Homocysteine and vascular disease

Whisnant, 1997, Modeling of risk factors for ischemic stroke: the Willis lecture, Stroke, 28, 1839, 10.1161/01.STR.28.9.1840 McCully, 1969, Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis, Am J Pathol, 56, 111 Ueland, 1995, Homocysteine species as components of plasma redox thiol status, Clin Chem, 41, 340, 10.1093/clinchem/41.3.340 Dudman, 1993, Disordered methionine/homocysteine metabolism in premature vascular disease: its occurrence, cofactor therapy, and enzymology, Arterioscler Thomb Vasc Biol, 12, 1253, 10.1161/01.ATV.13.9.1253 Still, 1998, Clinical implications of plasma homocysteine measurement in cardiovascular disease, J Clin Pathol, 51, 183, 10.1136/jcp.51.3.183 Refsum, 1997, Assessment of homocysteine status, J Inherit Metab Dis, 20, 286, 10.1023/A:1005321225893 Finkelstein, 1998, The metabolism of homocysteine: pathways and regulation, Eur J Pediatr, 157, S40, 10.1007/PL00014300 Mudd, 1985, The natural history of homocystinuria due to cystathionine beta-synthase deficiency, Am J Hum Genet, 37, 1 Kraus, 1998, Biochemistry and molecular genetics of cystathionine beta-synthase deficiency, Eur J Pediatr, 157, S50, 10.1007/PL00014304 Ogier de Baulny, 1998, Remethylation defects: guidelines for clinical diagnosis and treatment, Eur J Pediatr, 157, S77, 10.1007/PL00014307 Kang, 1988, Intermediate homocysteinemia: a thermolabile variant of methylenetetrahydrofolate reductase, Am J Hum Genet, 43, 414 Frosst, 1995, A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase, Nat Genet, 10, 111, 10.1038/ng0595-111 Malinow, 1997, The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes, Arterioscler Thromb Vasc Biol, 17, 1157, 10.1161/01.ATV.17.6.1157 Selhub, 1993, Vitamin status and intake as primary determinants of homocysteinemia in an elderly population, JAMA, 270, 2693, 10.1001/jama.1993.03510220049033 Kang, 1987, Homocysteinaemia due to folate deficiency, Metabolism, 36, 458, 10.1016/0026-0495(87)90043-6 Bostom, 1997, Homocysteinemia in end-stage renal disease: prevalence, etiology, and potential relationship to arteriosclerotic outcomes, Kidney Int, 52, 10, 10.1038/ki.1997.298 Savage, 1994, Sensitivity of serum methylmalonic acid and total homocysteine determinants for diagnosing cobalamin and folate deficiencies, Am J Med, 96, 239, 10.1016/0002-9343(94)90149-X Frantzen, 1998, Enzyme conversion immunoassay for determining total homocysteine in plasma or serum, Clin Chem, 44, 311, 10.1093/clinchem/44.2.311 Guttormsen, 1994, Plasma concentrations of homocysteine and other aminothiol compounds are related to food intake in healthy human subjects, J Nutr, 124, 1934, 10.1093/jn/124.10.1934 Graham, 1997, Plasma homocysteine as a risk factor for vascular disease: the European Concerted Action Project, JAMA, 277, 1775, 10.1001/jama.1997.03540460039030 Garg, 1997, Short-term and long-term variability of plasma homocysteine measurement, Clin Chem, 43, 141, 10.1093/clinchem/43.1.141 Nygard, 1998, Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine Study, Am J Clin Nutr, 67, 263, 10.1093/ajcn/67.2.263 Lindgren, 1995, Plasma homocysteine in the acute and convalescent phases of stroke, Stroke, 26, 796, 10.1161/01.STR.26.5.795 Egerton, 1996, Serial measures of plasma homocyst(e)ine after acute myocardial infarction, Am J Cardiol, 77, 759, 10.1016/S0002-9149(97)89213-2 Rasmussen, 1996, Age- and gender-specific reference intervals for total homocysteine and methylmalonic acid in plasma before and after vitamin supplementation, Clin Chem, 42, 630, 10.1093/clinchem/42.4.630 Dudman, 1996, Assay of plasma homocysteine: light sensitivity of the fluorescent 7-benzo-2-oxa-1,3- diazo-4-sulfonic acid derivative, and use of appropriate calibrators, Clin Chem, 42, 2028, 10.1093/clinchem/42.12.2028 McCully, 1996, Homocysteine and vascular disease, Nat Med, 2, 386, 10.1038/nm0496-386 Malinow, 1998, Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease, N Engl J Med, 338, 1009, 10.1056/NEJM199804093381501 Wilcken, 1976, The pathogenesis of coronary artery disease: a possible role for methionine metabolism, J Clin Invest, 57, 1079, 10.1172/JCI108350 Stampfer, 1992, A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians, JAMA, 268, 877, 10.1001/jama.1992.03490070059042 Wald, 1998, Homocysteine and ischemic heart disease: results of a prospective study with implications regarding prevention, Arch Intern Med, 158, 862, 10.1001/archinte.158.8.862 Arnesen, 1995, Serum total homocysteine and coronary heart disease, Int J Epidemiol, 24, 704, 10.1093/ije/24.4.704 Pery, 1995, Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men, Lancet, 346, 1395, 10.1016/S0140-6736(95)92407-8 Nygard, 1997, Plasma homocysteine levels and mortality in patients with coronary artery disease, N Engl J Med, 337, 230, 10.1056/NEJM199707243370403 Chasan-Taber, 1996, A prospective study of folate and vitamin B6 and risk of myocardial infarction in US physicians, J Am Coll Nutr, 15, 136, 10.1080/07315724.1996.10718578 Verhoef, 1997, Plasma total homocysteine and risk of angina pectoris with subsequent coronary artery bypass surgery, Am J Cardiol, 79, 799, 10.1016/S0002-9149(96)00874-0 Verhoef, 1994, A prospective study of plasma homocyst(e)ine and risk of ischemic stroke, Stroke, 25, 1924, 10.1161/01.STR.25.10.1924 Evans, 1997, Homocyst(e)ine and risk of cardiovascular disease in the Multiple Risk Factor Intervention Trial, Arterioscler Thromb Vasc Biol, 17, 1947, 10.1161/01.ATV.17.10.1947 Alfthan, 1994, Relation of serum homocysteine and lipoprotein(a) concentrations to atherosclerotic disease in a prospective Finnish population based study, Atherosclerosis, 106, 9, 10.1016/0021-9150(94)90078-7 Folsom, 1998, Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study, Circulation, 98, 204, 10.1161/01.CIR.98.3.204 Boushey, 1995, A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intake, JAMA, 274, 1049, 10.1001/jama.1995.03530130055028 Hopkins, 1995, Higher plasma homocysteine and increased susceptibility to adverse effects of low folate in early familial coronary artery disease, Arterioscler Thromb Vasc Biol, 15, 1314, 10.1161/01.ATV.15.9.1314 Dalery, 1995, Homocysteine and coronary artery disease in French Canadian subjects: relation with vitamins B12, B6, pyridoxal phosphate, and folate, Am J Cardiol, 75, 1107, 10.1016/S0002-9149(99)80739-5 Robinson, 1995, Hyperhomocysteinaemia and low pyridoxal phosphate: common and independent reversible risk factors for coronary artery disease, Circulation, 92, 2825, 10.1161/01.CIR.92.10.2825 Malinow, 1996, Plasma homocyst(e)ine levels and graded risk for myocardial infarction: findings in two populations at contrasting risk for coronary heart disease, Atherosclerosis, 26, 27, 10.1016/0021-9150(96)05890-X Markus, 1997, A common polymorphism in the methylenetetrahydrofolate reductase gene, homocysteine, and ischaemic cerebrovascular disease, Stroke, 28, 1739, 10.1161/01.STR.28.9.1739 Malinow, 1993, Carotid artery intimal-medial wall thickening and plasma homocyst(e)ine in asymptomatic adults: the Atherosclerosis Risk in Communities study, Circulation, 87, 1107, 10.1161/01.CIR.87.4.1107 Selhub, 1995, Association between plasma homocysteine concentrations and extracranial carotid-artery disease, N Engl J Med, 332, 286, 10.1056/NEJM199502023320502 Verhoef, 1997, Plasma total homocysteine, B vitamins, and risk of coronary atherosclerosis, Arterioscler Thromb Vasc Biol, 17, 989, 10.1161/01.ATV.17.5.989 Montalescot, 1997, Plasma homocysteine