Akira, 2006, Pathogen recognition and innate immunity, Cell, 124, 783, 10.1016/j.cell.2006.02.015
Allan, 2001, Cytokines and acute neurodegeneration, Nat Rev Neurosci, 2, 734, 10.1038/35094583
Almawi, 2002, Negative regulation of nuclear factor-kappaB activation and function by glucocorticoids, J Mol Endocrinol, 28, 69, 10.1677/jme.0.0280069
Arnett, 2001, TNFalpha promotes proliferation of oligodendrocyte progenitors and remyelination, Nat Neurosci, 4, 1116, 10.1038/nn738
Beutler, 2000, Tlr4: central component of the sole mammalian LPS sensor, Curr Opin Immunol, 12, 20, 10.1016/S0952-7915(99)00046-1
Bieber, 2003, Efficient central nervous system remyelination requires T cells, Ann Neurol, 53, 680, 10.1002/ana.10578
Blais, 2004, Effects of TNF-alpha and IFN-gamma on nitric oxide-induced neurotoxicity in the mouse brain, J Immunol, 172, 7043, 10.4049/jimmunol.172.11.7043
Blais, 2005, Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli, J Neurochem, 95, 1563, 10.1111/j.1471-4159.2005.03480.x
Blais, 2002, In altering the release of glucocorticoids, ketorolac exacerbates the effects of systemic immune stimuli on expression of proinflammatory genes in the brain, Endocrinology, 143, 4820, 10.1210/en.2002-220598
Bulut, 2001, J Immunol, 167, 987, 10.4049/jimmunol.167.2.987
Butovsky, 2006, Glatiramer acetate fights against Alzheimer’s disease by inducing dendritic-like microglia expressing insulin-like growth factor 1, Proc Natl Acad Sci U S A, 103, 11784, 10.1073/pnas.0604681103
Calza, 1998, Proliferation and phenotype regulation in the subventricular zone during experimental allergic encephalomyelitis: in vivo evidence of a role for nerve growth factor, Proc Natl Acad Sci U S A, 95, 3209, 10.1073/pnas.95.6.3209
Casal, 2002, Relationship between beta-AP peptide aggregation and microglial activation, Brain Res, 928, 76, 10.1016/S0006-8993(01)03362-5
Castano, 1998, Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system, J Neurochem, 70, 1584, 10.1046/j.1471-4159.1998.70041584.x
Cockeran, 2002, The role of pneumolysin in the pathogenesis of Streptococcus pneumoniae infection, Curr Opin Infect Dis, 15, 235, 10.1097/00001432-200206000-00004
Dinkel, 2002, Glucocorticoids and central nervous system inflammation, J Neurovirol, 8, 513, 10.1080/13550280290100914
Fontaine, 2002, Neurodegenerative and neuroprotective effects of tumor necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2, J Neurosci, 22, RC216, 10.1523/JNEUROSCI.22-07-j0001.2002
Foote, 2005, Inflammation stimulates remyelination in areas of chronic demyelination, Brain, 128, 528, 10.1093/brain/awh417
Frenkel, 2005, Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease, J Clin Invest, 115, 2423, 10.1172/JCI23241
Galon, 2002, Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells, FASEB J, 16, 61, 10.1096/fj.01-0245com
Ghosh, 2002, Missing pieces in the NF-kappaB puzzle, Cell, 109, S81, 10.1016/S0092-8674(02)00703-1
Glezer, 2006, Innate immunity triggers oligodendrocyte progenitor reactivity and confines damages to brain injuries, FASEB J, 20, 750, 10.1096/fj.05-5234fje
Glezer, 2003, MK-801 and 7-Ni attenuate the activation of brain NF-kappa B induced by LPS, Neuropharmacology, 45, 1120, 10.1016/S0028-3908(03)00279-X
Glezer, 2003, Modulation of the innate immune response by NMDA receptors has neuropathological consequences, J Neurosci, 23, 11094, 10.1523/JNEUROSCI.23-35-11094.2003
Glezer, 2004, Glucocorticoids: Protectors of the brain during innate immune responses, Neuroscientist, 10, 538, 10.1177/1073858404263494
Gonzalez-Scarano, 1999, Microglia as mediators of inflammatory and degenerative diseases, Annu Rev Neurosci, 22, 219, 10.1146/annurev.neuro.22.1.219
