Modulation of immunity by soluble mediators

Byron H. Waksman1
1Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, U.S.A.

Tài liệu tham khảo

Lawrence, 1969 Stetson, 1970, President's symposium on effectors of cellular immunity, Am. J. Path., 60, 435 Becker, 1973, In vitro studies of immunologically induced secretion of mediators from cells and related phenomena, Adv. Immun., 17, 93, 10.1016/S0065-2776(08)60732-4 1976, on mechanism of action and characterization of lymphocyte mediators, Cell Immun, 27, 332 Bloom, 1971 Bloom, 1973, In vitro methods in cell-mediated immunity: a progress report, Cell. Immun., 6, 331, 10.1016/0008-8749(73)90034-8 Bloom, 1976 Lawrence, 1974, Transfer factor: initiation and augmentation of cell-mediated immunity, 289 Paul, 1976, Cellular and soluble factors in the regulation of lymphocyte activation, Fedn Proc., 35, 2044 Munro, 1976, Products of the major histocompatibility complex and their relationship to the immune response, Nature, 264, 145, 10.1038/264145a0 Waksman, 1976, On soluble mediators of immunologic regulation, Cell. Immun., 21, 161, 10.1016/0008-8749(76)90337-3 Cooperband, 1976, Humoral immunosuppressive factors, Transplant. Proc., 8, 225 Houck, 1976 Epstein, 1976, The ability of macrophages to augment in vitro mitogen- and antigen-stimulated production of interferon and other mediators of cellular immunity by lymphocytes, 201 Johnson, 1976, Regulatory role of interferons in the immune response, IRCS J. Med. Sci., 4, 50 Ascher, 1976 Wedner, 1976, Lymphocyte activation, Prog. Allergy, 21, 195 Friedman, 1975, Thymus factors in immunity, Ann. N.Y. Acad. Sci., 249, 1 van Bekkum, 1975 Bach, 1976, Thymic factors, Prog. Allergy, 21, 342, 10.1159/000314007 Moller, 1974, Tumor-associated embryonic antigens, Transplant. Rev., 20, 1 Cooperband, 1976, Humoral immunosuppressive factors, Transplant. Proc., 8, 225 Nelson, 1976, Humoral factors influencing lymphocyte transformation, Prog. Allergy, 21, 261, 10.1159/000314004 Bloom, 1967, Transfer of delayed-type hypersensitivity. A critical review and experimental study in the guinea pig, Prog. Allergy, 10, 151 Spector, 1968, Mediators of delayed hypersensitivity reactions, 281 Dumonde, 1970, ‘ymphokines’: Molecular mediators of cellular immune responses in animals and man, Proc. R. Soc. M., 63, 899 Bloom, 1971, In vitro approaches to the mechanism of cell-mediated immune reactions, Adv. Immun., 13, 102 David, 1972, Cellular hypersensitivity and immunity: Inhibition of macrophage migration and the lymphocyte mediators, Prog. Allergy, 16, 300, 10.1159/000313176 Pick, 1972, The biological activities of soluble lymphocyte products, Clin. Exp. Immun., 10, 1 Remold, 1972, Purification and characterization of lymphocyte mediators in cellular immunity, Transplant. Rev., 10, 152 Pick, 1976, The mechanism of action of macrophage migration inhibitory factor (MIF). A personal view, Current Titles Immun, 4, 565 Pick, 1976, The mechanism of action of macrophage migration inhibitory factor (MIF). A personal view, Current Titles Immun, 4, 597 Rocklin, 1976, Products of activated lymphocytes, Clin. Immunobiol., 3, 195, 10.1016/B978-0-12-070003-5.50015-2 Waksman, 1976, Commentary: Immunoglobulins and lymphokines as mediators of inflammatory cell mobilization and target cell killing, Cell. Immun., 27, 309, 10.1016/0008-8749(76)90237-9 Shacks, 1971, Studies on in vitro models of cellular immunity, J. Reticuloendoth. Soc., 10, 28 Rosenau, 1976, Lymphotoxin. A review and analysis, Am. J. Path., 84, 580 Wolstenholme, 1971 Atkins, 1972, Fever, New Engl. J. Med., 286, 27, 10.1056/NEJM197201062860109 Alevy, 1976, Dextran-triggered T-cells heighten T- and B-cell reactions to mitogens, Immunology, 30, 379 Alevy, 1976, Characterization of dextran-activated T-cell factors, Immunology, 30, 391 Alter, 1970, Lymphocyte reactivity in vitro. I. Cellular reconstitution of purified lymphocyte response, Cell. Immun., 1, 207, 10.1016/0008-8749(70)90008-0 Altman, 1975, Physiocochemical characterization of chemotactic lymphokines produced by human T and B lymphocytes, J. Immun., 115, 18, 10.4049/jimmunol.115.1.18 Ambrose, 1969, Regulation of the secondary antibody response in vitro. Enhancement by actinomycin D and inhibition by a macromolecular product of stimulated lymph node cultures, J. exp. Med., 130, 1003, 10.1084/jem.130.5.1003 Ambrose, 1975, Regulation of the secondary antibody response in vitro. III. Inhibitor-containing cells of antigen-stimulated rabbit lymph node organ cultures, Annls d’Immun., 126C, 3 Amino, 1974, Human lymphotoxin obtained from established lymphoid lines: Purification and characteristics and inhibition by anti-immunoblobulin, J. Immun., 113, 1334, 10.4049/jimmunol.113.4.1334 Amos, 1967, Passive sensitization of tissue cells. II. Ability of cytophilic antibody to render the migration of guinea pig peritoneal exudate cells inhibitable for antigen, Int. Archs Allergy, 32, 496, 10.1159/000229961 Armerding, 1974, Activation of T and B lymphocyte in vitro. II. Biological and biochemical properties of an allogeneic effect factor (AEF) active in triggering specific B-lymphocytes, J. exp. Med., 140, 19, 10.1084/jem.140.1.19 Armerding, 1975, Activation of T. and B lymphocytes in vitro, IV. Regulatory influence on specific T cell functions by a thymus extract factor, J. Immun., 114, 1248, 10.4049/jimmunol.114.4.1248 Armerding, 1974, Activation of T and B lymphocytes in vitro. III. Presence of Ia determinants on allogeneic effect factor, J. exp. Med., 140, 1717, 10.1084/jem.140.6.1717 Ascher, 1976 Asherson, 1974, Suppression of contact sensitivity by T cells in the mouse. I. Demonstration that suppressor cells act on the effector stage of contact sensitivity; and their induction following in vitro exposure to antigen, Proc. R. Soc. B., 187, 329, 10.1098/rspb.1974.0078 Asherson, 1974, Suppression of contact sensitivity by T cells in the mouse. I. Demonstration that suppressor cells act on the effector stage of contact sensitivity; and their induction following in vitro exposure to antigen, Proc. R. Soc. B., 187, 329, 10.1098/rspb.1974.0078 Asherson, 1976, Adult thymectomy prevention of the appearance of suppressor T cells which depress contact sensitivity to picryl chloride and reversal of adult thymectomy effect by thymus extract, Eur. J. Immun., 6, 699, 10.1002/eji.1830061008 Askenase, 1977, The role of basophils, mast cells and vasoamines in hypersensitivity reactions with a delayed time course, Prog. Allergy, 23 Askenase, 1976, Cutaneous basophil hypersensitivity and inhibited macrophage migration in guinea-pigs with schistosomiasis, Clin. exp. Immun., 23, 318 Askonas, 1965, Immunogenicity of antigen-containing ribonucleic acid preparations from macrophages, Nature, 205, 470, 10.1038/205470a0 Askonas, 1974, The differentiation function of T cell-replacing factor in nu/nu spleen cell cultures, Eur. J. Immun., 4, 164, 10.1002/eji.1830040304 Atkins, 1972, Studies on the mechanism of fever accompanying delayed hypersensitivity. The role of the sensitized lymphocyte, J. exp. Med., 135, 1113, 10.1084/jem.135.5.1113 Bach, 1970, Lymphocyte reactivity in vitro. II. Soluble reconstituting factor permitting response of purified lymphocytes, Cell. Immun., 1, 219, 10.1016/0008-8749(70)90009-2 Bach, 1973, Studies on thymus products. VI. The effects of cyclic nucleotides and prostaglandins on rosette-forming cells. Inter-reactions with thymic factor, Eur. J. Immun., 3, 778, 10.1002/eji.1830031208 Bach, 1976, Cyclic AMP and T-cell differentiation, Annls d’Immun., 127C, 967 Bach, 1975, Regulation of θ-antigen expression by agents altering cyclic AMP level and by thymic factor, Ann. N.Y. Acad. Sci., 249, 316, 10.1111/j.1749-6632.1975.tb29079.x Badger, 1971, Direct observations on the effect of ‘proliferation inhibitory factor’ on the clonal growth of target cells, J. Immun., 107, 1259, 10.4049/jimmunol.107.5.1259 Badger, 1973, Culture conditions affecting induction and release of lymphocyte produced proliferation inhibitory factor (PIF), Cell. Immun., 8, 12, 10.1016/0008-8749(73)90089-0 Badger, 1973, Sensitivity of non-human cells to human lymphocyte proliferation inhibitory factor (PIF) in vitro, Clin. Exp. Immun., 15, 435 Balow, 1973, Glucocorticoid suppression of macrophage migration inhibitory factor, J. Exp. Med., 137, 1031, 10.1084/jem.137.4.1031 Bang, 1975, A search in Asterias and ascidia for the beginnings of vertebrate immune responses, Ann N.Y. Acad. Sci., 266, 334, 10.1111/j.1749-6632.1975.tb35115.x Bartfeld, 1969, Cytophilic nature of migration inhibitory factor associated with delayed hypersensitivity, Proc. Soc. exp. Biol. Med., 130, 497, 10.3181/00379727-130-33589 Becker, 1973, In vitro studies of immunologically induced secretion of mediators from cells and related phenomena, Adv. Immun., 17, 93, 10.1016/S0065-2776(08)60732-4 Bell, 1971, Conversion of non-immune rabbit spleen cells by ribonucleic acid of lymphoid cells from an immunized rabbit to produce IgM and IgG antibody of foreign heavy chain allotype, J. Immun., 107, 83, 10.4049/jimmunol.107.1.83 Bell, 1976, The effects of a macrophage-derived cytotoxin on the growth and metabolism of target cells, Cell. Immun., 22, 19, 10.1016/0008-8749(76)90003-4 Beller, 1977 Beller, 1977, Thymic maturation in vitro by a secretory product from macrophages, J. Immun., 118, 1780, 10.4049/jimmunol.118.5.1780 Benutzen, 1976, Some physicochemical properties of human leucocyte migration inhibitory factor (LIF), Acta Path. Microb. Scand. C, 84, 471 Benutzen, 1976, Affinity chromatography. A new technique for partial purification of human leucocyte migration inhibitory factor, J. Immun. Meth., 11, 147, 10.1016/0022-1759(76)90142-3 Bendtzen, 1977, Human leukocyte migration inhibitory factor (LIF). I. Effect of synthetic and naturally occurring estarase and protese inhibitors, Scand. J. Immun., 6, 125, 10.1111/j.1365-3083.1977.tb00327.x Benutzen, 1977, Human leukocyte migration inhibotory factor (LIF). II. Partial biochemical characterization of the substrate specificities of this lymphokine, Scand. J. Immun., 6, 133, 10.1111/j.1365-3083.1977.tb00328.x Bendtzen, 1977, In vitro modulation of human leucocyte migration and migration inhibitory factor (LIF) activity by cyclic 3′, 5′-AMP and cyclic 3′, 5′-GMP, Acta Path. Microb. Scand., 85, 78 Bennett, 1968, Reactions in vivo and in vitro produced by a soluble substance associated with delayed-type hypersensitivity, Proc. natn. Acad. Sci. USA, 59, 756, 10.1073/pnas.59.3.756 Bentley, 1977, Effect of in vivo stimulation of mice on the secretion of factor B of the alternative complement pathway by peritoneal macrophages, Eur. J. Immun., 7, 188, 10.1002/eji.1830070315 Berenbero, 1973, Chemotactic factor inactivation in normal human serum, J. Clin. Invest., 52, 1200, 10.1172/JCI107287 Bianco, 1977, Complement receptors, Contemp. Top. Mol. Immun., 6, 145, 10.1007/978-1-4684-2841-4_5 Binz, 1976, T-cell idiotypes are linked to immunoglobulin heavy chain genes, Nature, 264, 639, 10.1038/264639a0 Blomgren, 1976, Evidence for the release of mitogenic factors by both T and B lymphocytes in the human, Scand. J. Immunol., 5, 1173, 10.1111/j.1365-3083.1976.tb00259.x Blomgren, 1976, DNA synthetic responses of fractionated human lymphocytes exposed to lymphocyte-derived mitogenic factor, Scand. J. Immun., 5, 1179, 10.1111/j.1365-3083.1976.tb00260.x Blomgren, 1974, Effect of human leukocyte interferon on the response of lymphocytes to mitogenic stimuli in vitro, Scand. J. Immun., 3, 697, 10.1111/j.1365-3083.1974.tb01305.x Bloom, 1966, Mechanism of a reaction in vitro associated with delayed-type hypersensitivity, Science, 153, 80, 10.1126/science.153.3731.80 Bloom, 1972, Dissociation of MIF production and cell proliferation, J. Immunol., 109, 1395, 10.4049/jimmunol.109.6.1395 Bloom, 1975, Production of migration inhibitory factor and lymphotoxin by non-T cells, Eur. J. Immun., 5, 218, 10.1002/eji.1830050314 Blyden, 1977, Purification and properties of human lymphocyte activating factor (LAF), J. Immun., 118, 1631, 10.4049/jimmunol.118.5.1631 Boetcher, 1973, Basophil Chemotaxis: augmentation by a factor from stimulated lymphocyte cultures, Immun. Commun., 2, 421, 10.3109/08820137309022813 Borysenko, 1976, Phylogeny of immunity: an overview, Immunogenetics, 3, 305, 10.1007/BF01576964 Bosing-Schneider, 1976, Role of cyclic AMP on