Gut microbiome and serum metabolome analyses identify molecular biomarkers and altered glutamate metabolism in fibromyalgia

EBioMedicine - Tập 46 - Trang 499-511 - 2019
Marc Clos-Garcia1,2, Naiara Andrés-Marin3, Gorka Fernández-Eulate3,4, Leticia Abecia5, José L. Lavín6, Sebastiaan van Liempd7, Diana Cabrera7, Félix Royo1, Alejandro Valero8, Nerea Errazquin9, María Cristina Gómez Vega10, Leila Govillard11, Michael R. Tackett12, Genesis Tejada12, Esperanza Gónzalez1, Juan Anguita5,13, Luis Bujanda2, Ana María Callejo Orcasitas10, Ana M. Aransay14, Olga Maíz8
1Exosomes Laboratory, CIC bioGUNE, CIBERehd, Bizkaia Technology Park, Derio, Spain
2Department of Gastroenterology, Instituto Biodonostia, Universidad del País Vasco (UPV/EHU), CIBERehd (Centro de investigación en red de enfermedades hepáticas y digestiva) San Sebastian, Spain
3Department of Neurology, Donostia University Hospital, San Sebastian, Spain
4Neuroscience Area, Biodonostia Health Research Institute, San Sebastian, Spain
5Macrophage and Tick Vaccine Laboratory, CIC bioGUNE, Bizkaia Technology Park, Derio, Spain
6Bioinformatics Unit, CIC bioGUNE, Bizkaia Technology Park, Derio, Spain
7Metabolomics Platform, CIC bioGUNE, CIBERehd, Bizkaia Technology Park, Derio, Spain
8Department of Rheumatology, Donostia University Hospital, San Sebastian, Spain
9Department of Rheumatology, Gipuzcoa Policlinic, San Sebastian, Spain
10Department of Anesthesiology and Pain Unit, Hospital Galdakao-Usansolo, Bizkaia, Spain
11Deusto University, San Sebastian, Spain
12Abcam, Cambridge, MA, United States
13IKERBASQUE, Basque Foundation for Science, Bilbao, Spain
14Genome Analysis Platform, CIC bioGUNE, CIBERehd, Bizkaia Technology Park, Derio, Spain

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