Guo, 2004, Bone marrow transplantation reveals roles for brain macrophage/microglia TNF signaling and nitric oxide production in excitotoxic neuronal death, Neuromol Med, 5, 219, 10.1385/NMM:5:3:219
Hashimoto, 1988, The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein, Cell, 52, 269, 10.1016/0092-8674(88)90516-8
Hashioka, 2005, Amyloid-beta fibril formation is not necessarily required for microglial activation by the peptides, Neurochem Int, 47, 369, 10.1016/j.neuint.2005.05.001
Herx, 2000, Central nervous system-initiated inflammation and neurotrophism in trauma: IL-1beta is required for the production of ciliary neurotrophic factor, J Immunol, 165, 2232, 10.4049/jimmunol.165.4.2232
Hoebe, 2003, Identification of Lps2 as a key transducer of MyD88-independent TIR signalling, Nature, 424, 743, 10.1038/nature01889
Hoshino, 1999, Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product, J Immunol, 162, 3749, 10.4049/jimmunol.162.7.3749
Johnstone, 2001, P-glycoprotein does not protect cells against cytolysis induced by pore-forming proteins, J Biol Chem, 276, 16667, 10.1074/jbc.M010774200
Jones, 2001, Different Toll-like receptor agonists induce distinct macrophage responses, J Leukoc Biol, 69, 1036, 10.1189/jlb.69.6.1036
Kaltschmidt, 1999, Inhibition of NF-kappaB potentiates amyloid beta-mediated neuronal apoptosis, Proc Natl Acad Sci U S A, 96, 9409, 10.1073/pnas.96.16.9409
Kim, 2005, Microglia in health and disease, J Neurosci Res, 81, 302, 10.1002/jnr.20562
Koenigsknecht-Talboo, 2005, Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines, J Neurosci, 25, 8240, 10.1523/JNEUROSCI.1808-05.2005
Kopp, 2003, Recognition of microbial infection by Toll-like receptors, Curr Opin Immunol, 15, 396, 10.1016/S0952-7915(03)00080-3
Kotter, 2005, Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression, Neurobiol Dis, 18, 166, 10.1016/j.nbd.2004.09.019
Kukar, 2005, Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production, Nat Med, 11, 545, 10.1038/nm1235
Lacroix, 1998, The bacterial endotoxin lipopolysaccharide has the ability to target the brain in upregulating its membrane CD14 receptor within specific cellular populations, Brain Pathol, 8, 625, 10.1111/j.1750-3639.1998.tb00189.x
Laflamme, 2003, Cooperation between toll-like receptor 2 and 4 in the brain of mice challenged with cell wall components derived from Gram-negative and Gram-positive bacteria, Eur J Immunol, 33, 1127, 10.1002/eji.200323821
Laflamme, 1999, Effects of systemic immunogenic insults and circulating proinflammatory cytokines on the transcription of the inhibitory factor kappa B alpha within specific cellular populations of the rat brain, J Neurochem, 73, 309, 10.1046/j.1471-4159.1999.0730309.x
Laflamme, 2001, Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating Gram-negative bacterial cell wall components, FASEB J, 15, 155, 10.1096/fj.00-0339com
Laflamme, 2001, Circulating cell wall components derived from Gram-negative and not Gram-positive bacteria cause a profound transcriptional activation of the gene encoding toll-like receptor 2 in the CNS, J Neurochem, 70, 648
Larsen, 2003, Matrix metalloproteinase-9 facilitates remyelination in part by processing the inhibitory NG2 proteoglycan, J Neurosci, 23, 11127, 10.1523/JNEUROSCI.23-35-11127.2003
Lehnardt, 2002, The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS, J Neurosci, 22, 2478, 10.1523/JNEUROSCI.22-07-02478.2002
Lehnardt, 2003, Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway, Proc Natl Acad Sci U S A, 100, 8514, 10.1073/pnas.1432609100
Lemaitre, 1996, The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults, Cell, 86, 973, 10.1016/S0092-8674(00)80172-5
Liu, 2005, LPS receptor (CD14): a receptor for phagocytosis of Alzheimer’s amyloid peptide, Brain, 128, 1778, 10.1093/brain/awh531
