EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation
Tóm tắt
Từ khóa
Tài liệu tham khảo
Alizadeh, 2000, Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling, Nature, 403, 503, 10.1038/35000501
Beard, 2006, Efficient method to generate single-copy transgenic mice by site-specific integration in embryonic stem cells, Genesis, 44, 23, 10.1002/gene.20180
Bernstein, 2006, A bivalent chromatin structure marks key developmental genes in embryonic stem cells, Cell, 125, 315, 10.1016/j.cell.2006.02.041
Blackman, 1986, A model system for peptide hormone action in differentiation: interleukin 2 induces a B lymphoma to transcribe the J chain gene, Cell, 47, 609, 10.1016/0092-8674(86)90625-2
Cao, 2002, Role of histone H3 lysine 27 methylation in Polycomb-group silencing, Science, 298, 1039, 10.1126/science.1076997
Casola, 2006, Tracking germinal center B cells expressing germ-line immunoglobulin gamma1 transcripts by conditional gene targeting, Proc. Natl. Acad. Sci. USA, 103, 7396, 10.1073/pnas.0602353103
Cattoretti, 2005, Deregulated BCL6 expression recapitulates the pathogenesis of human diffuse large B cell lymphomas in mice, Cancer Cell, 7, 445, 10.1016/j.ccr.2005.03.037
Chase, 2011, Aberrations of EZH2 in cancer, Clinical cancer research: an official journal of the American Association for Cancer Research, 17, 2613, 10.1158/1078-0432.CCR-10-2156
Ci, 2008, B-cell lymphoma 6 and the molecular pathogenesis of diffuse large B-cell lymphoma, Curr. Opin. Hematol., 15, 381, 10.1097/MOH.0b013e328302c7df
Czermin, 2002, Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites, Cell, 111, 185, 10.1016/S0092-8674(02)00975-3
De, 2013, Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity, PLoS Genet., 9, e1003137, 10.1371/journal.pgen.1003137
Egle, 2004, VavP-Bcl2 transgenic mice develop follicular lymphoma preceded by germinal center hyperplasia, Blood, 103, 2276, 10.1182/blood-2003-07-2469
Giannopoulou, 2011, An integrated ChIP-seq analysis platform with customizable workflows, BMC Bioinformatics, 12, 277, 10.1186/1471-2105-12-277
Klein, 2008, Germinal centres: role in B-cell physiology and malignancy, Nat. Rev. Immunol., 8, 22, 10.1038/nri2217
Knutson, 2012, A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells, Nat. Chem. Biol., 8, 890, 10.1038/nchembio.1084
Lohr, 2012, Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing, Proc. Natl. Acad. Sci. USA, 109, 3879, 10.1073/pnas.1121343109
Mahmoudi, 2001, Chromatin silencing and activation by Polycomb and trithorax group proteins, Oncogene, 20, 3055, 10.1038/sj.onc.1204330
McCabe, 2012, Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27), Proc. Natl. Acad. Sci. USA, 109, 2989, 10.1073/pnas.1116418109
McCabe, 2012, EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations, Nature, 492, 108, 10.1038/nature11606
Morin, 2010, Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin, Nat. Genet., 42, 181, 10.1038/ng.518
Morin, 2011, Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma, Nature, 476, 298, 10.1038/nature10351
Mortazavi, 2008, Mapping and quantifying mammalian transcriptomes by RNA-Seq, Nat. Methods, 5, 621, 10.1038/nmeth.1226
Müller, 2002, Histone methyltransferase activity of a Drosophila Polycomb group repressor complex, Cell, 111, 197, 10.1016/S0092-8674(02)00976-5
O’Carroll, 2001, The polycomb-group gene Ezh2 is required for early mouse development, Mol. Cell. Biol., 21, 4330, 10.1128/MCB.21.13.4330-4336.2001
Qi, 2012, Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation, Proc. Natl. Acad. Sci. USA, 109, 21360, 10.1073/pnas.1210371110
Raaphorst, 2000, Cutting edge: polycomb gene expression patterns reflect distinct B cell differentiation stages in human germinal centers, J. Immunol., 164, 1, 10.4049/jimmunol.164.1.1
Shih, 2012, The role of mutations in epigenetic regulators in myeloid malignancies, Nat. Rev. Cancer, 12, 599, 10.1038/nrc3343
Shin, 2012, Global gene expression analysis of very small embryonic-like stem cells reveals that the Ezh2-dependent bivalent domain mechanism contributes to their pluripotent state, Stem Cells Dev., 21, 1639, 10.1089/scd.2011.0389
Sneeringer, 2010, Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas, Proc. Natl. Acad. Sci. USA, 107, 20980, 10.1073/pnas.1012525107
Su, 2003, Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement, Nat. Immunol., 4, 124, 10.1038/ni876
Taniguchi, 2012, Silencing of Kruppel-like factor 2 by the histone methyltransferase EZH2 in human cancer, Oncogene, 31, 1988, 10.1038/onc.2011.387
Trapnell, 2009, TopHat: discovering splice junctions with RNA-Seq, Bioinformatics, 25, 1105, 10.1093/bioinformatics/btp120
van Galen, 2004, Distinct expression patterns of polycomb oncoproteins and their binding partners during the germinal center reaction, Eur. J. Immunol., 34, 1870, 10.1002/eji.200424985
van Kemenade, 2001, Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma, Blood, 97, 3896, 10.1182/blood.V97.12.3896
Velichutina, 2010, EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis, Blood, 116, 5247, 10.1182/blood-2010-04-280149
Verma, 2012, Identification of potent, selective, cell-active inhibitors of the histone lysine methyltransferase EZH2, ACS Med. Chem. Lett., 3, 1091, 10.1021/ml3003346
Yap, 2011, Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation, Blood, 117, 2451, 10.1182/blood-2010-11-321208