Inhibition of climbing fibres is a signal for the extinction of conditioned eyelid responses

Nature - Tập 416 Số 6878 - Trang 330-333 - 2002
Javier F. Medina1, William L. Nores, Michael D. Mauk
1W. M. Keck Center for the Neurobiology of Learning and Memory, University of Texas Medical School, Houston 77030, USA.

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Marr, D. A theory of cerebellar cortex. J. Physiol. (Lond.) 202, 437–470 (1969).

Albus, J. S. A theory of cerebellar function. Math. Biosci. 10, 25–61 (1971).

Ito, M. Cerebellar control of the vestibulo-ocular reflex—around the flocculus hypothesis. Annu. Rev. Neurosci. 5, 275–296 (1982).

Thach, W. T., Goodkin, H. P. & Keating, J. G. The cerebellum and the adaptive coordination of movement. Annu. Rev. Neurosci. 15, 403–442 (1992).

Simpson, J. I., Wylie, D. R. & de Zeeuw, C. I. On climbing fiber signals and their consequence(s). Behav. Brain Sci. 19, 384–398 (1996).

de Zeeuw, C. I. et al. Microcircuitry and function of the inferior olive. Trends Neurosci. 21, 391–400 (1998).

Thompson, R. F., Thompson, J. K., Kim, J. J., Krupa, D. J. & Shinkman, P. G. The nature of reinforcement in cerebellar learning. Neurobiol. Learn. Mem. 70, 150–176 (1998).

Raymond, J . L., Lisberger, S. G. & Mauk, M. D. The cerebellum: a neuronal learning machine? Science 272, 1126–1131 (1996).

Hesslow, G. & Ivarsson, M. Inhibition of the inferior olive during conditioned responses in the decerebrate ferret. Exp. Brain Res. 110, 36–46 (1996).

Sears, L. L. & Steinmetz, J. E. Dorsal accessory inferior olive activity diminishes during acquisition of the rabbit classically conditioned eyelid response. Brain Res. 545, 114–122 (1991).

Kim, J. J., Krupa, D. J. & Thompson, R. F. Inhibitory cerebello-olivary projections and blocking effect in classical conditioning. Science 279, 570–573 (1998).

Mauk, M. D., Steinmetz, J. E. & Thompson, R. F. Classical conditioning using stimulation of the inferior olive as the unconditioned stimulus. Proc. Natl Acad. Sci. USA 83, 5349–5353 (1986).

Voogd, J. & Glickstein, M. The anatomy of the cerebellum. Trends Neurosci. 21, 370–375 (1998).

Medina, J. F., Garcia, K. S., Nores, W. L., Taylor, N. M. & Mauk, M. D. Timing mechanisms in the cerebellum: testing predictions of a large-scale computer simulation. J. Neurosci. 20, 5516–5525 (2000).

Medina, J. F. & Mauk, M. D. Computer simulation of cerebellar information processing. Nature Neurosci. 3 (Suppl.), 1205–1211 (2000).

Medina, J. F., Garcia, K. S. & Mauk, M. D. A mechanism for savings in the cerebellum. J. Neurosci. 21, 4081–4089 (2001).

Lang, E . J., Sugihara, I. & Llinas, R. GABAergic modulation of complex spike activity by the cerebellar nucleoolivary pathway in rat. J. Neurophysiol. 76, 255–275 (1996).

Demer, J. L., Echelman, D. A. & Robinson, D. A. Effects of electrical stimulation and reversible lesions of the olivocerebellar pathway on Purkinje cell activity in the flocculus of the cat. Brain Res. 346, 22–31 (1985).

Keating, J. G. & Thach, W. T. Nonclock behavior of inferior olive neurons: interspike interval of Purkinje cell complex spike discharge in the awake behaving monkey is random. J. Neurophysiol. 73, 1329–1340 (1995).

Ramnani, N. & Yeo, C. H. Reversible inactivations of the cerebellum prevent the extinction of conditioned nictitating membrane responses in rabbits. J. Physiol. (Lond.) 495, 159–168 (1996).

Linden, D . J. & Connor, J. A. Cellular mechanisms of long-term depression in the cerebellum. Curr. Opin. Neurobiol. 3, 401–406 (1993).

Sakurai, M. Synaptic modification of parallel fibre-Purkinje cell transmission in in vitro guinea-pig cerebellar slices. J. Physiol. (Lond.) 394, 463–480 (1987).

Hollerman, J. R. & Schultz, W. Dopamine neurons report an error in the temporal prediction of reward during learning. Nature Neurosci. 1, 304–309 (1998).

Schultz, W. & Dickinson, A. Neuronal coding of prediction errors. Annu. Rev. Neurosci. 23, 473–500 (2000).

Fanselow, M. S. Pavlovian conditioning, negative feedback, and blocking: mechanisms that regulate association formation. Neuron 20, 625–627 (1998).