Neurotropic virus infections as the cause of immediate and delayed neuropathology

Springer Science and Business Media LLC - Tập 131 - Trang 159-184 - 2015
Martin Ludlow1, Jeroen Kortekaas2, Christiane Herden3, Bernd Hoffmann4, Dennis Tappe5,6, Corinna Trebst7, Diane E. Griffin8, Hannah E. Brindle9,10, Tom Solomon9,11, Alan S. Brown12, Debby van Riel13, Katja C. Wolthers14, Dasja Pajkrt15, Peter Wohlsein16, Byron E. E. Martina13,17, Wolfgang Baumgärtner16,18, Georges M. Verjans1,13, Albert D. M. E. Osterhaus1,17,18
1Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine, Hannover, Germany
2Department of Virology, Central Veterinary Institute, Part of Wageningen University and Research Centre, Wageningen, The Netherlands
3Institute of Veterinary Pathology, Justus-Liebig-University Gießen, Giessen, Germany
4Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany
5Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
6German Centre for Infection Research (DZIF), Hamburg, Germany
7Department of Neurology, Hannover Medical School, Hannover, Germany
8W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
9Institute of Infection and Global Health, University of Liverpool, Liverpool, UK
10Wellcome Trust Liverpool Glasgow Centre for Global Health Research, University of Liverpool, Liverpool, UK
11NIHR Health Protection Research Unit in Emerging Infection and Zoonoses, Liverpool, UK
12Department of Psychiatry, Columbia University Medical Center, New York State Psychiatric Institute, New York, USA
13Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands
14Laboratory of Clinical Virology, Department of Medical Microbiology, Academic Medical Center, Amsterdam, The Netherlands
15Department of Pediatric Infectious Diseases, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands
16Department of Pathology, University of Veterinary Medicine Hannover, Germany
17Artemis One Health, Utrecht, The Netherlands
18Center of Systems Neuroscience, Hannover, Germany

Tóm tắt

A wide range of viruses from different virus families in different geographical areas, may cause immediate or delayed neuropathological changes and neurological manifestations in humans and animals. Infection by neurotropic viruses as well as the resulting immune response can irreversibly disrupt the complex structural and functional architecture of the central nervous system, frequently leaving the patient or affected animal with a poor or fatal prognosis. Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using examples of well-studied virus infections that are associated with these alterations in different populations throughout the world. A better understanding of the molecular, epidemiological and biological characteristics of these infections and in particular of mechanisms that underlie their clinical manifestations may be expected to provide tools for the development of more effective intervention strategies and treatment regimens.

Tài liệu tham khảo

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