differentiation of T- and B-lymphocytes during the immune induction, Cell. Immun., 27, 121, 10.1016/0008-8749(76)90160-X Bourne, 1974, Modulation of inflammation and immunity by cyclic AMP. Receptors for vasoactive hormones and mediators of inflammation regulate many leukocyte functions, Science, 184, 19, 10.1126/science.184.4132.19 Braun, 1965, Influence of oligodeoxyribonucleotides on early events in antibody formation, Proc. Soc. exp. Biol. Med., 119, 701, 10.3181/00379727-119-30276 Brodeur, 1974, Suppressive effect of interferon on the humoral immune response to sheep red blood cells in mice, J. Immun., 113, 1319, 10.4049/jimmunol.113.4.1319 Brodeur, 1975, Mechanism of the suppressive effect of interferon on antibody synthesis in vivo, J. Immun., 114, 1323, 10.4049/jimmunol.114.4.1323 Brooks, 1976, Regulation of the fibroblast cell cycle by serum, Nature, 260, 248, 10.1038/260248a0 Brun, 1976, Inhibition of Leishmania donovani transformation by hamster spleen homogenates and active human lymphocytes, Nature, 262, 689, 10.1038/262689a0 Bullock, 1971, Studies of immune mechanisms in leprosy. III. The role of cellular and humoral factors in impairment of the in vitro immune response, J. Immun., 106, 888, 10.4049/jimmunol.106.4.888 Bullough, 1965, Mitotic homeostasis, Nature, 205, 573, 10.1038/205573a0 Butterworth, 1977, Antibody-dependent eosinophil-mediated damage to 51Cr-labeled schistosomula of Schistosoma mansoni: damage by purified eosinophils, J. exp. Med., 145, 136, 10.1084/jem.145.1.136 Butterworth, 1975, Eosinophils as mediators of antibody-dependent damage to schistosomula, Nature, 256, 727, 10.1038/256727a0 Byrd, 1971, Restoration of the immune response to sheep erythrocytes by a serum factor, Nature New Biol., 231, 280, 10.1038/newbio231280a0 Calderon, 1975, The modulation of lymphocyte functions by molecules secreted by macrophages, J. exp. Med., 142, 151, 10.1084/jem.142.1.151 Calderon, 1974, An inhibitor of cell proliferation released by cultures of macrophages, Proc. natn. Acad. Sci. USA, 71, 4273, 10.1073/pnas.71.11.4273 Capron, 1975, Specific IgE antibodies in immune adherence of normal macrophages to Schistosoma mansoni schistosomules, Nature, 253, 474, 10.1038/253474a0 Capron, 1976, Macrophage cytotoxicity mediated by IgE antibody. In vitro study on S. mansoni schistosomules, 153 Carnegie, 1973, The macrophage electrophoretic migration (MEM) test for lymphocyte sensitization. A study of the kinetics, Clin. Exp. Immun., 14, 37 Carpenter, 1971, Immunosuppressive alpha globulin from bovine thymus. I. Preparation and assay, Cell. Immun., 2, 425, 10.1016/0008-8749(71)90053-0 Caspary, 1972, The mechanism of antigen-induced electrophoretic mobility reduction of guinea pig macrophages, Clin. Exp. Immun., 11, 305 Cerny, 1974, Stimulation of bone marrow haemopoietic stem cells by a factor from activated T cells, Nature, 249, 63, 10.1038/249063a0 Chen, 1976, Production of osteoclast-activating factor by normal human peripheral blood rosetting and nonrosetting lymphocytes, Eur. J. Immun., 6, 732, 10.1002/eji.1830061014 Chervenick, 1972, Human blood monocytes: Stimulators of granulocyte and mononuclear colony formation in vitro, Science, 178, 164, 10.1126/science.178.4057.164 Chess, 1975, Leukocyte inhibitory factor (LIF): production by purified human T and B lymphocytes, J. Immun., 115, 315, 10.4049/jimmunol.115.1.315 Clausen, 1971, Tuberculin-induced migration inhibition of human peripheral leucocytes in agarose medium, Acta aller., 26, 56, 10.1111/j.1398-9995.1971.tb01399.x Clausen, 1972, Migration inhibitory effect of cell-free supernatants from mixed human lymphocyte cultures, J. Immun., 108, 453, 10.4049/jimmunol.108.2.453 Cohen, 1965, Conversion of nonimmune spleen cells to antibody-forming cells by RNA: strain specificity of the response, J. Immun., 95, 583, 10.4049/jimmunol.95.4.583 Cohen, 1973, Biologic activity of extracts of delayed hypersensitivity skin reaction sites, Cell. Immun., 9, 363, 10.1016/0008-8749(73)90051-8 Cohn, 1963, The particulate hydrolases of macrophages. II. Biochemical and morphological response to particle ingestion, J. exp. Med., 118, 1009, 10.1084/jem.118.6.1009 Colley, 1973, Eosinophils and immune mechanisms. I. Eosinophil stimulation promoter (ESP): A lymphokine induced by specific antigen or phytohemagglutinin, J. Immun., 110, 1419, 10.4049/jimmunol.110.5.1419 Colley, 1976, Eosinophils and immune mechanisms. IV. Culture conditions, antigen requirements, production kinetics and immunologic specificity of the lymphokine eosinophil stimulation promoter, Cell. Immun., 24, 328, 10.1016/0008-8749(76)90216-1 Colten, 1968, Synthesis of the first component of guinea pig complement by columnar epithelial cells of the small intestine, J. Immun., 100, 788, 10.4049/jimmunol.100.4.788 Cone, 1974, Cytophilic properties of surface immunoglobulin of thymus-derived lymphocytes, Immunology, 26, 49 Cone, 1972, Regulation of the immune system by synthetic polynucleotides. IV. Amplification of proliferation of thymus-influenced lymphocytes, Cell. Immun., 3, 283, 10.1016/0008-8749(72)90167-0 Cone, 1972, Antigen-binding specificity of isolated cell-surface immunoglobulin from thymus cells activated to histocompatibility antigens, Proc. natn. Acad. Sci. USA, 69, 2556, 10.1073/pnas.69.9.2556 Cooper, 1974, Invertebrate immunology. Contemp, Topics Immunobiol, 4, 1 Cooperband, 1972, The effect of immunoregulatory α-globulin (IRA) upon lymphocytes in vitro, J. Immun., 109, 154, 10.4049/jimmunol.109.1.154 Cooperband, 1968, Transformation of human lymphocytes: inhibition by homologous alpha globulin, Science, 159, 1243, 10.1126/science.159.3820.1243 Crumpton, 1977, Isolation and structure of human histocompability (HLA) antigens, Contemp. Topics Mol. Immun., 6, 53, 10.1007/978-1-4684-2841-4_2 Curtis, 1973, Factors influencing adhesion of lymphoid cells, Nature New Biol., 244, 45, 10.1038/newbio244045a0 Curtiss, 1977, In vivo suppression of the primary immune response by a species of low density serum lipoprotein, J. Immun., 118, 648, 10.4049/jimmunol.118.2.648 Curtiss, 1976, Regulatory serum lipoproteins: regulation of lymphocyte stimulation by species of low density lipoprotein, J. Immun., 116, 145Z, 10.4049/jimmunol.116.5.1452 Darzynkewtcz, 1971, Effect of connective tissue intercellular matrix on lymphocyte stimulation. I. Suppression of lymphocyte stimulation by hyaluronic acidI Exp, Cell Res., 66, 113, 10.1016/S0014-4827(71)80018-6 David, 1966, Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction, Proc. natn. Acad. Sci. USA, 56, 73, 10.1073/pnas.56.1.72 Davies, 1976, Secretion of macrophage enzymes in relation to the pathogenesis of chronic inflammation, 428 Dean, 1975, Immune response of guinea pigs to Schistosoma mansoni. I. In vitro effects of antibody and neutrophils, eosinophils and macrophages on schistosomula, Am. J. Trop. Med., 24, 74, 10.4269/ajtmh.1975.24.74 de Franco, 1977, Leucocyte chemotactic activity in the parallel bioassay of guinea pig lymphokines, Immunology, 32, 179 Dekaris, 1971, Inhibition of macrophage spreading by supernatants of antigen-stimulated sensitized lymphocytes, Eur. J. Immun., 1, 402, 10.1002/eji.1830010521 Diamantstein, 1976, Two distinct lymphocyte-stimulating soluble factors (LAF) released from murine peritoneal cells. I. The cellular source and the effect of cGMP on their release, Immunology, 30, 741 Dickler, 1976, Lymphocyte receptors for immunoglobulin, Adv. Immun., 24, 167, 10.1016/S0065-2776(08)60330-2 Dinarello, 1974, Demonstration and characterization of two distinct human leukocytic pyrogens, J. exp. Med., 139, 1369, 10.1084/jem.139.6.1369 Doria, 1972, Enhancing activity of thymocyte culture cell-free medium on the in vitro immune response of spleen cells from neonatally thymectomized mice to sheep RBC, J. Immun., 108, 268, 10.4049/jimmunol.108.1.268 Dorrington, 1976, Properties of the Fc receptor on macrophages, Immun. Commun., 5, 263, 10.3109/08820137609044280 Douglas, 1972, Human monocyte aggregation in vitro, Int. Archs Allergy, 43, 72, 10.1159/000230822 Drutz, 1967, Further observations on the mechanism of reticuloendothelial blockade, J. exp. Med., 126, 1087, 10.1084/jem.126.6.1087 Dumonde, 1969, ‘Lymphokines’: non-antibody mediators of cellular immunity generated by lymphocyte activation, Nature, 224, 38, 10.1038/224038a0 Dwyer, 1973, Regulation of delayed hypersensitivity. Failure to transfer delayed hypersensitivity to desensitized guinea pigs, J. exp. Med., 137, 32, 10.1084/jem.137.1.32 Dwyer, 1975, In vivo suppression of delayed hypersensitivity: prolongation of desensitization in guinea pigs, J. exp. Med., 142, 588, 10.1084/jem.142.3.588 Dy, 1976, Nature of macrophage modifications induced by the macrophage activating factor(s) (MAF): Effect of enzymes and temperature, J. Reticuloendoth. Soc., 20, 93 Eifel, 1975, Standardization of a sensitive and rapid assay for lymphotoxin, Cell. Immun., 15, 208, 10.1016/0008-8749(75)90176-8 Emerson, 1971, Immunologically specific retention of long-lived lymphoid cells in antigenically stimulated lymph nodes, J. Immun., 106, 635, 10.4049/jimmunol.106.3.635 Epstein, 1971, The interaction of human macrophages and lymphocytes in the phytohemagglutinin stimulated production of interferon, J. Clin. Invest., 50, 744, 10.1172/JCI106545 Epstein, 1971, PPD-stimulated interferon: in vitro macrophage-lymphocyte interaction in the production of a mediator of cellular immunity, Cell. Immun., 2, 602, 10.1016/0008-8749(71)90008-6 Erb, 1975, The role of macrophages in the generation of T-helper cells. I. The requirement for macrophages in helper cell induction and characteristics of the macrophage-T cell interaction, Cell. Immun., 19, 356, 10.1016/0008-8749(75)90217-8 Erb, 1975, The role of macrophages in the generation of T-helper cells. III. Influence of macrophage-derived factors in helper cell induction, Eur. J. Immun., 5, 759, 10.1002/eji.1830051106 Erb, 1976, Role of macrophages in the genration of T-helper cells. IV. Nature of genetically related factor derived from macrophages incubated with soluble antigens, Eur. J. Immun., 6, 365, 10.1002/eji.1830060512 Erb, 1976, Two-gene control of T-helper cell induction, Nature, 263, 601, 10.1038/263601a0 Evans, 1972, Mechanism of immunologically specific killing of tumour cells by macrophages, Nature, 236, 168, 10.1038/236168a0 Evans, 1972, Role of macrophages in tumour-immunity. III. Cooperation between macrophages and lymphoid factors in an in vitro allograft situation, Immunology, 23, 677 Evans, 1972, Thymus-derived lymphocytes produce an immunologically specific macrophage-arming factor, J. exp. Med., 136, 1318, 10.1084/jem.136.5.1318 Falcoff, 1972, Synthesis of interferon in human lymphocytes stimulated in vitro by antilymphocytic serum, Rev. Eur. Et. Clin. Biol., 17, 20 Falk, 1972, Restoration of immunological competence in irradiated, thymectomized rats with bone marrow cells and thymus supernants, 359 Falk, 1970, Lymphocyte-activating factors released in vitro by sensitized and nonsensitized human lymphocytes, Cell. Immun., 1, 150, 10.1016/0008-8749(70)90002-X Fauci, 1971, Suppression of antibody synthesis. I. Evidence for a circulating inhibitor of antibody synthesis demonstrated at the cellular level, J. Immun., 107, 1052, 10.4049/jimmunol.107.4.1052 Fauci, 1971, Suppression of antibody synthesis. II. The effect of carrier-specific cells upon haptenic competition, J. Immun., 107, 1057, 10.4049/jimmunol.107.4.1057 Feldmann, 1972, Cell interactions in the immune response in vitro. V. Specific collaboration via complexes of antigen and thymus-derived cell immunoglobulin, J. exp. Med., 136, 737, 10.1084/jem.136.4.737 Feldmann, 1974, T cell suppression in vitro. I. Role in regulation of antibody responses, Eur. J. Immun., 4, 660, 10.1002/eji.1830041005 Feldmann, 1974, T cell suppression in vitro. II. Nature of specific suppressive factor, Eur. J. Immun., 4, 667, 10.1002/eji.1830041006 Feldmann, 1972, Cell interactions in the immune response in vitro. III. Specific collaboration across a cell impermeable membrane, J. exp. Med., 136, 49, 10.1084/jem.136.1.49 Feldmann, 1972, Cell interactions in the immune response in vitro, IV. Comparison of the effects of antigen-specific and allogeneic thymus-derived cell factors, J. exp. Med., 136, 722, 10.1084/jem.136.4.722 Fialkow, 1967, Chromosomal breakage induced by