Diagnostic value of whole‐body magnetic resonance imaging for bone metastases: a systematic review and meta‐analysis

Journal of Magnetic Resonance Imaging - Tập 34 Số 1 - Trang 128-135 - 2011
Lian‐Ming Wu1, Haiyan Gu1, Jasmine Zheng2, Xiaoxue Xu1, Lin‐Hua Lin1, Deng Xia1, Wei Zhang1, Jianrong Xu1
1Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Georgetown Univ Sch of Medicine, Washington, DC, USA

Tóm tắt

AbstractPurpose:To assess the overall diagnostic accuracy of whole‐body magnetic resonance imaging (WB‐MRI) in detecting bone metastases with a meta‐analysis.Materials and Methods:The MEDLINE, EMBASE, Cancerlit, and Cochrane Library databases were searched from January 1995 to September 2010 for studies evaluating the accuracy of WB‐MRI in detecting bone metastases. Histopathologic analysis and/or close clinical and imaging follow‐up for at least 6 months was assessed. Meta‐analysis methods were used to pool sensitivity and specificity and to construct summary receiver‐operating characteristics.Results:A total of 11 studies with 495 patients who fulfilled all of the inclusion criteria were considered for the analysis. No publication bias was found. WB‐MRI had a pooled sensitivity of 0.899 (95% confidence interval [CI], 0.845–0.939) and a pooled specificity of 0.918 (95% CI, 0.882–0.946). The subgroup without diffusion‐weighted imaging (DWI) positive results had higher pooled specificity 0.961 (95% CI, 0.922‐0.984) than the subgroup with DWI (P < 0.05).Conclusion:WB‐MRI was an accurate, cost‐effective tool in detecting bone metastases. WB‐MRI without DWI may improve the specificity of detecting bone metastases. DWI seems to be a sensitive but rather unspecific modality for the detection of bone metastatic disease. High‐quality prospective studies regarding WB‐MRI in detecting bone metastases still need to be conducted. J. Magn. Reson. Imaging 2011;. © 2011 Wiley‐Liss, Inc.

Từ khóa


Tài liệu tham khảo

Manyak MJ, 1998, The role of computerized tomography, magnetic resonance imaging, bone scan, and monoclonal antibody nuclear scan for prognosis prediction in prostate cancer, Semin Urol Oncol, 16, 145

10.1016/S0090-4295(99)00090-4

10.1056/NEJMoa022136

10.1016/j.athoracsur.2004.02.067

10.1016/S0012-3692(15)52634-2

10.1007/s11307-008-0131-x

10.1016/j.ejso.2005.09.018

10.1148/radiol.2492080038

10.2214/ajr.177.1.1770229

10.1148/radiol.2331030777

10.1002/jmri.21031

Ghanem N, 2006, Whole‐body MRI in comparison to skeletal scintigraphy in detection of skeletal metastases in patients with solid tumors, In Vivo, 20, 173

10.1097/01.rct.0000189593.41198.20

Mehta RC, 1995, MR evaluation of vertebral metastases: T1‐weighted short inversion time inversion recovery, fast spin echo, and inversion recovery fast spin‐echo sequences, Am J Neuroradiol, 16, 281

10.1007/s00330-004-2432-z

10.1007/s00330-005-2719-8

10.1016/S0140-6736(05)62352-5

10.1186/1471-2288-3-25

10.3748/wjg.v12.i2.246

10.1002/(SICI)1522-2586(200004)11:4<343::AID-JMRI1>3.0.CO;2-P

10.2463/mrms.4.11

10.2463/mrms.6.147

10.1002/jmri.21031

10.1007/s11547-008-0341-y

10.1007/s12032-007-9027-x

10.1259/bjr/52773262

10.1002/jmri.21858

10.1111/j.1754-9485.2009.02070.x

10.1016/j.mri.2009.12.008

10.1007/s00259-010-1399-z

10.1186/1471-2288-6-31

10.1111/j.1464-410X.2004.04849.x

Eustace SJ, 1999, Whole‐body MR imaging. Practical issues, clinical applications, and future directions, Magn Reson Imaging Clin N Am, 7, 209

10.2214/ajr.169.6.9393186

10.1097/00004728-199901000-00026

10.1007/s00330-002-1344-z

10.1007/s00330-003-1968-7

10.1148/radiographics.11.2.2028061

10.1007/s00330-005-0042-z

10.1016/j.ejrad.2007.11.039

10.1016/j.jtcvs.2007.10.035

10.1016/j.ejcts.2008.12.039

10.1016/j.ejrad.2008.09.034

10.1002/jmri.21638

10.1177/016327870102400202

10.1007/s11604-007-0128-4

Schlemmer H, 2007, Simultaneous MR/PET for brain imaging: first patient scans (abstract), J Nucl Med, 48, 45

10.1055/s-0029-1245463

10.1002/jmri.21570

10.1186/1471-2407-9-18

Thông tin
Thông tin xuất bản

Journal of Magnetic Resonance Imaging

Tập 34 Số 1

128-135

Thông tin tác giả