423, 349, 10.1038/nature01660 Henriksén, 1995, Testosterone inhibits and induces apoptosis in rat seminiferous tubules in a stage-specific manner: in situ quantification in squash preparations after administration of ethane dimethane sulfonate, Endocrinology, 136, 3285, 10.1210/endo.136.8.7628362 Hunter, 1982, The functional activity of adult mouse Leydig cells in monolayer culture. Effect of lutropin and foetal calf serum, Mol. Cell. Endocrinol., 25, 35, 10.1016/0303-7207(82)90167-8 Jamin, 2003, Genetic studies of the AMH/MIS signaling pathway for Müllerian duct regression, Mol. Cell. Endocrinol., 211, 15, 10.1016/j.mce.2003.09.006 Kanazawa, 2010, Serum osteocalcin level is positively associated with insulin sensitivity and secretion in patients with type 2 diabetes, Bone Karsenty, 2006, Convergence between bone and energy homeostases: leptin regulation of bone mass, Cell Metab., 4, 341, 10.1016/j.cmet.2006.10.008 Karsenty, 2009, Genetic control of bone formation, Annu. Rev. Cell Dev. Biol., 25, 629, 10.1146/annurev.cellbio.042308.113308 Khosla, 2001, Relationship of serum sex steroid levels to longitudinal changes in bone density in young versus elderly men, J. Clin. Endocrinol. Metab., 86, 3555, 10.1210/jcem.86.8.7736 Lee, 2007, Endocrine regulation of energy metabolism by the skeleton, Cell, 130, 456, 10.1016/j.cell.2007.05.047 Manolagas, 2002, Sex steroids and bone, Recent Prog. Horm. Res., 57, 385, 10.1210/rp.57.1.385 Nakamura, 2007, Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts, Cell, 130, 811, 10.1016/j.cell.2007.07.025 Nelson, 2001, Estrogen production and action, J. Am. Acad. Dermatol., 45, S116, 10.1067/mjd.2001.117432 Pi, 2005, Identification of a novel extracellular cation-sensing G-protein-coupled receptor, J. Biol. Chem., 280, 40201, 10.1074/jbc.M505186200 Pi, 2008, GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome, PLoS ONE, 3, e3858, 10.1371/journal.pone.0003858 Pi, 2010, GPRC6A mediates the non-genomic effects of steroids, J Biol. Chem., 285, 39953, 10.1074/jbc.M110.158063 Powlin, 1998, Ex vivo and in vitro testis and ovary explants: utility for identifying steroid biosynthesis inhibitors and comparison to a Tier I screening battery, Toxicol. Sci., 46, 61 Quigley, 2002, Editorial: The postnatal gonadotropin and sex steroid surge-insights from the androgen insensitivity syndrome, J. Clin. Endocrinol. Metab., 87, 24 Riggs, 1998, Long-term effects of calcium supplementation on serum parathyroid hormone level, bone turnover, and bone loss in elderly women, J. Bone Miner. Res., 13, 168, 10.1359/jbmr.1998.13.2.168 Rodan, 2000, Therapeutic approaches to bone diseases, Science, 289, 1508, 10.1126/science.289.5484.1508 Russell, 1990 Saleem, 2010, Serum osteocalcin is associated with measures of insulin resistance, adipokine levels, and the presence of metabolic syndrome, Arterioscler. Thromb. Vasc. Biol., 30, 1474, 10.1161/ATVBAHA.110.204859 Schumacher, 1978, Rapid isolation of mouse Leydig cells by centrifugation in Percoll density gradients with complete retention of morphological and biochemical integrity, FEBS Lett., 91, 333, 10.1016/0014-5793(78)81204-6 Sharpe, 1992, Testosterone and spermatogenesis. Identification of stage-specific, androgen-regulated proteins secreted by adult rat seminiferous tubules, J. Androl., 13, 172 Sheng, 2006, Gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is a transport protein involved in gene-specific mRNA export and protein translation during spermatogenesis, J. Biol. Chem., 281, 35048, 10.1074/jbc.M605086200 Simpson, 2003, Sources of estrogen and their importance, J. Steroid Biochem. Mol. Biol., 86, 225, 10.1016/S0960-0760(03)00360-1 Simpson, 2000, The role of local estrogen biosynthesis in males and females, Trends Endocrinol. Metab., 11, 184, 10.1016/S1043-2760(00)00254-X Sinha Hikim, 1999, Hormonal and genetic control of germ cell apoptosis in the testis, Rev. Reprod., 4, 38, 10.1530/ror.0.0040038 