An Interferon-α-Induced Tethering Mechanism Inhibits HIV-1 and Ebola Virus Particle Release but Is Counteracted by the HIV-1 Vpu Protein

Abada, 2005, Functional domains within the human immunodeficiency virus type 2 envelope protein required to enhance virus production, J. Virol., 79, 3627, 10.1128/JVI.79.6.3627-3638.2005 Asaoka, 2005, A retrovirus restriction factor TRIM5alpha is transcriptionally regulated by interferons, Biochem. Biophys. Res. Commun., 338, 1950, 10.1016/j.bbrc.2005.10.173 Bieniasz, 2004, Intrinsic immunity: A front-line defense against viral attack, Nat. Immunol., 5, 1109, 10.1038/ni1125 Bilello, 1982, Effect of interferon on the replication of mink cell focus-inducing virus in murine cells: Synthesis, processing, assembly, and release of viral proteins, J. Virol., 43, 213, 10.1128/JVI.43.1.213-222.1982 Biswas, 1992, Interferon gamma induces the expression of human immunodeficiency virus in persistently infected promonocytic cells (U1) and redirects the production of virions to intracytoplasmic vacuoles in phorbol myristate acetate-differentiated U1 cells, J. Exp. Med., 176, 739, 10.1084/jem.176.3.739 Bucci, 1992, The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway, Cell, 70, 715, 10.1016/0092-8674(92)90306-W Chatterjee, 1987, Recombinant human interferons inhibit replication of Mason-Pfizer monkey virus in primate cells, Virology, 157, 548, 10.1016/0042-6822(87)90299-6 Christeff, 2002, Increased serum interferon alpha in HIV-1 associated lipodystrophy syndrome, Eur. J. Clin. Invest., 32, 43, 10.1046/j.0014-2972.2001.00940.x Demirov, 2002, Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function, Proc. Natl. Acad. Sci. USA, 99, 955, 10.1073/pnas.032511899 Garrus, 2001, Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding, Cell, 107, 55, 10.1016/S0092-8674(01)00506-2 Goff, 2004, Retrovirus restriction factors, Mol. Cell, 16, 849, 10.1016/j.molcel.2004.12.001 Gottlinger, 1991, Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release, Proc. Natl. Acad. Sci. USA, 88, 3195, 10.1073/pnas.88.8.3195 Gottlinger, 1993, Vpu protein of human immunodeficiency virus type 1 enhances the release of capsids produced by gag gene constructs of widely divergent retroviruses, Proc. Natl. Acad. Sci. USA, 90, 7381, 10.1073/pnas.90.15.7381 Gummuluru, 2000, An in vitro rapid-turnover assay for human immunodeficiency virus type 1 replication selects for cell-to-cell spread of virus, J. Virol., 74, 10882, 10.1128/JVI.74.23.10882-10891.2000 Haller, 2002, Interferon-induced mx proteins: Dynamin-like GTPases with antiviral activity, Traffic, 3, 710, 10.1034/j.1600-0854.2002.31003.x Harila, 2006, Vpu and Tsg101 regulate intracellular targeting of the human immunodeficiency virus type 1 core protein precursor Pr55gag, J. Virol., 80, 3765, 10.1128/JVI.80.8.3765-3772.2006 Hout, 2004, Vpu: A multifunctional protein that enhances the pathogenesis of human immunodeficiency virus type 1, Curr. HIV Res., 2, 255, 10.2174/1570162043351246 Jouvenet, 2006, Plasma membrane is the site of productive HIV-1 particle assembly, PLoS Biol., 4, e435, 10.1371/journal.pbio.0040435 Klimkait, 1990, The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release, J. Virol., 64, 621, 10.1128/JVI.64.2.621-629.1990 Kornbluth, 1989, Interferons and bacterial lipopolysaccharide protect macrophages from productive infection by human immunodeficiency virus in