Current perspectives on FOXA1 regulation of androgen receptor signaling and prostate cancer

Carlsson, 2002, Forkhead transcription factors: key players in development and metabolism, Dev Biol, 250, 1, 10.1006/dbio.2002.0780 Benayoun, 2011, Forkhead transcription factors: key players in health and disease, Trends Genet, 27, 224, 10.1016/j.tig.2011.03.003 Weigel, 1989, The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo, Cell, 57, 645, 10.1016/0092-8674(89)90133-5 Augello, 2011, FOXA1: master of steroid receptor function in cancer, EMBO J, 30, 3885, 10.1038/emboj.2011.340 Carroll, 2005, Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1, Cell, 122, 33, 10.1016/j.cell.2005.05.008 Gao, 2003, The role of hepatocyte nuclear factor-3 alpha (Forkhead Box A1) and androgen receptor in transcriptional regulation of prostatic genes, Mol Endocrinol, 17, 1484, 10.1210/me.2003-0020 Sahu, 2013, FoxA1 specifies unique androgen and glucocorticoid receptor binding events in prostate cancer cells, Cancer Res, 73, 1570, 10.1158/0008-5472.CAN-12-2350 Costa, 1989, Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes, Mol Cell Biol, 9, 1415, 10.1128/MCB.9.4.1415 Besnard, 2004, Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues, Gene Expression Patterns, 5, 193, 10.1016/j.modgep.2004.08.006 Monaghan, 1993, Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm, Development, 119, 567, 10.1242/dev.119.3.567 Ang, 1993, The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins, Development, 119, 1301, 10.1242/dev.119.4.1301 Sasaki, 1993, Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo, Development, 118, 47, 10.1242/dev.118.1.47 Kaestner, 1999, Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo, Genes Dev, 13, 495, 10.1101/gad.13.4.495 Shih, 1999, Impaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3alpha-deficient mice, Proc Natl Acad Sci USA, 96, 10152, 10.1073/pnas.96.18.10152 Gao, 2008, Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development, Genes Dev, 22, 3435, 10.1101/gad.1752608 Besnard, 2005, Stage-specific regulation of respiratory epithelial cell differentiation by Foxa1, Am J Physiol Lung Cell Mol Physiol, 289, L750, 10.1152/ajplung.00151.2005 Wan, 2005, Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis, J Biol Chem, 280, 13809, 10.1074/jbc.M414122200 Lee, 2005, The initiation of liver development is dependent on Foxa transcription factors, Nature, 435, 944, 10.1038/nature03649 Domanskyi, 2014, Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance, Front Cell Neurosci, 8, 275, 10.3389/fncel.2014.00275 Bernardo, 2010, FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis, Development, 137, 2045, 10.1242/dev.043299 Gao, 2005, Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation, Development, 132, 3431, 10.1242/dev.01917 Mirosevich, 2005, Expression of Foxa transcription factors in the developing and adult murine prostate, Prostate, 62, 339, 10.1002/pros.20131 Marker, 2003, Hormonal, cellular, and molecular control of prostatic development, Dev Biol, 253, 165, 10.1016/S0012-1606(02)00031-3 Neben, 2005, Distinct gene expression patterns associated with FLT3- and NRAS-activating mutations in acute myeloid leukemia with normal karyotype, Oncogene, 24, 1580, 10.1038/sj.onc.1208344 Lin, 2002, The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas, Cancer Res, 62, 5273 Sano, 2010, Forkhead box A1 transcriptional pathway in KRT7-expressing esophageal squamous cell carcinomas with extensive lymph node metastasis, Int J Oncol, 36, 321 Nucera, 2009, FOXA1 is a potential oncogene in anaplastic thyroid carcinoma, Clin Cancer Res, 15, 3680, 10.1158/1078-0432.CCR-08-3155 Hu, 2009, Genetic alterations and oncogenic pathways associated with breast cancer subtypes, Mol Cancer Res, 7, 511, 10.1158/1541-7786.MCR-08-0107 Robbins, 2011, Copy number and targeted mutational analysis reveals novel somatic events in metastatic prostate tumors, Genome Res, 21, 47, 10.1101/gr.107961.110 Sahu, 2011, Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer, EMBO J, 30, 3962, 10.1038/emboj.2011.328 Gerhardt, 2012, FOXA1 promotes