A Controversial Problem: Is There a Relationship between Parathyroid Hormone Level and Parathyroid Size in Primary Hyperparathyroidism?

International Journal of Biological Markers - Tập 12 Số 3 - Trang 106-111 - 1997
Fabrizio Locchi1, M Tommasi1, Maria Luisa Brandi2, Francesco Tonelli3, U Meldolesi2,1,3
1Nuclear Medicine, University of Firenze, Firenze - Italy
2Endocrinology, University of Firenze, Firenze - Italy
3Surgery Units of the Department of Clinical Physiopathology, University of Firenze, Firenze - Italy

Tóm tắt

The current study was undertaken with the aim of studying the relationship between parathyroid hormone and hyperfunctioning parathyroids by a sophisticated method of analysis. Our clinical study included 25 patients undergoing surgery for primary hyperparathyroidism. The measurement of basal circulating intact PTH (pg/ml) and the volume (mm3) of the removed gland(s) were recorded. It was essential for the distribution of the sample values to be normal before Pearson's correlation and regression analysis were performed. The Kolmogorov-Smirnov test showed sufficient sample data agreement (p>20%) with normal distribution after their transformation into natural logarithm (ln) and so statistical analysis was performed utilizing ln transformed data. The regression line between basal ln of iPTH levels (x) and ln of tumor volume (y) was highly significant (y=2.3828+1.0424 x, r=.72504, p<.0001). In our opinion, the above is a correct statistical procedure with reliable results.

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International Journal of Biological Markers

Tập 12 Số 3

106-111

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