extracts of human allogeneic lymphocytes, Science, 155, 1676, 10.1126/science.155.3770.1676 Fialkow, 1966, Hyperploidy effect of lymphocte extract on fibroblasts in vitro, Nature, 211, 713, 10.1038/211713a0 Fialkow, 1968, Chromosomal abnormalities induced in vitro by extracts of mouse allogeneic lymphocytes, Exp. Cell Res., 49, 223, 10.1016/0014-4827(68)90539-9 Fidler, 1976, In vitro activation of mouse macrophages by rat lymphocyte mediators, J. Immun., 117, 666, 10.4049/jimmunol.117.2.666 Finlay, 1977, Interferon-induced antibody suppression: a selective effect on high density, late responding precursor cells, Eur. J. Immun., 7, 123, 10.1002/eji.1830070302 Fishman, 1961, Antibody formation in vitro, J. exp. Med., 114, 837, 10.1084/jem.114.6.837 Flax, 1966, Experimental allergic thyroiditis, Meth. Achievem. exp. Path., 1, 493 Florentin, 1973, T lymphocyte specificity of a lymphocyte-inhibiting factor (chalone) extracted from the thymus, Eur. J. Immun., 3, 624, 10.1002/eji.1830031006 Florentin, 1976, The lymphocyte inhibiting factor extracted from the thymus (Lift): inhibition of the DNA synthesis in vitro, Cell. Immun., 23, 1, 10.1016/0008-8749(76)90167-2 Foon, 1976, Serotonin-induced production of a monocyte chemotactic factor by human peripheral blood leukocytes, J. Immun., 117, 1545, 10.4049/jimmunol.117.5_Part_1.1545 Ford, 1976, Effect of the concentration of inducing agent on the output of lymphokines in the guinea pig, Eur. J. Immun., 6, 135, 10.1002/eji.1830060213 Forsdyke, 1973, Serum factors affecting the incorporation of 3H-thymidine by lymphocytes stimulated by antigen. I. Serum concentration, Immunology, 25, 583 Forsdyke, 1973, Serum factors affecting the incorporation of 3H-thymidine by lymphocytes stimulated by antigen. II. Evidence for a role of complement from studies with heated serum, Immunology, 25, 597 Forsdyke, 1973, Serum factors affecting the incorporation of 3H thymidine by lymphocytes stimulated by antigen. III. Evidence for a role of complement from studies with specific complement inhibitors, Immunology, 25, 613 Fowles, 1973, The enhancement of macrophage bacteriostasis by products of activated lymphocytes, J. exp. Med., 138, 952, 10.1084/jem.138.4.952 Fox, 1974, Macrophage receptors for migration inhibitory factor (MIF), migration stimulatory factor (MSF) and agglutinating factor, J. Immun., 112, 1867, 10.4049/jimmunol.112.5.1867 Friedman, 1965, Induction in vitro of antibodies to phage T2: Antigens in the RNA extract employed, Science, 149, 1106, 10.1126/science.149.3688.1106 Friedrich, 1975, Lymphokines. I. Use of insoluble concanavalin A for the production of migration inhibitory factor in guinea pig lymphocyte cultures, Int. Archs Allergy, 49, 504, 10.1159/000231432 Galindo, 1972, Antigen-mediated fusion of specifically sensitized rabbit alveolar macrophages, Infect. Immun., 5, 583, 10.1128/IAI.5.4.583-594.1972 Galindo, 1974, Fusion of normal rabbit alveolar macrophages induced by supernatant fluids from BCG-sensitized lymph node cells after elicitation by antigen, Infect. Immun., 9, 212, 10.1128/IAI.9.2.212-216.1974 Galindo, 1975, A macrophage agglutinating factor produced during a pulmonary delayed hypersensitivity reaction, J. Reticuloendoth. Soc., 18, 295 Garcia-Giralt, 1974, Differential effect of a lymphoid chalone on the target and nontarget cells in vitro, 457 Gately, 1975, The molecular dimensions of mitogenic factor from guinea pig lymph node cells, J. Immun., 114, 10, 10.4049/jimmunol.114.1_Part_1.10 Gately, 1976, Separation of lymphocyte mitogen from lymphotoxin and experiments on the production of lymphocoxin by lymphoid cells stimulated with the partially purified mitogen: A possible amplification mechanism of cellular immunity and allergy, J. Immun., 116, 669, 10.4049/jimmunol.116.3.669 Gately, 1975, Studies on lymphokines: the production of antibody to guinea pig lymphotoxin and its use to distinguish lymphotoxin from migration inhibitory factor and motogenic factor, J. Immun., 115, 817, 10.4049/jimmunol.115.3.817 Gately, 1972, The effect o antibodies to complement components C2. C3 and C5 on the production and action of lymphotoxin, J. Immun, 109, 728, 10.4049/jimmunol.109.4.728 Gately, 1976, Effect of anti-lymphotoxin on cell-mediated cytotoxicity. Evidence for the pathways, one involving lymphotoxin and the other requiring intimate contact between the plasma membranes of killer and target cells, Cell. Immun., 27, 82, 10.1016/0008-8749(76)90156-8 Geczy, 1976, Antibodies to guinea pig lymphokines. II. Suppression of delayed hypersensitivity reactions by a ‘second generation’ goat antibody against guinea pig lymphokines, J. Immun., 117, 66, 10.4049/jimmunol.117.1.66 Geczy, 1976, Antibodies to guinea pig lymphokines. IV. Suppression of the mixed leukocyte culture reaction by anti-lymphokine globulin, J. Immun., 117, 1824, 10.4049/jimmunol.117.5_Part_2.1824 Geha, 1974, Human lymphocyte mitogenic factor: Synthesis by sensitized thymus-derived lymphocytes. Dependence of expression on the presence of antigen, Cell Immun., 10, 86, 10.1016/0008-8749(74)90154-3 Geiger, 1973, The effect of irradiation on the release of lymphocyte activating factor (LAF), Cell Immun., 7, 177, 10.1016/0008-8749(73)90194-9 George, 1962, In vitro cell migration as a model for delayed hypersensitivity, Proc. Soc. exp. Biol. Med., 111, 514, 10.3181/00379727-111-27841 Gershon, 1975, Requirement for vasoactive amines for production of delayed-type hypersensitivity skin reactions, J. exp. Med., 142, 732, 10.1084/jem.142.3.732 Gery, 1971, Potentiation of cultured mouse thymocyte responses by factors released by peripheral leucocytes, J. Immun., 107, 1778, 10.4049/jimmunol.107.6.1778 Gery, 1972, Potentiation of lymphocyte responses to mitogens. I. The responding cell, J. exp. Med., 136, 128, 10.1084/jem.136.1.128 Gery, 1974, Potentiation of the T lymphocyte response to mitogens. III. Properties of the mediator(s) from adherent cells, Cell. Immun., 11, 162, 10.1016/0008-8749(74)90016-1 Gery, 1972, Potentiation of lymphocyte responses to mitogens. II. The cellular source of potentiating mediators, J. exp. Med., 136, 143, 10.1084/jem.136.1.143 Gery, 1975, Potentiation of the T lymphocyte response to mitogens. IV. Relationship between LAF production and ‘activation’ of macrophages, J. Reticuloendoth. Soc., 18, 252 Gesner, 1969, An autoradiographic study of the effect of neuraminidase or trypsin on transfused lymphocytes, Am. J. Path., 57, 215 Gifford, 1971, Interferon production in mixed lymphocyte cell cultures, Infect. Immun., 3, 164, 10.1128/IAI.3.1.164-166.1971 Girman, 1976, Immunosuppression by micromolecular fibrinogen degradation products in cancer, Nature, 259, 399, 10.1038/259399a0 Gisler, 1976, Inhibition of the in vitro 19S and 7S antibody response by immunoglobulin-binding factor (IBF) from alloantigen-actiyated T cells, Cell. Immun., 23, 99, 10.1016/0008-8749(76)90174-X Gisler, 1974, Effects of interferon on antibody synthesis in vitro, J. Immun., 113, 438, 10.4049/jimmunol.113.2.438 Gisler, 1973, Soluble mediators of T-B interaction, Eur. J. Immun., 3, 650, 10.1002/eji.1830031012 Glade, 1971, 27 Godal, 1974, The role of immune responses to Mycobacterium leprae in host defence and tissue damage in leprosy, Prog. Immun., 4, 161 Godal, 1971, Lymphocyte-mediated modification of blood-derived macrophage function in vitro; inhibition of growth of intracellular mycobacteria with lymphokines, Clin. Exp. Immun., 8, 625 Goguel, 1974, Lymphotoxine de cobaye. Mise en évidence et étude de certaines propriétés physicochimiques, Annls d’Immun., 125C, 569 Goguel, 1974, Guinea pig lymphotoxin. II. Study of its mechanism of action, its differentiation from migration inhibitory factor and interferon, Annals d’Immunol, 125C, 789 Goldberg, 1971, Studies on lymphocyte and monocyte function in chronic mucocutaneous candidiasis, Clin. Exp. Immun., 8, 37 Golde, 1972, Identification of the colony-stimulating cell in human peripheral blood, J. Clin. Invest., 51, 2981, 10.1172/JCI107124 Goldman, 1976, Relationship of functional levels of early components of complement to the H-2 complex of mice, J. Immun., 117, 1584, 10.4049/jimmunol.117.5_Part_1.1584 Gorczynski, 1973, Reconstitution of T cell-depleted spleen cell populations by factors derived from T cells. I. Conditions for the production of active T cell supernatants, J. Immun., 110, 968, 10.4049/jimmunol.110.4.968 Gorczynski, 1973, Reconstitution of T cell-depleted spleen cell populations by factors derived from T cells. III. Mechanism of action of T cell-derived factors, J. Immun., 111, 900, 10.4049/jimmunol.111.3.900 Gotoff, 1972, The macrophage aggregation assay for delayed hypersensitivity: development of the response, role of the macrophage, and the independence of humoral antibody, Cell. Immun., 3, 53, 10.1016/0008-8749(72)90225-0 Gottlieb, 1972, The multiple functions of macrophages in immunity, Critical Rev. Microbiol., Feb., 321, 10.3109/10408417209103870 Gowans, 1964, The route of recirculation of lymphocytes in the rat, Proc. R. Soc. B., 159, 257, 10.1098/rspb.1964.0001 Granger, 1970, Production of lymphotoxin and migration inhibitory factor by established human lymphocytic cell lines, J. Immun., 104, 1476, 10.4049/jimmunol.104.6.1476 Granger, 1964, Homograft target cells: specific destruction in vitro by contact interaction with immune macrophages, Science, 145, 1427, 10.1126/science.145.3639.1427 Granger, 1966, Homograft target cells: contact destruction in vitro by immune macrophages, Science, 151, 97, 10.1126/science.151.3706.97 Granger, 1968, Lymphocyte cytotoxicity in vitro: activation and release of a cytotoxic factor, Nature, 218, 1253, 10.1038/2181253a0 Grant, 1972, Thymocytes from mice immunized against an allograft render bone-marrow cells specifically cytotoxic, J. exp. Med., 135, 150, 10.1084/jem.135.1.150 Green, 1967, Production of a factor by blood lymphocytes which induces fibroblastoid transformation in epithelial cells, Fedn Proc., 26, 702 Green, 1970, Inhibition of target cell proliferation by supernatants from cultures of human peripheral lymphocytes, J. Immun., 105, 48, 10.4049/jimmunol.105.1.48 Green, 1974, Mitogen-stimulated lymphocyte inhibition by supernatants of crowded lymphocytoblasts, Transplantation, 18, 496, 10.1097/00007890-197412000-00004 Guimezanes, 1975, Immunoglobulin binding factor (IBF) produced by slow T cells: Selective interaction with slow migrating rabbit IgG, Annls Inst Pasteur, 126C, 541 Hacker, 1977, Lymphocyte activating factor production by mouse tumor in culture, Fedn Proc., 36, 1300 Hahn, 1967, Studies on the pathogenesis of fever. XV. The production of endogenous pyrogen by peritoneal macrophages, J. exp. Med., 126, 385, 10.1084/jem.126.2.385 Hamaoka, 1973, Mechanism of adjuvant action of poly A:U on antibody responses to hapten-carrier conjugates, Cell. Immun., 7, 246, 10.1016/0008-8749(73)90247-5 Hämmerling, 1976, The ontogeny of B lymphocytes. III. Opposite signals transmitted to B lymphocyte precursor cells by inducing agents and hormones, Bur. J. Immun., 6, 868, 10.1002/eji.1830061206 Hämmerung, 1975, The ontogeny of murine B lymphocytes. I. Induction of phenotypic conversion of Ia− to Ia+ lymphocytes, J. Immun., 115, 1425 Hammond, 1972, Antigen-induced stimuaation of glucosamine incorporation by guinea pig peritoneal macrophages in delayed hypersensitivity, J. exp. Med., 136, 1518, 10.1084/jem.136.6.1518 Han, 1975, Disparity in the production of lymphoblastogenesis inhibition factor by cultured human B and T lymphoid cell lines, Clin. Exp. Immun., 20, 73 Hanna, 1975, Inhibition of T- and B-lymphocyte functions by normal immunosuppressive protein, Immunology, 29, 433 Hart, 1973, Mitogenic factor from inbred guinea pigs. I. Isolation of the factor, Cell. Immun., 9, 173, 10.1016/0008-8749(73)90069-5 Harwell, 1976, Antigen-specific and nonspecific mediators of T cell/B cell cooperation. III. Characterization of the nonspecific mediator(s) from different sources, J. Immun., 116, 1379, 10.4049/jimmunol.116.5.1379 Harwell, 1977, Suppressor T-cell inactivation of a helper T-cell factor, Nature, 265, 57, 10.1038/265057a0 Haurani, 1973, Production of transferrin by the macrophages, J. Reticuloendoth. Soc., 14, 309 Havemann, 1970, Phythämagglutinin (PHA) und Serum Proteine in der Lymphocytenkultur. II. Die Precipitation von Serumproteine durch