Neuropsychiatric systemic lupus erythematosus: Tools for the diagnosis

Bernatsky, 2006, Mortality related to cerebrovascular disease in systemic lupus erythematosus, Lupus, 15, 835, 10.1177/0961203306073133 McNicholl, 1994, A prospective study of neurophysiologic, neurologic and immunologic abnormalities in systemic lupus erythematosus, J Rheumatol, 21, 1061 1999, The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes, Arthritis Rheum, 42, 599, 10.1002/1529-0131(199904)42:4<599::AID-ANR2>3.0.CO;2-F Stojanovich, 2007, Psychiatric manifestations in systemic lupus erythematosus, Autoimmun Rev, 6, 421, 10.1016/j.autrev.2007.02.007 Borchers, 2005, Neuropsychiatric features of systemic lupus erythematosus, Autoimmun Rev, 4, 329, 10.1016/j.autrev.2005.01.008 Castellino, 2008, Optimizing clinical monitoring of central nervous system involvement in SLE, Autoimmun Rev, 7, 297, 10.1016/j.autrev.2007.11.022 Shoenfeld, 1999, Frontiers of SLE: review of the 5th International Congress of Systemic Lupus Erythematosus, Cancun, Mexico, April 20-25, 1998, Semin Arthritis Rheum, 29, 112, 10.1016/S0049-0172(99)80042-0 Greenwood, 2002, Autoantibodies in neuropsychiatric lupus, Autoimmunity, 35, 79, 10.1080/08916930290016547 Borowoy, 2012, Neuropsychiatric lupus: the prevalence and autoantibody associations depend on the definition: results from the 1000 faces of lupus cohort, Semin Arthritis Rheum, 42, 179, 10.1016/j.semarthrit.2012.03.011 Goddard, 2007, Autoantibodies involved in neuropsychiatric SLE and antiphospholipid syndrome, Semin Arthritis Rheum, 36, 297, 10.1016/j.semarthrit.2006.11.003 Kimura, 2010, Antibodies in patients with neuropsychiatric systemic lupus erythematosus, Neurology, 74, 1372, 10.1212/WNL.0b013e3181dad590 Gerli, 2002, Clinical and serological associations of ribosomal P autoAbs in systemic lupus erythematosus: prospective evaluation in a large cohort of Italian patients, Rheumatology (Oxford), 41, 1357, 10.1093/rheumatology/41.12.1357 Efthimiou, 2009, Pathogenesis of neuropsychiatric systemic lupus erythematosus and potential biomarkers, Mod Rheumatol, 19, 457, 10.3109/s10165-009-0198-5 Hanly, 2011, Autoantibodies as biomarkers for the prediction of neuropsychiatric events in systemic lupus erythematosus, Ann Rheum Dis, 70, 1726, 10.1136/ard.2010.148502 Barros, 2011, Pathological gambling and primary antiphospholipid (Hughes) syndrome: a unique neuropsychiatric association, Lupus, 20, 1086, 10.1177/0961203310397564 Zardi, 2012, Transient global amnesia as the first symptom of primary antiphospholipid syndrome: a case report, Int J Immunopathol Pharmacol, 25, 275, 10.1177/039463201202500131 Govoni, 2012, Italian Society of Rheumatology. Factors and comorbidities associated with first neuropsychiatric event in systemic lupus erythematosus: does a risk profile exist? A large multicentre retrospective cross-sectional study on 959 Italian patients, Rheumatology (Oxford), 51, 157, 10.1093/rheumatology/ker310 Hanly, 1999, A prospective analysis of cognitive function and anticardiolipin antibodies in systemic lupus erythematosus, Arthritis Rheum, 42, 728, 10.1002/1529-0131(199904)42:4<728::AID-ANR16>3.0.CO;2-O Menon, 1999, A longitudinal study of anticardiolipin antibody levels and cognitive functioning in systemic lupus erythematosus, Arthritis Rheum, 42, 735, 10.1002/1529-0131(199904)42:4<735::AID-ANR17>3.0.CO;2-L Afeltra, 2003, Neuropsychiatric lupus syndromes: relationship with antiphospholipid antibodies, Neurology, 61, 108, 10.1212/01.WNL.0000058904.94330.A7 Steens, 2006, Association between microscopic brain damage as indicated by magnetization