The Influence of Spray-Drying Parameters on Phase Behavior, Drug Distribution, and In Vitro Release of Injectable Microspheres for Sustained Release

Journal of Pharmaceutical Sciences - Tập 104 - Trang 1451-1460 - 2015
Joke Meeus1, Maité Lenaerts1, David J. Scurr2, Katie Amssoms3, Martyn C. Davies2, Clive J. Roberts2, Guy Van den mooter1
1Drug Delivery and Disposition, KU Leuven, Leuven, Belgium
2Laboratory of Biophysics and Surface Analysis, School of Pharmacy, The University of Nottingham, Nottingham NG7 2RD, United Kingdom
3Pharmaceutical Companies of Johnson and Johnson, Discovery Sciences, PD&S_PDM, Beerse, Belgium

Tài liệu tham khảo

Twaites, 2005, Synthetic polymers as drugs and therapeutics, J Mater Chem, 15, 441, 10.1039/B410799N Rhee, 2011, Sustained-release delivery of octreotide from biodegradable polymeric microspheres, AAPS Pharm SciTech, 12, 1293, 10.1208/s12249-011-9693-z Eerdekens, 2004, Pharmacokinetics and tolerability of long-acting risperidone in schizophrenia, Schizophr Res, 70, 91, 10.1016/j.schres.2003.11.001 Meeus, 2012, Nanoscale surface characterization and miscibility study of a spray-dried injectable polymeric matrix consisting of poly(lactic-co-glycolic acid) and polyvinylpyrrolidone, J Pharm Sci, 101, 3473, 10.1002/jps.23131 Meeus, 2013, Surface characteristics of a spray-dried polymeric matrix consisting of PLGA and PVP: Relating the influence of temperature and humidity to the thermal characteristics of these polymers, Mol Pharm, 10, 3213, 10.1021/mp400263d Vehring, 2008, Pharmaceutical particle engineering via spray drying, Pharm Res, 25, 999, 10.1007/s11095-007-9475-1 Cal, 2010, Spray drying technique. I: Hardware and process parameters, J Pharm Sci, 99, 575, 10.1002/jps.21886 Paudel, 2013, Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: Formulation and process considerations, Int J Pharm, 453, 253, 10.1016/j.ijpharm.2012.07.015 Nandiyanto, 2011, Progress in developing spray- drying methods for the production of controlled morphology particles: From the nanometer to submicrometer size ranges, Adv Powder Tech- nol, 22, 1, 10.1016/j.apt.2010.09.011 Elversson, 2003, Droplet and particle size relationship and shell thickness of inhal- able lactose particles during spray drying, J Pharm Sci, 92, 900, 10.1002/jps.10352 Wan, 2013, Critical solvent properties affecting the particle formation process and characteristics of celecoxib-loaded PLGA microparticles via spray-drying, Pharm Res, 30, 1065, 10.1007/s11095-012-0943-x Paudel, 2012, Influence of solvent composition on the miscibility and physical stability of naproxen/PVP K 25 solid dispersions prepared by cosolvent spray-drying, Pharm Res, 29, 251, 10.1007/s11095-011-0539-x Paudel, 2013, An investigation into the effect of spray drying temperature and atomizing conditions on miscibility, physical stability, and performance of naproxen-PVP K 25 solid dispersions, J Pharm Sci, 102, 1249, 10.1002/jps.23459 Rizi, 2011, Production of pH-responsive microparticles by spray drying: investigation of experimental parameter effects on morphological and release properties, J Pharm Sci, 100, 566, 10.1002/jps.22291 Friesen, 2002, Hydroxypropyl methylcellulose acetate succinate- based spray-dried dispersions: An overview, Mol Pharm, 5, 1003, 10.1021/mp8000793 Craig, 2002, The mechanisms of drug release from solid dispersions in water-soluble polymers, Int J Pharm, 231, 131, 10.1016/S0378-5173(01)00891-2 Siepmann, 2004, Effect of the size of biodegradable microparticles on drug release: Experiment and theory, J Control Release, 96, 123, 10.1016/j.jconrel.2004.01.011 Berkland, 2003, PLG microsphere size controls drug release rate through several competing factors, Pharm Res, 20, 1055, 10.1023/A:1024466407849 Klose, 2006, How porosity and size affect the drug release mechanisms from PLGA- based microparticles, Int J Pharm, 314, 198, 10.1016/j.ijpharm.2005.07.031 Pikal, 2004, Evaluation of glassy-state dynamics from the width of the glass transition: Results from theoretical simulation of differential scanning calorimetry and comparisons with experiment, J Pharm Sci, 93, 981, 10.1002/jps.10582 Bruning, 1996, Fragility of glass-forming systems and the width of the glass transition, J Non-Cryst Solids, 205–207, 480, 10.1016/S0022-3093(96)00264-5 Savin, 2004, Effect of the composition on the width of the calorimetric glass transition in polymer-solvent and solvent-solvent mixtures, J Polym Sci Part B: Polym Phys, 42, 1155, 10.1002/polb.10776 Kaerger, 2004, Influence of particle size and shape on flowability and compactibility of binary mixtures of paracetamol and microcrystalline cellulose, Eur J Pharm Sci, 22, 173, 10.1016/j.ejps.2004.03.005 Guo, 1985, A simple relationship between particle shape effects and density, flow rate and Hausner ratio, Powder Technol, 43, 279, 10.1016/0032-5910(85)80009-7 Fu, 2012, Effect of particle shape and size on flow properties of lactose powders, Particuology, 10, 203, 10.1016/j.partic.2011.11.003 Bodmeier, 1988, Solvent selection in the preparation of poly(D, L-lactide) microspheres prepared by the solvent evaporation method, Int J Pharm, 43, 179, 10.1016/0378-5173(88)90073-7 Dunn, 1990 Shard, 1997, XPS and SSIMS analysis revealing surface segregation and short-range order in solid films of block copolymers of PEO and PLGA, Macromolecules, 30, 3051, 10.1021/ma9519021 Opdahl, 2002, Surface segregation of methyl side branches monitored by sum frequency geeneration (SGF) vibrational spectroscopy for a series of random poly(ethylene- co-propylene) copolymers, J Phys Chem B, 106, 5212, 10.1021/jp013741a Wang, 2001, Different surface restructuring behaviors of poly(methacrylate)s detected by SGF in water, J Am Chem Soc, 123, 9470, 10.1021/ja0164071 Thanki, 2006, Surface characteristics of PLA and PLGA films, Appl Surface Sci, 253, 2758, 10.1016/j.apsusc.2006.05.047 Verheyen, 2002, Mechanism of increased dissolution of diazepam and temazepam from polyethylene glycol 6000 solid dispersions, Int J Pharm, 249, 45, 10.1016/S0378-5173(02)00532-X Andersson, 2013, Effects of molecular weight on permeability and microstructure of mixed ethyl-hydroxypropyl-cellulose films, Eur J Pharm Sci, 48, 240, 10.1016/j.ejps.2012.11.003