PHA, Z. ges. exp. Med., 153, 308, 10.1007/BF02048092 Havemann, 1970, Phythämagglutinin (PHA) und Serum Proteine in der Lymphocytenkulture. I. Nachweis von Fördernden und Hemmenden Serum Faktoren, Z. ges. exp. Med., 153, 297, 10.1007/BF02048091 Havemann, 1972, Protease activity as a possible mechanism of migration inhibitory factor, Eur. J. Immun., 2, 97, 10.1002/eji.1830020118 Hay, 1973, The appearance of migration inhibition factor and a mitogen in lymph draining tuberculin reactions, Eur. J. Immun., 3, 127, 10.1002/eji.1830030303 Heise, 1968, In vitro studies on the mechanism of macrophage migration inhibition in tuberculin sensitivity, J. Immun., 101, 1004, 10.4049/jimmunol.101.5.1004 Heise, 1969, Factors in delayed sensitivity: Lymphocyte and macrophage cytotoxins in the tuberculin reaction, J. Immun., 103, 570, 10.4049/jimmunol.103.3.570 Henney, 1974, On the relation of products of activated lymphocytes to cell-mediated cytolysis, J. exp. Med., 140, 837, 10.1084/jem.140.3.837 Heron, 1976, Regulatory effects of interferon on T cells in vitro, J. Immun., 117, 1370, 10.4049/jimmunol.117.4.1370 Hersh, 1974, Mechanisms of production of inhibitor of lymphocyte blastogenic response to mitogens by cultured lymphoblastoid cell line cells, Trans-plantation, 17, 21 Hersh, 1974, Inhibition of in vitro lymphocyte blastogenesis by inhibitor produced by cultured human lymphoblasts, Clin. Exp. Immun., 17, 463 Higgins, 1976, Effect of isoprotirenol and aminophylline on cyclic AMP levels of guinea pig macrophages, Cell. Immun., 27, 1, 10.1016/0008-8749(76)90147-7 Higgins, 1976, Effect of migration inhibitory factor (MIF) on cyclic AMP levels of guinea pig macrophages, Cell. Immun., 27, 11, 10.1016/0008-8749(76)90148-9 Higgins, 1976, Effect of migration inhibitory factor (MIF) on cyclic AMP levels of guinea pig macrophages, Cell. Immun., 27, 11, 10.1016/0008-8749(76)90148-9 Hirashima, 1976, The mediation of tissue eosinophils in hypersensitivity reactions. II. Separation of a delayed eosinophil chemotactic factor trom macrophage chemotactic factors, Immunology, 31, 263 Hirschberg, 1974, Production of blastogenic factor by mitomycin-treated cells in mixed lymphocyte cultures, Transplantation, 17, 323, 10.1097/00007890-197403000-00018 Hiserodt, 1976, Identification of multiple cytolytic components associated with the β-LT class of lymphotoxin released by mitogen activated human lymphocytes in vitro, J. Immun., 117, 1503, 10.4049/jimmunol.117.5_Part_1.1503 Hiserodt, 1976, In vitro lymphocyte cytotoxicity. II. Unstable lymphotoxins (P-LT) secreted and inactivated by mitogen-stimulated human lymphocytes, Cell. Immun., 26, 211, 10.1016/0008-8749(76)90365-8 Hiserodt, 1976, In vitro lymphocyte cytotoxicity. I. Evidence of multiple cytotoxic molecules secreted by mitogen activated human lymphoid cells in vitro, Cell. Immun., 24, 277, 10.1016/0008-8749(76)90212-4 Hochová, 1975, Further characterization of antigen-dependent migration inhibitory factor in mice, Immunology, 29, 231 Hoessli, 1977, Potentiation of the T-lymphocyte response to mitogens. IV. Serum-free production and testing of macrophage soluble products, Cell. Immun., 30, 310, 10.1016/0008-8749(77)90074-0 Hoffmann, 1971, Immune response restoration with macrophage culture super- natants, Science, 172, 1047, 10.1126/science.172.3987.1047 Holzman, 1973, Preparation and properties of cloning inhibitory factor. I. Inhibition of HeLa cell cloning by stimulated lymphocytes and their culture supernatants, Cell. Immun., 8, 249, 10.1016/0008-8749(73)90114-7 Holzman, 1973, Preparation and properties of cloning inhibitory factor. II. Factors affecting its production and assay, Cell. Immun., 8, 259, 10.1016/0008-8749(73)90115-9 Horton, 1974, Macrophage-lymphocyte synergy in the production of the osteoclast activating factor, J. Immun., 113, 1278, 10.4049/jimmunol.113.4.1278 Horwitz, 1977, Serum effects on mitogenic reactivity in subjects with systemic lupus erythematosus, rheumatoid arthritis and scleroderma. Technical considerations and lack of correlation with anti-lymphocyte antibodies, Clin. Exp. Immun., 27, 100 Houck, 1973, Immunosuppressive properties of the lymphocyte chalone, Nature, 245, 148, 10.1038/245148a0 Houck, 1971, Lymphocyte DNA synthesis inhibition, Science, 173, 1139, 10.1126/science.173.4002.1139 Houck, 1977, Lymphocyte and fibroblast chalones: some chemical properties, Science, 196, 896, 10.1126/science.140460 Houck, 1973, Fibroblast chalone and serum mitogen (anti- chalone), Nature New Biol., 246, 111, 10.1038/newbio246111a0 Houck, 1972, Evidence for a fibroblast chalone, Nature New Biol., 240, 210, 10.1038/newbio240210a0 Howell, 1976, The structure-activity relations of synthetic peptides as chemotactic factors and inducers of lysosomal enzyme secretion for neutrophils, J. exp. Med., 143, 1154, 10.1084/jem.143.5.1154 Hsu, 1973, The effects of foetinin on lymphocytes; lymphocyte-stimulating property, Clin. Exp. Immun., 15, 427 Hunter, 1974, Mode of action of a supernatant activity from T-cell cultures that nonspecifically stimulates the humoral immune response, Proc. natn. Acad. Sci. USA, 71, 512, 10.1073/pnas.71.2.512 Isac, 1977, Antigen-specific T cell factors: a fine analysis of specificity, J. Immun., 118, 584, 10.4049/jimmunol.118.2.584 Ishizaka, 1976, Functions and development of cell receptors for IgE, 199 Jacobson, 1973, In vitro studies of allotype suppression in mice, Eur. J. Immun., 3, 619, 10.1002/eji.1830031005 Jacobsson, 1975, Characterization of mouse spleen cells releasing or responding to mitogenic factor induced by phytomitogens in vitro, J. Immun., 114, 1631, 10.4049/jimmunol.114.5.1631 James, 1975, Eosinophils and immune mechanisms: production of the lymphokine eosinophil stimulation promotor (ESP) in vitro by isolated intact granulomas, J. Reticuloendolh. Soc., 18, 283 Jeffes, 1975, Relationship of cloning inhibition factor, ‘lymphotoxin’ factor and proliferation inhibition factor release in vitro by mitogen activated human lymphocytes, J. Immun., 114, 64, 10.4049/jimmunol.114.1_Part_1.64 Jeffes, 1976, Relationship of CIF, LT and PIF released in vitro by activated human lymphocytes, II. A further functional comparison of LT and PIF activities on HeLa and L-929 target cells, J. Immun., 117, 174, 10.4049/jimmunol.117.1.174 Jegasothy, 1976, Cytokine inhibition of DNA synthesis: effect on cyclic adenosine,monophosphate in lymphocytes, Science, 193, 1260, 10.1126/science.183266 Jegasothy, 1978, Regulatory substances produced by lymphocytes. VII. IDS (Inhibitor of DNA synthesis) inhibits stimulated lymphocytes proliferation by activating of membrane adenylate cyclase at a restriction point in G1, Immunochemistry, 10.1016/0161-5890(78)90007-X Johanovský, 1962, Characteristics of fever produced by hypersensitivity pyrogen, Folia Microb., 7, 12, 10.1007/BF02926327 Johnson, 1975, Interferon inhibition of the primary in vitro antibody response to a thymus-independent antigen, Cell. Immun., 20, 104, 10.1016/0008-8749(75)90089-1 Jokipii, 1973, Migration inhibition of peritoneal exudate cells from sensitized and desensitized rats, Immunology, 25, 283 Jones, 1973, Mitogenic factor from inbred guinea pigs. II. Properties of the factor, Cell. Immun., 9, 186, 10.1016/0008-8749(73)90070-1 Jureziz, 1968, Transfer with RNA extracts of the cell migration inhibition correlate of delayed hypersensitivity in the guinea pig, J. Immun., 101, 823, 10.4049/jimmunol.101.5.823 Kamrin, 1959, Successful skin homografts in mature non-littermate rats treated with fractions containing alpha-globulins, Proc. Soc. exp. Biol. Med., 100, 58, 10.3181/00379727-100-24522 Kantor, 1971, Regulatory mechanisms in delayed hypersensitivity, 213 Kapp, 1977, Immunosuppressive factor(s) extracted from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). II. Cellular source and effect on responder and nonresponder mice, J. exp. Med., 145, 829, 10.1084/jem.145.4.828 Kapp, 1976, Immunosuppressive factor(s) extraced from lymphoid cells of nonresponder mice primed with L-glutamic acid 60L-alanine30-L-tyrosine10 (GAT). I. Activity and antigenic specificity, J. Immunol., 116, 305, 10.4049/jimmunol.116.2.305 Kasakura, 1965, A factor stimulating DNA synthesis derived from the medium of leucocyte cultures, Nature, 208, 794, 10.1038/208794a0 Kasahara, 1976, Splenic suppressing factor: purification and characterization of a factor suppressing thymidine incorporation into activated lymphocytes, J. Immun., 116, 1251, 10.4049/jimmunol.116.5.1251 Katz, 1976, The role of histocompatibility gene products in lymphocyte triggering and differentiation, Fedn. Proc., 35, 2053 1974 Kelly, 1972, Role of lymphocyte activation products (LAP) in cell-mediated immunity. II. Effect of lymphocyte activation products on lymph node architecture and evidence for peripheral release of LAP following antigenic stimulation, Clin. Exp. Immun., 10, 49 Kierszenbaum, 1977, Mechanisms of action of ‘lymphocyte activating factor’ (LAF). I. Association of LAF action with early DNA synthesis in PHA-stimulated lymphocytes, Immunology, 33, 663 Kiger, 1971, Isolation and immunological study of thymic lymphocytic inhibitory factors, Rev. Eur. Etudes Clin. Biol., 16, 566 Kiger, 1973, Inhibition of graft-versus-host reaction by preincubation of the graft with a thymic extract (lymphocyte chalone), Transplantation, 16, 393, 10.1097/00007890-197311000-00001 Kirov, 1976, Carrier-specific B-cells play a role in the production of an antigen-specific T-cell replacing factor, Scand. J. Immun., 5, 1155, 10.1111/j.1365-3083.1976.tb00269.x Kishimoto, 1973, Regulation of antibody response in vitro. VII. Enhancing soluble factors for IgG and IgE antibody response, J. Immun., 111, 1194, 10.4049/jimmunol.111.4.1194 Kishimoto, 1974, Regulation of antibody response in vitro. VIII. Multiplicity of soluble factors released from carrier-specific cells, J. Immun., 112, 1685, 10.4049/jimmunol.112.5.1685 Kishimoto, 1975, Immunologic and physicochemical properties of enhancing soluble factors for IgG and IgE antibody responses, J. Immun., 114, 1177, 10.4049/jimmunol.114.4.1177 Klun, 1973, Relationship between mouse migration-inhibitory factor in supernatant fluids from mouse lymphocyte cultures, J. Reticuloendoth. Soc., 13, 310 Knyszynski, 1971, Stimulation of DNA synthesis in vitro in mouse thymic cells by bone marrow preparation, Blood, 37, 231, 10.1182/blood.V37.2.231.231 Kolb, 1968, Lymphocyte in vitro cytotoxicity: characterization of human lymphotoxin, Proc. natn. Acad. Sci. USA, 61, 1250, 10.1073/pnas.61.4.1250 Koltai, 1975, Anaphylactoid-inflammation- promoting factor. An insulin-induced factor derived from non-sensitized lymphocytes increases anaphylactoid inflammation in rats, Int. Arcs Allergy, 49, 358, 10.1159/000231417 Kontiainen, 1977, Suppressor cell induction in vitro. III. Antigen-specific suppression by supernatants of suppressor cells, Eur. J. Immun., 7, 310, 10.1002/eji.1830070514 Kook, 1974, Hormone-like activity of a thymus humoral factor on the induction of immune competence in lymphoid cells, J. exp. Med., 139, 193, 10.1084/jem.139.1.193 Kook, 1975, Intracellular events involved in the induction of immune competence in lymphoid cells by a thymus humoral factor, J. Immun., 114, 151, 10.4049/jimmunol.114.1_Part_1.151 Koopman, 1973, Prevention of MIF activity by agents known to increase cellular cyclic AMP, J. Immun., 110, 1609, 10.4049/jimmunol.110.6.1609 Koopman, 1976, Interaction of soluble C3 fragments with guinea pig lymphocytes. Comparison of effects of C3a, C3b, C3c, C3d on lymphokine production and lymphocyte proliferation, J. Immun., 117, 331, 10.4049/jimmunol.117.1.331 Korcaková, 1975, Mouse lymph node activating factor release during contact of HL-A different blood lymphocytes, Transplantation, 20, 273, 10.1097/00007890-197510000-00001 Krahenbuhl, 1971, In vitro induction of nonspecific resistance in macrophages by specifically sensitized lymphocytes, Infect. Immun., 4, 337, 10.1128/IAI.4.4.337-343.1971 Krakauer, 1977, Prevent.on of autoimmunity in experimental lupus erythematosus by soluble immune response suppressor, Science, 196, 56, 10.1126/science.300174 Kramer, 1972, The in vitro induction and release of a cell toxin by immune C57 B1/6 mouse peritoneal macrophages, Cell. Immun., 3, 88, 10.1016/0008-8749(72)90229-8 Kramer, 1975, The role of lymphotoxin in target cell destruction