transfer imaging and anticardiolipin antibodies in neuropsychiatric lupus, Arthritis Res Ther, 8, R38, 10.1186/ar1892 Katzav, 2010, The pathogenesis of neural injury in animal models of the antiphospholipid syndrome, Clin Rev Allergy Immunol, 38, 196, 10.1007/s12016-009-8154-x DeGiorgio, 2001, A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus, Nat Med, 7, 1189, 10.1038/nm1101-1189 Jenks, 2009, Altered B cell receptor signaling in human systemic lupus erythematosus, Autoimmun Rev, 8, 209, 10.1016/j.autrev.2008.07.047 Pisetsky, 2010, The blood nucleome in the pathogenesis of SLE, Autoimmun Rev, 10, 35, 10.1016/j.autrev.2010.07.007 Cagnoli, 2012, Changes in regional brain morphology in neuropsychiatric systemic lupus erythematosus, J Rheumatol, 39, 959, 10.3899/jrheum.110833 Postal, 2011, Neuropsychiatric manifestations in systemic lupus erythematosus: epidemiology, pathophysiology and management, CNS Drugs, 25, 721, 10.2165/11591670-000000000-00000 Tatsukawa, 2005, Evaluation of average amount of cerebral blood flow measured by brain perfusion index in patients with neuropsychiatric systemic lupus erythematosus, Lupus, 14, 445, 10.1191/0961203305lu2127oa Hanly, 1992, Brain pathology in systemic lupus erythematosus, J Rheumatol, 19, 732 Luyendijk, 2011, Neuropsychiatric systemic lupus erythematosus: lessons learned from magnetic resonance imaging, Arthritis Rheum, 63, 722, 10.1002/art.30157 Brooks, 2010, The histopathologic associates of neurometabolite abnormalities in fatal neuropsychiatric systemic lupus erythematosus, Arthritis Rheum, 62, 2055 Bertsias, 2010, EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestation: report of a task force of the EULAR standing committee for clinical affairs, Ann Rheum Dis, 69, 2074, 10.1136/ard.2010.130476 Monov, 2008, Classification criteria for neuropsychiatric systemic lupus erythematosus: do they need a discussion?, Hippokratia, 12, 103 Jennekens, 2002, The central nervous system in systemic lupus erythematosus. Part 1. Clinical syndromes: a literature investigation, Rheumatology (Oxford), 41, 605, 10.1093/rheumatology/41.6.605 Karassa, 2006, Accuracy of anti-ribosomal P protein antibody testing for the diagnosis of neuropsychiatric systemic lupus erythematosus: an international meta-analysis, Arthritis Rheum, 54, 312, 10.1002/art.21539 Mitsikostas, 2004, A meta-analysis for headache in systemic lupus erythematosus: the evidence and the myth, Brain, 127, 1200, 10.1093/brain/awh146 Sanna, 2000, Central nervous system involvement in systemic lupus erythematosus: cerebral imaging and serological profile in patients with and without overt neuropsychiatric manifestations, Lupus, 9, 573, 10.1191/096120300678828695 Brey, 2002, Neuropsychiatric syndromes in lupus: prevalence using standardized definitions, Neurology, 58, 1214, 10.1212/WNL.58.8.1214 Tan, 1982, The 1982 revised criteria for the classification of systemic lupus erythematosus, Arthritis Rheum, 25, 1271, 10.1002/art.1780251101 Hochberg, 1997, Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus, Arthritis Rheum, 40, 1725, 10.1002/art.1780400928 Petri, 2012, Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus, Arthritis Rheum, 64, 2677, 10.1002/art.34473 Rood, 1999, The accuracy of diagnosing neuropsychiatric systemic lupus erythematosus in a series of 49 hospitalized patients, Clin Exp Rheumatol, 17, 55 Emmer, 2008, Arthritis Rheum, 58, 1451, 10.1002/art.23452 Emmer, 2006, Detection of change in CNS involvement in neuropsychiatric SLE: a magnetization transfer study, J Magn Reson Imaging, 24, 812, 10.1002/jmri.20706 Kitagawa, 1990, Stroke