Malm, 2005, Bone-marrow-derived cells contribute to the recruitment of microglial cells in response to beta-amyloid deposition in APP/PS1 double transgenic Alzheimer mice, Neurobiol Dis, 18, 134, 10.1016/j.nbd.2004.09.009
Marchetti, 2004, Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation, J Biol Chem, 279, 32869, 10.1074/jbc.M311766200
Mason, 2001, Interleukin-1beta promotes repair of the CNS, J Neurosci, 21, 7046, 10.1523/JNEUROSCI.21-18-07046.2001
Massengale, 2005, Hematopoietic cells maintain hematopoietic fates upon entering the brain, J Exp Med, 201, 1579, 10.1084/jem.20050030
Medvedev, 2003, Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections, J Exp Med, 198, 521, 10.1084/jem.20030701
Medzhitov, 1997, Innate immunity: the virtues of a nonclonal system of recognition, Cell, 91, 295, 10.1016/S0092-8674(00)80412-2
Nadeau, 2000, Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and NF-κB activity in the brain during endotoxemia, J Neurosci, 20, 3456, 10.1523/JNEUROSCI.20-09-03456.2000
Nadeau, 2001, The complement system is an integrated part of the natural innate immune response in the brain, FASEB J, 15, 1410, 10.1096/fj.00-0709fje
Nadeau, 2002, Endotoxemia prevents the cerebral inflammatory wave induced by intraparenchymal lipopolysaccharide injection: role of glucocorticoids and CD14, J Immunol, 169, 3370, 10.4049/jimmunol.169.6.3370
Nadeau, 2003, Glucocorticoids play a fundamental role in protecting the brain during innate immune response, J Neurosci, 23, 5536, 10.1523/JNEUROSCI.23-13-05536.2003
Nau, 2002, Neuronal injury in bacterial meningitis: mechanisms and implications for therapy, Trends Neurosci, 25, 38, 10.1016/S0166-2236(00)02024-5
Nguyen, 2002, Innate immunity: the missing link in neuroprotection and neurodegeneration, Nat Rev Neurosci, 3, 216, 10.1038/nrn752
Ogawa, 2005, Molecular determinants of crosstalk between nuclear receptors and toll-like receptors, Cell, 122, 707, 10.1016/j.cell.2005.06.029
Ogura, 2006, The inflammasome: first line of the immune response to cell stress, Cell, 126, 659, 10.1016/j.cell.2006.08.002
Picard-Riera, 2002, Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice, Proc Natl Acad Sci U S A, 99, 13211, 10.1073/pnas.192314199
Pitzalis, 2002, Regulation of leukocyte-endothelial interactions by glucocorticoids, Ann N Y Acad Sci, 966, 108, 10.1111/j.1749-6632.2002.tb04208.x
Poltorak, 1998, Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene, Science, 282, 2085, 10.1126/science.282.5396.2085
Priller, 2001, Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment, Nat Med, 7, 1356, 10.1038/nm1201-1356
Priller, 2001, Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo, J Cell Biol, 155, 733, 10.1083/jcb.200105103
Priller, 2006, Early and rapid engraftment of bone marrow-derived microglia in scrapie, J Neurosci, 26, 11753, 10.1523/JNEUROSCI.2275-06.2006
Richartz, 2005, Decline of immune responsiveness: A pathogenetic factor in Alzheimer’s disease, J Psychiatr Res, 39, 535, 10.1016/j.jpsychires.2004.12.005
Rogers, 2002, Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide, Glia, 40, 260, 10.1002/glia.10153
Schaaf, 2002, Molecular mechanisms of glucocorticoid action and resistance, J Steroid Biochem Mol Biol, 83, 37, 10.1016/S0960-0760(02)00263-7
Shie, 2005, Microglia lacking E prostanoid receptor subtype 2 have enhanced Abeta phagocytosis yet lack Abeta-activated neurotoxicity, Am J Pathol, 166, 1163, 10.1016/S0002-9440(10)62336-X
Simard, 2004, Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia, FASEB J, 18, 998, 10.1096/fj.04-1517fje
Simard, 2006, Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer’s disease, Neuron, 49, 489, 10.1016/j.neuron.2006.01.022