by mitogen-activated human lymphocytes. I. The correlation of target cell sensitivity to lymphotoxin and the intact lymphocyte, Cell. Immun., 15, 57, 10.1016/0008-8749(75)90164-1 Kramer, 1976, The role of lymphotoxin in target cell destruction induced by mitogen-activated human lymphocytes in vitro. II. The correlation of temperature and trypsin-sensitive phases of lymphotoxin-induced and lymphocyte-mediated cytotoxicity, J. Immun., 116, 562, 10.4049/jimmunol.116.2.562 Krejčí, 1968, Demonstration of migration inhibiting substances in sera of guinea pigs with delayed type hypersensitivity to ovalbumin influenced with systemic antigen administration, Z. Immunitstät., 136, 259 Kuhner, 1976, Partial characterization of murine migration inhibitory factor (MIF) J, Immun., 116, 140 Kuratsuji, 1976, Anti-lymphokine antibody. II. Specificity of biolocical activity, J. Immun., 117, 1985, 10.4049/jimmunol.117.5_Part_2.1985 Kushner, 1961, Studies of acute phase protein. I. An immunohistochemical method for the localization of Cx-reaction protein in rabbits. Association with necrosis in local inflammatory lesions, J. exp. Med., 114, 961, 10.1084/jem.114.6.961 Lachman, 1976, Electromobility and purification of human lymphocyte activating factor, Fedn Proc., 35, 489 Lai, 1975, In vitro synthesis of some complement components (C1q. C3 and C4) by lymphoid tissues and circulating leucocytes in man, Immunology, 28, 359 Lee, 1976, Regulatory factors produced by lymphocytes. I. The occurrence of multiple α-Iymphotoxins associated with ribonuclease activity, J. Immun., 117, 283, 10.4049/jimmunol.117.1.283 Lee, 1977, Regulatory factors produced by lymphocytes.TL Inhibition of cellular DNA synthesis associated with a factor inhibiting DNA polymerase a activity, J. Immun., 118, 88, 10.4049/jimmunol.118.1.88 Lee, 1976, Soluble factors in immune sera of mice. I. Specific and non-specific suppressive activity, Clin. Exp. Immun., 24, 177 Lee, 1976, Soluble factors in immune sera of mice. II. Reversible loss of surface immunoglobulin induced in vitro, Clin. Exp. Immun., 24, 185 Lefkovits, 1975, T-cell-dependent mediator and B-cell clones, Immunology, 28, 1149 Leonard, 1976, Characterization of mouse lymphocyte-derived chemotactic factor, Cell. Immun., 26, 200, 10.1016/0008-8749(76)90364-6 Lett-Brown, 1976, Chemotactic responses of normal human basophils to C5a and to lymphocyte-derived chemotactic factor, J. Immun., 117, 246, 10.4049/jimmunol.117.1.246 Leu, 1972, Mechanism of action of migration inhibitory factor (MIF). I. Evidence for a receptor for MIF present on the peritoneal macrophage but not on the alveolar macrophages, J. exp. Med., 136, 589, 10.1084/jem.136.3.589 Lewis, 1977, Antibodies against human lymphokines. I. Methods for induction of antibodies capable of neutralizing stable (α) and unstable (β) lymphotoxins released in vitro by activated human lymphocytes, J. Immun. Meth., 14, 163, 10.1016/0022-1759(77)90006-0 Littman, 1977, Production of the second component of complement by human monocytes: stimulation by antigen-activated lymphocytes or lymphokines, J. exp. Med., 145, 1344, 10.1084/jem.145.5.1344 Lodmell, 1976, Inhibition of vaccinia virus replication in skin of tuberculin-sensitized animals challenged with PPD, J. Immun., 117, 1757, 10.4049/jimmunol.117.5_Part_2.1757 Lolekha, 1970, Macrophage aggregation in vitro. A correlate of delayed hypersensitivity, J. Immun., 104, 296, 10.4049/jimmunol.104.2.296 Lomnitzer, 1975, Production of leucocyte inhibitory factor (LIF) and macrophage inhibitory factor (MIF) by PHA-stimulated lymphocytes, Clin. Exp. Immun., 22, 522 Lovchik, 1977, Antibody-dependent cell-mediated cytolysis (ADCC), Prog. Allergy, 22, 1 Lozzio, 1973, Regulators of cell division. A review. I. Endogenous mitotic inhibitors of hematopoietic cells, Exp. Hematol., 1, 309 Lykke, 1967, Thymic permeability factor: its relationship to lymph-node permeability factor and its antagonism by pyridinol carbamate agents, J. Path. Bact., 94, 381, 10.1002/path.1700940218 Mackaness, 1969, The influence of immunologically committed lymphoid cells on macrophage activity in vivo, J. exp. Med., 129, 973, 10.1084/jem.129.5.973 Maillard, 1972, Interactions between ‘sensitized lymphocytes’ and antigen in vitro. V. Vascular permeability induced by skin-reactive factor, Int. Archs. Allergy, 42, 50, 10.1159/000230592 Maini, 1971, The production of lymphocyte mitogenic factor and migration-inhibition factor by antigen-stimulated lymphocytes of subjects with grass pollen allergy, Clin. Exp. Immun., 9, 449 Mangi, 1974, The immunological competence of subjects with sarcoidosis, Clin. Exp. Immun., 18, 505 Mangi, 1974, The effect of plasma upon lymphocyte response in vitro. Demonstration of a humoral inhibitor in patients with sarcoidosis, Clin. Exp. Immun., 18, 519 Mannick, 1967, Prolongation of allograft survival by an alpha globulin isolated from normal blood, Transplantation, S, 1231, 10.1097/00007890-196707001-00063 1975, Hemolymph components in invertebrate immunity, 201 Marrack (Hunter), 1975, Antigen-specific and nonspecific mediators of T cellJB cell cooperation. I. Evidence for their production by different T cells, J. Immun., 114, 1116, 10.4049/jimmunol.114.3.1116 Marrack, 1976, Antigen-specific and nonspecific mediators of T cellJB cell cooperation. II. Two helper T cells distinguished by their antigen sensitivities, J. Immun., 116, 1373, 10.4049/jimmunol.116.5.1373 McConnell, 1977, Complement receptors and cell-associated complement components, Immun. Commun., 6, 111, 10.3109/08820137709055806 McIvor, 1971, Mechanisms of target cell destruction by alloimmune peritoneal macrophages. I. The effect of treatment with sodium fluoride, Immunology, 20, 307 McIvor, 1971, Mechanisms of target cell destruction by alloimmune peritoneal macrophages. II. Release of a specific cytotoxin from interacting cells, Immunology, 20, 315 McKenzie, 1977, la antigenic specificities are oligosaccharide in Nature: hapten-inhibition studies, J. exp. Med., 145, 1039, 10.1084/jem.145.4.1039 McKenzie, 1976, Secretion of la antigens by a subpopulation of T cells which are Ly-1+, Ly-2−, and Ia−, J. exp. Med., 144, 847, 10.1084/jem.144.3.847 McMaster, 1975, Immunosuppression of normal typhoid cells by serum from mice undergoing chronic graft-vs-host disease, J. Immun., 115, 1400, 10.4049/jimmunol.115.5.1400 Meacock, 1968, Further studies on the suppression of delayed hypersensitivity reactions in the rat and guinea pig by antibody against lymph node abstracts, Immunology, 15, 115 Meade, 1974, A sensitive assay for cellular hypersensitivity based on the uptake of radioactive colloidal gold, Immunology, 27, 227 Melsom, 1974, Evidence for a cytolytic factor released by macrophages, J. exp. Med., 140, 1085, 10.1084/jem.140.4.1085 Meltzer, 1977, Bidirectional amplification of macrophage-lymphocyte interactions: enhanced lymphocyte activation factor production by activated mouse peritoneal cells, J. Immun., 118, 77, 10.4049/jimmunol.118.1.77 Mendelsohn, 1971, The rapid induction by phytohemagglutinin of increased a-aminoisobutyric acid uptake by lymphocytes, J. Clin. Invest., SO, 818, 10.1172/JCI106553 Menzoian, 1974, Regulation of T lymphocyte function by immunoregulatory alpha globulin (IRA), J. Immun., 113, 266, 10.4049/jimmunol.113.1.266 Miller, 1977, The induction of hapten-specific T cell tolerance using hapten-modified lymphoid membranes. II. Relative roles of suppressor T cells and clone inhibition in the tolerant state, Eur. J. Immun., 7, 165, 10.1002/eji.1830070310 Mills, 1975, Characterization of guinea pig mitogenic factor, J. Immun., 114, 45, 10.4049/jimmunol.114.1_Part_1.45 Milthorp, 1973, Serum factors affecting the incorporation of (3H) uridine by lymphocytes stimulated by concanavalin A. Studies of the role of complement, Biochem. J., 132, 803, 10.1042/bj1320803 Milton, 1972, Reversible loss of surface receptors on lymphocytes, Immunology, 23, 599 Molenaar, 1977, Spontaneous release of Fc receptor-like material from human lymphoblastoid cell lines, Eur. J. Immun., 7, 230, 10.1002/eji.1830070409 1973, Effector cells in cell-mediated immunity, Transplant. Rev., 17, 1 1976, Specificity of effector T lymphocytes, Transplant. Rev., 29, 1 1976, Biochemistry and biology of la antigens, Transplant. Rev., 30, 1 Moncada, 1973, Prostaglandins, aspirin-like drugs and the oedema of inflammation, Nature, 246, 217, 10.1038/246217a0 Mooney, 1970, Activation of normal rabbit macrophage monolayers by supernatants of antigen-stimulated lymphocyte, J. Immun., 105, 1138, 10.4049/jimmunol.105.5.1138 Moore, 1976, Regulatory role of macrophages in hemopoiesis, J. Reticuloendoth. Soc., 20, 89 Moore, 1973, In vitro colony formation by normal and leukemic human hematopoietic cells: interaction between colony-forming and colony-stimulating cells, J. natn. Ca. Inst., 50, 591, 10.1093/jnci/50.3.591 Mortensen, 1977, Effects of C-reactive protein on lymphocyte functions. III. Inhibition of antigen-induced lymphocyte stimulation and lymphokine production, Cell. Immun., 28, 59, 10.1016/S0008-8749(77)80006-3 Mortensen, 1976, Enects of C-reactive protein on the lymphoid system. II. Inhibition of mixed lymphocyte reactivity and generation of cytotoxic lymphocytes, J. Immun., 116, 1244, 10.4049/jimmunol.116.5.1244 Mortensen, 1975, Effects of C-reactive protein on the lymphoid system. I. Binding to thymus-dependent lymphocytes and alteration of their functions, J. exp. Med., 141, 821, 10.1084/jem.141.4.821 Mosier, 1975, Ontogeny of mouse lymphocyte function. II. Development of the ability to produce antibody is modulated by T-lymphocytes, J. exp. Med., 141, 216, 10.1084/jem.141.1.216 Mowbray, 1963, Ability of large doses of an alpha2 plasma protein fraction to inhibit antibody production, Immunology, 6, 217 Moy, 1977, Evidence that human α-lymphotoxin is not a RNase, J. Immun., 118, 1507, 10.4049/jimmunol.118.4.1507 Munro, 1974, Antigen-specific T-cell factor in cell cooperation: physical properties and mapping in the left hand (K) half of N-2, J. exp. Med., 140, 1579, 10.1084/jem.140.6.1579 Murgita, 1976, The immunosuppressive role of alpha-fetoprotein during pregnancy, Scand. J. Immun., 5, 1003, 10.1111/j.1365-3083.1976.tb03052.x Murgita, 1977, α-fetoprotein induces suppressor cells in vitro, Nature, 267, 257, 10.1038/267257a0 Murgita, 1975, Suppression of the immune response by α-fetoprotein. I. The effect of mouse α-fetoprotein on the primary and secondary antibody response, J. exp. Med., 141, 269, 10.1084/jem.141.2.269 Murgita, 1975, Suppression of the immune response by α-fetoprotein. II. The effect of mouse a-fetoprotein on mixed lymphocyte reactivity and mitogen-induced lymphocyte transformation, J. exp. Med., 141, 440 Murgita, 1976, The effects of mouse alpha-fetoprotein on T-cell-dependent and T-cell-independent immune responses in vitro, Scand. J. Immun., 5, 1215, 10.1111/j.1365-3083.1976.tb00265.x Mutchnick, 1977, Mouse thymocyte membrane uptake of polyadenylic-polyuridylic acid complexes, Proc. Soc. exp. Biol. Med., 154, 264, 10.3181/00379727-154-39651 Nakamura, 1976, Interaction between lymphocytes and inflammatory exudate cells. II. A proteolytic enzyme released by PMN as a possible mediator for enhancement of thymocyte response, J. Immun., 117, 1, 10.4049/jimmunol.117.1.1 Namba, 1977, Regulatory substances produced by lymphocites. V. Production of inhibitor of DNA synthesis (IDS) by proliferating T-lymphocytes, J. Immun., 118, 1379, 10.4049/jimmunol.118.4.1379 Namba, 1975, Analysis of T-cell-specific functions in continuous lymphocytic cell lines. I. Combined expression of thymocyte antigen and MIF production in rat-mouse hybrid lines, Exp. Cell Res., 94, 22, 10.1016/0014-4827(75)90527-3 Namba, 1975, Regulatory substances produced by lymphocytes. I. Inhibitor of DNA synthesis in the rat, Inflammation, I, 5, 10.1007/BF00918056 Namba, 1975, Regulatory substances produced by lymphocytes. II. Lymphotoxin in the rat, J. Immun., 115, 1018, 10.4049/jimmunol.115.4.1018 Namba, 1976, Regulatory substances produced by lymphocytes. III. Evidence that lymphotoxin and proliferation inhibitory factor are identical and differ from the inhibitor of DNA synthesis, J. Immun., 116, 1140, 10.4049/jimmunol.116.4.1140 Namba, 1977, Regulatory substances produced by lymphocytes. IV. Further characterization of the inhibitor of DNA