tumor progression in prostate cancer and represents a novel hallmark of castration-resistant prostate cancer, Am J Pathol, 180, 848, 10.1016/j.ajpath.2011.10.021 Jin, 2013, Androgen receptor-independent function of FoxA1 in prostate cancer metastasis, Cancer Res, 73, 3725, 10.1158/0008-5472.CAN-12-3468 Wang, 2011, Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA, Nature, 474, 390, 10.1038/nature10006 Robinson, 2013, FOXA1 mutations in hormone-dependent cancers, Front Oncol, 3, 20, 10.3389/fonc.2013.00020 Grasso, 2012, The mutational landscape of lethal castration-resistant prostate cancer, Nature, 487, 239, 10.1038/nature11125 Barbieri, 2012, Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer, Nat Genet, 44, 685, 10.1038/ng.2279 Gao, 2014, Organoid cultures derived from patients with advanced prostate cancer, Cell, 159, 176, 10.1016/j.cell.2014.08.016 Hu, 2010, A novel polymorphism in a forkhead box A1 (FOXA1) binding site of the human UDP glucuronosyltransferase 2B17 gene modulates promoter activity and is associated with altered levels of circulating androstane-3alpha,17beta-diol glucuronide, Mol Pharmacol, 78, 714, 10.1124/mol.110.065953 Hazelett, 2013, A rare variant, which destroys a FoxA1 site at 8q24, is associated with prostate cancer risk, Cell Cycle, 12, 379, 10.4161/cc.23201 Hannenhalli, 2009, The evolution of Fox genes and their role in development and disease, Nat Rev Genet, 10, 233, 10.1038/nrg2523 Clark, 1993, Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5, Nature, 364, 412, 10.1038/364412a0 Cirillo, 1998, Binding of the winged-helix transcription factor HNF3 to a linker histone site on the nucleosome, EMBO J, 17, 244, 10.1093/emboj/17.1.244 Cirillo, 2002, Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4, Mol Cell, 9, 279, 10.1016/S1097-2765(02)00459-8 Lupien, 2008, FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription, Cell, 132, 958, 10.1016/j.cell.2008.01.018 Wang, 2007, A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth, Mol Cell, 27, 380, 10.1016/j.molcel.2007.05.041 Lupien, 2009, Cistromics of hormone-dependent cancer, Endocr Relat Cancer, 16, 381, 10.1677/ERC-09-0038 Jin, 2014, Cooperativity and equilibrium with FOXA1 define the androgen receptor transcriptional program, Nat Commun, 5, 3972, 10.1038/ncomms4972 Serandour, 2011, Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers, Genome Res, 21, 555, 10.1101/gr.111534.110 Wang, 2015, Epidaurus: aggregation and integration analysis of prostate cancer epigenome, Nucleic Acids Res, 43, e7, 10.1093/nar/gku1079 Eeckhoute, 2009, Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers, Genome Res, 19, 372, 10.1101/gr.084582.108 Xu, 2006, Androgens induce prostate cancer cell proliferation through mammalian target of rapamycin activation and post-transcriptional increases in cyclin D proteins, Cancer Res, 66, 7783, 10.1158/0008-5472.CAN-05-4472 Knudsen, 1998, Multiple G1 regulatory elements control the androgen-dependent proliferation of prostatic carcinoma cells, J Biol Chem, 273, 20213, 10.1074/jbc.273.32.20213 Balk, 2008, AR, the cell cycle, and prostate cancer, Nucl Recept Signal, 6, e001, 10.1621/nrs.06001 Wang, 2009, Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer, Cell, 138, 245, 10.1016/j.cell.2009.04.056 DeGraff, 2014, FOXA1 deletion in luminal epithelium causes prostatic hyperplasia and alteration of differentiated phenotype, Lab Invest, 94, 726, 10.1038/labinvest.2014.64 Wang, 2013, A systematic approach identifies FOXA1 as a key factor in the loss of epithelial traits during the epithelial-to-mesenchymal transition in lung cancer, BMC Genomics, 14, 680, 10.1186/1471-2164-14-680 Song, 2010, Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pancreatic cancer, Cancer Res, 70, 2115, 10.1158/0008-5472.CAN-09-2979 Jain, 2011, High-level expression of forkhead-box protein A1 in metastatic prostate cancer, Histopathology, 58, 766, 10.1111/j.1365-2559.2011.03796.x Liu, 2014, FoxA1 directs the lineage and immunosuppressive properties of a novel regulatory T cell population in EAE and MS, Nat Med, 20, 272, 10.1038/nm.3485