and the extent of atherosclerosis in patients with coronary artery disease, Int J Cardiol, 60, 295, 10.1016/S0167-5273(97)00099-5 Konnecky, 1997, Correlation between plasma homocyst(e)ine and aortic atherosclerosis, Am Heart J, 133, 534, 10.1016/S0002-8703(97)70148-0 van den Berg, 1996, Plasma homocysteine and severity of atherosclerosis in young adults with lowerlimb atherosclerotic disease, Arterioscler Thromb Vasc Biol, 16, 165, 10.1161/01.ATV.16.1.165 Brattstrom, 1998, Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease, Circulation, 98, 2520, 10.1161/01.CIR.98.23.2520 Blom, 1998, Mutated 5,10-methylenetetrahydrofolate reductase and moderate hyperhomocysteinaemia, Eur J Pediatr, 157 Ray, 1998, Meta-analysis of hyperhomocysteinemia as a risk factor for venous thromboembolic disease, Arch Intern Med, 158, 2101, 10.1001/archinte.158.19.2101 Ridker, 1997, Interrelation of hyperhomocyst(e)inaemia, factor V Leiden, and risk of future venous thromboembolism, Circulation, 95, 1777, 10.1161/01.CIR.95.7.1777 Petri, 1996, Plasma homocysteine as a risk factor for atherothrombotic events in systemic lupus erythematosus, Lancet, 348, 1120, 10.1016/S0140-6736(96)03032-2 Nygard, 1995, Total plasma homocysteine and cardiovascular risk profile, JAMA, 224, 1526, 10.1001/jama.1995.03530190040032 Welch, 1997, Hyperhomocyst(e)inaemia and atherothrombosis, Ann N Y Acad Sci, 811, 48, 10.1111/j.1749-6632.1997.tb51988.x Oakley, 1998, Eat right and take a multivitamin, N Engl J Med, 338, 1060, 10.1056/NEJM199804093381509 den Heijer, 1998, Vitamin supplementation reduces blood homocysteine levels: a controlled trial in patients with venous thrombosis and healthy volunteers, Arterioscler Thromb Vasc Biol, 18, 356, 10.1161/01.ATV.18.3.356 1998, Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials, BMJ, 316, 894, 10.1136/bmj.316.7135.894 Savage, 1995, Folate-cobalamin interactions, 237 Wilcken, 1997, The natural history of vascular disease in homocystinuria and the effects of treatment, J Inher Metab Dis, 20, 295, 10.1023/A:1005373209964 Peterson, 1998, Vitamins and progression of atherosclerosis in hyperhomocyst(e)inaemia, Lancet, 351, 263, 10.1016/S0140-6736(05)78275-1 1992, Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects, MMWR, 41, 1 Bots, 1999, Homocysteine and short-term risk of myocardial infarction and stroke in the elderly: the Rotterdam study, Archj Intern Med, 159, 3844 Carraneo, 1999, Hyperhomocysteinemia, atherosclerosis and thrombosis, Thromb Haemost, 81, 165, 10.1055/s-0037-1614438 1998, Homocysteine and vascular disease: review in depth, J Cardiovasc Risk, 5, 21355 D'Angelo, 1997, Homocysteine and thrombotic disease, Blood, 90, 111, 10.1182/blood.V90.1.1 Kuller, 1998, Homocysteine, vitamins and cardiovascular disease, Circulation, 98, 196, 10.1161/01.CIR.98.3.196 Mayer, 1996, Homocysteine and coronary atherosclerosis, J Am Cell Cardiol, 27, 51727, 10.1016/0735-1097(95)00508-0 McCully, 1998, Homocysteine, folate, vitamin B6, and cardiovascular disease, JAMA, 279, 39293, 10.1001/jama.279.5.392 1999, Homocyst(e)ine, diet, and cardiovascular disease: a statement for healthcare professionals from the Nutrition Committee, American Heart Association, Circulation, 99, 17882 Refsum, 1998, Homocysteine and cardiovascular disease, Annu Rev Med, 49, 3162, 10.1146/annurev.med.49.1.31 Stein, 1998, Hyperhomocysteinemia and atherothrombotic vascular disease: pathophysiology, screening, and treatment, Arch Intern Med, 158, 130106, 10.1001/archinte.158.12.1301 Ueland, 1993, Total Hom ocysteine in plasma or serum: methods and clinical application, Clin Chem, 39, 1764, 10.1093/clinchem/39.9.1764 Welch, 1998, Homocysteine and atherothrombosis, N Engl J Med, 338, 104250.s, 10.1056/NEJM199804093381507