Choreography of the DNA Damage Response

Cell - Tập 118 Số 6 - Trang 699-713 - 2004
Michael Lisby1, Jacqueline H. Barlow, Rebecca C. Burgess2, Rodney Rothstein
1Department of Genetics and Development, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, NY 10032, USA.
2Department of Biological Sciences, Columbia University, New York, NY 10027, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Alani, 1992, Characterization of DNA-binding and strand-exchange stimulation properties of y-RPA, a yeast single-strand-DNA-binding protein, J. Mol. Biol, 227, 54, 10.1016/0022-2836(92)90681-9

Alexeev, 2003, Rad54 protein possesses chromatin-remodeling activity stimulated by the Rad51-ssDNA nucleoprotein filament, Nat. Struct. Biol, 10, 182, 10.1038/nsb901

Allen, 1994, The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast, Genes Dev, 8, 2401, 10.1101/gad.8.20.2401

Andersen, 1991, Studies of the topoisomerase II-mediated cleavage and religation reactions by use of a suicidal double-stranded DNA substrate, J. Biol. Chem, 266, 9203, 10.1016/S0021-9258(18)31571-0

Aten, 2004, Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains, Science, 303, 92, 10.1126/science.1088845

Benson, 1998, Synergistic actions of Rad51 and Rad52 in recombination and DNA repair, Nature, 391, 401, 10.1038/34937

Borde, 2004, Association of Mre11p with double-strand break sites during yeast meiosis, Mol. Cell, 13, 389, 10.1016/S1097-2765(04)00034-6

Boulton, 1998, Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing, EMBO J, 17, 1819, 10.1093/emboj/17.6.1819

Carson, 2003, The Mre11 complex is required for ATM activation and the G2/M checkpoint, EMBO J, 22, 6610, 10.1093/emboj/cdg630

Chan, 2003, Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining, Mol. Cell, 11, 1379, 10.1016/S1097-2765(03)00174-6

Chang, 2002, A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage, Proc. Natl. Acad. Sci. USA, 99, 16934, 10.1073/pnas.262669299

Clever, 1997, Recombinational repair in yeast, EMBO J, 16, 2535, 10.1093/emboj/16.9.2535

Costanzo, 2003, An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication, Mol. Cell, 11, 203, 10.1016/S1097-2765(02)00799-2

D'Amours, 2001, The yeast Xrs2 complex functions in S phase checkpoint regulation, Genes Dev, 15, 2238, 10.1101/gad.208701

Davis, 2001, The yeast recombinational repair protein Rad59 interacts with Rad52 and stimulates single-strand annealing, Genetics, 159, 515, 10.1093/genetics/159.2.515

de Jager, 2001, Human Rad50/Mre11 is a flexible complex that can tether DNA ends, Mol. Cell, 8, 1129, 10.1016/S1097-2765(01)00381-1

de la Torre-Ruiz, 1998, RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation, EMBO J, 17, 2687, 10.1093/emboj/17.9.2687

Desany, 1998, Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway, Genes Dev, 12, 2956, 10.1101/gad.12.18.2956

Frank-Vaillant, 2002, Transient stability of DNA ends allows nonhomologous end joining to precede homologous recombination, Mol. Cell, 10, 1189, 10.1016/S1097-2765(02)00705-0

Frei, 2000, The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci, Genes Dev, 14, 81, 10.1101/gad.14.1.81

Friedl, 1998, Radiation-induced chromosome aberrations in Saccharomyces cerevisiae, Genetics, 148, 975, 10.1093/genetics/148.3.975

Fujimori, 2001, Rad52 partially substitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cells, EMBO J, 20, 5513, 10.1093/emboj/20.19.5513

Game, 1974, A genetic study of x-ray sensitive mutants in yeast, Mutat. Res, 24, 281, 10.1016/0027-5107(74)90176-6

Gasior, 1998, Rad52 associates with RPA and functions with Rad55 and Rad57 to assemble meiotic recombination complexes, Genes Dev, 12, 2208, 10.1101/gad.12.14.2208

Gasior, 2001, Assembly of RecA-like recombinases, Proc. Natl. Acad. Sci. USA, 98, 8411, 10.1073/pnas.121046198

Gavin, 2002, Functional organization of the yeast proteome by systematic analysis of protein complexes, Nature, 415, 141, 10.1038/415141a

Gilbert, 2001, Budding yeast Rad9 is an ATP-dependent Rad53 activating machine, Mol. Cell, 8, 129, 10.1016/S1097-2765(01)00267-2