in systemic lupus erythematosus, Stroke, 21, 1533, 10.1161/01.STR.21.11.1533 Huizinga, 2001, Imaging modalities in central nervous system systemic lupus erythematosus, Curr Opin Rheumatol, 13, 383, 10.1097/00002281-200109000-00007 Govoni, 2004, Recent advances and future perspective in neuroimaging in neuropsychiatric systemic lupus erythematosus, Lupus, 13, 149, 10.1191/0961203304lu1000rr Hanly, 2005, Management of neuropsychiatric lupus, Best Pract Res Clin Rheumatol, 19, 799, 10.1016/j.berh.2005.04.003 Sibbitt, 1999, Neuroimaging in neuropsychiatric systemic lupus erythematosus, Arthritis Rheum, 42, 2026, 10.1002/1529-0131(199910)42:10<2026::AID-ANR2>3.0.CO;2-J McCune, 1988, Identification of brain lesions in neuropsychiatric systemic lupus erythematosus by magnetic resonance scanning, Arthritis Rheum, 31, 159, 10.1002/art.1780310202 Brooks, 1997, Neurochemistry of brain lesions determined by spectroscopic imaging in systemic lupus erythematosus, J Rheumatol, 24, 2323 Sundgren, 2005, MRI and 2D-CSI MR spectroscopy of the brain in the evaluation of patients with acute onset of neuropsychiatric systemic lupus erythematosus, Neuroradiology, 47, 576, 10.1007/s00234-005-1371-y Friedman, 1998, Brain injury and neurometabolic abnormalities in systemic lupus erythematosus, Radiology, 209, 79, 10.1148/radiology.209.1.9769816 Sibbitt, 1994, Analysis of cerebral structural changes in systemic lupus erythematosus by proton MR spectroscopy, AJNR Am J Neuroradiol, 15, 923 Sabet, 1998, Neurometabolite markers of cerebral injury in the antiphospholipid antibody syndrome of systemic lupus erythematosus, Stroke, 29, 2254, 10.1161/01.STR.29.11.2254 Ishikawa, 1994, Cerebral lesions in systemic lupus erythematosus detected by magnetic resonance imaging. Relationship to anticardiolipin antibody, J Rheumatol, 21, 87 Jarek, 1994, Magnetic resonance imaging in systemic lupus erythematosus patients without a history of neuropsychiatric lupus erythematosus, Arthritis Rheum, 37, 1609, 10.1002/art.1780371108 Sewell, 1989, Magnetic resonance imaging versus computed tomographic scanning in neuropsychiatric systemic lupus erythematosus, Am J Med, 86, 625, 10.1016/0002-9343(89)90403-8 Sibbitt, 1989, Magnetic resonance and computed tomographic imaging in the evaluation of acute neuropsychiatric disease in systemic lupus erythematosus, Ann Rheum Dis, 48, 1014, 10.1136/ard.48.12.1014 Sibbitt, 2003, Fluid attenuated Inversion Recovery (FLAIR) imaging in neuropsychiatric systemic lupus erythematosus, J Rheumatol, 30, 1983 Jennings, 2004, Value of MRI of the brain in patients with systemic lupus erythematosus and neurologic disturbance, Neuroradiology, 46, 15, 10.1007/s00234-003-1049-2 Monastero, 2001, Prevalence and pattern of cognitive impairment in systemic lupus erythematosus patients with and without overt neuropsychiatric manifestations, J Neurol Sci, 184, 33, 10.1016/S0022-510X(00)00492-5 Provenzale, 1996, Patients with antiphospholipid antibodies: CT and MR findings of the brain, AJR Am J Roentgenol, 167, 1573, 10.2214/ajr.167.6.8956600 Zirkzee, 2012, Prospective study of clinical phenotypes in neuropsychiatric systemic lupus erythematosus; multidisciplinary approach to diagnosis and therapy, J Rheumatol, 39, 2118, 10.3899/jrheum.120545 Karassa, 2000, Predictors of clinical outcome and radiologic progression in patients with neuropsychiatric manifestations of systemic lupus erythematosus, Am J Med, 109, 628, 10.1016/S0002-9343(00)00603-3 Stimmler, 1993, Magnetic resonance imaging of the brain in neuropsychiatric systemic lupus erythematosus, Semin Arthritis Rheum, 22, 335, 