Integrative Molecular Analysis of Intrahepatic Cholangiocarcinoma Reveals 2 Classes That Have Different Outcomes

Gastroenterology - Tập 144 - Trang 829-840 - 2013
Daniela Sia1,2, Yujin Hoshida3, Augusto Villanueva1,4, Sasan Roayaie3, Joana Ferrer5, Barbara Tabak6, Judit Peix1,4, Manel Sole1, Victoria Tovar1, Clara Alsinet1, Helena Cornella1, Brandy Klotzle7, Jian–Bing Fan7, Christian Cotsoglou2, Swan N. Thung3, Josep Fuster1,5, Samuel Waxman3, Juan Carlos Garcia–Valdecasas5, Jordi Bruix1,4, Myron E. Schwartz3
1Barcelona-Clínic Liver Cancer Group (HCC Translational Research Laboratory, Liver Unit, Pathology Department), Institut d'Investigacions Biomèdiques August Pi I Sunyer, Liver Unit, Hospital Clínic, Universitat de Barcelona, Barcelona, Catalonia, Spain
2Gastrointestinal Surgery and Liver Transplantation Unit, Department of Experimental Oncology, National Cancer Institute, Milan, Italy
3Mount Sinai Liver Cancer Program, Division of Liver Diseases, Department of Medicine, Tisch Cancer Institute, Department of Pathology, Recanati Miller Transplantation Institute, Department of Surgical Oncology, Mount Sinai School of Medicine, New York, New York
4Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid, Spain
5Surgical Department, Hospital Clínic, Barcelona, Catalonia, Spain
6Cancer Program, Broad Institute, Cambridge, Massachusetts
7Illumina, Inc., San Diego, California.

