The immune system in extreme longevity

Experimental Gerontology - Tập 43 - Trang 61-65 - 2008
P. Sansoni1, R. Vescovini1, F. Fagnoni2, C. Biasini1, F. Zanni1, L. Zanlari1, A. Telera1, G. Lucchini1, G. Passeri1, D. Monti3, C. Franceschi4, M. Passeri1
1Dipartimento di Medicina Interna e Scienze Biomediche, Università di Parma, Via Gramsci 14, 43100 Parma, Italy
2Divisione di Medicina Oncologica, IRCCS, Fondazione Maugeri, Clinica del Lavoro e della Riabilitazione, Istituto Scientifico di Pavia, Pavia, Italy
3Dipartimento di Patologia e Oncologia Sperimentali,Via Morgagni 50, 50134 Firenze, Italy
4Dipartimento di Patologia Sperimentale, Università di Bologna, Via S. Giacomo 12, 40126 Bologna, Italy

Tài liệu tham khảo

Brambilla, 2001, Plasma concentrations of interleukin-1-beta, interleukin-6 and tumour factor-alpha, and of their soluble receptors and receptor antagonist in anorexia nervosa, Psychiatry Res., 103, 107, 10.1016/S0165-1781(01)00283-9 Browner, 1991, Non-trauma mortality in elderly women with low bone mineral density, Lancet, 338, 355, 10.1016/0140-6736(91)90489-C Daynes, 1993, Altered regulation of IL-6 production with normal aging. Possible linkage to the ageassociated decline in dehydroepiandrosterone and its sulfated derivative, J. Immunol., 150, 5219, 10.4049/jimmunol.150.12.5219 Ershler, 2000, Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty, Annu. Rev. Med., 51, 245, 10.1146/annurev.med.51.1.245 Facchini, 1987, Increased number od circulating Leu 11+(CD16) large granular lymphocytes and decreased NK activity during human ageing, Clin. Exp. Immunol., 68, 340 Fagiolo, 1993, Increased cytokine production in mononuclear cells of healthy elderly people, Eur. J. Immunol., 23, 2375, 10.1002/eji.1830230950 Fagnoni, 1996, Expansion of cytotoxic CD8+ CD28− T cells in healthy ageing people, including centenarians, Immunology, 88, 501, 10.1046/j.1365-2567.1996.d01-689.x Fagnoni, 2000, Shortage of circulating naive CD8 T cells provides new insights on immunodeficiency in aging, Blood, 95, 2860, 10.1182/blood.V95.9.2860.009k35_2860_2868 Ferrucci, 1999, Serum IL-6 level and the development of disability in older persons, J. Am. Geriatr. Soc., 47, 755, 10.1111/j.1532-5415.1999.tb01604.x Franceschi, 1995, The immunology of exceptional individuals: the lesson of centenarians, Immunol. Today, 16, 12, 10.1016/0167-5699(95)80064-6 Franceschi, 2000, Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space, Vaccine, 18, 1717, 10.1016/S0264-410X(99)00513-7 Franceschi, 2000, Inflamm-aging. An evolutionary perspective on immunosenescence, Ann. N.Y. Acad. Sci., 908, 244, 10.1111/j.1749-6632.2000.tb06651.x Giuliani, 2001, Serum interleukin-6, soluble interleukin-6 receptor and soluble gp130 exhibit different patterns of age- and menopause-related changes, Exp. Gerontol., 36, 547, 10.1016/S0531-5565(00)00220-5 Globerson, 2000, Ageing of lymphocytes and lymphocytes in the aged, Immunol. Today, 21, 515, 10.1016/S0167-5699(00)01714-X Harris, 1999, Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly, Am. J. Med., 106, 506, 10.1016/S0002-9343(99)00066-2 Khan, 2002, Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals, J. Immunol., 169, 1984, 10.4049/jimmunol.169.4.1984 Krishnaraj, 1987, Age-associated alterations in human natural killer cells. 