Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content

Cell - Tập 140 - Trang 62-73 - 2010
Salvatore Pece1,2,3, Daniela Tosoni1,3, Stefano Confalonieri1, Giovanni Mazzarol3, Manuela Vecchi1, Simona Ronzoni3, Loris Bernard3, Giuseppe Viale2,3, Pier Giuseppe Pelicci2,3, Pier Paolo Di Fiore1,2,3
1IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Via Adamello 16, 20139, Milan, Italy
2Dipartimento di Medicina, Chirurgia ed Odontoiatria, Universita' degli Studi di Milano, Via di Rudini' 8, 20122 Milan, Italy
3Istituto Europeo di Oncologia, Via Ripamonti 435, 20141 Milan, Italy

Tài liệu tham khảo

Ben-Porath, 2008, An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors, Nat. Genet., 40, 499, 10.1038/ng.127 Carter, 1990, Distinct functions for integrins alpha 3 beta 1 in focal adhesions and alpha 6 beta 4/bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: relation to hemidesmosomes, J. Cell Biol., 111, 3141, 10.1083/jcb.111.6.3141 Chepko, 1997, Three division-competent, structurally-distinct cell populations contribute to murine mammary epithelial renewal, Tissue Cell, 29, 239, 10.1016/S0040-8166(97)80024-9 Cicalese, 2009, The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells, Cell, 138, 1083, 10.1016/j.cell.2009.06.048 Dontu, 2003, In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells, Genes Dev., 17, 1253, 10.1101/gad.1061803 Eirew, 2008, A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability, Nat. Med., 14, 1384, 10.1038/nm.1791 Gönczy, 2008, Mechanisms of asymmetric cell division: flies and worms pave the way, Nat. Rev. Mol. Cell Biol., 9, 355, 10.1038/nrm2388 Huang, 1999, Symmetry of initial cell divisions among primitive hematopoietic progenitors is independent of ontogenic age and regulatory molecules, Blood, 94, 2595, 10.1182/blood.V94.8.2595.420k37_2595_2604 Ivshina, 2006, Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer, Cancer Res., 66, 10292, 10.1158/0008-5472.CAN-05-4414 Jones, 2004, Expression profiling of purified normal human luminal and myoepithelial breast cells: identification of novel prognostic markers for breast cancer, Cancer Res., 64, 3037, 10.1158/0008-5472.CAN-03-2028 Kuperwasser, 2004, Reconstruction of functionally normal and malignant human breast tissues in mice, Proc. Natl. Acad. Sci. USA, 101, 4966, 10.1073/pnas.0401064101 Lanzkron, 1999, Hematopoietic stem cell tracking in vivo: a comparison of short-term and long-term repopulating cells, Blood, 93, 1916, 10.1182/blood.V93.6.1916.406k15_1916_1921 Liao, 2007, Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity, Cancer Res., 67, 8131, 10.1158/0008-5472.CAN-06-4493 Lim, 2009, Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers, Nat. Med., 15, 907, 10.1038/nm.2000 McCaffrey, 2009, The Par3/aPKC interaction is essential for end bud remodeling and progenitor differentiation during mammary gland morphogenesis, Genes Dev., 23, 1450, 10.1101/gad.1795909 Pawitan, 2005, Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts, Breast Cancer Res., 7, R953, 10.1186/bcr1325 Pece, 2004, Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis, J. Cell Biol., 167, 215, 10.1083/jcb.200406140 Perou, 2000, Molecular portraits of human breast tumours, Nature, 406, 747, 10.1038/35021093 Proia, 2006, Reconstruction of human mammary tissues in a mouse model, Nat. Protoc., 1, 206, 10.1038/nprot.2006.31 Raouf, 2008, Transcriptome analysis of the normal human mammary cell commitment and differentiation process, Cell Stem Cell, 3, 109, 10.1016/j.stem.2008.05.018 Shackleton, 2006, Generation of a