Sorrells, 2006, An inflammatory review of glucocorticoid actions in the CNS, Brain Behav Immun, 21, 259, 10.1016/j.bbi.2006.11.006
Soulet, 2003, Polyamines play a critical role in the control of the innate immune response in the mouse CNS, J Cell Biol, 162, 257, 10.1083/jcb.200301097
Sreedhar, 2003, Hsp90 inhibition accelerates cell lysis, J Biol Chem, 278, 35231, 10.1074/jbc.M301371200
Sriram, 1997, Indictment of the microglia as the villain in multiple sclerosis, Neurology, 48, 464, 10.1212/WNL.48.2.464
Streit, 2005, Microglia and neuroprotection: implications for Alzheimer’s disease, Brain Res Brain Res Rev, 48, 234, 10.1016/j.brainresrev.2004.12.013
Tahara, 2006, Role of toll-like receptor signalling in Abeta uptake and clearance, Brain, 129, 3006, 10.1093/brain/awl249
Takata, 2003, Possible involvement of small oligomers of amyloid-beta peptides in 15-deoxy-delta 12,14 prostaglandin J2-sensitive microglial activation, J Pharmacol Sci, 91, 330, 10.1254/jphs.91.330
Takeda, 2003, Toll-like receptors, Annu Rev Immunol, 21, 335, 10.1146/annurev.immunol.21.120601.141126
Thibeault, 2001, Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines, J Comp Neurol, 434, 461, 10.1002/cne.1187
Turrin, 2006, Tumor necrosis factor alpha but not interleukin 1beta mediates neuroprotection in response to acute nitric oxide excitotoxicity, J Neurosci, 26, 143, 10.1523/JNEUROSCI.4032-05.2006
Vallières, 1997, Regulation of the genes encoding interleukin-6, its receptor, and gp130 in the rat brain in response to the immune activator lipopolysaccharide and the proinflammatory cytokine interleukin-1β, J Neurochem, 69, 1668, 10.1046/j.1471-4159.1997.69041668.x
Vallieres, 2003, Bone marrow-derived cells that populate the adult mouse brain preserve their hematopoietic identity, J Neurosci, 23, 5197, 10.1523/JNEUROSCI.23-12-05197.2003
Vigo, 1985, Effect of C-reactive protein on platelet-activating factor-induced platelet aggregation and membrane stabilization, J Biol Chem, 260, 3418, 10.1016/S0021-9258(19)83638-4
Villeneuve, 2005, Tumor necrosis factor reduces brain tumor growth by enhancing macrophage recruitment and microcyst formation, Cancer Res, 65, 3928, 10.1158/0008-5472.CAN-04-3612
Vizzardelli, 2006, Effects of dexamethasone on LPS-induced activation and migration of mouse dendritic cells revealed by a genome-wide transcriptional analysis, Eur J Immunol, 36, 1504, 10.1002/eji.200535488
Wald, 2003, SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling, Nat Immunol, 4, 920, 10.1038/ni968
Walker, 2005, Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer’s disease and other neurodegenerative diseases, J Neurosci Res, 81, 412, 10.1002/jnr.20484
Walsh, 2004, Inflammatory processes and Alzheimer’s disease, Expert Rev Neurother, 4, 793, 10.1586/14737175.4.5.793
Wegiel, 2004, Cells of monocyte/microglial lineage are involved in both microvessel amyloidosis and fibrillar plaque formation in APPsw tg mice, Brain Res, 1022, 19, 10.1016/j.brainres.2004.06.058
Wegiel, 2003, Origin and turnover of microglial cells in fibrillar plaques of APPsw transgenic mice, Acta Neuropathol (Berl), 105, 393, 10.1007/s00401-002-0660-3
Wegiel, 2001, The role of microglial cells and astrocytes in fibrillar plaque evolution in transgenic APP(SW) mice, Neurobiol Aging, 22, 49, 10.1016/S0197-4580(00)00181-0
Wyss-Coray, 2002, Inflammation in neurodegenerative disease: a double-edged sword, Neuron, 35, 419, 10.1016/S0896-6273(02)00794-8
Yamamoto, 2003, TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway, Nat Immunol, 4, 1144, 10.1038/ni986
Yin, 2006, Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells, Nat Neurosci, 9, 843, 10.1038/nn1701
Zhang, 2002, Negative regulation of toll-like receptor-mediated signaling by tollip, J Biol Chem, 277, 7059, 10.1074/jbc.M109537200