The anatomy of the normal placenta

Journal of Clinical Pathology - Tập 61 Số 12 - Trang 1296-1302 - 2008
Berthold Huppertz1
1Institute of Cell Biology, Histology and Embryology, Centre of Molecular Medicine, Medical University of Graz, Harrachgasse 21/7, 8010 Graz, Austria

Tóm tắt

The placenta is the fetal organ providing the interchange between mother and fetus. This organ needs to provide its function such as transport and secretion even during its development and thus all developmental changes need to be in accordance with its function. This review describes development of the placenta during the first few weeks of pregnancy until the villous trees with their vasculature are established. The macroscopic anatomy of the delivered placenta as well as the microscopic anatomy and histology of this organ are also described. This includes the different types of villi and the most important cellular components of the villi such as villous trophoblast, Hofbauer cells, mesenchymal cells and endothelium. Fibrinoid and its localisation is also described.

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Tài liệu tham khảo

10.1053/beog.2000.0116

Boyd JD Hamilton WJ . The human placenta. Cambridge: Heffer and Sons, 1970.

McLennan, 1968, Implications of eccentricity of the human umbilical cord., Am J Obstet Gynecol, 101, 1124, 10.1016/0002-9378(68)90359-1

Jauniaux, 1990, Pathologic features of placentas from singleton pregnancies obtained by in vitro fertilization and embryo transfer., Obstet Gynecol, 76, 61

Potgens, 2002, Mechanisms of syncytial fusion: a review., Placenta, 23, S107, 10.1053/plac.2002.0772

10.1002/aja.1000980306

Carter, 1997, When is the maternal placental circulation established in Man?, Placenta, 18, 83, 10.1016/S0143-4004(97)90075-8

Hamilton, 1960, Development of the human placenta in the first three months of gestation., J Anat, 94, 297

10.1002/aja.1001520106

Enders, 1988, Formation and differentiation of extraembryonic mesoderm in the rhesus monkey., Am J Anat, 118, 327, 10.1002/aja.1001810402

Pijnenborg, 1990, Trophoblast invasion and placentation in the human: morphological aspects., Trophoblast Res, 4, 33

10.1095/biolreprod.102.014977

10.1002/aja.1001340207

Demir, 1989, Fetal vasculogenesis and angiogenesis in human placental villi., Acta Anat, 136, 190, 10.1159/000146886

Jackson, 1992, Quantitative description of the elaboration and maturation of villi from 10 weeks of gestation to term., Placenta, 13, 357, 10.1016/0143-4004(92)90060-7

10.1016/0028-2243(76)90050-2

Kaufmann, 1985, Basic morphology of the fetal and maternal circuits in the human placenta., Contrib Gynecol Obstet, 13, 5, 10.1159/000410663

Schuhmann, 1982, Placentone structure of the human placenta., Biblthca Anat, 22, 46

Sen, 1979, Classification of placental villi. II. Morphometry., Cell Tissue Res, 200, 425, 10.1007/BF00234853

Kaufmann, 1979, Classification of human placental villi. 1. Histology., Cell Tissue Res, 200, 409, 10.1007/BF00234852

Kaufmann, 1982, Development and differentiation of the human placental villous tree., Biblthca Anat, 22, 29

Castellucci, 1990, The development of the human placental villous tree., Anat Embryol, 181, 117, 10.1007/BF00198951

10.1093/humupd/6.5.485

Kohnen, 1996, Placental villous stroma as a model system for myofibroblast differentiation., Histochem Cell Biol, 101, 415, 10.1007/BF01457655

10.1002/(SICI)1097-0029(19970701/15)38:1/2<29::AID-JEMT5>3.0.CO;2-P

Graf, 1994, The extravascular contractile system in the human placenta. Morphological and immunocytochemical investigation., Anat Embryol, 190, 541, 10.1007/BF00190104

10.1007/s004410050965

Feneley, 1991, Villous composition and membrane thickness in the human placenta at tern: a stereological study using unbiased estimators and optimal fixation techniques., Placenta, 12, 131, 10.1016/0143-4004(91)90017-A

