Low penetrance hereditary retinoblastoma in a family: what should we consider in the genetic counselling process and follow up?

Seregard S, Lundell G, Svedberg H et al (2004) Incidence of retinoblastoma from 1958 to 1998 in Northern Europe: advantages of birth cohort analysis. Ophthalmology 111:1228–1232

Corson TW, Gallie BL (2007) One hit, two hits, three hits, more? Genomic changes in the development of retinoblastoma. Genes Chromosomes Cancer 46(7):617–634

Burkhart DL, Sage J (2008) Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat Rev Cancer 8:671–682

Harbour JW (2001) Molecular basis of low-penetrance retinoblastoma. Arch Ophthalmol 119:1699–1704

Fletcher O, Easton D, Anderson K et al (2004) Lifetime risks of common cancers among retinoblastoma survivors. J Natl Cancer Inst 96:357–363

Marees T, Moll AC, Imhof SM et al (2008) Risk of second malignancies in survivors of retinoblastoma: more than 40 years of follow-up. J Natl Cancer Inst 100:1771–1779

Alonso J, García-Miguel P, Abelairas J et al (2001) Spectrum of germline RB1 gene mutations in spanish retinoblastoma patients: Phenotypic and molecular epidemiological implications. Hum Mutat 17:412–422

Alonso J, Garcia-Miguel P, Abelairas J et al (2001) A microsatellite fluorescent method for linkage analysis in familial retinoblastoma and deletion detection at the RB1 locus in retinoblastoma and osteosarcoma. Diag Mol Pathol. 10:9–14

Strong LC, Knudson AG Jr (1973) Letter. Second cancers in retinoblastoma. Lancet 2:1086

Yu CL, Tucker MA, Abramson DH et al (2009) Cause-specific mortality in long-term survivors of retinoblastoma. J Natl Cancer Inst 101:581–591

Kleinerman RA, Tucker MA, Tarone RE et al (2005) Risk of new cancers after radiotherapy in long-term survivors of retinoblastoma: an extended follow-up. J Clin Oncol 23:2272–2279

Tanguay C, Harvey I, Houde M et al (2003) Leiomyosarcoma of urinary bladder following cyclophosphamide therapy: report of two cases. Mod Pathol 16:512–514

Moss SD, Rockswold GL, Chou SN et al (1988) Radiation-induced meningiomas in pediatric patients. Neurosurgery 22:758–761

Kivelä T, Asko-Seljavaara S, Pihkala U et al (2001) Sebaceous Carcinoma of the Eyelid Associated with Retinoblastoma. Ophthalmology 108:1124–1128

Valverde JR, Alonso J, Palacios I et al (2005) RB1 gene mutation up-date, a meta-analysis based on 932 reported mutations available in a searchable database. BMC Genet 6:53

Shields CL, Honavar SG, Meadows AT et al (2002) Chemoreduction for unilateral retinoblastoma. Arch Ophthalmol 120:1653–1658

Kleinerman RA, Tarone RE, Abramson DH et al (2000) Hereditary retinoblastoma and risk of lung cancer. J Natl Cancer Inst 92:2037–2039

Foster MC, Kleinerman RA, Abramson DH et al (2006) Tobacco use in adult long-term survivors of retinoblastoma. Cancer Epidemiol Biomark Prev 15:1464–1468

Dommering CJ, van den Heuvel MR, Moll AC et al (2010) Reproductive decision-making: a qualitative study among couples at increased risk of having a child with retinoblastoma. Clin Genet 78:334–341