Renal involvement in primary antiphospholipid syndrome

Springer Science and Business Media LLC - Tập 29 - Trang 507-515 - 2016
Carmelita Marcantoni1, Carmela Emmanuele2, Francesco Scolari3
1Division of Nephrology and Dialysis, Ospedale Cannizzaro, Catania, Italy
2Pathology Unit, Ospedale Cannizzaro, Catania, Italy
3Division of Nephrology and Dialysis, Ospedale di Montichiari, Spedali Civili di Brescia, Brescia, Italy

Tóm tắt

Antiphospholipid syndrome is an autoimmune disorder characterized by recurrent venous or arterial thrombosis and/or pregnancy-related problems associated with persistently elevated levels of antiphospholipid antibodies. The kidney is a major target organ in both primary and secondary antiphospholipid syndrome. This review describes several aspects of the renal involvement in the primary form of the syndrome, in particular the histological pattern of the so-called antiphospholipid syndrome nephropathy (APSN). APSN is a vascular nephropathy characterized by small vessel vaso-occlusive lesions associated with fibrous intimal hyperplasia of interlobular arteries, recanalizing thrombi in arteries and arterioles, and focal atrophy, a constellation of morphological lesions suggestive of primary antiphospholipid syndrome.

Tài liệu tham khảo

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