Cell replacement therapies to promote remyelination in a viral model of demyelination

Aharonowiz, 2008, Neuroprotective effect of transplanted human embryonic stem cell-derived neural precursors in an animal model of multiple sclerosis, PLoS One, 3, e3145, 10.1371/journal.pone.0003145 Akesson, 2009, Human neural stem cells and astrocytes, but not neurons, suppress an allogeneic lymphocyte response, Stem Cell Res, 2, 56, 10.1016/j.scr.2008.06.002 Akiyama, 2002, Remyelination of the rat spinal cord by transplantation of identified bone marrow stromal cells, J Neurosci, 22, 6623, 10.1523/JNEUROSCI.22-15-06623.2002 Amariglio, 2009, Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient, PLoS Med, 6, e1000029, 10.1371/journal.pmed.1000029 Ascherio, 2007, Environmental risk factors for multiple sclerosis. Part I: the role of infection, Ann Neurol, 61, 288, 10.1002/ana.21117 Ascherio, 2007, Environmental risk factors for multiple sclerosis. Part II: noninfectious factors, Ann Neurol, 61, 504, 10.1002/ana.21141 Beech, 2007, The MHP36 line of murine neural stem cells expresses functional CXCR1 chemokine receptors that initiate chemotaxis in vitro, J Neuroimmunol, 184, 198, 10.1016/j.jneuroim.2006.12.015 Ben-Hur, 1998, Growth and fate of PSA-NCAM+precursors of the postnatal brain, J Neurosci, 18, 5777, 10.1523/JNEUROSCI.18-15-05777.1998 Bergmann, 2006, Coronavirus infection of the central nervous system: host-virus stand-off, Nat Rev Microbiol, 4, 121, 10.1038/nrmicro1343 Blakemore, 2008, Endogenous or exogenous oligodendrocytes for remyelination, J Neurol Sci, 265, 43, 10.1016/j.jns.2007.08.004 Brustle, 1999, Embryonic stem cell-derived glial precursors: a source of myelinating transplants, Science, 285, 754, 10.1126/science.285.5428.754 Brustle, 1999, Embryonic stem cell-derived glial precursors: a source of myelinating transplants, Science, 285, 754, 10.1126/science.285.5428.754 Cao, 2002, Stem cell repair of central nervous system injury, J Neurosci Res, 68, 501, 10.1002/jnr.10240 Dziembowska, 2005, A role for CXCR4 signaling in survival and migration of neural and oligodendrocyte precursors, Glia, 50, 258, 10.1002/glia.20170 Ebers, 1995, A genetic basis for familial aggregation in multiple sclerosis. Canadian Collaborative Study Group, Nature, 377, 150, 10.1038/377150a0 Einstein, 2006, Transplanted neural precursor cells reduce brain inflammation to attenuate chronic experimental autoimmune encephalomyelitis, Exp Neurol, 198, 275, 10.1016/j.expneurol.2005.11.007 Fleming, 1986, Pathogenicity of antigenic variants of murine coronavirus JHM selected with monoclonal antibodies, J Virol, 58, 869, 10.1128/JVI.58.3.869-875.1986 Franklin, 2002, Why does remyelination fail in multiple sclerosis?, Nat Rev Neurosci, 3, 705, 10.1038/nrn917 Glass, 2004, Antibody targeting of the CC chemokine ligand 5 results in diminished leukocyte infiltration into the central nervous system and reduced neurologic disease in a viral model of multiple sclerosis, J Immunol, 172, 4018, 10.4049/jimmunol.172.7.4018 Glass, 2001, Reduced macrophage infiltration and demyelination in mice lacking the chemokine receptor CCR5 following infection with a neurotropic coronavirus, Virology, 288, 8, 10.1006/viro.2001.1050 Gordon, 2009, Chemokines direct neural progenitor cell migration following striatal cell loss, Mol Cell Neurosci, 41, 219, 10.1016/j.mcn.2009.03.001 Grinnemo, 2006, Human embryonic stem cells are immunogenic in allogeneic and xenogeneic settings, Reprod Biomed Online, 13, 712, 10.1016/S1472-6483(10)60663-3 Guan, 2008, Upregulation of chemokine receptor expression by IL-10/IL-4 in adult neural stem cells, Exp Mol Pathol, 85, 232, 10.1016/j.yexmp.2008.07.003 Halfpenny, 2002, Cell transplantation, myelin repair, and multiple sclerosis, Lancet Neurol, 1, 31, 10.1016/S1474-4422(02)00004-2 Hardison, 2006, Transplantation of glial-committed progenitor cells into a viral