10.1016/S0049-0172(05)80012-5 Bell, 1991, Magnetic resonance imaging of central nervous system lesions in patients with lupus erythematosus. Correlation with clinical remission and antineurofilament and anticardiolipin antibody titers, Arthritis Rheum, 34, 432, 10.1002/art.1780340408 Sibbitt, 2010, Magnetic resonance imaging and brain histopathology in neuropsychiatric systemic lupus erythematosus, Semin Arthritis Rheum, 40, 32, 10.1016/j.semarthrit.2009.08.005 de Leeuw, 2002, Hypertension and cerebral white matter lesions in a prospective cohort study, Brain, 125, 765, 10.1093/brain/awf077 Sanna, 2006, Cerebral manifestations in the antiphospholipid (Hughes) syndrome, Rheum Dis Clin North Am, 32, 465, 10.1016/j.rdc.2006.05.010 Roldan, 2007, Valvular heart disease by transthoracic echocardiography is associated with focal brain injury and central neuropsychiatric systemic lupus erythematosus, Cardiology, 108, 331, 10.1159/000099104 Kruit, 2004, Migraine as a risk factor for subclinical brain lesions, JAMA, 291, 427, 10.1001/jama.291.4.427 Sachdev, 2008, White matter hyperintensities in mid-adult life, Curr Opin Psychiatry, 21, 268, 10.1097/YCO.0b013e3282f945d5 Brey, 2007, Neuropsychiatric lupus: clinical and imaging aspects, Bull NYU Hosp Jt Dis, 65, 194 Cuadrado, 2000, Can neurologic manifestations of Hughes (antiphospholipid) syndrome be distinguished from multiple sclerosis? Analysis of 27 patients and review of the literature, Medicine (Baltimore), 79, 57, 10.1097/00005792-200001000-00006 Cotton, 2004, MRI of central nervous system in a series of 58 systemic lupus erythematosus (SLE) patients with or without overt neuropsychiatric manifestations, Rev Med Interne, 25, 8, 10.1016/S0248-8663(03)00265-0 Muscal, 2010, Cerebral and cerebellar volume loss in children and adolescents with systemic lupus erythematosus: a review of clinically acquired brain magnetic resonance imaging, J Rheumatol, 37, 1768, 10.3899/jrheum.090983 Amoroso, 1999, Primary antiphospholipid syndrome and cerebral atrophy: a rare association?, Am J Med Sci, 317, 425 Appenzeller, 2005, Evidence of reversible axonal dysfunction in systemic lupus erythematosus: a proton MRS study, Brain, 128, 2933, 10.1093/brain/awh646 Axford, 2001, Sensitivity of quantitative (1)H magnetic resonance spectroscopy of the brain in detecting early neuronal damage in systemic lupus erythematosus, Ann Rheum Dis, 60, 106, 10.1136/ard.60.2.106 Bosma, 2004, Multisequence magnetic resonance imaging study of neuropsychiatric systemic lupus erythematosus, Arthritis Rheum, 50, 3195, 10.1002/art.20512 Steens, 2004, Selective gray matter damage in neuropsychiatric lupus, Arthritis Rheum, 50, 2877, 10.1002/art.20654 Castellino, 2008, Single photon emission computed tomography and magnetic resonance imaging evaluation in SLE patients with and without neuropsychiatric involvement, Rheumatology (Oxford), 47, 319, 10.1093/rheumatology/kem354 Zhang, 2005, Diagnostic value of single-photon-emission computed tomography in severe central nervous system involvement of systemic lupus erythematosus: a case-control study, Arthritis Rheum, 53, 845, 10.1002/art.21591 Weiner, 2000, Diagnosis and monitoring of central nervous system involvement in systemic lupus erythematosus: value of F-18 fluorodeoxyglucose PET, Ann Rheum Dis, 59, 377, 10.1136/ard.59.5.377 Popescu, 2011, Neuropsychiatric systemic lupus erythematosus, Curr Neuropharmacol, 9, 449, 10.2174/157015911796557984 DiFrancesco, 2007, Functional magnetic resonance imaging assessment of cognitive function in childhood-onset systemic lupus erythematosus: a pilot study, Arthritis