Kaufmann, 1996, The fibrinoids of the human placenta: origin, composition and functional relevance., Annals Anat, 178, 485, 10.1016/S0940-9602(96)80102-6

10.1016/S0143-4004(96)90019-3

Mayhew, 1999, Proliferation, differentiation and apoptosis in villous trophoblast at 13–41 weeks of gestation (including observations on annulate lamellae and nuclear pore complexes., Placenta, 20, 407, 10.1053/plac.1999.0399

Simpson, 1992, From 13 weeks to term, the trophoblast of human placenta grows by the continuous recruitment of new proliferative units: a study of nuclear number using the disector., Placenta, 13, 501, 10.1016/0143-4004(92)90055-X

Kosanke, 1998, Maternal anemia results in increased proliferation in human placental villi., Trophoblast Res, 11, 339

10.1016/0892-0354(91)90019-9

10.1053/plac.2002.0882

10.1016/S0143-4004(85)80066-7

10.1007/s004290050254

Benirschke K Kaufmann P Baergen R . Pathology of the human placenta. New York: Springer, 2006.

10.1007/BF00305702

10.3181/00379727-106-26490

Huppertz, 1999, Apoptosis cascade progresses during turnover of human trophoblast: analysis of villous cytotrophoblast and syncytial fragments in vitro., Lab Invest, 79, 1687

Ockleford CD Wakely J . The skeleton of the placenta. In: Harrison R J Holmes R L , eds. Progress in anatomy. London: Cambridge University Press, 1981:19–48.

Dearden L Ockleford CD . Structure of human trophoblast: correlation with function. In: Loke Y W Whyte A , eds. Biology of trophoblast. Amsterdam: Elsevier, 1983:69–110.

Kaufmann, 1983, Die funktionelle Bedeutung der Langhanszellen der menschlichen Placenta., Anat Anz, 77, 435

10.1007/s004180050311

Jones, 1977, Syncytial knots and intervillous bridges in the human placenta: an ultrastructural study., J Anat, 124, 275

Cantle, 1987, Interpretation of syncytial sprouts and bridges in the human placenta., Placenta, 8, 221, 10.1016/0143-4004(87)90046-4

10.1053/plac.1999.0422

Iklé, 1961, Trophoblastzellen im strömenden Blut., Schweiz Med Wochenschr, 91, 934

10.1007/BF01369794

10.1111/j.1471-0528.1998.tb10178.x

Marzioni, 2001, Hyaluronate and CD44 expression patterns in the human placenta throughout pregnancy., Eur J Histochem, 45, 131, 10.4081/1623

10.1016/j.placenta.2003.11.011

10.1007/BF00221471

10.1016/0143-4004(92)90057-Z

Lang I Schweizer A Hiden U . Human fetal placental endothelial cells have a mature arterial and a juvenile venous phenotype with adipogenic and osteogenic differentiation potential. Differentiation, in press.

Frank, 1994, Immunohistochemistry of two different types of placental fibrinoid., Acta Anat, 150, 55, 10.1159/000147602

10.1159/000147615

Huppertz, 1996, Extracellular matrix components of the placental extravillous trophoblast: immunocytochemistry and ultrastructural distribution., Histochem Cell Biol, 106, 291, 10.1007/BF02473239

Faulk, 1989, Placental fibrin., Am J Reprod Immunol, 19, 132, 10.1111/j.1600-0897.1989.tb00562.x

10.1016/S0143-4004(82)80006-4

Castellucci M Crescimanno C Schröter CA . Extravillous trophoblast: immunohistochemical localization of extracellular matrix molecules. In: Genazzani A R Petraglia F Genazzani A D , eds. Frontiers in gynecologic and obstetric investigation. New York: Parthenon, 1993:19–25.

10.1002/(SICI)1097-0029(19970701/15)38:1/2<42::AID-JEMT6>3.0.CO;2-W

Leivo, 1989, Expression of merosin, a tissue-specific basement membrane protein, in the intermediate trophoblast cells of choriocarcinoma and placenta., Lab Invest, 60, 783

10.1073/pnas.87.9.3264