Epigenetic field cancerization in gastrointestinal cancers

Cancer Letters - Tập 375 - Trang 360-366 - 2016
Yoshifumi Baba1, Takatsugu Ishimoto1, Junji Kurashige1, Masaaki Iwatsuki1, Yasuo Sakamoto1, Naoya Yoshida1, Masayuki Watanabe2, Hideo Baba1
1Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Japan
2Department of Gastroenterological Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Japan

Tài liệu tham khảo

Baba, 2013, Review of the alterations in DNA methylation in esophageal squamous cell carcinoma, Surg. Today, 43, 1355, 10.1007/s00595-012-0451-y Slaughter, 1953, Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin, Cancer, 6, 963, 10.1002/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q Dakubo, 2007, Clinical implications and utility of field cancerization, Cancer Cell Int, 7, 2, 10.1186/1475-2867-7-2 Heaphy, 2009, Mammary field cancerization: molecular evidence and clinical importance, Breast Cancer Res. Treat, 118, 229, 10.1007/s10549-009-0504-0 Utsunomiya, 2014, Specific molecular signatures of non-tumor liver tissue may predict a risk of hepatocarcinogenesis, Cancer Sci, 105, 749, 10.1111/cas.12431 Lee, 2011, Revisit of field cancerization in squamous cell carcinoma of upper aerodigestive tract: better risk assessment with epigenetic markers, Cancer Prev. Res. (Phila), 4, 1982, 10.1158/1940-6207.CAPR-11-0096 Di Domenico, 2011, Epigenetic fingerprint in endometrial carcinogenesis: the hypothesis of a uterine field cancerization, Cancer Biol. Ther, 12, 447, 10.4161/cbt.12.5.15963 Taby, 2010, Cancer epigenetics, CA Cancer J. Clin, 60, 376, 10.3322/caac.20085 Rodriguez-Paredes, 2011, Cancer epigenetics reaches mainstream oncology, Nat. Med, 17, 330, 10.1038/nm.2305 Ushijima, 2007, Epigenetic field for cancerization, J. Biochem. Mol. Biol, 40, 142 Ramachandran, 2012, DNA methylation and field cancerization, Epigenomics, 4, 243, 10.2217/epi.12.12 Ushijima, 2013, Epigenetic field for cancerization: its cause and clinical implications, BMC Proc, 7, K22, 10.1186/1753-6561-7-S2-K22 Nakajima, 2006, Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers, Cancer Epidemiol. Biomarkers Prev, 15, 2317, 10.1158/1055-9965.EPI-06-0436 Partridge, 2000, A case-control study confirms that microsatellite assay can identify patients at risk of developing oral squamous cell carcinoma within a field of cancerization, Cancer Res, 60, 3893 Eads, 2000, Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma, Cancer Res, 60, 5021 Nakajima, 2008, DNA methylation: a marker for carcinogen exposure and cancer risk, Environ. Health Prev. Med, 13, 8, 10.1007/s12199-007-0005-x Fang, 2016, Common BRAF(V600E)-directed pathway mediates widespread epigenetic silencing in colorectal cancer and melanoma, Proc. Natl. Acad. Sci. U.S.A., 113, 1250, 10.1073/pnas.1525619113 Ehrlich, 2009, DNA hypomethylation in cancer cells, Epigenomics, 1, 239, 10.2217/epi.09.33 Gaudet, 2003, Induction of tumors in mice by genomic hypomethylation, Science, 300, 489, 10.1126/science.1083558 Cordaux, 2009, The impact of retrotransposons on human genome evolution, Nat. Rev. Genet, 10, 691, 10.1038/nrg2640 Enzinger, 2003, Esophageal cancer, N. Engl. J. Med, 349, 2241, 10.1056/NEJMra035010 Agarwal, 2012, Role of epigenetic alterations in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma, Int. J. Clin. Exp. Pathol, 5, 382 Eads, 2001, Epigenetic patterns in the progression of esophageal adenocarcinoma, Cancer Res, 61, 3410 Jin, 2008, Hypermethylation of the AKAP12 promoter is a biomarker of Barrett's-associated esophageal neoplastic progression, Cancer Epidemiol. Biomarkers Prev, 17, 111, 10.1158/1055-9965.EPI-07-0407 Clement, 2004, Monoallelic methylation of the APC promoter is altered in normal gastric mucosa associated with neoplastic lesions, Cancer Res, 64, 6867, 10.1158/0008-5472.CAN-03-2503 Clement, 2006, Methylation of APC, TIMP3, and TERT: a new predictive marker to distinguish Barrett's oesophagus patients at risk for malignant transformation, J. Pathol, 208, 100, 10.1002/path.1884 Wang, 2009, DNA promoter hypermethylation of p16 and APC predicts neoplastic progression in Barrett's esophagus, Am. J. Gastroenterol, 104, 2153, 10.1038/ajg.2009.300 Jin, 2008, Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factors, Int. J. Cancer, 123, 2331, 10.1002/ijc.23804 Lee, 2005, Hypermethylation and loss of expression of glutathione peroxidase-3 in Barrett's tumorigenesis, Neoplasia, 7, 854, 10.1593/neo.05328 Kuester, 2009, Silencing of MGMT expression by promoter hypermethylation in the metaplasia-dysplasia-carcinoma sequence of Barrett's esophagus, Cancer Lett, 275, 117, 10.1016/j.canlet.2008.10.009 Klump, 1998, Hypermethylation of the CDKN2/p16 promoter during neoplastic progression in Barrett's esophagus, Gastroenterology, 115, 1381, 10.1016/S0016-5085(98)70016-2 Schulmann, 2005, Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk, Oncogene, 24, 4138, 10.1038/sj.onc.1208598 Jin, 2009, A multicenter, double-blinded validation study of methylation biomarkers for progression prediction in Barrett's esophagus, Cancer Res, 69, 4112, 10.1158/0008-5472.CAN-09-0028 Smith, 2008, Similarity of aberrant DNA methylation in Barrett's esophagus and esophageal adenocarcinoma, Mol. Cancer, 7, 75, 10.1186/1476-4598-7-75 Jin, 2007, Hypermethylation of tachykinin-1 is a potential biomarker in human esophageal cancer, Clin. Cancer Res, 13, 6293, 10.1158/1078-0432.CCR-07-0818 Kuester, 2007, Early involvement of death-associated protein kinase promoter hypermethylation in the carcinogenesis of Barrett's esophageal adenocarcinoma and its association with clinical progression, Neoplasia, 9, 236, 10.1593/neo.06802 Peng, 2009, DNA hypermethylation regulates the expression of members of the Mu-class glutathione S-transferases and glutathione peroxidases in Barrett's adenocarcinoma, Gut, 58, 5, 10.1136/gut.2007.146290 Ishii, 2007, Oesophageal squamous cell carcinoma may develop within a background of accumulating DNA methylation in normal and dysplastic mucosa, Gut, 56, 13, 10.1136/gut.2005.089813 Tanaka, 2010, Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles, Gut, 59, 1457, 10.1136/gut.2009.205724 Steevens, 2010, Alcohol consumption, cigarette smoking and risk of subtypes of oesophageal and gastric cancer: a prospective cohort study, Gut, 59, 39, 10.1136/gut.2009.191080 Oka, 2009, The presence of aberrant DNA methylation in noncancerous esophageal mucosae in association with smoking history: a target for risk diagnosis and prevention of esophageal cancers, Cancer, 115, 3412, 10.1002/cncr.24394 Baba, 2014, Clinical implications of the LINE-1 methylation levels in patients with gastrointestinal cancer, Surg. Today, 44, 1807, 10.1007/s00595-013-0763-6 Shigaki, 2012, LINE-1 hypomethylation in noncancerous esophageal mucosae is associated with smoking history, Ann. Surg. Oncol, 19, 4238, 10.1245/s10434-012-2488-y Matsuda, 2012, Hypomethylation of Alu repetitive elements in esophageal mucosa, and its potential contribution to the epigenetic field for cancerization, Cancer Causes Control, 23, 865, 10.1007/s10552-012-9955-4 Park, 