synthesis, Immunochemistry, 14, 143, 10.1016/0019-2791(77)90293-2 Nathan, 1971, Alterations of macrophage functions by mediators from lymphocytes, J. exp. Med., 133, 1356, 10.1084/jem.133.6.1356 Nathan, 1973, Characterization of a lymphocyte factor which alters macrophage functions, J. exp. Med., 137, 275, 10.1084/jem.137.2.275 1976 Nelken, 1973, Normal immunosuppressive protein (NIP), J. Immun., 110, 1161, 10.4049/jimmunol.110.4.1161 Nelson, 1973, Production by stimulated macrophages of factors depressing lymphocyte transformation, Nature, 246, 306, 10.1038/246306a0 1976 Nelson, 1975, Depressive effect of serum from patients with leprosy on mixed lymphocyte reactions. Influence of anti-leprosy treatment, Clin. Exp. Immun., 22, 385 Nelson, 1974, Effect of normal mouse serum on mouse lymphocyte transformation in vitro, Eur. J. Immun., 4, 79, 10.1002/eji.1830040205 Nepom, 1976, Purification and partial characterization of a tumor-specific blocking factor from sera of mice with growing chemically induced sarcomas, J. Immun., 117, 1846, 10.4049/jimmunol.117.5_Part_2.1846 Ngan, 1976, The suppressive effect of interferon on the ability of mouse spleen cells synthesizing IgE to sensitize rat skin for heterologous adoptive cutaneous anaphylaxis, J. Immun., 117, 1063, 10.4049/jimmunol.117.4.1063 North, 1976, Subversion of host defense mechanisms by murine tumors. I. A circulating factor that suppresses macrophage-mediated resistance to infection, J. exp. Med., 143, 559, 10.1084/jem.143.3.559 Novogrodsky, 1972, Enhancement of mouse thymus cells response to periodate treatment by a soluble factor, J. Immun., 109, 1278, 10.4049/jimmunol.109.6.1278 Nussenzweig, 1974, Receptors for immune complexes on lymphocytes, Adv. Immun., 19, 217, 10.1016/S0065-2776(08)60253-9 Oates, 1972, Thymus and bursa .dependence of lymphocyte mitogenic factor in the chicken, Nature New Biol., 239, 137, 10.1038/newbio239137a0 Occhino, 1973, Isolation of an immunosuppressive peptide fraction from human plasma, J. Immun., 110, 685, 10.4049/jimmunol.110.3.685 Ohishi, 1975, Functional activation of immune lymphocytes by antigenic stimulation in cell mediated immunity. I. Requirement for macrophages in antigen-induced MIF production by guinea pig immune lymphocytes in vitro, Cell. Immun., 18, 220, 10.1016/0008-8749(75)90050-7 Oishi, 1973, Relationship of c-reactive protein in autologous plasma of cancer patients and choline phosphate in lymphocyte responses to phyto- hemagglutinin, J. Reticuloendoth. Sco., 14, 242 Ökumura, 1974, Regulation of homocytotropic antibody formation in the rat. IX. Further characterization of the antigen-specific inhibitory T cell factor in hapten-specific homocytotropic antibody response, J. Immun., 112, 783 Olding, 1974, Inhibition of mitosis of lymphocytes from, human adults by lymphocytes from human newborns, Clin. Immun. Immunopath., 3, 79, 10.1016/0090-1229(74)90025-7 Olsen, 1974, Uptake and release of DNA by lymphoid tissue and cells, Immunology, 27, 973 Opitz, 1975, Biochemical characterization of a factor released by macrophages, Cell. Immun., 18, 70, 10.1016/0008-8749(75)90037-4 Opitz, 1975, Inhibition of 3H-thymidine incorporation of lymphocytes by a soluble factor from macrophages, Cell. Immun., 16, 379, 10.1016/0008-8749(75)90126-4 Oppenheim, 1976, Enhancement of DNA synthesis and cAMP content of mouse thymocytes by mediator(s) derived from adherent cells, J. Immun., 116, 1466, 10.4049/jimmunol.116.5.1466 Outteridge, 1973, Immunosuppressive factors released by transforming lymphocytes in the delayed hypersensitivity skin response to tuberculin, Immunology, 25, 981 Papageorgiou, 1972, Production and characterization of migration inhibitory factor(s) (MIF) of established lymphoid and non-lymphoid cell lines, J. Immun., 108, 494, 10.4049/jimmunol.108.2.494 Papageorgiou, 1974, Presence of a reversible inhibitor(s) for human lymphoid cell RNA, protein, and DNA synthesis in the extracts of established human lympoid cell lines, Cell. Immun., 11, 354, 10.1016/0008-8749(74)90034-3 Parish, 1976, Low molecular weight la antigens in normal mouse serum. II. Demonstration of their T cell origin, Immunogenetics, 3, 129, 10.1007/BF01576945 Parker, 1974, Production of colony-stimulating factor in mitogen-stimulated lymphocyte cultures, J. Immun., 112, 502, 10.4049/jimmunol.112.2.502 Parker, 1974, Production of colony-stimulating factor in mixed leucocyte cultures, Immunology, 26, 1039 Parrott, 1971, Thymus-dependent and thymus-independent populations: origin, migratory patterns and lifespan, Clin. Exp. Immun., 8, 663 Patterson, 1970, Demonstration in tissue culture of lymphocyte-mediated immunity to tuberculosis, Inf. Immunity, 1, 600, 10.1128/IAI.1.6.600-603.1970 Paul, 1977, Independent populations of primed F1 guinea pig T lymphocytes respond to antigen-pulsed parental peritoneal exudate cells, J. exp. Med., 145, 618, 10.1084/jem.145.3.618 Peter, 1973, Characteristics of a cytotoxin (‘lymphotoxin’) produced by stimulation of human lympoid tissue, J. Immun., 111, 770, 10.4049/jimmunol.111.3.770 Phillips, 1975, Immunosuppressive globulin from bovine thymus and serum: mode of action upon afferent and efferent arcs of the mouse immune response, Ann. N. Y. Acad. Sci., 249, 236, 10.1111/j.1749-6632.1975.tb29071.x Pick, 1972, Cyclic AMP effects macrophage migration, Nature New Biol., 238, 176, 10.1038/newbio238176a0 Pick, 1974, Soluble lymphocytic mediators. I. Inhibition of macrophage migration inhibitory factor production by drugs, Immunology, 26, 649 Pick, 1973, Blocking of macrophage migration inhibitory factor action by micro-tubular disruptive drugs, Int. Archs Allergy, 44, 215, 10.1159/000230930 Pick, 1970, Interaction between ‘sensitized lymphocytes’ and antigen in vitro. II. Mitogen-induced release of skin reactive and macrophage migration inhibitory factors, Cell. Immun., 1, 92, 10.1016/0008-8749(70)90063-8 Pick, 1969, Interaction between ‘sensitized lymphocytes’ and antigen in vitro. I. The release of skin reactive factor, Immunology, 17, 741 Pick, 1970, Release of skin reactive factor from guinea pig lymphocytes by mitogens, Nature, 225, 236, 10.1038/225236a0 Pincus, 1967, Formation of cytotoxic factor by macrophages from normal guinea pigs, J. Reticuloendoth. Soc., 4, 122 Pincus, 1967, Cell-free cytotoxic fluids from tuberculin-treated normal guinea pigs, J. Reticuloendoth. Soc., 4, 140 Pincus, 1971, Cytotoxic factor from peritoneal cells: site of action, J. Reticuloendoth. Soc., 9, 552 Pincus, 1970, Immune-specific cytotoxic factor formation by small lymphocytes, J. Reticuloendoth. Soc., 7, 220 Piper, 1975, Alloimmune peritoneal macrophages as specific effector cells: characterization of specific macrophage cytotoxin, Cell. Immun., 17, 423, 10.1016/S0008-8749(75)80046-3 Postlethwaite, 1976, Guinea pig lymphocyte-derived macrophage aggregation factor: its separation from macrophage migration inhibitory factor, J. Immun., 117, 1651, 10.4049/jimmunol.117.5_Part_1.1651 Postlethwaite, 1976, The chemotactic attraction of human fibroblasts to a lymphocyte-derived factor, J. Immun., 144, 1188 Poulter, 1975, Studies on the effect of soluble lymphocyte products (lympho.- kines) on macrophage physiology. I. Early changes in enzyme activity and permeability, Cell. Immum., 20, 12, 10.1016/0008-8749(75)90079-9 Poulter, 1975, Studies on the effect of soluble lymphocyte products (lymphokines) on macrophage physiology. II. Cytochemical changes associated with activation, Cell. Immun., 20, 25, 10.1016/0008-8749(75)90080-5 Powles, 1971, Specific autostimulating factor released by lymphocytes, Nature, 231, 161, 10.1038/231161a0 Prendergast, 1976, Isolation and characterization of sea star factor, Scand. J. Immun., 5, 873, 10.1111/j.1365-3083.1976.tb03037.x Prystowsky, 1975, Intracellular localization of the migration inlubitory factor (MIF) in a long-term human lympoid cell line, Int. Archs Allergy, 48, 225, 10.1159/000231309 Ptak, 1977, Interference with the transmission of T cell derived messages by macrophage membranes, J. Immun, 119, 444, 10.4049/jimmunol.119.2.444 Rabinovitch, 1968, Effect of the uptake of staphylococci on the ingestion of glutaraldehyde-treated red cells attached to macrophages, Exp. Cell Res., 52, 363, 10.1016/0014-4827(68)90477-1 Radovich, 1967, Antigenic competition: cellular or humoral, Science, 158, 512, 10.1126/science.158.3800.512 Ramseier, 1969, Quantitative studies on antigenic recognition. I. Immunological and nonimmunological parameters of the response, J. exp. Med., 130, 1279, 10.1084/jem.130.6.1279 Ramseier, 1977, Studies on the product of antigenic recognition. I. Formation of the product in recognition of alloantigens, Exp. Cell Biol., 45, 60 Ramseier, 1977, Studies on the product of antigenic recognition. II Formation of the product in recognition of alloreceptors, Exp. Cell Biol., 45, 89 Ramseier, 1977, Studies on the product of antigenic recognition III Nature of PAR, Exp. Cell Biol., 45, 100 Ranney, 1973, In vitro generation of lymphocytic chalone by rat spleen cells, Fedn Proc., 32, 979 Ranney, 1976, Differences in the age-dependent release of a low molecular weight suppressor (LMWS) and stimulators by normal and NZB/W lymphoid organs, J. Immun., 117, 1219, 10.4049/jimmunol.117.4.1219 Remold, 1973, requirement for α-L-fucose on the macrophage membrane receptor for MIF, J. exp. Med., 138, 1065, 10.1084/jem.138.5.1065 Remold, 1974, The enhancement of MIF activity by inhibition of macrophage associated esterases, J. Immun., 112, 1571, 10.4049/jimmunol.112.4.1571 Remold, 1972, Characterization of migration inhibitory factor (MIF) from guinea pig lymphocytes stimulated with concanavalin A, J. Immun., 109, 578, 10.4049/jimmunol.109.3.578 Remold, 1975, Decrease of three lysosomal enzymes in guinea pig macrophages activated by lymphocyte mediators, Inflammation, 1, 175, 10.1007/BF00917528 Rich, 1941, The significance of hypersensitivity in infections, Physiol. Revs., 21, 70, 10.1152/physrev.1941.21.1.70 Rich, 1927, Mechanism of allergy in tuberculosis, Proc. Soc. exp. Biol. Med., 25, 596, 10.3181/00379727-25-3969 Rich, 1974, Biological expressions of lymphocyte activation. III. Suppression of plaque-forming cell responses in vitro by supernatant fluids from concanavalin A-activated spleen cell cultures, J. Immun., 112, 1360, 10.4049/jimmunol.112.4.1360 Rich, 1974, Regulatory mechanisms in cell-mediated immune responses. I. Regulation of mixed lymphocyte reactions by alloantigen-activated thymus-derived lymphocytes, J. exp. Med., 140, 1588, 10.1084/jem.140.6.1588 Rich, 1975, Regulatory mechanisms in cell-mediated immune responses. II. A genetically restricted suppressor of mixed lymphocyte reactions released by alloantigen-activated spleen cells, J. exp. Med., 142, 1391, 10.1084/jem.142.6.1391 Rich, 1967, Regulatory mechanisms in cell-mediated immune response. III. I-region control of suppressor cell interaction with responder cells in mixed lymphocyte reactions, J. exp. Med., 143, 672, 10.1084/jem.143.3.672 Rich, 1976, Regulatory mechanisms in cell-mediated immune responses. IV. Expression of a receptor for mixed lymphocyte reaction suppressor factor on activated T lymphoytes, J. exp. Med., 144, 1214, 10.1084/jem.144.5.1214 Rittenberg, 1960, Macrophages, nucleic acids, and the induction of antibody formation, Am. Nat., 94, 321, 10.1086/282136 Rocklin, 1973, Production of migration inhibitory factor by non-dividing lymphocytes, J. Immun., 110, 674, 10.4049/jimmunol.110.3.674 Rocklin, 1974, Products of activated lymphocytes: leukocyte inhibitory factor (LIF) distinct from migration inhibitory factor (MIF), J. Immun., 112, 1461, 10.4049/jimmunol.112.4.1461 Rockun, 1975, Partial characterization of leukocyte inhibitory factor by concanavalin A-stimulated human lymphocytes (LIF Con A), J. Immun., 114, 1161, 10.4049/jimmunol.114.4.1161 Rocklin, 1976, Role of monosaccharides in the interaction of two lymphocyte mediators with their target cells, J. Immun., 116, 816, 10.4049/jimmunol.116.3.816 Rocklin, 1977, Histamine-induced suppressor factor (HSF): effect on migration inhibitory factor (MIF) production and proliferation, J. Immun., 118, 1734, 10.4049/jimmunol.118.5.1734 Rocklin, 1974, Studies on mediator production by highly purified human T and B lymphocytes, J. exp. Med., 140, 1303, 10.1084/jem.140.5.1303 Rocklin, 1970, An in vitro assay for cellular hypersensitivity