An integrative metabolomics and network pharmacology method for exploring the effect and mechanism of Radix Bupleuri and Radix Paeoniae Alba on anti-depression

Paykel, 2006, Depression: major problem for public health, Epidemiol. Psichiatr. Soc., 15, 4, 10.1017/S1121189X00001974 Moussavi, 2007, Depression, chronic diseases, and decrements in health: results from the World Health Surveys, Lancet, 370, 851, 10.1016/S0140-6736(07)61415-9 Liu, 2015, Plasma-metabolite-biomarkers for the therapeutic response in depressed patients by the traditional Chinese medicine formula Xiaoyaosan: a (1)H NMR-based metabolomics approach, J. Affect. Disord., 185, 156, 10.1016/j.jad.2015.05.005 Wang, 2016, Antidepressant-like effects of the Radix Bupleuri and Radix Paeoniae Alba drug pair, Neurosci. Lett., 633, 14, 10.1016/j.neulet.2016.09.001 Zheng, 2012, Plasma metabonomics as a novel diagnostic approach for major depressive disorder, J. Proteome Res., 11, 1741, 10.1021/pr2010082 Antoniuk, 2019, Chronic unpredictable mild stress for modeling depression in rodents: meta-analysis of model reliability, Neurosci. Biobehav. Rev., 99, 101, 10.1016/j.neubiorev.2018.12.002 Du, 2016, Metabonomic identification of the effects of the Zhimu-Baihe saponins on a chronic unpredictable mild stress-induced rat model of depression, J. Pharm. Biomed. Anal., 128, 469, 10.1016/j.jpba.2016.06.019 Moulton, 2015, The link between depression and diabetes: the search for shared mechanisms, Lancet Diab. Endocrinol., 3, 461, 10.1016/S2213-8587(15)00134-5 Jia, 2017, Banxia-houpu decoction restores glucose intolerance in cums rats through improvement of insulin signaling and suppression of NLRP3 inflammasome activation in liver and brain, Ethnopharmacology, 209, 219, 10.1016/j.jep.2017.08.004 Liu, 2015, Severe disturbance of glucose metabolism in peripheral blood mononuclear cells of schizophrenia patients: a targeted metabolomic study, J. Transl. Med., 13, 226, 10.1186/s12967-015-0540-y Zhai, 2015, A simple LC-MS/MS method for the determination of cortisol, cortisone and tetrahydro-metabolites in human urine: assay development, validation and application in depression patients, J. Pharm. Biomed. Anal., 107, 450, 10.1016/j.jpba.2015.01.041 Wichmann, 2017, Cortisol stress response in post-traumatic stress disorder, panic disorder, and major depressive disorder patients, Psychoneuroendocrinology, 83, 135, 10.1016/j.psyneuen.2017.06.005 Lebedeva, 2018, Longitudinal relationships among depressive symptoms, cortisol, and brain atrophy in the neocortex and the hippocampus, Acta Psychiatr. Scand., 491, 10.1111/acps.12860 Adzic, 2018, Therapeutic strategies for treatment of inflammation-related depression, Curr. Neuropharmacol., 16, 176, 10.2174/1570159X15666170828163048 Bortolato, 2016, Cognitive remission: a novel objective for the treatment of major depression?, BMC Med., 14, 9, 10.1186/s12916-016-0560-3 Fujita, 2017, cAMP signaling in brain is decreased in unmedicated depressed patients and increased by treatment with a selective serotonin reuptake inhibitor, Mol. Psychiatry, 22, 754, 10.1038/mp.2016.171 Wray, 2019, NMDAR-independent, cAMP-dependent antidepressant actions of ketamine, Mol. Psychiatry, 24, 1833, 10.1038/s41380-018-0083-8 Nair, 2006, Cyclic AMP response element binding protein and brain-derived neurotrophic factor: molecules that modulate our mood?, J. Biosci., 31, 423, 10.1007/BF02704114 Gabbay, 2010, The kynurenine pathway in adolescent depression: preliminary findings from a proton MR spectroscopy study, Prog. Neuropsychopharmacol. Biol. Psychiatry, 34, 37, 10.1016/j.pnpbp.2009.09.015 Fogaça, 2019, Cortical GABAergic dysfunction in stress and depression: new insights for therapeutic interventions, Front. Cell. Neurosci., 13, 87, 10.3389/fncel.2019.00087 Mahan, 2019, Neurointegrity and neurophysiology: astrocyte, glutamate, and carbon monoxide interactions, Med. Gas Res., 9, 24 Xiao, 1999, L-pyroglutamic acid protects rat cortical neurons against sodium glutamate-induced injury, Zhongguo Yao Li Xue Bao, 20, 733 Baranyi, 2015, Nitric oxide-related biological pathways in patients with major depression, PLoS One, 10, e0143397, 10.1371/journal.pone.0143397 Selley, 2004, Increased (E)-4-hydroxy-2-nonenal and asymmetric dimethylarginine concentrations and decreased nitric oxide concentrations in the plasma of patients with major depression, J. Affect. Disord., 80, 249, 10.1016/S0165-0327(03)00135-6 Zhao, 2016, Structural features and potent antidepressant effects of total sterols and β-sitosterol extracted from Sargassum horneri, Mar. Drugs, 14, 123, 10.3390/md14070123 Mineur, 2013, Cholinergic signaling in the hippo -campus regulates social stress resilience and anxiety and depression-like behavior, Proc. Natl. Acad. Sci. U. S. A., 110, 3573, 10.1073/pnas.1219731110 Leonard, 2018, Inflammation and depression: a causal or coincidental link to the pathophysiology?, Acta Neuropsychiatr., 30, 1, 10.1017/neu.2016.69 Ziegler, 2018, Epigenetic signature of MAOA and MAOB genes in mental disorders, J. Neural Transm. (Vienna), 125, 1581, 10.1007/s00702-018-1929-6 Abdulla, 2005, Beta-adrenergic receptor modulation of the LPS-mediated depression in CYP1A activity in astrocytes, Biochem. Pharmacol., 69, 741, 10.1016/j.bcp.2004.11.020 Kotsovolou, 2010, Hepatic drug metabolizing profile of Flinders Sensitive Line rat model of depression, Prog. Neuropsychopharmacol. Biol. Psychiatry, 34, 1075, 10.1016/j.pnpbp.2010.05.029