Grenon, 2001, Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex, Nat. Cell Biol, 3, 844, 10.1038/ncb0901-844

Haaf, 1995, Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes, Proc. Natl. Acad. Sci. USA, 92, 2298, 10.1073/pnas.92.6.2298

Haaf, 1999, Sequestration of mammalian Rad51-recombination protein into micronuclei, J. Cell Biol, 144, 11, 10.1083/jcb.144.1.11

Hays, 1995, Complex formation in yeast double-strand break repair, Proc. Natl. Acad. Sci. USA, 92, 6925, 10.1073/pnas.92.15.6925

Hays, 1998, Studies of the interaction between Rad52 protein and the yeast single-stranded DNA binding protein RPA, Mol. Cell. Biol, 18, 4400, 10.1128/MCB.18.7.4400

Jiang, 1996, Direct association between the yeast Rad51 and Rad54 recombination proteins, J. Biol. Chem, 271, 33181, 10.1074/jbc.271.52.33181

Katou, 2003, S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex, Nature, 424, 1078, 10.1038/nature01900

Keeney, 1995, Covalent protein-DNA complexes at the 5′ strand termini of meiosis-specific double-strand breaks in yeast, Proc. Natl. Acad. Sci. USA, 92, 11274, 10.1073/pnas.92.24.11274

Kim, 2001, Rfc4 interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces cerevisiae, Mol. Cell. Biol, 21, 3725, 10.1128/MCB.21.11.3725-3737.2001

Kim, 2003, MEC1-dependent phosphorylation of yeast RPA1 in vitro, DNA Repair (Amst.), 2, 1321, 10.1016/j.dnarep.2003.07.004

Klein, 1997, RDH54, a RAD54 homologue in Saccharomyces cerevisiae, is required for mitotic diploid-specific recombination and repair and for meiosis, Genetics, 147, 1533, 10.1093/genetics/147.4.1533

Krejci, 2001, Molecular dissection of interactions between Rad51 and members of the recombination-repair group, Mol. Cell. Biol, 21, 966, 10.1128/MCB.21.3.966-976.2001

Lee, 2004, Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex, Science, 304, 93, 10.1126/science.1091496

Lee, 1998, Saccharomyces Ku70, Mre11/Rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage, Cell, 94, 399, 10.1016/S0092-8674(00)81482-8

Lee, 2001, The Saccharomyces recombination protein Tid1p is required for adaptation from G2/M arrest induced by a double-strand break, Curr. Biol, 11, 1053, 10.1016/S0960-9822(01)00296-2

Lisby, 2001, Rad52 forms DNA repair and recombination centers during S phase, Proc. Natl. Acad. Sci. USA, 98, 8276, 10.1073/pnas.121006298

Lisby, 2003, Cell cycle-regulated centers of DNA double-strand break repair, Cell Cycle, 2, 479, 10.4161/cc.2.5.483

Lisby, 2003, Colocalization of multiple DNA double-strand breaks at a single Rad52 repair centre, Nat. Cell Biol, 5, 572, 10.1038/ncb997

Lobachev, 2002, The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements, Cell, 108, 183, 10.1016/S0092-8674(02)00614-1

Lopes, 2001, The DNA replication checkpoint response stabilizes stalled replication forks, Nature, 412, 557, 10.1038/35087613

Lucca, 2004, Checkpoint-mediated control of replisome-fork association and signalling in response to replication pausing, Oncogene, 23, 1206, 10.1038/sj.onc.1207199

Lukas, 2003, Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage, Nat. Cell Biol, 5, 255, 10.1038/ncb945

Majka, 2003, Yeast Rad17/Mec3/Ddc1, Proc. Natl. Acad. Sci. USA, 100, 2249, 10.1073/pnas.0437148100

Manke, 2003, BRCT repeats as phosphopeptide-binding modules involved in protein targeting, Science, 302, 636, 10.1126/science.1088877

Martin, 1999, Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast, Cell, 97, 621, 10.1016/S0092-8674(00)80773-4

Maser, 1997, hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks, Mol. Cell. Biol, 17, 6087, 10.1128/MCB.17.10.6087

Melo, 2002, A unified view of the DNA-damage checkpoint, Curr. Opin. Cell Biol, 14, 237, 10.1016/S0955-0674(02)00312-5

Melo, 2001, Two checkpoint complexes are independently recruited to sites of DNA damage in vivo, Genes Dev, 15, 2809, 10.1101/gad.903501