in man, J. Immun., 104, 95, 10.4049/jimmunol.104.1.95 Roehm, 1977, Induction of splenomegaly with stimulated leukocyte supernatants, Transplantation, 23, 49, 10.1097/00007890-197701000-00009 Rogers, 1976, Characterization of DNA excreted from phytohemagglutinin-stimulated lymphocytes, J. exp. Med., 143, 1249, 10.1084/jem.143.5.1249 Rogers, 1972, Excretion of deoxyribonucleic acid by lymphocytes stimulated with phytohemagglutinin or antigen, Proc. natn. Acad. Sci. USA, 69, 1685, 10.1073/pnas.69.7.1685 Rosenau, 1973, Early biochemical alterations induced by lymphotoxin in target cells, J. Immun., 111, 1128, 10.4049/jimmunol.111.4.1128 Rosenthal, 1976, Macrophage function in antigen recognition by T lymphocytes, 131 Rubin, 1972, Specific heterologous enhancement of immune responses. III. Partial characterization of supernatant material with enhancing activity, J. Immun., 108, 1597, 10.4049/jimmunol.108.6.1597 Rubin, 1972, Specific heterologous enhancement of immune responses. IV. Specific generation of a thymus-derived enhancing factor, J. exp. Med., 136, 1501, 10.1084/jem.136.6.1501 Rubin, 1976, Partial characterization of an immunoenhancing factor from allogeneic human lymphocytic cell lines, Immunology, 30, 69 Rubin, 1973, Specific heterologous enhancement of immune responses. V. Isolation of a soluble enhancing factor from supernatants of specifically stimulated and allogeneically induced lymphoid cells, J. Immun., 111, 1314, 10.4049/jimmunol.111.5.1314 Ruddle, 1968, Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivty. I. Characterization of the phenomenon, J. exp. Med., 128, 1237, 10.1084/jem.128.6.1237 Ruddle, 1968, Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. II. Correlation of the in vitro response with skin reactivity, J. exp. Med., 128, 1255, 10.1084/jem.128.6.1255 Ruddle, 1968, Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. III. Analysis of mechanism, J. exp. Med., 128, 1267, 10.1084/jem.128.6.1267 Rohl, 1974, Effect of L-asparaginase and hydrocortisone on human lymphocyte transformation and production of a mononuclear leucocyte chemotactic factor in vitro, Immunology, 26, 989 Ruppert, 1977, Phytohemagglutinin response of murine spleen cells during pregnancy and inhibition of normal phytohemagglutinin response by pregnancy or post-partum serum, Exp. Hemat., 5, 59 Ruscetti, 1975, Regulation of the release of colony stimulating activity from mitogen-stimulated lymphocytes, J. Immun., 114, 1513, 10.4049/jimmunol.114.5.1513 Russell, 1972, Purification of human lymphotoxin, J. Immun., 109, 784, 10.4049/jimmunol.109.4.784 Russell, 1972, Cytolysis induced by human lymphotoxin, Am. J. Path., 69, 103 Salvin, 1975, Migration inhibitory factor and Type II interferon in the circulation of mice sensitized with mycobacterial components, J. Immun., 114, 354, 10.4049/jimmunol.114.1_Part_2.354 Salvin, 1973, Migration inhibitory factor and interferon in the circulation of mice with delayed hypersensitivity, Infect. Immunity, 7, 68, 10.1128/IAI.7.1.68-75.1973 Sarma, 1973, Synthesis and fragmentation of DNA in phytohaemagglutinin-stimulated human peripheral blood lymphocytes, Immun. Commun., 2, 277, 10.3109/08820137309022799 Sawada, 1975, Purification and characterization of guinea pig lymphotoxin produced by lymph node cells stimulated by phytohemagglutinin, Transplantation, 19, 335, 10.1097/00007890-197504000-00009 Sbarra, 1972, Role of the phagocyte in host-parasite interactions. XXXVIII. Metabolic activities of the phagocyte as related to antimicrobial action, J. Reticuloendoth. Soc., 12, 109 Scheid, 1973, Differentiation of T cells induced by preparations from thymus and by nonthymic agents. The determined state of the precursor cell, J. exp. Med., 138, 1027, 10.1084/jem.138.4.1027 Schimpl, 1972, Replacement of T-cell function by a T-cell product, Nature New Biol., 237, 15, 10.1038/newbio237015a0 Schrader, 1973, Mechanism of activation of the bone marrow-derived lymphocyte. III. A distinction between a macrophage-produced triggering signal and the amplifying effect in triggered B lymphocytes of allogeneic interactions, J. exp. Med., 138, 1466, 10.1084/jem.138.6.1466 Schwartz, 1970, Concanavalin A-induced release of skin-reactive factor from lymphoid cells, J. Immun., 104, 265, 10.4049/jimmunol.104.1.265 Shacks, 1973, Studies on in vitro models of cellular immunity: The role of T and B cells in the secretion of lymphotoxin, Cell. Immun., 7, 313, 10.1016/0008-8749(73)90253-0 Sharma, 1977, Partial purification and properties of an antibacterial product of peritoneal exudate cell cultures from BCG-infected guinea pigs, Infect. Immunity, 15, 737, 10.1128/IAI.15.3.737-744.1977 Sharma, 1977, Antibacterial product of peritoneal exudate cell cultures from guinea pigs infected with mycobacterial, listeriae, and rickettsiae, Infect. Immunity, 15, 745, 10.1128/IAI.15.3.745-750.1977 Shevach, 1976, The role of the macrophage in genetic control of the immune response, Fedn Proc., 35, 2048 Sidky, 1975, Lymphocyte-induced angiogenesis: a quantitative and sensitive assay of the graft vs. host reaction, J. exp. Med., 141, 1084, 10.1084/jem.141.5.1084 Siegert, 1967, Correlation between fever and interferon titer in rabbits after induction with myxoviruses, Life Sci., 6, 615, 10.1016/0024-3205(67)90097-5 Simon, 1971, Cellular immunity in vitro. I. Immunologically mediated enhancement of macrophage bactericidal capacity, J. exp. Med., 133, 1377, 10.1084/jem.133.6.1377 Simon, 1972, Enhancement of macrophage bactericidal capacity by antigenically stimulated immune lymphocytes, Cell. Immun., 4, 163, 10.1016/0008-8749(72)90015-9 Simon, 1972, Migration inhibitory factor and macrophage bactericidal function, Infect. Immunity, 6, 101, 10.1128/IAI.6.2.101-103.1972 Sintek, 1970, Cytotoxic factor from peritoneal cells: purification and characteristics, J. Reticuloendoth. Soc., 8, 508 Sjöberg, 1972, Reconstitution of the antibody response in vitro of T cell-deprived spleen cells by supernatants from spleen cell cultures, J. Immun., 109, 1379, 10.4049/jimmunol.109.6.1379 Smith, 1970, Studies of an inhibitor of DNA synthesis and a nonspecific mitogen elaborated by human lymphoblasts, Am. J. Path., 60, 495 Søborg, 1970, In vitro demonstration of microbial cellular hypersensitivity in man, Proc. R. Soc. M, 63, 903 Sonozaki, 1975, Densensitization: effects on cutaneous and peritoneal manifestations of delayed hypersensitivity in relation to lymphokine production, J. Immun., 115, 1657, 10.4049/jimmunol.115.6.1657 Sorg, 1973, Products of activated lymphocytes. I. The use of radiolabeling techniques in the characterization and partial purification of the migration inhibitory factor of the guinea pig, J. exp. Med., 137, 148, 10.1084/jem.137.1.148 Sorg, 1976, Antibodies to guinea pig lymphokines. III. Reactions with radiolabeled lymphocyte activation products, Eur. J. Immun., 6, 688, 10.1002/eji.1830061006 Spector, 1964, The effect of vascular permeability factors on the emigration of leucocytes, J. Path. Bact., 87, 341, 10.1002/path.1700870214 Spitler, 1969, Inhibition of capillary migration by antigen-antibody complexes, J. Immun., 102, 404, 10.4049/jimmunol.102.2.404 Stanley, 1976, Factors regulating macrophage production and growth: identity of colony-stimulating factor and macrophage growth factor, J. exp. Med., 143, 631, 10.1084/jem.143.3.631 Stecher, 1967, Sites of production of primate serum proteins associated with the complement system, Proc. Soc. exp. Biol. Med., 124, 433, 10.3181/00379727-124-31758 Strunk, 1975, Complement biosynthesis in vitro by rat hepatoma cell strains, J. Immun., 114, 331, 10.4049/jimmunol.114.1_Part_2.331 Švejcar, 1968, Studies on production of biologically active substances which inhibit cell migration in supernatants and extracts of hypersensitive lymphoid cells incubated with specific antigen in vitro, Immunology, 15, 1 Švejcar, 1969, Tissue culture studies on the mechanism of delayed type hypersensitivity. XIII. Passive transfer of the cell migration inhibition capacity by means of a factor released following interaction of lymph node cells from sensitized rabbits with specific antigen, Zsch. Immunitatsf., 138, 342 Tada, 1976, T cell-mediated regulation of IgE antibody production Tada, 1973, Regulation of homocytotropic antibody formation in the rat. VIII. An antigen-specific T cell factor that regulates anti-hapten homocytotropic antibody response, J. Immun., 111, 952, 10.4049/jimmunol.111.3.952 Tada, 1976, Properties of the antigen-specific suppressive T cell factor in the regulation of antibody response of the mouse. IV. Special subregion assignment of the gene(s) that codes for the suppressive T-cell factor in the H-2 histocompatibility complex, J. exp. Med., 144, 713, 10.1084/jem.144.3.713 Tada, 1976, The role of receptors for T cell products in antibody formation, Immun. Commun., 5, 717, 10.3109/08820137609047616 Tadakuma, 1976, Biological expressions of lymphocyte activation. V. Characterization of a soluble immune response suppressor (SIRS) produced by concanavalin A-activated spleen cells, J. Immun., 117, 323, 10.4049/jimmunol.117.1.323 Tadakuma, 1976, Site of action of a soluble immune response suppressor (SIRS) produced by concanavalin A-activated spleen cells, J. Immun., 117, 967, 10.4049/jimmunol.117.3.967 Takada, 1974, Immunological functions of human T-lymphoid cell line (MOLT). I. Release of immunosuppressive factors from the mixture of MOLT-4 cells and sheep red blood cells, J. exp. Med., 140, 538, 10.1084/jem.140.2.538 Takemori, 1975, Properties of antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. I. In vivo activity and immunochemical characterization, J. exp. Med., 142, 1241, 10.1084/jem.142.5.1241 Taniguchi, 1976, Properties of antigen-specific suppressive T cell factor in the regulation of antibody response of the mouse. II. In vitro activity and evidence for the I region gene product, J. Immun., 116, 542, 10.4049/jimmunol.116.2.542 Taniguchi, 1974, Regulation of homocytropic antibody formation in the rat. X. Ig T-like molecule for the induction of homocytotropic antibody response, J. Immun., 113, 1757, 10.4049/jimmunol.113.6.1757 Taniguchi, 1976, Properties of the antigen-specific suppressive T-cell factor in the regulation of antibody response of the mouse. III. Dual gene control of the t-cell-mediated suppression of the antibody response, J. exp. Med., 144, 20, 10.1084/jem.144.1.20 Taub, 1970, The effect of localized injection of adjuvant material on the draining lymph node. I. Histology, Immunology, 18, 171 Taussig, 1976, I-region products in Cell-interaction, 71 Taussig, 1976, Antigen-specific helper factors in rabbit lacking both V and C region Ig determinants, Nature, 264, 776, 10.1038/264776a0 Taussig, 1976, Antigen-specific T-cell factor in cell cooperation and genetic control of the immune response, Fedn Proc., 35, 2061 Taussig, 1975, Antigen-specific T-cell factor in cell cooperation. Mapping within the I region of the H-2 complex and ability to cooperate across allogeneic barriers, J. exp. Med., 142, 694, 10.1084/jem.142.3.694 Theze, 1977, Immunosuppressive factor(s) extracted from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). III. Immunochemical properties of the GAT-specific suppressive factor, J. exp. Med., 145, 839, 10.1084/jem.145.4.839 Thomas, 1972, The restriction of the release of mibration inhibitory factor to certain phases of the cell cycle of murine leukemia, L 1210, Eur. J. Immun., 2, 478, 10.1002/eji.1830020521 Thomas, 1975, Regulation of the immune response: production of a soluble suppressor by immune spleen cells in vitro, J. Immun., 114, 1616, 10.4049/jimmunol.114.5.1616 Thomas, 1975, Inhibition of tumor cell proliferation: a second role for suppressor cells?, J. Immun., 115, 1366, 10.4049/jimmunol.115.5.1366 Thor, 1967, Delayed hypersensitivity in man: a correlate in vitro and transfer by an RNA extract, Science, 157, 1567, 10.1126/science.157.3796.1567 Thor, 1968, The cell migration-inhibition correlate of delayed hypersensitivity. Conversion of human nonsensitive lymph node cells to sensitive cells with an RNA extract, J. Immun., 101, 469, 10.4049/jimmunol.101.3.469 Thrasher, 1973, Alteration of macrophage interfacial tension by supernatants of antigen-activated lymphocyte cultures, J. Immun., 110, 321, 10.4049/jimmunol.110.2.321 Tibbetts, 1975, Presence of a reversible