Positional cloning of ZNF 217 and NABC 1 : Genes amplified at 20q13.2 and overexpressed in breast carcinoma

Proceedings of the National Academy of Sciences of the United States of America - Tập 95 Số 15 - Trang 8703-8708 - 1998
Colin C. Collins1, Johanna M. Rommens1, David Kowbel1, Tony E. Godfrey1, Minna Tanner1, Soo-in Hwang1, Daniel Polikoff1, Genevieve H. Nonet1, Joanne F. Cochran1, Ken Myambo1, Karen E. Jay1, Jeff Froula1, Thomas Cloutier1, Wen-Lin Kuo1, Paul Yaswen1, Shanaz H. Dairkee1, Jennifer Giovanola1, G B Hutchinson1, Jorma Isola1, Olli Kallioniemi1, Mike Palazzolo1, Chris Martin1, Cheryl Ericsson1, Dan Pinkel1,2, Donna G. Albertson1,2, Wu Bo Li3,1, Joe W. Gray1,2
1Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720; Department of Genetics, University of Toronto, ON Canada M5G 1X8; Laboratory for Cancer Genetics, Tampere University Hospital and Institute of Medical Technology, P.O. Box 2000, Fin-33521 Tampere, Finland; University of California San Francisco Cancer Center, San Francisco, CA 94143; Department of Medical Genetics, University of British Columbia, Vancouver, BC Canada V6T 2B5; Laboratory of Cancer Genetics, National...
2University of California at San Francisco
3LIFE TECHNOLOGIES INCORPORATED

Tóm tắt

We report here the molecular cloning of an ≈1-Mb region of recurrent amplification at 20q13.2 in breast cancer and other tumors and the delineation of a 260-kb common region of amplification. Analysis of the 1-Mb region produced evidence for five genes, ZNF217 , ZNF218 , and NABC1 , PIC1L ( PIC1-l ike), CYP24 , and a pseudogene CRP ( C yclophillin R elated P seudogene). ZNF217 and NABC1 emerged as strong candidate oncogenes and were characterized in detail. NABC1 is predicted to encode a 585-aa protein of unknown function and is overexpressed in most but not all breast cancer cell lines in which it was amplified. ZNF217 is centrally located in the 260-kb common region of amplification, transcribed in multiple normal tissues, and overexpressed in all cell lines and tumors in which it is amplified and in two in which it is not. ZNF217 is predicted to encode alternately spliced, Kruppel-like transcription factors of 1,062 and 1,108 aa, each having a DNA-binding domain (eight C2H2 zinc fingers) and a proline-rich transcription activation domain.

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Thông tin xuất bản

Proceedings of the National Academy of Sciences of the United States of America

Tập 95 Số 15

8703-8708

Thông tin tác giả