Inhibiting microRNA-424 in bone marrow mesenchymal stem cells-derived exosomes suppresses tumor growth in colorectal cancer by upregulating TGFBR3

Keramida, 2019, Cardiovascular complications of metastatic colorectal cancer treatment, J. Gastrointest. Oncol., 10, 797, 10.21037/jgo.2019.03.04 Ferlay, 2015, Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012, Int. J. Canc., 136, E359, 10.1002/ijc.29210 Naing, 2017, Immediately modifiable risk factors attributable to colorectal cancer in Malaysia, BMC Publ. Health, 17, 637, 10.1186/s12889-017-4650-8 Song, 2018, Colorectal cancer susceptibility loci and influence on survival, Genes Chromosomes Cancer, 57, 630, 10.1002/gcc.22674 Keum, 2019, Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies, Nat. Rev. Gastroenterol. Hepatol., 16 Rejhova, 2018, Natural compounds and combination therapy in colorectal cancer treatment, Eur. J. Med. Chem., 144, 582, 10.1016/j.ejmech.2017.12.039 Li, 2019, MiR-421 is overexpressed and promotes cell proliferation in non-small cell lung cancer, Med. Princ. Pract., 80 Wang, 2017, Serum microRNA-135a-5p as an auxiliary diagnostic biomarker for colorectal cancer, Ann. Clin. Biochem., 54, 76, 10.1177/0004563216638108 Zhang, 2017, Knockdown of miR-27a sensitizes colorectal cancer stem cells to TRAIL by promoting the formation of Apaf-1-caspase-9 complex, Oncotarget, 8, 45213, 10.18632/oncotarget.16779 Zhou, 2015, MicroRNA-320b promotes colorectal cancer proliferation and invasion by competing with its homologous microRNA-320a, Canc. Lett., 356, 669, 10.1016/j.canlet.2014.10.014 Zhang, 2017, MiR-424 promotes non-small cell lung cancer progression and metastasis through regulating the tumor suppressor gene TNFAIP1, Cell. Physiol. Biochem., 42, 211, 10.1159/000477314 Boldrup, 2015, Downregulation of miRNA-424: a sign of field cancerisation in clinically normal tongue adjacent to squamous cell carcinoma, Br. J. Canc., 112, 1760, 10.1038/bjc.2015.150 Jepsen, 2016, Intra-tumor heterogeneity of microRNA-92a, microRNA-375 and microRNA-424 in colorectal cancer, Exp. Mol. Pathol., 100, 125, 10.1016/j.yexmp.2015.12.004 Bilandzic, 2011, Betaglycan: a multifunctional accessory, Mol. Cell. Endocrinol., 339, 180, 10.1016/j.mce.2011.04.014 Li, 2018, miR-19a and miR-424 target TGFBR3 to promote epithelial-to-mesenchymal transition and migration of tongue squamous cell carcinoma cells, Cell Adhes. Migrat., 12, 236, 10.1080/19336918.2017.1365992 Liu, 2013, Dual role of TGFBR3 in bladder cancer, Oncol. Rep., 30, 1301, 10.3892/or.2013.2599 Ridge, 2017, Mesenchymal stem cells: key players in cancer progression, Mol. Canc., 16, 31, 10.1186/s12943-017-0597-8 Yamashita, 2018, Possibility of exosome-based therapeutics and challenges in production of exosomes eligible for therapeutic application, Biol. Pharm. Bull., 41, 835, 10.1248/bpb.b18-00133 Chen, 2020, MicroRNA-4461 derived from bone marrow mesenchymal stem cell exosomes inhibits tumorigenesis by downregulating COPB2 expression in colorectal cancer, Biosci. Biotechnol. Biochem., 84, 338, 10.1080/09168451.2019.1677452 Ohno, 2013, Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells, Mol. Ther., 21, 185, 10.1038/mt.2012.180 Tu, 2021, Endocytic pathway inhibition attenuates extracellular vesicle-induced reduction of chemosensitivity to bortezomib in multiple myeloma cells, Theranostics, 11, 2364, 10.7150/thno.47996 Zhao, 2019, Long non-coding RNA PVT1 encapsulated in bone marrow mesenchymal stem cell-derived exosomes promotes osteosarcoma growth and metastasis by stabilizing ERG and sponging miR-183-5p, Aging (Albany NY), 11, 9581, 10.18632/aging.102406 Deng, 2021, Bone marrow mesenchymal stem cells-derived exosomal microRNA-19b-3p targets SOCS1 to facilitate progression of esophageal cancer, Life Sci., 278, 119491, 10.1016/j.lfs.2021.119491 Washington, 2010, 7th edition of the AJCC cancer staging manual: stomach, Ann. Surg Oncol., 17, 3077, 10.1245/s10434-010-1362-z Jian, 2015, Bauhinia championii flavone inhibits apoptosis and autophagy via the PI3K/Akt pathway in myocardial ischemia/reperfusion injury in rats, Drug Des. Dev. Ther., 9, 5933 Deng, 2019, Prognostic and predictive role of DNA mismatch repair status in stage II-III colorectal cancer: a systematic review and meta-analysis, