Oncogene addiction

Beer, S., Zetterberg, A., Ihrie, R.A., McTaggart, R.A., Yang, Q., Bradon, N., Arvanitis, C., Attardi, L.D., Feng, S., Ruebner, B., et al. (2004). Developmental context determines latency of MYC-induced tumorigenesis. PLoS Biol 2(11): e332 DOI: 10.1371/journal.pbio.0020332. Boxer, R.B., Jang, J.W., Sintasath, L., and Chodosh, L.A. (2004). Lack of sustained regression of c-MYC-induced mammary adenocarcinomas following brief or prolonged MYC inactivation. Cancer Cell, this issue. D'Cruz, 2001, c-MYC induces mammary tumorigenesis by means of a preferred pathway involving spontaneous Kras2 mutations, Nat. Med, 7, 235, 10.1038/84691 Ewald, 1996, Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigen, Science, 273, 1384, 10.1126/science.273.5280.1384 Felsher, 1999, Reversible tumorigenesis by MYC in hematopoietic lineages, Mol. Cell, 4, 199, 10.1016/S1097-2765(00)80367-6 Jain, 2002, Sustained loss of a neoplastic phenotype by brief inactivation of MYC, Science, 297, 102, 10.1126/science.1071489 Jonkers, 2002, Conditional mouse models of sporadic cancer, Nat. Rev. Cancer, 2, 251, 10.1038/nrc777 Karlsson, 2003, Genomically complex lymphomas undergo sustained tumor regression upon MYC inactivation unless they acquire novel chromosomal translocations, Blood, 101, 2797, 10.1182/blood-2002-10-3091 Pao, 2003, Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance, Proc. Natl. Acad. Sci. USA, 100, 8764, 10.1073/pnas.1133333100 Pardal, 2003, Applying the principles of stem-cell biology to cancer, Nat. Rev. Cancer, 3, 895, 10.1038/nrc1232 Pelengaris, 1999, Reversible activation of c-Myc in skin, Mol. Cell, 3, 565, 10.1016/S1097-2765(00)80350-0 Pelengaris, 2002, Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression, Cell, 109, 321, 10.1016/S0092-8674(02)00738-9 Robanus-Maandag, 2003, Association of C-MYC amplification with progression from the in situ to the invasive stage in C-MYC-amplified breast carcinomas, J. Pathol, 201, 75, 10.1002/path.1385 Shachaf, 2004, MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer, Nature, 431, 1112, 10.1038/nature03043 Shah, 2003, Mechanisms of resistance to STI571 in Philadelphia chromosome-associated leukemias, Oncogene, 22, 7389, 10.1038/sj.onc.1206942 Weinstein, 2002, Cancer. Addiction to oncogenes–The Achilles heal of cancer, Science, 297, 63, 10.1126/science.1073096 Wilson, 2004, c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation, Genes Dev, 18, 2747, 10.1101/gad.313104