model of multiple sclerosis induces remyelination in the absence of an attenuated inflammatory response, Exp Neurol, 197, 420, 10.1016/j.expneurol.2005.10.016 Hatch, 2009, Endogenous remyelination is induced by transplant rejection in a viral model of multiple sclerosis, J Neuroimmunol, 212, 74, 10.1016/j.jneuroim.2009.05.002 Herndon, 1975, Mouse hepatitis virus-induced recurrent demyelination. A preliminary report, Arch Neurol, 32, 32, 10.1001/archneur.1975.00490430054008 Hori, 2003, Neural progenitor cells lack immunogenicity and resist destruction as allografts, Stem Cells, 21, 405, 10.1634/stemcells.21-4-405 Hori, 2007, Neural progenitor cells lack immunogenicity and resist destruction as allografts. 2003, Ocul Immunol Inflamm, 15, 261, 10.1080/09273940701382242 Hosking, 2009, The biology of persistent infection: inflammation and demyelination following murine coronavirus infection of the central nervous system, Curr Immunol Rev, 5, 267, 10.2174/157339509789504005 Imitola, 2004, Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway, Proc Natl Acad Sci U S A, 101, 18,117, 10.1073/pnas.0408258102 Itoh, 2009, The relationship between SDF-1alpha/CXCR4 and neural stem cells appearing in damaged area after traumatic brain injury in rats, Neurol Res, 31, 90, 10.1179/174313208X332995 Keirstead, 2005, Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury, J Neurosci, 25, 4694, 10.1523/JNEUROSCI.0311-05.2005 Lane, 1997, Murine coronavirus infection: a paradigm for virus-induced demyelinating disease, Trends Microbiol, 5, 9, 10.1016/S0966-842X(97)81768-4 Lane, 2000, A central role for CD4(+) T cells and RANTES in virus-induced central nervous system inflammation and demyelination, J Virol, 74, 1415, 10.1128/JVI.74.3.1415-1424.2000 Lin, 1997, Mouse hepatitis virus is cleared from the central nervous systems of mice lacking perforin-mediated cytolysis, J Virol, 71, 383, 10.1128/JVI.71.1.383-391.1997 Liu, 2001, Neutralization of the chemokine CXCL10 reduces inflammatory cell invasion and demyelination and improves neurological function in a viral model of multiple sclerosis, J Immunol, 167, 4091, 10.4049/jimmunol.167.7.4091 Marten, 2001, MHV infection of the CNS: mechanisms of immune-mediated control, Viral Immunol, 14, 1, 10.1089/08828240151061329 Mason, 1986, The fate of allogeneic and xenogeneic neuronal tissue transplanted into the third ventricle of rodents, Neuroscience, 19, 685, 10.1016/0306-4522(86)90292-7 Modo, 2002, Transplantation of neural stem cells in a rat model of stroke: assessment of short-term graft survival and acute host immunological response, Brain Res, 958, 70, 10.1016/S0006-8993(02)03463-7 Nicholas, 1987, Rejection of fetal neocortical neural transplants by H-2 incompatible mice, J Immunol, 139, 2275, 10.4049/jimmunol.139.7.2275 Nicholas, 1987, An in vivo and in vitro analysis of systemic immune function in mice with histologic evidence of neural transplant rejection, J Neurosci Res, 18, 245, 10.1002/jnr.490180135 Nistor, 2005, Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation, Glia, 49, 385, 10.1002/glia.20127 Oksenberg, 1993, Genetic factors in multiple sclerosis, Jama, 270, 2362, 10.1001/jama.270.19.2362 Parra, 1999, IFN-gamma is required for viral clearance from central nervous system oligodendroglia, J Immunol, 162, 1641, 10.4049/jimmunol.162.3.1641 Pearce, 1994, Cytokine induction during T-cell-mediated clearance of mouse hepatitis virus from neurons in vivo, J Virol, 68, 5483, 10.1128/JVI.68.9.5483-5495.1994 Perlman, 1999, Coronaviruses: hepatitis, peritonitis, and central nervous system disease, 331 Pluchino, 2009, Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates, Ann Neurol, 66, 343, 10.1002/ana.21745 Pluchino, 2003, Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis, Nature, 422, 688, 10.1038/nature01552 Pluchino, 2009, Regeneration and repair in multiple sclerosis: the role of cell