Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages

Anitha, 2012, Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling, Gastroenterology, 143, 1006, 10.1053/j.gastro.2012.06.034 Ayres, 2012, Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiota, Nat. Med., 18, 799, 10.1038/nm.2729 Barron, 2011, Downregulation of Dlx5 and Dlx6 expression by Hand2 is essential for initiation of tongue morphogenesis, Development, 138, 2249, 10.1242/dev.056929 Bogunovic, 2009, Origin of the lamina propria dendritic cell network, Immunity, 31, 513, 10.1016/j.immuni.2009.08.010 Bohórquez, 2015, Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells, J. Clin. Invest., 125, 782, 10.1172/JCI78361 Cai, 2002, Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro, Neuron, 35, 711, 10.1016/S0896-6273(02)00826-7 Chiu, 2013, Bacteria activate sensory neurons that modulate pain and inflammation, Nature, 501, 52, 10.1038/nature12479 Danielian, 1998, Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase, Curr. Biol., 8, 1323, 10.1016/S0960-9822(07)00562-3 Davalos, 2005, ATP mediates rapid microglial response to local brain injury in vivo, Nat. Neurosci., 8, 752, 10.1038/nn1472 del Rey, 2008, Sympathetic nervous system-immune interactions in autoimmune lymphoproliferative diseases, Neuroimmunomodulation, 15, 29, 10.1159/000135621 Denning, 2007, Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses, Nat. Immunol., 8, 1086, 10.1038/ni1511 Diehl, 2013, Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX(3)CR1(hi) cells, Nature, 494, 116, 10.1038/nature11809 El Khoury, 2007, Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease, Nat. Med., 13, 432, 10.1038/nm1555 Estévez, 2006, Arginase 1 regulation of nitric oxide production is key to survival of trophic factor-deprived motor neurons, J. Neurosci., 26, 8512, 10.1523/JNEUROSCI.0728-06.2006 Farache, 2013, Luminal bacteria recruit CD103+ dendritic cells into the intestinal epithelium to sample bacterial antigens for presentation, Immunity, 38, 581, 10.1016/j.immuni.2013.01.009 Furness, 1999, Nutrient tasting and signaling mechanisms in the gut. II. The intestine as a sensory organ: neural, endocrine, and immune responses, Am. J. Physiol., 277, G922 Gautier, 2012, Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages, Nat. Immunol., 13, 1118, 10.1038/ni.2419 Gershon, 2007, The serotonin signaling system: from basic understanding to drug development for functional GI disorders, Gastroenterology, 132, 397, 10.1053/j.gastro.2006.11.002 Ghisletti, 2010, Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages, Immunity, 32, 317, 10.1016/j.immuni.2010.02.008 Guereschi, 2013, Beta2-adrenergic receptor signaling in CD4+ Foxp3+ regulatory T cells enhances their suppressive function in a PKA-dependent manner, Eur. J. Immunol., 43, 1001, 10.1002/eji.201243005 Hadis, 2011, Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria, Immunity, 34, 237, 10.1016/j.immuni.2011.01.016 Harris, 2014, Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation, Front. Neural Circuits, 8, 76, 10.3389/fncir.2014.00076 Hashimoto, 2013, Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes, Immunity, 38, 792, 10.1016/j.immuni.2013.04.004 Hendershot, 2007, Expression of Hand2 is sufficient for neurogenesis and cell type-specific gene expression in the enteric nervous system, Dev. Dyn., 236, 93, 10.1002/dvdy.20989 Kinoshita, 2007, Possible involvement of muscularis resident macrophages in impairment of interstitial cells of Cajal and myenteric nerve systems in rat models of TNBS-induced colitis, Histochem. Cell Biol., 127, 41, 10.1007/s00418-006-0223-0 Lavin, 2014, Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment, Cell, 159, 1312, 10.1016/j.cell.2014.11.018 Li, 2010, Dependence of serotonergic and other nonadrenergic enteric neurons on norepinephrine transporter expression, J. Neurosci., 30, 16730, 10.1523/JNEUROSCI.2276-10.2010 Mazzini, 2014, Oral tolerance can be established via gap junction transfer of fed antigens from CX3CR1+ macrophages to CD103+ dendritic cells, Immunity, 40, 248, 10.1016/j.immuni.2013.12.012 McVey Neufeld, 2015, The gut microbiome restores intrinsic and extrinsic nerve function in germ-free mice accompanied by changes in calbindin, Neurogastroenterol. Motil., 27, 627, 10.1111/nmo.12534 Medzhitov, 2012, Disease tolerance as a defense strategy, Science, 335, 936, 10.1126/science.1214935 Meisel, 2014, Chemosensation of bacterial secondary metabolites modulates neuroendocrine signaling and behavior of C. elegans, Cell, 159, 267, 10.1016/j.cell.2014.09.011 Meseguer, 2014, TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins, Nat. Commun., 5, 3125, 10.1038/ncomms4125 Muller, 2014, Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility, Cell, 158, 300, 10.1016/j.cell.2014.04.050 Nakai, 2014, Control of lymphocyte egress from lymph nodes through β2-adrenergic receptors, J. Exp. Med., 211, 2583, 10.1084/jem.20141132 Nguyen, 2011, Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis, Nature, 480, 104, 10.1038/nature10653 Niess, 2005, CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance, Science, 307, 254, 10.1126/science.1102901 Nimmerjahn, 2005, Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo, Science, 308, 1314, 10.1126/science.1110647 Ohman, 2010, Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions, Nat. Rev. Gastroenterol. Hepatol., 7, 163, 10.1038/nrgastro.2010.4 Okabe, 2014, Tissue-specific signals control reversible program of localization and functional polarization of macrophages, Cell, 157, 832, 10.1016/j.cell.2014.04.016 Parkhurst, 2013, Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor, Cell, 155, 1596, 10.1016/j.cell.2013.11.030 Phillips, 2012, Macrophages associated with the intrinsic and extrinsic autonomic innervation of the rat gastrointestinal tract, Auton. Neurosci., 169, 12, 10.1016/j.autneu.2012.02.004 Pullinger, 2010, 6-hydroxydopamine-mediated release of norepinephrine increases faecal excretion of Salmonella enterica serovar Typhimurium in pigs, Vet. Res., 41, 68, 10.1051/vetres/2010040 Råberg, 2007, Disentangling genetic variation for resistance and tolerance to infectious diseases in animals, Science, 318, 812, 10.1126/science.1148526 Rakoff-Nahoum, 2004, Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis, Cell, 118, 229, 10.1016/j.cell.2004.07.002 Renier, 2014, iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging, Cell, 159, 896, 10.1016/j.cell.2014.10.010 Sanz, 2009, Cell-type-specific isolation of ribosome-associated mRNA from complex tissues, Proc. Natl. Acad. Sci. USA, 106, 13939, 10.1073/pnas.0907143106 Schreiber, 2013, Intestinal monocytes and macrophages are required for T cell polarization in response to Citrobacter rodentium, J. Exp. Med., 210, 2025, 10.1084/jem.20130903 Soares, 2014, Tissue damage control in disease tolerance, Trends Immunol., 35, 483, 10.1016/j.it.2014.08.001 Spengler, 1994, Endogenous norepinephrine regulates tumor necrosis factor-alpha production from macrophages in vitro, J. Immunol., 152, 3024, 10.4049/jimmunol.152.6.3024 Tracey, 2009, Reflex control of immunity, Nat. Rev. Immunol., 9, 418, 10.1038/nri2566 Tsolis, 1999, Identification of a putative Salmonella enterica serotype typhimurium host range factor with homology to IpaH and YopM by signature-tagged mutagenesis, Infect. Immun., 67, 6385, 10.1128/IAI.67.12.6385-6393.1999 Van Dyken, 2013, Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease, Annu. Rev. Immunol., 31, 317, 10.1146/annurev-immunol-032712-095906 Wang, 2012, IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia, Nat. Immunol., 13, 753, 10.1038/ni.2360 Wang, 2015, TREM2 lipid sensing sustains the microglial response in an Alzheimer’s disease model, Cell, 160, 1061, 10.1016/j.cell.2015.01.049 Wilson, 2013, The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch, Cell, 155, 285, 10.1016/j.cell.2013.08.057 Zariwala, 2012, A Cre-dependent GCaMP3 reporter mouse for neuronal imaging in vivo, J. Neurosci., 32, 3131, 10.1523/JNEUROSCI.4469-11.2012 Zigmond, 2014, Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis, Immunity, 40, 720, 10.1016/j.immuni.2014.03.012