EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation

Cancer Cell - Tập 23 Số 5 - Trang 677-692 - 2013
Wendy Béguelin1, Relja Popovic2, Matt Teater1,3, Yanwen Jiang1,3, Karen Bunting1, Monica W. Rosen1, Hao Shen1, Shao Ning Yang1, Ling Wang1, Teresa Ezponda2, Eva Martínez-García2, Haikuo Zhang4, Yupeng Zheng5, Sharad K. Verma6, Michael T. McCabe6, Heidi M. Ott6, Glenn S. Van Aller6, Ryan G. Kruger6, Yan Liu6, Charles F. McHugh6, David W. Scott7, Young Rock Chung8,9, Neil L. Kelleher5, Rita Shaknovich1, Caretha L. Creasy6, Randy D. Gascoyne7, Kwok‐Kin Wong4, Leandro Cerchietti10,1, Ross L. Levine8,9, Omar Abdel‐Wahab8,9, Jonathan D. Licht2, Olivier Elemento3, Ari Melnick10,1
1Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY 10021, USA
2Division of Hematology/Oncology, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
3Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY 10021, USA
4Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA
5Departments of Chemistry and Molecular Biosciences, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208, USA
6Cancer Epigenetics Discovery Performance Unit, Cancer Research, Oncology R&D, GlaxoSmithKline, 1250 S. Collegeville Road, Collegeville, PA 19426, USA
7Centre for Lymphoid Cancer, Departments of Pathology and Experimental Therapeutics, British Columbia Cancer Agency, British Columbia Cancer Research Centre, Vancouver, BC V5Z 1L3, Canada
8Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
9Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
10Department of Pharmacology, Weill Cornell Medical College, New York, NY 10021, USA

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