Rheum, 56, 4151, 10.1002/art.23132 Rocca, 2006, An fMRI study of the motor system in patients with neuropsychiatric systemic lupus erythematosus, Neuroimage, 30, 478, 10.1016/j.neuroimage.2005.09.047 Wolinsky, 2002, Magnetic resonance spectroscopy in multiple sclerosis: window into the diseased brain, Curr Opin Neurol, 15, 247, 10.1097/00019052-200206000-00004 Petrella, 2005, Increasing memory load modulates regional brain activity in older adults as measured by fMRI, J Neuropsychiatry Clin Neurosci, 17, 75, 10.1176/jnp.17.1.75 Fuller, 2004, A prospective longitudinal in?vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDS, BMC Neurosci, 5, 10, 10.1186/1471-2202-5-10 West, 1995, Neuropsychiatric lupus erythematosus: a 10-year prospective study on the value of diagnostic tests, Am J Med, 99, 153, 10.1016/S0002-9343(99)80135-1 Chinn, 1997, Magnetic resonance imaging of the brain and cerebral proton spectroscopy in patients with systemic lupus erythematosus, Arthritis Rheum, 40, 36, 10.1002/art.1780400107 Davie, 1995, Proton magnetic resonance spectroscopy of systemic lupus erythematosus involving the central nervous system, J Neurol, 242, 522, 10.1007/BF00867424 Colamussi, 1997, Brain perfusion SPET and proton magnetic resonance spectroscopy in the evaluation of two systemic lupus erythematosus patients with mild neuropsychiatric manifestations, Nucl Med Commun, 18, 269, 10.1097/00006231-199703000-00012 Sibbitt, 1993, Magnetic resonance spectroscopy and positron emission tomography scanning in neuropsychiatric systemic lupus erythematosus, Rheum Dis Clin North Am, 19, 851, 10.1016/S0889-857X(21)00210-6 Sibbitt, 1997, Neurometabolism of active neuropsychiatric lupus determined with proton MR spectroscopy, AJNR Am J Neuroradiol, 18, 1271 Davie, 1994, Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions, Brain, 117, 49, 10.1093/brain/117.1.49 Brenner, 1993, The proton NMR spectrum in acute EAE: the significance of the change in the Cho:Cr ratio, Magn Reson Med, 29, 737, 10.1002/mrm.1910290605 Häussinger, 1994, Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy, Gastroenterology, 107, 1475, 10.1016/0016-5085(94)90552-5 Videen, 1995, Human cerebral osmolytes during chronic hyponatremia. A proton magnetic resonance spectroscopy study, J Clin Invest, 95, 788, 10.1172/JCI117728 Kozora, 2011, Cognitive dysfunction and white matter abnormalities in systemic lupus erythematosus, J Int Neuropsychol Soc, 22, 1 Balaban, 1992, Magnetization transfer contrast in magnetic resonance imaging, Magn Reson Q, 8, 116 Le Bihan, 1991, Molecular diffusion nuclear magnetic resonance imaging, Magn Reson Q, 7, 1 Rovaris, 2000, The value of new magnetic resonance techniques in multiple sclerosis, Curr Opin Neurol, 13, 249, 10.1097/00019052-200006000-00003 Otte, 1998, Neuropsychiatric systemic lupus erythematosus before and after immunosuppressive treatment: a FDG PET study, Lupus, 7, 57, 10.1191/096120398678919651 Breitbach, 1998, Determinants of cognitive performance in systemic lupus erythematosus, J Clin Exp Neuropsychol, 20, 157, 10.1076/jcen.20.2.157.1166 Denburg, 2003, Cognitive dysfunction and antiphospholipid antibodies in systemic lupus erythematosus, Lupus, 12, 883, 10.1191/0961203303lu497oa Borrelli, 2003, Evaluation with MR, perfusion MR and cerebral flowSPECT in NPSLE patients, Radiol Med, 105, 482 Tatum, 1994, Technetium-99m-HMPAO SPECT in partial status epilepticus, J Nucl Med, 35, 1087 Castellino, 2011, Repeated brain conventional MRI and SPECT evaluation in systemic lupus erythematosus patients with and without neuropsychiatric involvement: a follow up