Tài liệu tham khảo

Bleachacz, 2008, Cholangiocarcinoma, Clin Liver Dis, 12, 131, 10.1016/j.cld.2007.11.003 Sempoux, 2011, Intrahepatic cholangiocarcinoma: new insights in pathology, Semin Liver Dis, 31, 104, 10.1055/s-0031-1272838 Khan, 2002, Changing international trends in mortality rates for liver, biliary and pancreatic tumours, J Hepatol, 37, 806, 10.1016/S0168-8278(02)00297-0 Singh, 2006, Advances in the diagnosis, evaluation and management of cholangiocarcinoma, Curr Opin Gastroenterol, 22, 294, 10.1097/01.mog.0000218967.60633.64 Valle, 2010, Cisplatin plus gemcitabine versus gemcitabine for biliary tract cancer, N Engl J Med, 362, 1273, 10.1056/NEJMoa0908721 Tan, 2008, Surgical management of intrahepatic cholangiocarcinoma–a population-based study, Ann Surg Oncol, 15, 600, 10.1245/s10434-007-9627-x Sia, 2013, Intrahepatic cholangiocarcinoma: pathogenesis and rationale for molecular therapies, Oncogene, 10.1038/onc.2012.617 Wehbe, 2006, Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression, Cancer Res, 66, 10517, 10.1158/0008-5472.CAN-06-2130 Isomoto, 2005, Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells, Hepatology, 42, 1329, 10.1002/hep.20966 Tannapfel, 2000, Frequency of p16 (INK4A) alterations and K-ras mutations in intrahepatic cholangiocarcinoma of the liver, Gut, 47, 721, 10.1136/gut.47.5.721 Momoi, 2001, Microsatellite instability and alternative genetic pathway in intrahepatic cholangiocarcinoma, J Hepatol, 35, 235, 10.1016/S0168-8278(01)00106-4 Terada, 1998, Immunohistochemical demonstration of MET overexpression in human intrahepatic cholangiocarcinoma and in hepatolithiasis, Hum Pathol, 29, 175, 10.1016/S0046-8177(98)90229-5 Terada, 1998, c-erbB-2 protein is expressed in hepatolithiasis and cholangiocarcinoma, Histopathology, 33, 325, 10.1046/j.1365-2559.1998.00496.x Llovet, 2008, Sorafenib in advanced hepatocellular carcinoma, N Engl J Med, 359, 378, 10.1056/NEJMoa0708857 Bengala, 2010, Sorafenib in patients with advanced biliary tract carcinoma: a phase II trial, Br J Cancer, 102, 68, 10.1038/sj.bjc.6605458 Brunet, 2004, Metagenes and molecular pattern discovery using matrix factorization, Proc Natl Acad Sci U S A, 101, 4164, 10.1073/pnas.0308531101 Lee, 2004, Classification and prediction of survival in hepatocellular carcinoma by gene expression profiling, Hepatology, 40, 667, 10.1002/hep.20375 Woo, 2010, Identification of a cholangiocarcinoma-like gene expression trait in hepatocellular carcinoma, Cancer Res, 70, 3034, 10.1158/0008-5472.CAN-09-2823 Boyault, 2007, Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets, Hepatology, 45, 42, 10.1002/hep.21467 Hoshida, 2009, Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma, Cancer Res, 69, 7385, 10.1158/0008-5472.CAN-09-1089 Bromberg, 1999, Stat3 as an oncogene, Cell, 98, 295, 10.1016/S0092-8674(00)81959-5 Gentile, 2011, Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesis, Cancer Res, 71, 3132, 10.1158/0008-5472.CAN-10-2662 Montpetit, 2002, A detailed transcriptional map of the chromosome 12p12 tumour suppressor locus, Eur J Hum Genet, 10, 62, 10.1038/sj.ejhg.5200766 Lee, 2010, The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis, Proc Natl Acad Sci U S A, 107, 8248, 10.1073/pnas.0912203107 Andersen, 2012, Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors, Gastroenterology, 142, 1021, 10.1053/j.gastro.2011.12.005 Oishi, 2012, Transcriptomic profiling reveals hepatic stem-like gene signatures and interplay of mir-200c and EMT in intrahepatic cholangiocarcinoma, Hepatology, 56, 1792, 10.1002/hep.25890 Zhang, 1999, Transcriptional profiling of human microvascular endothelial cells in the proliferative and quiescent state using cDNA arrays, Angiogenesis, 3, 211, 10.1023/A:1009085422384 de Jong, 2011, Intrahepatic cholangiocarcinoma: an international multi-institutional analysis of prognostic factors and lymph node assessment, J Clin Oncol, 29, 3140, 10.1200/JCO.2011.35.6519 Wang, 2009, IL-17 can promote tumor growth through an IL-6-Stat3 signaling pathway, J Exp Med, 206, 1457, 10.1084/jem.20090207 Isomoto, 2007, Sustained IL-6/STAT-3 signaling in cholangiocarcinoma cells due to SOCS-3 epigenetic silencing, Gastroenterology, 132, 384, 10.1053/j.gastro.2006.10.037 Schreiber, 2011, Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion, Science, 331, 1565, 10.1126/science.1203486 Roskams, 2006, Liver stem cells and their implication in hepatocellular and cholangiocarcinoma, Oncogene, 25, 3818, 10.1038/sj.onc.1209558 Chiang, 2008, Focal gains of VEGFA and molecular classification of hepatocellular carcinoma, Cancer Res, 68, 6779, 10.1158/0008-5472.CAN-08-0742 Blechacz, 2008, Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment, Hepatology, 48, 308, 10.1002/hep.22310 Rossi, 2010, A phase I/II study of siltuximab (CNTO 328), an anti-interleukin-6 monoclonal antibody, in metastatic renal cell cancer, Br J Cancer, 103, 1154, 10.1038/sj.bjc.6605872 Verstovsek, 2010, Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis, N Engl J Med, 363, 1117, 10.1056/NEJMoa1002028 Wang, 2006, Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags, Biochem Biophys Res Commun, 345, 1022, 10.1016/j.bbrc.2006.04.175 Jinawath, 2006, Comparison of gene expression profiles between Opisthorchis viverrini and non-Opisthorchis viverrini associated human intrahepatic cholangiocarcinoma, Hepatology, 44, 1025, 10.1002/hep.21330 Miller, 2009, Genome wide analysis and clinical correlation of chromosomal and transcriptional mutations in cancers of the biliary tract, J Exp Clin Cancer Res, 28, 62, 10.1186/1756-9966-28-62 Yang, 2005, Promoter methylation profiles of tumor suppressor genes in intrahepatic and extrahepatic cholangiocarcinoma, Mod Pathol, 18, 412, 10.1038/modpathol.3800287 Karamitopoulou, 2008, Clinical significance of cell cycle- and apoptosis-related markers in biliary tract cancer: a tissue microarray-based approach revealing a distinctive immunophenotype for intrahepatic and extrahepatic cholangiocarcinomas, Am J Clin Pathol, 130, 780, 10.1309/AJCP35FDCAVANWMM Hezel, 2010, Genetics of biliary tract cancers and emerging targeted therapies, J Clin Oncol, 28, 3531, 10.1200/JCO.2009.27.4787 Chin, 2011, Cancer genomics: from discovery science to personalized medicine, Nat Med, 17, 297, 10.1038/nm.2323 Davies, 2002, Mutations of the BRAF gene in human cancer, Nature, 417, 949, 10.1038/nature00766 Soda, 2007, Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer, Nature, 448, 561, 10.1038/nature05945 Flaherty, 2010, Inhibition of mutated, activated BRAF in metastatic melanoma, N Engl J Med, 363, 809, 10.1056/NEJMoa1002011 Chabner, 2011, Early accelerated approval for highly targeted cancer drugs, N Engl J Med, 364, 1087, 10.1056/NEJMp1100548 Stokes, 2011, Copy number and loss of heterozygosity detected by SNP array of formalin-fixed tissues using whole-genome amplification, PLoS One, 6, e24503, 10.1371/journal.pone.0024503 Quandt, 2011, B7-h4 expression in human melanoma: its association with patients' survival and antitumor immune response, Clin Cancer Res, 17, 3100, 10.1158/1078-0432.CCR-10-2268 Krambeck, 2006, B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival, Proc Natl Acad Sci U S A, 103, 10391, 10.1073/pnas.0600937103 Lu, 2010, Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver, Proc Natl Acad Sci U S A, 107, 1437, 10.1073/pnas.0911427107