The Staphylococcal Toxin Panton-Valentine Leukocidin Targets Human C5a Receptors

Cell Host & Microbe - Tập 13 Số 5 - Trang 584-594 - 2013
András N. Spaan1, Thomas Henry2,3,4,5, Willemien J. M. van Rooijen1, Magali Perret2,3,4,5, Cédric Badiou2,3,4,5, Piet C. Aerts1, Johan Kemmink6, Carla J. C. de Haas1, Kok P. M. van Kessel1, François Vandenesch2,3,4,7,5, Gérard Lina2,3,4,7,5, Jos A. G. van Strijp1
1Medical Microbiology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands
2CIRI, International Center for Infectiology Research, LabEx Ecofect, Université Lyon 1, 69007 Lyon, France
3CNRS, UMR5308, 69007 Lyon, France
4Ecole Normale Supérieure de Lyon, 69007 Lyon, France
5Inserm, U1111, 69007 Lyon, France
6Medicinal Chemistry and Chemical Biology, Utrecht University, 3584CX Utrecht, The Netherlands
7Hospices Civils de Lyon, 69007 Lyon, France

Tóm tắt

Từ khóa


Tài liệu tham khảo

Alcaïs, 2009, Human genetics of infectious diseases: between proof of principle and paradigm, J. Clin. Invest., 119, 2506, 10.1172/JCI38111

Alonzo, 2013, CCR5 is a receptor for Staphylococcus aureus leukotoxin ED, Nature, 493, 51, 10.1038/nature11724

Bardoel, 2012, Identification of an immunomodulating metalloprotease of Pseudomonas aeruginosa (IMPa), Cell. Microbiol., 14, 902, 10.1111/j.1462-5822.2012.01765.x

Bubeck Wardenburg, 2007, Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia, Nat. Med., 13, 1405, 10.1038/nm1207-1405

Bunschoten, 2009, A general sequence independent solid phase method for the site specific synthesis of multiple sulfated-tyrosine containing peptides, Chem. Commun. (Camb.), 2999, 10.1039/b823425f

Chen, 1998, Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin, J. Biol. Chem., 273, 10411, 10.1074/jbc.273.17.10411

Colin, 1994, Interaction of the two components of leukocidin from Staphylococcus aureus with human polymorphonuclear leukocyte membranes: sequential binding and subsequent activation, Infect. Immun., 62, 3184, 10.1128/IAI.62.8.3184-3188.1994

de Haas, 2004, Chemotaxis inhibitory protein of Staphylococcus aureus, a bacterial antiinflammatory agent, J. Exp. Med., 199, 687, 10.1084/jem.20031636

DeLeo, 2010, Community-associated meticillin-resistant Staphylococcus aureus, Lancet, 375, 1557, 10.1016/S0140-6736(09)61999-1

Diep, 2006, Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureus, Lancet, 367, 731, 10.1016/S0140-6736(06)68231-7

Diep, 2010, Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury, Proc. Natl. Acad. Sci. USA, 107, 5587, 10.1073/pnas.0912403107

Gao, 2005, Evidence for a functional role of the second C5a receptor C5L2, FASEB J., 19, 1003, 10.1096/fj.04-3424fje

Gauduchon, 2001, Flow cytometric determination of Panton-Valentine leucocidin S component binding, Infect. Immun., 69, 2390, 10.1128/IAI.69.4.2390-2395.2001

Gerard, 1991, The chemotactic receptor for human C5a anaphylatoxin, Nature, 349, 614, 10.1038/349614a0

Gillet, 2002, Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients, Lancet, 359, 753, 10.1016/S0140-6736(02)07877-7

Graves, 2012, Sublytic concentrations of Staphylococcus aureus Panton-Valentine leukocidin alter human PMN gene expression and enhance bactericidal capacity, J. Leukoc. Biol., 92, 361, 10.1189/jlb.1111575

Haas, 2005, The structure of the C5a receptor-blocking domain of chemotaxis inhibitory protein of Staphylococcus aureus is related to a group of immune evasive molecules, J. Mol. Biol., 353, 859, 10.1016/j.jmb.2005.09.014

Haviland, 1995, Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on nonmyeloid cells of the liver and lung, J. Immunol., 154, 1861, 10.4049/jimmunol.154.4.1861

Hidron, 2009, Emergence of community-acquired meticillin-resistant Staphylococcus aureus strain USA300 as a cause of necrotising community-onset pneumonia, Lancet Infect. Dis., 9, 384, 10.1016/S1473-3099(09)70133-1

Hongo, 2009, Phenol-soluble modulin alpha 3 enhances the human neutrophil lysis mediated by Panton-Valentine leukocidin, J. Infect. Dis., 200, 715, 10.1086/605332

Ippel, 2009, Structure of the tyrosine-sulfated C5a receptor N terminus in complex with chemotaxis inhibitory protein of Staphylococcus aureus, J. Biol. Chem., 284, 12363, 10.1074/jbc.M808179200