study, Lupus, 20, 1387, 10.1177/0961203311415304 Giovacchini, 2010, Cerebral blood flow in depressed patients with systemic lupus erythematosus, J Rheumatol, 37, 1844, 10.3899/jrheum.100121 Qiu, 2013, Single photon emission computed tomography evaluation for severe neuropsychiatric systemic lupus erythematosus, Clin Exp Rheumatol, 31, 159 Ishimori, 2007, Posterior reversible encephalopathy syndrome: another manifestation of CNS SLE?, Lupus, 16, 436, 10.1177/0961203307078682 Fong, 2010, Neuropsychiatric lupus: clinical challenges, brain-reactive autoantibodies and treatment strategies, Lupus, 19, 1399, 10.1177/0961203310374338 Okamoto, 2010, Cytokines and chemokines in neuropsychiatric syndromes of systemic lupus erythematosus, J Biomed Biotechnol, 2010, 268436, 10.1155/2010/268436 Kao, 1999, Discrepancy between regional cerebral blood flow and glucose metabolism of the brain in systemic lupus erythematosus patients with normal brain magnetic resonance imaging findings, Arthritis Rheum, 42, 61, 10.1002/1529-0131(199901)42:1<61::AID-ANR8>3.0.CO;2-9 Rennen, 2001, Imaging infection/inflammation in the new millennium, Eur J Nucl Med, 28, 241, 10.1007/s002590000447 Hamilton, 2009, The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases, Arthritis Rheum, 60, 1210, 10.1002/art.24505 Basu, 2010, PET and PET-CT imaging in infection and inflammation: its critical role in assessing complications related to therapeutic interventions in patients with cancer, Indian J Cancer, 47, 371, 10.4103/0019-509X.73562 Lee, 2012, The efficacy of brain (18)F-fluorodeoxyglucose positron emission tomography in neuropsychiatric lupus patients with normal brain magnetic resonance imaging findings, Lupus, 21, 1531, 10.1177/0961203312459104 Stoppe, 1990, Positron emission tomography in neuropsychiatric lupus erythematosus, Neurology, 40, 304, 10.1212/WNL.40.2.304 Krakauer, 2009, FDG PET brain imaging in neuropsychiatric systemic lupus erythematosus with choreic symptoms, Clin Nucl Med, 34, 122, 10.1097/RLU.0b013e318192c4d2 Levine, 1990, Cerebrovascular and neurologic disease associated with antiphospholipid antibodies: 48 cases, Neurology, 40, 1181, 10.1212/WNL.40.8.1181 Di Geso, 2012, Comparison between conventional and automated software-guided ultrasound assessment of bilateral common carotids intima-media thickness in patients with rheumatic diseases, Clin Rheumatol, 31, 881, 10.1007/s10067-011-1915-y Cacciapaglia, 2009, Stiffness parameters, intima-media thickness and early atherosclerosis in systemic lupus erythematosus patients, Lupus, 18, 249, 10.1177/0961203308097571 Zardi, 2010, Endothelial dysfunction and vascular stiffness in systemic lupus erythematosus: are they early markers of subclinical atherosclerosis?, Autoimmun Rev, 9, 684, 10.1016/j.autrev.2010.05.018 Zardi, 2011, How to predict subclinical atherosclerosis in systemic lupus erythematosus, Rheumatology (Oxford), 50, 821, 10.1093/rheumatology/keq283 Vadacca, 2013, Leptin, adiponectin and vascular stiffness parameters in women with systemic lupus erythematosus, Intern Emerg Med, 8, 705, 10.1007/s11739-011-0726-0 Wright, 2009, Colour Doppler ultrasound of the ocular circulation in patients with systemic lupus erythematosus identifies altered microcirculatory haemodynamics, Lupus, 18, 950, 10.1177/0961203309104865 Waterloo, 2001, Neuropsychological dysfunction in systemic lupus erythematosus is not associated with changes in cerebral blood flow, J Neurol, 485, 595, 10.1007/s004150170138 Huang, 2002, Objective evidence of abnormal regional cerebral blood flow in patients with systemic lupus erythematosus on Tc-99m