2009, Comparison of CpG island hypermethylation and repetitive DNA hypomethylation in premalignant stages of gastric cancer, stratified for Helicobacter pylori infection, J. Pathol, 219, 410, 10.1002/path.2596 Bae, 2012, ALU and LINE-1 hypomethylations in multistep gastric carcinogenesis and their prognostic implications, Int. J. Cancer, 131, 1323, 10.1002/ijc.27369 Kosumi, 2015, Relationship between LINE-1 hypomethylation and Helicobacter pylori infection in gastric mucosae, Med. Oncol, 32, 117, 10.1007/s12032-015-0571-5 Yamamoto, 2008, LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis, Cancer Epidemiol. Biomarkers Prev, 17, 2555, 10.1158/1055-9965.EPI-08-0112 Kamiyama, 2012, DNA demethylation in normal colon tissue predicts predisposition to multiple cancers, Oncogene, 31, 5029, 10.1038/onc.2011.652 Liu, 2012, Relative distribution of folate species is associated with global DNA methylation in human colorectal mucosa, Cancer Prev. Res. (Phila), 5, 921, 10.1158/1940-6207.CAPR-11-0577 Correa, 2003, Bacterial infections as a cause of cancer, J. Natl Cancer Inst, 95, E3, 10.1093/jnci/95.7.E3 Correa, 2003, Helicobacter pylori infection and gastric cancer, Cancer Epidemiol. Biomarkers Prev, 12, 238s Szaleczky, 2000, Increased cell proliferation in chronic Helicobacter pylori positive gastritis and gastric carcinoma – correlation between immuno-histochemistry and Tv image cytometry, Anal. Cell. Pathol, 20, 131, 10.1155/2000/830906 Chan, 2003, Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer, Gut, 52, 502, 10.1136/gut.52.4.502 Maekita, 2006, High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk, Clin. Cancer Res, 12, 989, 10.1158/1078-0432.CCR-05-2096 Yoshida, 2016, Epigenetic inactivation of FAT4 contributes to gastric field cancerization, Gastric Cancer Miyazaki, 2007, E-cadherin gene promoter hypermethylation in H. pylori-induced enlarged fold gastritis, Helicobacter, 12, 523, 10.1111/j.1523-5378.2007.00519.x Nakajima, 2010, Persistence of a component of DNA methylation in gastric mucosae after Helicobacter pylori eradication, J. Gastroenterol, 45, 37, 10.1007/s00535-009-0142-7 Vitkute, 2001, Specificities of eleven different DNA methyltransferases of Helicobacter pylori strain 26695, J. Bacteriol, 183, 443, 10.1128/JB.183.2.443-450.2001 Issa, 2001, Accelerated age-related CpG island methylation in ulcerative colitis, Cancer Res, 61, 3573 Ushijima, 2012, Molecular pathways: involvement of Helicobacter pylori-triggered inflammation in the formation of an epigenetic field defect, and its usefulness as cancer risk and exposure markers, Clin. Cancer Res, 18, 923, 10.1158/1078-0432.CCR-11-2011 Hur, 2011, Insufficient role of cell proliferation in aberrant DNA methylation induction and involvement of specific types of inflammation, Carcinogenesis, 32, 35, 10.1093/carcin/bgq219 Leodolter, 2015, Somatic DNA hypomethylation in H. pylori-associated high-risk gastritis and gastric cancer: enhanced somatic hypomethylation associates with advanced stage cancer, Clin. Transl. Gastroenterol, 6, e85, 10.1038/ctg.2015.14 Kim, 2012, Association between genetic instability and Helicobacter pylori infection in gastric epithelial dysplasia, Gastroenterol. Res. Pract, 2012, 360929, 10.1155/2012/360929 Nanjo, 2012, Identification of gastric cancer risk markers that are informative in individuals with past H. pylori infection, Gastric Cancer, 15, 382, 10.1007/s10120-011-0126-1 Asada, 2015, Demonstration of the usefulness of epigenetic cancer risk prediction by a multicentre prospective cohort study, Gut, 64, 