Fullerenol cytotoxicity in kidney cells is associated with cytoskeleton disruption, autophagic vacuole accumulation, and mitochondrial dysfunction

Toxicology and Applied Pharmacology - Tập 248 Số 3 - Trang 249-258 - 2010
Denise N. Johnson-Lyles1, Kimberly A. Peifley2, Stephen Lockett2, Barry W. Neun1, Matthew Hansen1, Jeffrey D. Clogston1, Stęphan T. Stern1, Scott E. McNeil1
1Nanotechnology Characterization Lab (NCL), Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD 21702, USA
2Optical Microscopy Analysis Lab (OMAL), Advanced Technology Program, SAIC-Frederick, Inc., NCI-Frederick, Frederick, MD 21702, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Anderson, 2006, Gadolinium-fullerenol as a paramagnetic contrast agent for cellular imaging, Investig. Radiol., 41, 332, 10.1097/01.rli.0000192420.94038.9e

Anesti, 2006, The relationship between mitochondrial shape and function and the cytoskeleton, Biochim. Biophys. Acta, 1757, 692, 10.1016/j.bbabio.2006.04.013

Bensasson, 2000, Reactions of e–aq, CO2●–, HO●, O2●– and O2(1g) with a Dendro[60] Fullerene and C60 [C(COOH)2]n (n_ 2_6), Free Radical Biol. Med., 29, 26, 10.1016/S0891-5849(00)00287-2

Bjorkoy, 2005, p62/SQSTM1 forms protein aggregates degraded by autophagy andhas a protective effect on huntingtin-induced cell death, J. Cell. Biol., 171, 603, 10.1083/jcb.200507002

Bolskar, 2008, Gadofullerene MRI contrast agents, Nanomedicine, 3, 201, 10.2217/17435889.3.2.201

Chaudhuri, 2009, Fullerenol-cytotoxic conjugates for cancer chemotherapy, ACS Nano, 3, 2505, 10.1021/nn900318y

Dugan, 1997, Carboxyfullerenes as neuroprotective agents, Proc. Natl. Acad. Sci. USA, 94, 9434, 10.1073/pnas.94.17.9434

Fass, 2006, Microtubules support production of starvation-induced autophagosomes but not their targeting and fusion with lysosomes, J. Biol. Chem., 281, 36303, 10.1074/jbc.M607031200

Gelderman, 2008, Adverse effects of fullerenes on endothelial cells: fullerenol C60(OH)24 induced tissue factor and ICAM-1 membrane expression and apoptosis in vitro, Int. J. Nanomed., 3, 59

Gharbi, 2005, [60] Fullerene is a powerful antioxidant in vivo with no acute or subacute toxicity, Nano Lett., 5, 2578, 10.1021/nl051866b

Gourlay, 2004, A role for the actin cytoskeleton in cell death and aging in yeast, J. Cell Biol., 164, 803, 10.1083/jcb.200310148

Hall, 2007, Characterization of nanoparticles for therapeutics, Nanomedicine, 2, 789, 10.2217/17435889.2.6.789

Harhaji, 2007, Multiple mechanisms underlying the anticancer action of nanocrystalline fullerene, Eur. J. Pharmacol., 568, 89, 10.1016/j.ejphar.2007.04.041

Injac, 2008, Cardioprotective effects of fullerenol C60(OH)24 on a single dose doxorubicin-induced cardiotoxicity in rats with malignant neoplasm, Technol. Cancer Res. Treat., 7, 15, 10.1177/153303460800700102

Injac, 2008, Potential hepatoprotective effects of fullerenol C60(OH)24 in doxorubicin-induced hepatotoxicity in rats with mammary carcinomas, Biomaterials, 29, 3451, 10.1016/j.biomaterials.2008.04.048

Injac, 2008, Acute doxorubicin nephrotoxicity in rats with malignant neoplasm can be successfully treated with fullerenol C60(OH)24 via suppression of oxidative stress, Pharmacol. Rep., 60, 742

Injac, 2009, Protective effects of fullerenol C60(OH)24 against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats with colorectal cancer, Biomaterials, 30, 1184, 10.1016/j.biomaterials.2008.10.060

Klionsky, 2007, Methods for monitoring autophagy from yeast to human, Autophagy, 3, 181, 10.4161/auto.3678

Kochl, 2006, Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes, Traffic, 7, 129, 10.1111/j.1600-0854.2005.00368.x

Komatsu, 2007, Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy deficient mice, Cell, 131, 1149, 10.1016/j.cell.2007.10.035

Lee, 2010, HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy, EMBO, 29, 969, 10.1038/emboj.2009.405

Molitoris, 1996, Cellular ATP depletion induces disruption of the spectrin cytoskeletal network, Am. J. Physiol., 271, F790

Monastyrska, 2008, Arp2 links autophagic machinery with the actin cytoskeleton, Mol. Biol. Cell, 19, 1962, 10.1091/mbc.E07-09-0892

Monteiro-Riviere, 2009, Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line, Toxicol. Appl. Pharmacol., 234, 222, 10.1016/j.taap.2008.09.030

Narendra, 2009, Parkin-induced mitophagy in the pathogenesis of Parkinson disease, Autophagy, 5, 706, 10.4161/auto.5.5.8505

Nicotera, 1992, Calcium-mediated mechanisms in chemically induced cell death, Annu. Rev. Pharmacol. Toxicol., 32, 449, 10.1146/annurev.pa.32.040192.002313

Nishida, 2008, Crosstalk between autophagy and apoptosis in heart disease, Circ. Res., 103, 343, 10.1161/CIRCRESAHA.108.175448