ECD brain SPECT, Rheumatol Int, 22, 178, 10.1007/s00296-002-0224-9 Aaslid, 1982, Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries, J Neurosurg, 57, 769, 10.3171/jns.1982.57.6.0769 Gosling, 1974, Arterial assessment by Doppler-shift ultrasound, Proc R Soc Med, 67, 447 Arnolds, 1986, Transcranial Doppler sonography. Examination technique and normal reference values, Ultrasound Med Biol, 21, 115, 10.1016/0301-5629(86)90016-5 Greene, 2012, Middle cerebral artery resistivity and pulsatility indices in systemic lupus erythematosus: evidence for hyperperfusion, Lupus, 21, 380, 10.1177/0961203311428458 Zardi, 2012, Systemic lupus erythematosus patients with and without neuropsychiatric manifestations: a neck and transcranial duplex sonography study, Int J Immunopathol Pharmacol, 25, 1157, 10.1177/039463201202500434 Tsivgoulis, 2009, Advances in transcranial Doppler ultrasonography, Curr Neurol Neurosci Rep, 9, 46, 10.1007/s11910-009-0008-7 Markus, 2004, Cerebral perfusion and stroke, J Neurol Neurosurg Psychiatry, 75, 353, 10.1136/jnnp.2003.025825 Davey, 2010, The role of endothelial dysfunction in the pathogenesis of neuropsychiatric systemic lupus erythematosus, Lupus, 19, 797, 10.1177/0961203309359780 West, 1996, Lupus and the central nervous system, Curr Opin Rheumatol, 8, 408, 10.1097/00002281-199609000-00004 Hess, 1997, Cerebral lupus vasculopathy. Mechanisms and clinical relevance, Ann N Y Acad Sci, 823, 154, 10.1111/j.1749-6632.1997.tb48388.x Baizabal-Carvallo, 2010, Microembolic signals in systemic lupus erythematosus and other cerebral small vessel diseases, J Neurol, 257, 503, 10.1007/s00415-009-5421-y Russell, 1991, Detection of arterial emboli using Doppler ultrasound in rabbits, Stroke, 22, 253, 10.1161/01.STR.22.2.253 Spencer, 1990, Detection of middle cerebral artery emboli during carotid endarterectomy using transcranial Doppler ultrasonography, Stroke, 21, 415, 10.1161/01.STR.21.3.415 Specker, 1997, Cerebral microemboli in patients with antiphospholipid syndrome, Lupus, 6, 638, 10.1177/096120339700600804 Rademacher, 1999, Cerebral microembolism, a disease marker for ischemic cerebrovascular events in the antiphospholipid syndrome of systemic lupus erythematosus?, Acta Neurol Scand, 99, 356, 10.1111/j.1600-0404.1999.tb07364.x Specker, 1998, Detection of cerebral microemboli in APS—introducing a novel investigation method and implications of analogies with carotid artery disease, Lupus, 7, S75, 10.1177/096120339800700217 Azarpazhooh, 2010, Microembolic signals in patients with systemic lupus erythematosus, Can J Neurol Sci, 37, 371, 10.1017/S0317167100010271 Kron, 2001, Prevalence of cerebral microemboli in systemic lupus erythematosus: transcranial Doppler, J Rheumatol, 28, 2222 Kumral, 2002, Detection of microembolic signals in patients with neuropsychiatric lupus erythematosus, Eur Neurol, 47, 131, 10.1159/000047970 Cantú-Brito, 2010, The clinical significance of microembolic signals in patients with systemic lupus erythematosus, Neurol Res, 32, 134, 10.1179/016164109X12478302362699 Dahl, 2006, Detection of cerebral embolic signals in patients with systemic lupus erythematosus, J Neurol Neurosurg Psychiatry, 77, 774, 10.1136/jnnp.2005.084285 Baizabal-Carvallo, 2008, Acute neurolupus manifested by seizures is associated with high frequency of abnormal cerebral blood flow velocities, Cerebrovasc Dis, 25, 348, 10.1159/000118381 Toledano, 2013, Neuropsychiatric systemic lupus erythematosus: magnetic resonance imaging findings and correlation with clinical and immunological features, Autoimmun Rev, 12, 1166, 10.1016/j.autrev.2013.07.004