1. Increased activity as per conventional and kinetic analysis, Clin. Immunol. Immunopathol., 45, 268, 10.1016/0090-1229(87)90042-0 Levy, 1991, Persistently low natural killer cell activity, age, and environmental stress as predictors of infectious morbidity, Nat. Immun. Cell Growth Regul., 10, 289 Ligthart, 1989, Natural killer cell function is not diminished in the healthy aged and is proportional to the number of NK cells in the peripheral blood, Immunology, 68, 396 Ligthart, 1990, Necessity of the assessment of healthy status in human immunogerontological studies: evaluation of the SENIEUR protocol, Mech. Ageing Dev., 55, 89, 10.1016/0047-6374(90)90108-R Luciani, 2001, A stochastic model for CD8(+) T cell dynamics in human immunosenescence: implications for survival and longevity, J. Theor. Biol., 213, 587, 10.1006/jtbi.2001.2433 Makinodan, 1980, Age influence on immune system, Adv. Immunol., 29, 287, 10.1016/S0065-2776(08)60047-4 Manolagas, 1995, Bone marrow, cytokines, and bone remo-deling. Emerging insights into the pathophysiology of osteoporosis, N. Engl. J. Med., 332, 305, 10.1056/NEJM199502023320506 Mariani, 1999, Vitamin D, thyroid hormones and muscle mass influence natural killer (NK) innate immunity in healthy nonagenarians and centenarians, Clin. Exp. Immunol., 116, 19, 10.1046/j.1365-2249.1999.00855.x Mariotti, 1992, Thyroid and other organ-specific autoantibodies in healthy centena-rians, Lancet, 339, 1506, 10.1016/0140-6736(92)91265-A Mariotti, 1995, The aging thyroid, Endocr. Rev., 16, 686, 10.1210/edrv-16-6-686 Murasko, 1986, Immuno-logic response in an elderly population with a mean age of 85, Am. J. Med., 81, 612, 10.1016/0002-9343(86)90546-2 Murasko, 1987, Decline in mitogen induced proliferation of lymphocytes with increasing age, Clin. Exp. Immunol., 70, 440 Nociari, 1999, Post-thymic development of CD28−CD8+ T cell subset: age-associated expansion and shift from memory to naive phenotype, J. Immunol., 162, 3327, 10.4049/jimmunol.162.6.3327 Olsson, 2000, Age-related change in peripheral blood T-lymphocyte subpo-pulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study, Mech. Ageing Dev., 121, 187, 10.1016/S0047-6374(00)00210-4 O’Mahony, 1998, Quantitative intracellular cytokine measurement: age-related changes in proinflammatory cytokine production, Clin. Exp. Immunol., 113, 213, 10.1046/j.1365-2249.1998.00641.x Ottaviani, 1997, The invertebrate phagocytic immunocyte: clues to a common evolution of immune and neuroendocrine systems, Immunol. Today, 18, 169, 10.1016/S0167-5699(97)84663-4 Paganelli, 1992, Changes in circulating B cells and immunoglobulin classes and subclasses in a healthy aged population, Clin. Exp. Immunol., 90, 351, 10.1111/j.1365-2249.1992.tb07954.x Posnett, 1994, Level of human TCRBV3S1 (V beta 3) expression correlates with allelic polymorphism in the spacer region of the recombination signal sequence, J. Exp. Med., 179, 1707, 10.1084/jem.179.5.1707 Sansoni, 1993, Lymphocyte subsets and natural killer cell activity in healthy old-people and centenarians, Blood, 82, 2767, 10.1182/blood.V82.9.2767.2767 Sansoni, 1997, Tlymphocyte proliferative capability to defined stimuli and costimulatory CD28 pathway is not impaired in healthy centenarians, Mech. Ageing Dev., 96, 127, 10.1016/S0047-6374(97)01887-3 Shodell, 2002, Circulating, interferon-producing plasmacytoid dendritic cells decline during human ageing, Scand. J. Immunol., 56, 518, 10.1046/j.1365-3083.2002.01148.x Steger, 1996, Morphologically and functionally intact dendritic cells can be derived from the peripheral blood of aged individuals, Clin. Exp. Immunol., 105, 544, 10.1046/j.1365-2249.1996.d01-790.x Vescovini, 2004, Different contribution of EBV and CMV infections in very long-term carriers to age-related alterations of CD8+ T cells, Exp. Gerontol., 39, 1233, 10.1016/j.exger.2004.04.004 Zanni, 2003, Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8(+) T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence, Exp. Gerontol., 38, 981, 10.1016/S0531-5565(03)00160-8