transplantation, Neurosci Lett, 456, 101, 10.1016/j.neulet.2008.03.097 Pluchino, 2005, Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism, Nature, 436, 266, 10.1038/nature03889 Poser, 1994, The epidemiology of multiple sclerosis: a general overview, Ann Neurol, 36, S180, 10.1002/ana.410360805 Raine, 1994, The Dale E. McFarlin Memorial Lecture: the immunology of the multiple sclerosis lesion, Ann Neurol, 36, S61, 10.1002/ana.410360716 Rizvi, 2004, Current approved options for treating patients with multiple sclerosis, Neurology, 63, S8, 10.1212/WNL.63.12_suppl_6.S8 Robertson, 2007, Embryonic stem cell-derived tissues are immunogenic but their inherent immune privilege promotes the induction of tolerance, Proc Natl Acad Sci U S A, 104, 20,920, 10.1073/pnas.0710265105 Sayer, 2006, Methylprednisolone treatment in acute spinal cord injury: the myth challenged through a structured analysis of published literature, Spine J, 6, 335, 10.1016/j.spinee.2005.11.001 Sher, 2008, Oligodendrocyte differentiation and implantation: new insights for remyelinating cell therapy, Curr Opin Neurol, 21, 607, 10.1097/WCO.0b013e32830f1e50 Sim, 2002, The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation, J Neurosci, 22, 2451, 10.1523/JNEUROSCI.22-07-02451.2002 Sospedra, 2005, Immunology of multiple sclerosis, Annu Rev Immunol, 23, 683, 10.1146/annurev.immunol.23.021704.115707 Steinman, 1996, Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system, Cell, 85, 299, 10.1016/S0092-8674(00)81107-1 Stiles, 2006, Differential roles for CXCR3 in CD4+ and CD8+ T cell trafficking following viral infection of the CNS, Eur J Immunol, 36, 613, 10.1002/eji.200535509 Stohlman, 1998, CTL effector function within the central nervous system requires CD4+ T cells, J Immunol, 160, 2896, 10.4049/jimmunol.160.6.2896 Swijnenburg, 2008, Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts, Proc Natl Acad Sci U S A, 105, 12,991, 10.1073/pnas.0805802105 Tepavcevic, 2006, Haplotype matching is not an essential requirement to achieve remyelination of demyelinating CNS lesions, Glia, 54, 880, 10.1002/glia.20425 Totoiu, 2004, Remyelination, axonal sparing, and locomotor recovery following transplantation of glial-committed progenitor cells into the MHV model of multiple sclerosis, Exp Neurol, 187, 254, 10.1016/j.expneurol.2004.01.028 Tran, 2007, Chemokine receptor expression by neural progenitor cells in neurogenic regions of mouse brain, J Comp Neurol, 500, 1007, 10.1002/cne.21229 van der Meulen, 2009, The role of CXC chemokine ligand (CXCL)12-CXC chemokine receptor (CXCR)4 signalling in the migration of neural stem cells towards a brain tumour, Neuropathol Appl Neurobiol, 35, 579, 10.1111/j.1365-2990.2009.01036.x Weiner, 1973, Pathogenesis of demyelination induced by a mouse hepatitis, Arch Neurol, 28, 298, 10.1001/archneur.1973.00490230034003 Whitman, 2009, IFN-gamma-mediated suppression of coronavirus replication in glial-committed progenitor cells, Virology, 384, 209, 10.1016/j.virol.2008.10.036 Williamson, 1990, Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells, J Virol, 64, 4589, 10.1128/JVI.64.9.4589-4592.1990 Williamson, 1991, Characterization of brain-infiltrating mononuclear cells during infection with mouse hepatitis virus strain JHM, J Neuroimmunol, 32, 199, 10.1016/0165-5728(91)90189-E Wolswijk, 1992, Cooperation between PDGF and FGF converts slowly dividing O-2Aadult progenitor cells to rapidly dividing cells with characteristics of O-2Aperinatal progenitor cells, J Cell Biol, 118, 889, 10.1083/jcb.118.4.889 Wu, 2000, CD4 and CD8 T cells have redundant but not identical roles in virus-induced demyelination, J Immunol, 165, 2278, 10.4049/jimmunol.165.4.2278 Wu, 1999, Macrophage infiltration, but not apoptosis, is correlated with immune-mediated demyelination following murine infection with a neurotropic coronavirus, J Virol, 73, 8771, 10.1128/JVI.73.10.8771-8780.1999