Jayasinghe, 2005, The leukocidin pore: evidence for an octamer with four LukF subunits and four LukS subunits alternating around a central axis, Protein Sci., 14, 2550, 10.1110/ps.051648505

Kalant, 2003, The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein, J. Biol. Chem., 278, 11123, 10.1074/jbc.M206169200

Kew, 1997, Undifferentiated U937 cells transfected with chemoattractant receptors: a model system to investigate chemotactic mechanisms and receptor structure/function relationships, J. Leukoc. Biol., 61, 329, 10.1002/jlb.61.3.329

Kobayashi, 2011, Comparative analysis of USA300 virulence determinants in a rabbit model of skin and soft tissue infection, J. Infect. Dis., 204, 937, 10.1093/infdis/jir441

Labandeira-Rey, 2007, Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia, Science, 315, 1130, 10.1126/science.1137165

Lina, 1999, Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia, Clin. Infect. Dis., 29, 1128, 10.1086/313461

Lipinska, 2011, Panton-Valentine leukocidin does play a role in the early stage of Staphylococcus aureus skin infections: a rabbit model, PLoS ONE, 6, e22864, 10.1371/journal.pone.0022864

Löffler, 2010, Staphylococcus aureus panton-valentine leukocidin is a very potent cytotoxic factor for human neutrophils, PLoS Pathog., 6, e1000715, 10.1371/journal.ppat.1000715

Meyer, 2009, Analysis of the specificity of Panton-Valentine leucocidin and gamma-hemolysin F component binding, Infect. Immun., 77, 266, 10.1128/IAI.00402-08

Monk, 2007, Function, structure and therapeutic potential of complement C5a receptors, Br. J. Pharmacol., 152, 429, 10.1038/sj.bjp.0707332

Niemann, 2012, Combined action of influenza virus and Staphylococcus aureus panton-valentine leukocidin provokes severe lung epithelium damage, J. Infect. Dis., 206, 1138, 10.1093/infdis/jis468

Olsen, 2010, Lack of a major role of Staphylococcus aureus Panton-Valentine leukocidin in lower respiratory tract infection in nonhuman primates, Am. J. Pathol., 176, 1346, 10.2353/ajpath.2010.090960

Panton, 1932, Staphylococcal toxin, Lancet, 219, 506, 10.1016/S0140-6736(01)24468-7

Perret, 2012, Cross-talk between Staphylococcus aureus leukocidins-intoxicated macrophages and lung epithelial cells triggers chemokine secretion in an inflammasome-dependent manner, Cell. Microbiol., 14, 1019, 10.1111/j.1462-5822.2012.01772.x

Postma, 2005, Residues 10-18 within the C5a receptor N terminus compose a binding domain for chemotaxis inhibitory protein of Staphylococcus aureus, J. Biol. Chem., 280, 2020, 10.1074/jbc.M412230200

Prat, 2009, A homolog of formyl peptide receptor-like 1 (FPRL1) inhibitor from Staphylococcus aureus (FPRL1 inhibitory protein) that inhibits FPRL1 and FPR, J. Immunol., 183, 6569, 10.4049/jimmunol.0801523

Rooijakkers, 2005, Staphylococcal innate immune evasion, Trends Microbiol., 13, 596, 10.1016/j.tim.2005.10.002

Shallcross, 2013, The role of the Panton-Valentine leucocidin toxin in staphylococcal disease: a systematic review and meta-analysis, Lancet Infect. Dis., 13, 43, 10.1016/S1473-3099(12)70238-4

Vandenesch, 2003, Community-acquired methicillin-resistant Staphylococcus aureus carrying Panton-Valentine leukocidin genes: worldwide emergence, Emerg. Infect. Dis., 9, 978, 10.3201/eid0908.030089

Ventura, 2010, Identification of a novel Staphylococcus aureus two-component leukotoxin using cell surface proteomics, PLoS ONE, 5, e11634, 10.1371/journal.pone.0011634

Voyich, 2006, Is Panton-Valentine leukocidin the major virulence determinant in community-associated methicillin-resistant Staphylococcus aureus disease?, J. Infect. Dis., 194, 1761, 10.1086/509506

Woodin, 1959, Fractionation of a leucocidin from Staphylococcus aureus, Biochem. J., 73, 225, 10.1042/bj0730225

Woodruff, 2011, Inhibiting the C5-C5a receptor axis, Mol. Immunol., 48, 1631, 10.1016/j.molimm.2011.04.014

Yoong, 2012, Immune-activating properties of Panton-Valentine leukocidin improve the outcome in a model of methicillin-resistant Staphylococcus aureus pneumonia, Infect. Immun., 80, 2894, 10.1128/IAI.06360-11

Zivkovic, 2011, TLR 2 and CD14 mediate innate immunity and lung inflammation to staphylococcal Panton-Valentine leukocidin in vivo, J. Immunol., 186, 1608, 10.4049/jimmunol.1001665