Moreau, 1999, The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance, Mol. Cell. Biol, 19, 556, 10.1128/MCB.19.1.556

Moreau, 2001, Overlapping functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 nucleases in DNA metabolism, Genetics, 159, 1423, 10.1093/genetics/159.4.1423

Nakada, 2003, ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism, Genes Dev, 17, 1957, 10.1101/gad.1099003

Nelms, 1998, In situ visualization of DNA double-strand break repair in human fibroblasts, Science, 280, 590, 10.1126/science.280.5363.590

New, 1998, Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A, Nature, 391, 407, 10.1038/34950

Nugent, 1998, Telomere maintenance is dependent on activities required for end repair of double-strand breaks, Curr. Biol, 8, 657, 10.1016/S0960-9822(98)70253-2

Padmore, 1991, Temporal comparison of recombination and synaptonemal complex formation during meiosis in S. cerevisiae, Cell, 66, 1239, 10.1016/0092-8674(91)90046-2

Paulovich, 1997, RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage, Genetics, 145, 45, 10.1093/genetics/145.1.45

Petukhova, 2000, Promotion of Rad51-dependent D-loop formation by yeast recombination factor Rdh54/Tid1, Genes Dev, 14, 2206, 10.1101/gad.826100

Raderschall, 1999, Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage, Proc. Natl. Acad. Sci. USA, 96, 1921, 10.1073/pnas.96.5.1921

Reichard, 1988, Interactions between deoxyribonucleotide and DNA synthesis, Annu. Rev. Biochem, 57, 349, 10.1146/annurev.bi.57.070188.002025

Rijkers, 1998, Targeted inactivation of mouse RAD52 reduces homologous recombination but not resistance to ionizing radiation, Mol. Cell. Biol, 18, 6423, 10.1128/MCB.18.11.6423

Shinohara, 1992, Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein, Cell, 69, 457, 10.1016/0092-8674(92)90447-K

Shinohara, 1997, Characterization of the roles of the Saccharomyces cerevisiae RAD54 gene and a homologue of RAD54, RDH54/TID1, in mitosis and meiosis, Genetics, 147, 1545, 10.1093/genetics/147.4.1545

Sogo, 2002, Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects, Science, 297, 599, 10.1126/science.1074023

Sugawara, 2003, In vivo roles of Rad52, Rad54, and Rad55 proteins in Rad51-mediated recombination, Mol. Cell, 12, 209, 10.1016/S1097-2765(03)00269-7

Sung, 1997, Function of yeast Rad52 protein as a mediator between replication protein A and the Rad51 recombinase, J. Biol. Chem, 272, 28194, 10.1074/jbc.272.45.28194

Sung, 1997, Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase, Genes Dev, 11, 1111, 10.1101/gad.11.9.1111

Symington, 2002, Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair, Microbiol. Mol. Biol. Rev, 66, 630, 10.1128/MMBR.66.4.630-670.2002

Takata, 2004, Reciprocal association of the budding yeast ATM-related proteins Tel1 and Mec1 with telomeres in vivo, Mol. Cell, 14, 515, 10.1016/S1097-2765(04)00262-X

Tercero, 2001, Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint, Nature, 412, 553, 10.1038/35087607

Trujillo, 2001, DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex, J. Biol. Chem, 276, 35458, 10.1074/jbc.M105482200

Trujillo, 2003, Yeast Xrs2 binds DNA and helps target Rad50 and Mre11 to DNA ends, J. Biol. Chem, 49, 48957, 10.1074/jbc.M309877200

Usui, 2001, A DNA damage response pathway controlled by Tel1 and the Mre11 complex, Mol. Cell, 7, 1255, 10.1016/S1097-2765(01)00270-2

Uziel, 2003, Requirement of the MRN complex for ATM activation by DNA damage, EMBO J, 22, 5612, 10.1093/emboj/cdg541

Van Dyck, 1999, Binding of double-strand breaks in DNA by human Rad52 protein, Nature, 398, 728, 10.1038/19560

Yu, 2003, The BRCT domain is a phospho-protein binding domain, Science, 302, 639, 10.1126/science.1088753

Zou, 2002, Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin, Genes Dev, 16, 198, 10.1101/gad.950302

Zou, 2003, Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes, Science, 300, 1542, 10.1126/science.1083430

Zou, 2003, Replication protein A-mediated recruitment and activation of Rad17 complexes, Proc. Natl. Acad. Sci. USA, 100, 13827, 10.1073/pnas.2336100100