BMPR2 Germline Mutation in Chronic Thromboembolic Pulmonary Hypertension

Yu-Xuan Feng1, Dong Liu2, Ming-Li Sun2, Xin Jiang3, Na Sun2, Yi-Min Mao1, Zhi-Cheng Jing3
1Department of Respiratory Medicine, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang, China
2Department of Cardio-Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
3State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

Tóm tắt

Heterozygous germline mutations of the bone morphogenetic protein type II receptor (BMPR2) gene BMPR2 are the most important predisposing factors for heritable pulmonary arterial hypertension. BMPR2 mutation was occasionally reported in pulmonary veno-occlusive disease, appetite suppressant-related pulmonary arterial hypertension (PAH), and PAH with congenital heart disease. In this study we identified a missense mutation (c.2296A > G) located in BMPR2 exon 12 in a patient with chronic thromboembolic pulmonary hypertension (CTEPH). It is the first report of a BMPR2 mutation in CTEPH. Our study provides innovative insight into etiology of CTEPH. The genetic predisposing factor is an important component in the process of this CTEPH patient.

Tài liệu tham khảo

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