Suárez, 1987, Initiation of hyperactivated flagellar bending in mouse sperm within the female reproductive tract, Biol. Reprod., 36, 1191, 10.1095/biolreprod36.5.1191 Tsai-Morris, 2007, Polymorphism of the GRTH/DDX25 gene in normal and infertile Japanese men: a missense mutation associated with loss of GRTH phosphorylation, Mol. Hum. Reprod., 13, 887, 10.1093/molehr/gam065 Tsai-Morris, 2010, Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) gene: cell-specific expression and transcriptional regulation by androgen in transgenic mouse testis, J. Cell. Biochem., 109, 1142 Walker, 2009, Molecular mechanisms of testosterone action in spermatogenesis, Steroids, 74, 602, 10.1016/j.steroids.2008.11.017 Wang, 2003, Effects of insulin-like growth factor I on steroidogenic enzyme expression levels in mouse leydig cells, Endocrinology, 144, 5058, 10.1210/en.2003-0563 Wellendorph, 2004, Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor, Gene, 335, 37, 10.1016/j.gene.2004.03.003 Wellendorph, 2005, Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids, Mol. Pharmacol., 67, 589, 10.1124/mol.104.007559 Yeap, 2010, Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels, Eur. J. Endocrinol., 163, 265, 10.1530/EJE-10-0414 Zhang, 2005, Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues, Proc. Natl. Acad. Sci. USA, 102, 4459, 10.1073/pnas.0501076102 Ferron, M., Hinoi, E., Karsenty, G., and Ducy, P. (2008). Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc. Natl. Acad. Sci. USA 105, 5266–5270. Ferron, M., Wei, J., Yoshizawa, T., Ducy, P., and Karsenty, G. (2010). An ELISA-based method to quantify osteocalcin carboxylation in mice. Biochem. Biophys. Res. Commun. 397, 691–696. Häkkinen, L., Koivisto, L., and Larjava, H. (2001). An improved method for culture of epidermal keratinocytes from newborn mouse skin. Methods Cell Sci. 23, 189–196. Lee, N.K., Sowa, H., Hinoi, E., Ferron, M., Ahn, J.D., Confavreux, C., Dacquin, R., Mee, P.J., McKee, M.D., Jung, D.Y., et al. (2007). Endocrine regulation of energy metabolism by the skeleton. Cell 130, 456–469. Powlin, S.S., Cook, J.C., Novak, S., and O'Connor, J.C. (1998). Ex vivo and in vitro testis and ovary explants: utility for identifying steroid biosynthesis inhibitors and comparison to a Tier I screening battery. Toxicol. Sci. 46, 61–74. Qin, J., Tsai, M.J., and Tsai, S.Y. (2008). Essential roles of COUP-TFII in Leydig cell differentiation and male fertility. PLoS ONE 3, e3285. Russell, L.D., Attlin, R., Sinha Hikim, A., and Clegg, E. (1990). Histological and histopathological evaluation of the testis (Clearwater, FL: Cache River Press). Springer, M.L., and Blau, H.M. (1997). High-efficiency retroviral infection of primary myoblasts. Somat. Cell Mol. Genet. 23, 203–209. Suárez, S.S., and Osman, R.A. (1987). Initiation of hyperactivated flagellar bending in mouse sperm within the female reproductive tract. Biol. Reprod. 36, 1191–1198. Walters, K.A., Allan, C.M., Jimenez, M., Lim, P.R., Davey, R.A., Zajac, J.D., Illingworth, P., and Handelsman, D.J. (2007). Female mice haploinsufficient for an inactivated androgen receptor (AR) exhibit age-dependent defects that resemble the AR null phenotype of dysfunctional late follicle development, ovulation, and fertility. Endocrinology 148, 3674–3684. Wang, G.M., O'Shaughnessy, P.J., Chubb, C., Robaire, B., and Hardy, M.P. (2003). Effects of insulin-like growth factor I on steroidogenic enzyme expression levels in mouse leydig cells. Endocrinology 144, 5058–5064. Wreford, N.G. (1995). Theory and practice of stereological techniques applied to the estimation of cell number and nuclear volume in the testis. Microsc. Res. Tech. 32, 423–436. Zhang, X., Odom, D.T., Koo, S.H., Conkright, M.D., Canettieri, G., Best, J., Chen, H., Jenner, R., Herbolsheimer, E., Jacobsen, E., et al. (2005). Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc. Natl. Acad. Sci. USA 102, 4459–4464.