388, 10.1136/gutjnl-2014-307094 Woo, 2012, Global DNA hypomethylation in peripheral blood leukocytes as a biomarker for cancer risk: a meta-analysis, PLoS ONE, 7, e34615, 10.1371/journal.pone.0034615 Gao, 2012, Blood leukocyte Alu and LINE-1 methylation and gastric cancer risk in the Shanghai Women's Health Study, Br. J. Cancer, 106, 585, 10.1038/bjc.2011.562 Hou, 2010, Blood leukocyte DNA hypomethylation and gastric cancer risk in a high-risk Polish population, Int. J. Cancer, 127, 1866, 10.1002/ijc.25190 Takeshima, 2015, Frequent involvement of chromatin remodeler alterations in gastric field cancerization, Cancer Lett, 357, 328, 10.1016/j.canlet.2014.11.038 Van Assche, 2013, Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 3: special situations, J. Crohns Colitis, 7, 1, 10.1016/j.crohns.2012.09.005 Hsieh, 1998, Hypermethylation of the p16INK4a promoter in colectomy specimens of patients with long-standing and extensive ulcerative colitis, Cancer Res, 58, 3942 Sato, 2002, Hypermethylation of the p14(ARF) gene in ulcerative colitis-associated colorectal carcinogenesis, Cancer Res, 62, 1148 Fujii, 2005, Methylation of the oestrogen receptor gene in non-neoplastic epithelium as a marker of colorectal neoplasia risk in longstanding and extensive ulcerative colitis, Gut, 54, 1287, 10.1136/gut.2004.062059 Tahara, 2011, Host genetic factors, related to inflammatory response, influence the CpG island methylation status in colonic mucosa in ulcerative colitis, Anticancer Res, 31, 933 Markowitz, 2009, Molecular origins of cancer: molecular basis of colorectal cancer, N. Engl. J. Med, 361, 2449, 10.1056/NEJMra0804588 Rashid, 2001, CpG island methylation in colorectal adenomas, Am. J. Pathol, 159, 1129, 10.1016/S0002-9440(10)61789-0 Li, 2003, SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers, Proc. Natl. Acad. Sci. U.S.A., 100, 8412, 10.1073/pnas.1430846100 Chan, 2002, CpG island methylation in aberrant crypt foci of the colorectum, Am. J. Pathol, 160, 1823, 10.1016/S0002-9440(10)61128-5 Toyota, 1999, CpG island methylator phenotype in colorectal cancer, Proc. Natl. Acad. Sci. U.S.A., 96, 8681, 10.1073/pnas.96.15.8681 Worthley, 2010, DNA methylation within the normal colorectal mucosa is associated with pathway-specific predisposition to cancer, Oncogene, 29, 1653, 10.1038/onc.2009.449 Luo, 2014, Field cancerization in the colon: a role for aberrant DNA methylation?, Gastroenterol. Rep. (Oxf), 2, 16, 10.1093/gastro/got039 Belshaw, 2008, Profiling CpG island field methylation in both morphologically normal and neoplastic human colonic mucosa, Br. J. Cancer, 99, 136, 10.1038/sj.bjc.6604432 Belshaw, 2010, Patterns of DNA methylation in individual colonic crypts reveal aging and cancer-related field defects in the morphologically normal mucosa, Carcinogenesis, 31, 1158, 10.1093/carcin/bgq077 Alonso, 2015, Methylation of MGMT and ADAMTS14 in normal colon MUCOSA: biomarkers of a field defect for cancerization preferentially targeting elder African-Americans, Oncotarget, 6, 3420, 10.18632/oncotarget.2852 Figueiredo, 2009, Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors, Cancer Epidemiol. Biomarkers Prev, 18, 1041, 10.1158/1055-9965.EPI-08-0926 Iacopetta, 2007, Methylation levels of LINE-1 repeats and CpG island loci are inversely related in normal colonic mucosa, Cancer Sci, 98, 1454, 10.1111/j.1349-7006.2007.00548.x Takeshima, 2012, Induction of aberrant trimethylation of histone H3 lysine 27 by inflammation in mouse colonic epithelial cells, Carcinogenesis, 33, 2384, 10.1093/carcin/bgs294