Okuda, 1996, Superoxide radical quenching and cytochrome C peroxidase-like Activity of C60-dimalonic acid, C62(COOH)4, Bioorg. Med. Chem. Lett., 6, 539, 10.1016/0960-894X(96)00064-9

Palacino, 2004, Mitochondrial dysfunction and oxidative damage in parkin-deficient mice, J. Biol. Chem., 279, 18614, 10.1074/jbc.M401135200

Peer, 2007, Nanocarriers as an emerging platform for cancer therapy, Nat. Nanotechnol., 2, 751, 10.1038/nnano.2007.387

Perazella, 2009, Renal vulnerability to drug toxicity, Clin. J. Am. Soc. Nephrol., 4, 1275, 10.2215/CJN.02050309

Petiot, 2000, Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells, J. Biol. Chem., 275, 992, 10.1074/jbc.275.2.992

Pfaller, 1998, Nephrotoxicity testing in vitro- what we know and what we need to know, Environ. Health Perspect., 106, 559

Qingnuan, 2002, Preparation of 99Tm-C60(OH)x and its biodistribution studies, Nucl. Med. Radiol., 29, 707, 10.1016/S0969-8051(02)00313-X

Rodriguez-Enriquez, 2006, Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes, Autophagy, 2, 39, 10.4161/auto.2229

Sayes, 2004, The differential cytotoxicity of water soluble fullerenes, Nano Lett., 4, 1181, 10.1021/nl0489586

Stern, 2008, Nanotechnology safety concerns revisited, Toxicol. Sci., 101, 4, 10.1093/toxsci/kfm169

Stern, 2008, Induction of autophagy in porcine kidney cells by quantum dots: a common cellular response to nanomaterials?, Toxicol. Sci., 106, 140, 10.1093/toxsci/kfn137

Su, 2010, Cellular uptake and cytotoxic evaluation of fullerenol in different cell lines, Toxicology, 269, 155, 10.1016/j.tox.2009.11.015

Takamura, 2008, Enhanced autophagy and mitochondrial aberrations in murine G(M1)-ganliosidosis, Biochem. Biophys. Res. Commun., 367, 616, 10.1016/j.bbrc.2007.12.187

Takenouchi, 2004, Role of caveolin-1 and cytoskeletal proteins, actin, and vimentin, in adipogenesis of bovine intramuscular preadipocyte cells, Cell Biol. Int., 28, 615, 10.1016/j.cellbi.2004.05.003

Tian, 2006, Cytotoxicity of single-wall carbon nanotubes on human fibroblasts, Toxicol. In Vitro, 20, 1202, 10.1016/j.tiv.2006.03.008

Ueng, 1997, Suppression of microsomal cytochrome P450-dependent monooxygenases and mitochondrial oxidative phosphorylation by fullerenol, a polyhydroxylated fullerene C60, Toxicol. Lett., 93, 29, 10.1016/S0378-4274(97)00071-4

Verbeeck, 2009, Pharmacokinetics and dosage adjustment in patients with renal dysfunction, Eur. J. Clin. Pharmacol., 65, 757, 10.1007/s00228-009-0678-8

Walker, 2009, Potential in vitro effects of carbon nanotubes on human aortic endothelial cells, Toxicol. Appl. Pharmacol., 236, 319, 10.1016/j.taap.2009.02.018

Wang, 1999, C60 and water-soluble fullerene derivatives as antioxidants against radical-initiated lipid peroxidation, J. Med. Chem., 42, 4614, 10.1021/jm990144s

Ward, 2010, The amyloid precursor protein intracellular domain (AICD) disrupts actin dynamics and mitochondrial bioenergetics, J. Neurochem., 113, 275, 10.1111/j.1471-4159.2010.06615.x

Williams, 1989, The application of renal cells in culture in studying drug-induced nephrotoxicity, In Vitro Cell. Dev. Biol., 25, 800, 10.1007/BF02623663

Xia, 2006, Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm, Nano Lett., 6, 1794, 10.1021/nl061025k

Xiao, 2005, Antioxidant effects of water-soluble fullerene derivatives against ultraviolet ray or peroxylipid through their action of scavenging the reactive oxygen species in human skin keratinocytes, Biomed. Pharmacother., 59, 351, 10.1016/j.biopha.2005.02.004

Xing, 2004, Influences of structural properties on stability of fullerenols, J. Phys. Chem. B, 108, 11473, 10.1021/jp0487962

Yamago, 1995, In vivo biological behavior of a water-miscible fullerene: 14C labeling, absorption, distribution, excretion and acute toxicity, Chem. Biol., 2, 385, 10.1016/1074-5521(95)90219-8

Yamawaki, 2006, Cytotoxicity of water-soluble fullerene in vascular endothelial cells, Am. J. Physiol. Cell Physiol., 290, 1495, 10.1152/ajpcell.00481.2005

Yang, 2007, Induction of autophagy in neurite degeneration of mouse superior cervical ganglion neurons, Eur. J. Neurosci., 26, 2979, 10.1111/j.1460-9568.2007.05914.x

Yang, 2010, Pharmacological and toxicological target organelles and safe use of single-walled carbon nanotubes as drug carriers in treating Alzheimer disease, Nanomedicine, 6, 427, 10.1016/j.nano.2009.11.007

Zhang, 2007, The role of autophagy in mitochondria maintenance, Autophagy, 3, 337, 10.4161/auto.4127

Zhang, 2007, Synthesis and in vivo study of metallofullerene based MRI contrast agent, J. Radioanal. Nucleic Chem., 272, 605, 10.1007/s10967-007-0632-0

Zhang, 2009, Autophagy-mediated chemosensitization in cancer cells by fullerene C60 nanocrystal, Autophagy, 5, 1, 10.4161/auto.5.8.9842