The gene encoding cyclooxygenase-2 is regulated by IL-1β and prostaglandins in 832/13 rat insulinoma cells

Weir, 2004, Five stages of evolving beta-cell dysfunction during progression to diabetes, Diabetes, 53, S16, 10.2337/diabetes.53.suppl_3.S16 Mathis, 2001, Beta-cell death during progression to diabetes, Nature, 414, 792, 10.1038/414792a Donath, 2011, Type 2 diabetes as an inflammatory disease, Nat. Rev. Immunol., 11, 98, 10.1038/nri2925 Wang, 2010, Cytokines in the progression of pancreatic beta-cell dysfunction, Int. J. Endocrinol., 2010, 515136, 10.1155/2010/515136 Eizirik, 2009, The role of inflammation in insulitis and beta-cell loss in type 1 diabetes, Nat. Rev. Endocrinol., 5, 219, 10.1038/nrendo.2009.21 Kutlu, 2003, Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic beta-cells, Diabetes, 52, 348, 10.2337/diabetes.52.2.348 Darville, 1998, Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells, Diabetologia, 41, 1101, 10.1007/s001250051036 Corbett, 1993, IL-1 beta induces the coexpression of both nitric oxide synthase and cyclooxygenase by islets of Langerhans: activation of cyclooxygenase by nitric oxide, Biochemistry, 32, 13767, 10.1021/bi00213a002 Robertson, 1998, Dominance of cyclooxygenase-2 in the regulation of pancreatic islet prostaglandin synthesis, Diabetes, 47, 1379, 10.2337/diabetes.47.9.1379 Smith, 1996, Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2, J. Biol. Chem., 271, 33157, 10.1074/jbc.271.52.33157 Oshima, 2006, Destruction of pancreatic beta-cells by transgenic induction of prostaglandin E2 in the islets, J. Biol. Chem., 281, 29330, 10.1074/jbc.M602424200 Shanmugam, 2006, Increased expression of cyclooxygenase-2 in human pancreatic islets treated with high glucose or ligands of the advanced glycation endproduct-specific receptor (AGER) and in islets from diabetic mice, Diabetologia, 49, 100, 10.1007/s00125-005-0065-7 Tabatabaie, 2000, COX-2 inhibition prevents insulin-dependent diabetes in low-dose streptozotocin-treated mice, Biochem. Biophys. Res. Commun., 273, 699, 10.1006/bbrc.2000.2959 Tran, 2002, Inhibition of interleukin-1beta-induced COX-2 and EP3 gene expression by sodium salicylate enhances pancreatic islet beta-cell function, Diabetes, 51, 1772, 10.2337/diabetes.51.6.1772 Tran, 1999, Prostaglandin E(2) mediates inhibition of insulin secretion by interleukin-1beta, J. Biol. Chem., 274, 31245, 10.1074/jbc.274.44.31245 Hayden, 2008, Shared principles in NF-κB signaling, Cell, 132, 344, 10.1016/j.cell.2008.01.020 Zhong, 1997, The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism, Cell, 89, 413, 10.1016/S0092-8674(00)80222-6 Levy, 2002, Stats: transcriptional control and biological impact, Na. Rev. Mol. Cell. Biol., 3, 651, 10.1038/nrm909 Moore, 2011, STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation, J. Biol. Chem., 286, 929, 10.1074/jbc.M110.162131 Kim, 2007, STAT1 as a key modulator of cell death, Cell. Signal., 19, 454, 10.1016/j.cellsig.2006.09.003 Hohmeier, 2000, Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion, Diabetes, 49, 424, 10.2337/diabetes.49.3.424 T.C. Becker, R.J. Noel, W.S. Coats, A.M. Gomez-Foix, T. Alam, R.D. Gerard, C.B. Newgard, Use of recombinant adenovirus for metabolic engineering of mammalian cells, Methods Cell Biol 43 Pt A (1994) 161-189. Lavine, 2010, Contamination with E1A-positive wild-type adenovirus accounts for species-specific stimulation of islet cell proliferation by CCK: a cautionary note, Mol. Endocrinol., 24, 464, 10.1210/me.2009-0384 Stewart, 2001, Interferon-tau activates multiple signal transducer and activator of transcription proteins and has complex effects on interferon-responsive gene transcription in ovine endometrial epithelial cells, Endocrinology, 142, 98, 10.1210/endo.142.1.7891 Hinz, 2002, Cyclooxygenase-2 – 10 years later, J. Pharmacol. Exp. Ther., 300, 367, 10.1124/jpet.300.2.367 Dubois, 1998, Cyclooxygenase in biology and disease, FASEB J., 12, 1063, 10.1096/fasebj.12.12.1063 Collier, 2006, Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines, Diabetes, 55, 1398, 10.2337/db05-1000 J.J. Collier, S.J. Burke, M.E. Eisenhauer, D. Lu, R.C. Sapp, C.J. Frydman, S.R. Campagna, Pancreatic beta-cell Death in Response to Pro-inflammatory Cytokines is Distinct from Genuine Apoptosis, PLoS ONE In Press http://dx.plos.org/10.1371/journal.pone.0022485 (2011). Kang, 2007, Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradation, Prog. Lipid Res., 46, 108, 10.1016/j.plipres.2007.01.001 Jobin, 1998, Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells, J. Immunol., 160, 410, 10.4049/jimmunol.160.1.410 Jobin, 1998, Specific NF-κB blockade selectively inhibits tumour necrosis factor-alpha-induced COX-2 but not constitutive COX-1 gene expression in HT-29 cells, Immunology, 95, 537, 10.1046/j.1365-2567.1998.00646.x Ushikubi, 2000, Roles of prostanoids revealed from studies using mice lacking specific prostanoid receptors, Jpn. J. Pharmacol., 83, 279, 10.1016/S0021-5198(19)30561-X Kim, 2007, Essential role for signal transducer and activator of transcription-1 in pancreatic beta-cell death and autoimmune type 1 diabetes of nonobese diabetic mice, Diabetes, 56, 2561, 10.2337/db06-1372 Eldor, 2006, Conditional and specific NF-κB blockade protects pancreatic beta cells from diabetogenic agents, Proc. Natl. Acad. Sci. USA, 103, 5072, 10.1073/pnas.0508166103 Giannoukakis, 2000, Protection of human islets from the effects of interleukin-1beta by adenoviral gene transfer of an Iκ B repressor, J. Biol. Chem., 275, 36509, 10.1074/jbc.M005943200 Poligone, 2001, Positive and negative regulation of NF-κB by COX-2: roles of different prostaglandins, J. Biol. Chem., 276, 38658, 10.1074/jbc.M106599200 Sakata, 2010, Prostaglandin E2, an immunoactivator, J. Pharmacol. Sci., 112, 1, 10.1254/jphs.09R03CP Yao, 2009, Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion, Nat. Med., 15, 633, 10.1038/nm.1968 Donath, 2009, Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes, Physiology (Bethesda), 24, 325 Gepts, 1965, Pathologic anatomy of the pancreas in juvenile diabetes mellitus, Diabetes, 14, 619, 10.2337/diab.14.10.619 Heitmeier, 2004, Role of cyclooxygenase-2 in cytokine-induced beta-cell dysfunction and damage by isolated rat and human islets, J. Biol. Chem., 279, 53145, 10.1074/jbc.M410978200 Cozar-Castellano, 2006, Molecular control of cell cycle progression in the pancreatic beta-cell, Endocr. Rev., 27, 356, 10.1210/er.2006-0004