inhibitor for human lymphoid cell DNA synthesis in the extracts of human peripheral lymphocytes, Cell. Immun., 18, 384, 10.1016/0008-8749(75)90067-2 Torisu, 1973, Lymphocyte-derived eosinophil chemotactic factor. II. Studies on the mechanism of activation of the precursor substance by immune complexes, J. Immun., 111, 1450, 10.4049/jimmunol.111.5.1450 Tormey, 1972, Biological effects of transferrin on human lymphocytes in vitro, Exp. Cell. Res., 74, 220, 10.1016/0014-4827(72)90500-9 Trivers, 1976, Mouse lymphotoxin, J. Immun., 117, 130, 10.4049/jimmunol.117.1.130 Tsoukas, 1977, Inhibition of lymphotoxin- and lymphocyte-mediated cytolysis by high molecular weight dextran, Proc. Soc. exp. Biol. Med., 154, 215, 10.3181/00379727-154-39640 Tsuchimoto, 1972, Synthesis of macrophage migration inhibitory factor (MIF) by immunoglobulin-producing lymphocyte lines and their clones, J. Immun., 109, 884, 10.4049/jimmunol.109.4.884 Tubergen, 1972, Production of macrophage migration inhibition factor by continuous cell lines, J. exp. Med., 135, 255, 10.1084/jem.135.2.255 Ulrich, 1976, Lymphocyte activating factor from alveolar macrophages, Fedn Proc., 35, 280 Ulrich, 1977, Studies of lymphocyte activating factor from alveolar macrophages, J. Reticuloendoth. Soc., 21, 33 Unanue, 1976, Secretory function of mononuclear phagocytes, Am. J. Path., 83, 396 Unanue, 1976, The modulation of lymphocyte functions by molecules secreted by macrophages. II. Conditions leading to increased secretion, J. exp. Med., 144, 155, 10.1084/jem.144.1.155 Valentine, 1972, The dissociation by 95 per cent oxygen of the production of lymphocyte transforming factor and the proliferation of lymphocytes stimulated with antigen, 337 Veit, 1973, Characterization of an immunosuppressive factor present in mouse serum, J. Immun., 111, 341, 10.4049/jimmunol.111.2.341 Vischer, 1972, Mitogenic factors produced by lymphocyte activation: effect on T- and B-cells, J. Immun., 109, 401, 10.4049/jimmunol.109.2.401 Vischer, 1976, In vitro stimulation of lymphocytes by neutral proteinases from human polymorphonuclear leukocyte granules, J. exp. Med., 144, 863, 10.1084/jem.144.4.863 Voisin, 1977, A. (1977) Anticorps régulateurs et cellules suppressives: leur interactions dans le cadre de la réaction de facilitation, Annals Immun., 128C, 431 Wagshal, 1977, Cell cycle specificity of inhibitor of DNA synthesis action, Fedn Proc., 36, 1320 Wagshal, 1978, Regulatory substances produced by lymphocytes. VI. Cell cycle specificity of inhibitor of DNA synthesis in L cells, J. exp. Med., 147, 171, 10.1084/jem.147.1.171 Wagshal, 1978, Regulatory substances produced by lymphocytes. VIII. Cell cycle specificity of inhibitor of DNA synthesis (IDS) action in lymphocytes, J. Immun. Wahl, 1974, Induction of guinea pig β-cell lymphokine synthesis by mitogenic and nonmitogenic signals to Fe, Ig and C3 receptors, J. exp. Med., 140, 1631, 10.1084/jem.140.6.1631 Wahl, 1976, Role of B-lymphocytes in cell-mediated immunity. I. Requirement for T-cells or T-cell products for antigen-induced B-cell activation, J. exp. Med., 144, 1175, 10.1084/jem.144.5.1175 Waksman, 1960, A comparative histopathological study of delayed hypersensitive reactions, 280 Waksman, 1958, The effect of tuberculin on peritoneal exudate cells of sensitized guinea pigs in surviving cell culture, J. Immun., 81, 220, 10.4049/jimmunol.81.3.220 Waksman, 1976, Specialized amplification elements in the immune system. The role of nodular lymphoid organs in the mucous membranes, Prog. Allergy, 21, 1, 10.1159/000313994 Waldmann, 1975, T cell-dependent mediator in the immune response. III. The role of non-specific factor (NSF) in the in vitro immune response, Immunology, 28, 497 Waldmann, 1973, T cell-dependent mediator in the immune response, Nature, 243, 356, 10.1038/243356a0 Waldmann, 1974, T cell-dependent mediator in the immune response. II. Physical and biological properties, Immunology, 27, 53 Waldmann, 1976, Antigen non-specific T-cell factor in B-cell activation. Origin, biological properties and failure to show a relationship to H-2, Immunology, 30, 723 Waldmann, 1973, Macrophage regulation of DNA synthesis in lymphoid cells: effects of a soluble factor from macrophages, Cell. Immun., 9, 142, 10.1016/0008-8749(73)90175-5 Walker, 1976, Cytotoxic activity of lymphocytes. VI. Heterogeneity of cytotoxins in supernants of mitogen-activated lymphocytes, J. Immun., 116, 807, 10.4049/jimmunol.116.3.807 Walker, 1972, Cytotoxic activity of lymphocytes. II. Studies on mechanism of lymphotoxin-mediated cytotoxicity, J. Immun., 109, 1233, 10.4049/jimmunol.109.6.1233 Walker, 1974, Cytotoxic activity of lymphocytes. IV. Preparation of heterologous antibody to human lymphotoxin, J. Immun., 113, 813, 10.4049/jimmunol.113.3.813 Ward, 1974, Defective regulation of inflammatory mediators in Hodgkin's disease. Supernormal levels of chemotactic-factor inactivator, New Engl. J. Med., 290, 76, 10.1056/NEJM197401102900203 Ward, 1975, Chemotaxis of basophils by lymphocyte-dependent and lymphocyte-independent mechanisms, J. Immun., 114, 1523, 10.4049/jimmunol.114.5.1523 Ward, 1971, Chemoattractants of leukocytes, with special reference to lymphocytes, Fedn Proc., 30, 1721 Ward, 1969, Leukotactic factor produced by sensitized lymphocytes, Science, 163, 1079, 10.1126/science.163.3871.1079 Ward, 1970, The production by antigen-stimulated lymphocytes of a leukotactic factor distinct from migration inhibitory factor, Cell. Immun., 1, 162, 10.1016/0008-8749(70)90003-1 Ward, 1975, Regulation of MIF by a factor in human serum, J. Immun., 115, 309, 10.4049/jimmunol.115.1.309 Ward, 1973, Deficiency of the chemotactic factor inactivator in human sera with α1-anti trypsin deficiency, J. Clin. Invest., 52, 516, 10.1172/JCI107209 Ward, 1975, The elaboration of leukotactic mediators during the interaction between parental-type lymphocytes and F1 hybrid cells, J. Immun., 115, 1394, 10.4049/jimmunol.115.5.1394 Warrington, 1976, Inflammation-inducing factors from human lymphocytes. Correlation with polymorphonuclear leucocyte migration enhancement or inhibition, Int. Arch. Allergy, 51, 186, 10.1159/000231591 Watson, 1973, The role of humoral factors in the initiation of in vitro primary immune responses. III. Characterization of factors that replace thymus-derived cells, J. Immun., 111, 1301, 10.4049/jimmunol.111.5.1301 Watson, 1975, Cyclic nucleotides as intracellular mediators of B cell activation, Transplant. Rev., 23, 223 Watson, 1975, The influence of intracellular levels of cyclic nucleotides on cell proliferation and the induction of antibody synthesis, J. exp. Med., 141, 97, 10.1084/jem.141.1.97 Watson, 1973, The role of humoral factors in the initiation of in vitro primary immune responses. I. Effects of deficient bovine serum, J. Immun., 110, 31, 10.4049/jimmunol.110.1.31 Watson, 1973, Cyclic nucleotides as intracellular mediators of the expression of antigen-sensitive cells, Nature, 246, 405, 10.1038/246405a0 Watson, 1972, A factor that can be used to regulate an in vitro primary immune response, Proc. natn. Acad. Sci. USA, 69, 594, 10.1073/pnas.69.3.594 Webb, 1977, An induced alteration in splenic prostaglandin and cyclic nucleotide levels in NZB mice, J. Immun., 118, 446, 10.4049/jimmunol.118.2.446 Weisbart, 1974, Migration enhancement factor: a new lymphokine, Proc. natn. Acad. Sci. USA, 71, 875, 10.1073/pnas.71.3.875 Weisbart, 1975, Human polymorphonuclease leucocyte migration inhibitory factor. Evidence for antigen dependency, Immunology, 29, 223 Weston, 1973, Site of action of cortisol in cellular immunity, J. Immun., 110, 880, 10.4049/jimmunol.110.3.880 Whitfield, 1971, The roles of calcium and cyclic AMP in the stimulatory action of parathyroid hormone on thymic lymphocyte proliferation, J. Cell Phys., 78, 355, 10.1002/jcp.1040780305 Williams, 1968, Lymphocyte in vitro cytotoxicity: lymphotoxins of several mammalian species, Nature, 219, 1076, 10.1038/2191076a0 Williams, 1969, Lymphocyte in vitro cytotoxicity: mechanism of lymphotoxin-induced target cell destruction, J. Immun., 102, 911, 10.4049/jimmunol.102.4.911 Williams, 1973, Lymphocyte in vitro cytotoxicity: mechanism of human lymphotoxin-induced target cell destruction, J. Immun., 6, 171 Williams, 1973, Prostaglandins as potentiators of increased vascular permeability in inflammation, Nature, 246, 215, 10.1038/246215a0 Willoughby, 1963, A factor capable of increasing vascular permeability present in lymph node cells. A possible mediator of the delayed reaction, Immunology, 6, 484 Willoughby, 1964, A lymph-node permeability factor in the tuberculin reaction, J. Path. Bact., 87, 353, 10.1002/path.1700870216 Wolstencroft, 1970, In vitro studies of cell-mediated immunity. I. Induction of lymphocyte transformation by a soluble ‘mitogenic’ factor derived from interaction of sensitized guinea pig lymphoid cells with specific antigen, Immunology, 18, 599 1970 Wood, 1975, Studies on the mechanism of stimulation of the humoral response of murine spleen cultures by culture fluids from human monocytes, J. Immun., 114, 1094, 10.4049/jimmunol.114.3.1094 Wood, 1976, Stimulation of the release of a B cell-activating factor from human monocytes, Cell. Immun., 21, 133, 10.1016/0008-8749(76)90334-8 Wood, 1976, Resolution of a factor that enhances the antibody response of T cell-depleted murine splenocytes from several other monocyte products, Cell. Immun., 21, 88, 10.1016/0008-8749(76)90330-0 Wood, 1974, Enhancement of the humoral response of T cell-depleted murine spleens by a factor derived from human monocytes in vitro, J. Immun., 113, 925, 10.4049/jimmunol.113.3.925 Yachnin, 1975, Fetuin, an inhibitor of lymphocyte transformation. The interaction of fetuin with phytomitogens and a possible role for fetuin in fetal development, J. exp. Med., 141, 242, 10.1084/jem.141.1.242 Yonkosky, 1976, Suppression of antibody responses in allogeneic mice by products of lymphoid tissue. I. Allogeneic suppressive factor (ASF) from spleens repopulated with thymus cells, J. Immun., 116, 1688, 10.4049/jimmunol.116.6.1688 Yonkosky, 1976, Suppression of antibody responses in allogeneic mice by products of lymphoid tissue. II. Lack of antigenic specificity and immunogenetic requirements of allogeneic suppressive factor (ASF), J. Immun., 116, 1695, 10.4049/jimmunol.116.6.1695 Yoshida, 1975, Biologic and antigenic similarity of virus-induced migration inhibition factor to conventional lymphocyte-derived migration inhibition factor, Proc. natn. Acad. Sci. USA, 72, 1641, 10.1073/pnas.72.4.1641 Yshida, 1975, The production of anti-guinea pig lymphokine antibody, J. Immun., 114, 688, 10.4049/jimmunol.114.2_Part_1.688 Yoshida, 1974, Lymphokine activity in vivo in relation to circulating monocyte levels and delayed skin reactivity, J. Immun., 112, 1540, 10.4049/jimmunol.112.4.1540 Yoshida, 1974, In vivo manifestations of lymphokine and lymphokine-like activity, 43 Yoshida, 1976, Lymphokine-like factors produced by human lymphoid cell lines with B or T cell surface markers, J. Immun., 117, 548, 10.4049/jimmunol.117.2.548 Yoshida, 1973, The production of migration inhibition factor by B and T cells of the guinea pig, J. exp. Med., 138, 784, 10.1084/jem.138.4.784 Yoshinaga, 1973, Regulation of lymphocyte response in vitro. IV. Role of macrophages in rat lymphocyte responses and their inhibition by cytochalasin B, Ann. Immun., 124C, 97 Youmans, 1971, The role of lymphocytes and other factors in antimicrobial cellular immunity, J. Reticuloendoth. Soc., 10, 100 Zatz, 1974, Thymus dependence of lymphocyte trapping, J. Immun., 112, 101, 10.4049/jimmunol.112.1.101 Zatz, 1970, The distribution of chromium51-labelled lymphoid cells in the mouse. A survey of anatomical compartments, Cell. Immun., 1, 3, 10.1016/0008-8749(70)90057-2 Zatz, 1971, The distribution of 51Cr-labeled lymphocytes into antigen stimulated mice. Lymphocyte trapping, J. exp. Med., 134, 224, 10.1084/jem.134.1.224 Zembala, 1974, T cell suppression of contact sensitivity in the mouse. II. The role of soluble suppressor factor and its interaction with macrophages, Eur. J. Immun., 4, 799, 10.1002/eji.1830041206 Ziff, 1974, B- and T-lymphocytes in rheumatoid synovitis and the effect of cyclophosphamide, Proc. R. Soc. Med., 67, 536 Zinsser, 1926, An experimental analysis of bacterial allergy, J. exp. Med., 44, 753, 10.1084/jem.44.6.753