The Lipid Mediator Protectin D1 Inhibits Influenza Virus Replication and Improves Severe Influenza

Cell - Tập 153 - Trang 112-125 - 2013
Masayuki Morita1, Keiji Kuba1, Akihiko Ichikawa1, Mizuho Nakayama1, Jun Katahira2, Ryo Iwamoto3,4, Tokiko Watanebe5,6,7, Saori Sakabe5,7, Tomo Daidoji8, Shota Nakamura9, Ayumi Kadowaki1, Takayo Ohto1, Hiroki Nakanishi10, Ryo Taguchi10, Takaaki Nakaya8, Makoto Murakami11, Yoshihiro Yoneda2, Hiroyuki Arai3, Yoshihiro Kawaoka5,6,7, Josef M. Penninger12
1Department of Biological Informatics and Experimental Therapeutics, Graduate School of Medicine, Akita University, Akita 010-8543, Japan
2Biomolecular Networks Laboratories, Biomolecular Dynamics Laboratory, Graduate School of Frontier Biosciences, Osaka University, Osaka 565-0871, Japan
3Department of Health Chemistry, University of Tokyo, Tokyo 113-0033, Japan
4Business-Academia-Collaborative Laboratory, Graduate School of Pharmaceutical Science, University of Tokyo, Tokyo 113-0033, Japan
5Division of Virology, Department of Microbiology and Immunology and International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 113-0033, Japan
6ERATO Infection-Induced Host Responses Project, Japan Science and Technology Agency, Saitama 332-0012, Japan
7Influenza Research Institute, University of Wisconsin-Madison, Madison, WI 53711, USA
8Department of Infectious Diseases, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
9Department of Infection Metagenomics, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan
10Department of Metabolome, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan
11Biomembrane Signaling Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan
12IMBA (Institute of Molecular Biotechnology in the Austrian Academy of Sciences), Vienna 1030, Austria

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