functional mammary gland from a single stem cell, Nature, 439, 84, 10.1038/nature04372 Shipitsin, 2007, Molecular definition of breast tumor heterogeneity, Cancer Cell, 11, 259, 10.1016/j.ccr.2007.01.013 Sørlie, 2001, Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications, Proc. Natl. Acad. Sci. USA, 98, 10869, 10.1073/pnas.191367098 Stingl, 2007, Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis, Nat. Rev. Cancer, 7, 791, 10.1038/nrc2212 Stingl, 1998, Phenotypic and functional characterization in vitro of a multipotent epithelial cell present in the normal adult human breast, Differentiation, 63, 201, 10.1111/j.1432-0436.1998.00201.x Stingl, 2006, Purification and unique properties of mammary epithelial stem cells, Nature, 439, 993, 10.1038/nature04496 Vecchi, 2007, Gene expression analysis of early and advanced gastric cancers, Oncogene, 26, 4284, 10.1038/sj.onc.1210208 Visvader, 2008, Cancer stem cells in solid tumours: accumulating evidence and unresolved questions, Nat. Rev. Cancer, 8, 755, 10.1038/nrc2499 Wei, 2006, A global map of p53 transcription-factor binding sites in the human genome, Cell, 124, 207, 10.1016/j.cell.2005.10.043 Williams, 1983, Mammary ductal elongation: differentiation of myoepithelium and basal lamina during branching morphogenesis, Dev. Biol., 97, 274, 10.1016/0012-1606(83)90086-6 Al-Hajj, M., Wicha, M.S., Benito-Hernandez, A., Morrison, S.J., and Clarke, M.F. (2003). Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. USA 100, 3983–3988. Andersen, C.L., Monni, O., Wagner, U., Kononen, J., Bärlund, M., Bucher, C., Haas, P., Nocito, A., Bissig, H., Sauter, G., and Kallioniemi, A. (2002). High-throughput copy number analysis of 17q23 in 3520 tissue specimens by fluorescence in situ hybridization to tissue microarrays. Am. J. Pathol. 161, 73–79. Athanassiadou, P., Grapsa, D., Gonidi, M., Athanassiadou, A.M., Tsipis, A., and Patsouris, E. (2009). CD24 expression has a prognostic impact in breast carcinoma. Pathol. Res. Pract. 205, 524–533. Bircan, S., Kapucuoglu, N., Baspinar, S., Inan, G., and Candir, O. (2006). CD24 expression in ductal carcinoma in situ and invasive ductal carcinoma of breast: an immunohistochemistry-based pilot study. Pathol. Res. Pract. 202, 569–576. Bouras, T., Pal, B., Vaillant, F., Harburg, G., Asselin-Labat, M.L., Oakes, S.R., Lindeman, G.J., and Visvader, J.E. (2008). Notch signaling regulates mammary stem cell function and luminal cell-fate commitment. Cell Stem Cell 3, 429–441. Colaluca, I.N., Tosoni, D., Nuciforo, P., Senic-Matuglia, F., Galimberti, V., Viale, G., Pece, S., and Di Fiore, P.P. (2008). NUMB controls p53 tumour suppressor activity. Nature 451, 76–80. Dontu, G., Jackson, K.W., McNicholas, E., Kawamura, M.J., Abdallah, W.M., and Wicha, M.S. (2004). Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res. 6, R605–R615. Estrach, S., Ambler, C.A., Lo Celso, C., Hozumi, K., and Watt, F.M. (2006). Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Development 133, 4427–4438. Fogel, M., Friederichs, J., Zeller, Y., Husar, M., Smirnov, A., Roitman, L., Altevogt, P., and Sthoeger, Z.M. (1999). CD24 is a marker for human breast carcinoma. Cancer Lett. 143, 87–94. Ginestier, C., Hur, M.H., Charafe-Jauffret, E., Monville, F., Dutcher, J., Brown, M., Jacquemier, J., Viens, P., Kleer, C.G., Liu, S., et al. (2007). ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1, 555–567. Gray, D.H., Chidgey, A.P., and Boyd, R.L. (2002). Analysis of thymic stromal cell populations using flow cytometry. J. Immunol. Methods 260, 15–28. Hubbell, E., Liu, W.M., and Mei, R. (2002). Robust estimators for expression analysis. Bioinformatics 18, 1585–1592. Kosodo, Y., Röper, K., Haubensak, W., Marzesco, A.M., Corbeil, D., and Huttner, W.B. (2004). Asymmetric distribution of the apical plasma membrane during neurogenic divisions of mammalian neuroepithelial cells. EMBO J. 23, 2314–2324. Kristiansen, G., Winzer, K.J., Mayordomo, E., Bellach, J., Schlüns, K., Denkert, C., Dahl, E., Pilarsky, C., Altevogt, P., Guski, H., and Dietel, M. (2003). CD24 expression is a new prognostic marker in breast cancer. Clin. Cancer Res. 9, 4906–4913. Leong, K.G., Niessen, K., Kulic, I., Raouf, A., Eaves, C., Pollet, I., and Karsan, A. (2007). Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. J. Exp. Med. 204, 2935–2948. Li, Y., Welm, B., Podsypanina, K., Huang, S., Chamorro, M., Zhang, X., Rowlands, T., Egeblad, M., Cowin, P., Werb, Z., et al. (2003). Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc. Natl. Acad. Sci. USA 100, 15853–15858. Liu, B.Y., McDermott, S.P., Khwaja, S.S., and Alexander, C.M. (2004). The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells. Proc. Natl. Acad. Sci. USA 101, 4158–4163. Liu, W.M., Mei, R., Di, X., Ryder, T.B., Hubbell, E., Dee, S., Webster, T.A., Harrington, C.A., Ho, M.H., Baid, J., and Smeekens, S.P. (2002). Analysis of high density expression microarrays with signed-rank call algorithms. Bioinformatics 18, 1593–1599. Liu, Y., Elf, S.E., Miyata, Y., Sashida, G., Liu, Y., Huang, G., Di Giandomenico, S., Lee, J.M., Deblasio, A., Menendez, S., et al. (2009). p53 regulates hematopoietic stem cell quiescence. Cell Stem Cell 4, 37–48. Minucci, S., Monestiroli, S., Giavara, S., Ronzoni, S., Marchesi, F., Insinga, A., Diverio, D., Gasparini, P., Capillo, M., Colombo, E., et al. (2002). PML-RAR induces promyelocytic leukemias with high efficiency following retroviral gene transfer into purified murine hematopoietic progenitors. Blood 100, 2989–2995. Pardal, R., Clarke, M.F., and Morrison, S.J. (2003). Applying the principles of stem-cell biology to cancer. Nat. Rev. Cancer 3, 895–902. Pruszak, J., Sonntag, K.C., Aung, M.H., Sanchez-Pernaute, R., and Isacson, O. (2007). Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations. Stem Cells 25, 2257–2268. Rubinson, D.A., Dillon, C.P., Kwiatkowski, A.V., Sievers, C., Yang, L., Kopinja, J., Rooney, D.L., Zhang, M., Ihrig, M.M., McManus, M.T., et al. (2003). A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat. Genet. 33, 401–406. Seidl, J., Knuechel, R., and Kunz-Schughart, L.A. (1999). Evaluation of membrane physiology following fluorescence activated or magnetic cell separation. Cytometry 36, 102–111. Shackleton, M., Vaillant, F., Simpson, K.J., Stingl, J., Smyth, G.K., Asselin-Labat, M.L., Wu, L., Lindeman, G.J., and Visvader, J.E. (2006). Generation of a functional mammary gland from a single stem cell. Nature 439, 84–88. Straight, A.F., Cheung, A., Limouze, J., Chen, I., Westwood, N.J., Sellers, J.R., and Mitchison, T.J. (2003). Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. Science 299, 1743–1747. Subramanian, A., Tamayo, P., Mootha, V.K., Mukherjee, S., Ebert, B.L., Gillette, M.A., Paulovich, A., Pomeroy, S.L., Golub, T.R., Lander, E.S., and Mesirov, J.P. (2005). Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 102, 15545–15550. Villadsen, R., Fridriksdottir, A.J., Rønnov-Jessen, L., Gudjonsson, T., Rank, F., LaBarge, M.A., Bissell, M.J., and Petersen, O.W. (2007). Evidence for a stem cell hierarchy in the adult human breast. J. Cell Biol. 177, 87–101.