Comparison of the antitussive effects of codeine phosphate 20 mg, dextromethorphan 30 mg and noscapine 30 mg using citric acid-induced cough in normal subjects

D. W. Empey1,2, Lauri A. Laitinen1,2, Gerald A. Young1,2, Carole Bye1,2, David J. Hughes2,1
1Clinical Research Division, The Wellcome Research Laboratories, Beckenham, UK
2Pulmonary Research Unit, The London Hospital, Whitechapel, London, UK

Tóm tắt

Từ khóa


Tài liệu tham khảo

Bickerman, H. A., Barach, A. L.: The experimental production of cough in human subjects induced by citric acid aerosols. Preliminary studies on the evaluation of antitussive agents. Am. J. Med. Sci.228, 156?163 (1954)

Bickerman, H. A., German, E., Cohen, B. M., Itkin, S. E.: The cough response of healthy human subjects stimulated by citric acid aerosols: II. Evaluation of antitussive agents. Am. J. Med. Sci.234, 191?205 (1957)

Calesnick, B., Christensen, J. A.: Latency of the cough response as a measure of antitussive agents. Clin. Pharm. Ther.8, 374?380 (1967)

Eddy, N. B., Friebel, H., Hahn, K. J., Halbach, H.: Codeine and its alternates for pain and cough relief. Geneva: World Health Organisation. 1970

Empey, D. W., Laitinen, L. A., Jacobs, L., Gold, W. M., Nadel, J. A.: Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am. Rev. Resp. Dis.113, 131?139 (1976)

Gravenstein, J. S., Devloo, R. A., Beecher, M. K.: Effect of antitussive agents on experimental and pathological cough in man. J. Appl. Physiol.7, 119?139 (1954)

Hughes, D. T. D.: Diseases of the respiratory system: Cough suppressants, expectorants and mucolytic agents. Br. Med. J.1978/I, 1202?1203

Haslreiter, E.: Der Acetylcholin-Hustentest im Rahmen der Pr�fung einer neuen hustenstillenden Substanz. Arzneim. Forsch.9, 769?773 (1959)

H�glund, N.-J., Micha�lsson, M.: A method for determining the cough threshold with some preliminary experiments on the effect of codeine. Acta Physiol. Scand.21, 168?173 (1950)

Prime, F. J.: The assessment of antitussive drugs in man. Br. Med. J.1961/I, 1149?1151

Winter, C. A., Flataker, L.: Antitussive compounds: testing method and results. J. Pharmacol. Exp. Ther.112, 99?108 (1954)

Woolf, C. R., Rosenburg, A.: Objective assessment of cough suppressants under clinical conditions. Thorax19, 125?130 (1964)