vitro, J. Exp. Med., 169, 1137, 10.1084/jem.169.3.1137 Lama, 1999, Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner, Curr. Biol., 9, 622, 10.1016/S0960-9822(99)80284-X Levy, 2003, Protection from HIV/AIDS: The importance of innate immunity, Clin. Immunol., 108, 167, 10.1016/S1521-6616(03)00178-5 Li, 1993, Structure-function relationship of the small GTPase rab5, J. Biol. Chem., 268, 24475, 10.1016/S0021-9258(20)80550-X Martin-Serrano, 2001, HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress, Nat. Med., 7, 1313, 10.1038/nm1201-1313 Martin-Serrano, 2004, Context-dependent effects of L domains and ubiquitination on viral budding, J. Virol., 78, 5554, 10.1128/JVI.78.11.5554-5563.2004 Neil, 2006, HIV-1 Vpu promotes release and prevents endocytosis of nascent retrovirus particles from the plasma membrane, PLoS Pathog, 2, e39, 10.1371/journal.ppat.0020039 Okumura, 2006, Innate antiviral response targets HIV-1 release by the induction of ubiquitin-like protein ISG15, Proc. Natl. Acad. Sci. USA, 103, 1440, 10.1073/pnas.0510518103 Peng, 2006, Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activity, J. Exp. Med., 203, 41, 10.1084/jem.20051512 Poli, 1989, Interferon-alpha but not AZT suppresses HIV expression in chronically infected cell lines, Science, 244, 575, 10.1126/science.2470148 Ross, 1999, Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein, Curr. Biol., 9, 613, 10.1016/S0960-9822(99)80283-8 Samuel, 2001, Antiviral actions of interferons, Clin. Microbiol. Rev., 14, 778, 10.1128/CMR.14.4.778-809.2001 Shirazi, 1992, Alpha interferon inhibits early stages of the human immunodeficiency virus type 1 replication cycle, J. Virol., 66, 1321, 10.1128/JVI.66.3.1321-1328.1992 Shirazi, 1993, Interferon alpha-mediated inhibition of human immunodeficiency virus type 1 provirus synthesis in T-cells, Virology, 193, 303, 10.1006/viro.1993.1126 Siegal, 2001, Interferon-alpha generation and immune reconstitution during antiretroviral therapy for human immunodeficiency virus infection, AIDS, 15, 1603, 10.1097/00002030-200109070-00002 Smith, 1991, Inhibition of human immunodeficiency virus type 1 morphogenesis in T cells by alpha interferon, Antimicrob. Agents Chemother., 35, 62, 10.1128/AAC.35.1.62 Stenmark, 1994, Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis, EMBO J., 13, 1287, 10.1002/j.1460-2075.1994.tb06381.x Stetson, 2006, Type I interferons in host defense, Immunity, 25, 373, 10.1016/j.immuni.2006.08.007 Strebel, 1988, A novel gene of HIV-1, vpu, and its 16-kilodalton product, Science, 241, 1221, 10.1126/science.3261888 Tanaka, 2006, Anti-viral protein APOBEC3G is induced by interferon-alpha stimulation in human hepatocytes, Biochem. Biophys. Res. Commun., 341, 314, 10.1016/j.bbrc.2005.12.192 van Boxel-Dezaire, 2006, Complex modulation of cell type-specific signaling in response to type I interferons, Immunity, 25, 361, 10.1016/j.immuni.2006.08.014 Varthakavi, 2003, Viral protein U counteracts a human host cell restriction that inhibits HIV-1 particle production, Proc. Natl. Acad. Sci. USA, 100, 15154, 10.1073/pnas.2433165100 von Schwedler, 2003, Functional surfaces of the human immunodeficiency virus type 1 capsid protein, J. Virol., 77, 5439, 10.1128/JVI.77.9.5439-5450.2003 Wagner, 2002, Functional balance between haemagglutinin and neuraminidase in influenza virus infections, Rev. Med. Virol., 12, 159, 10.1002/rmv.352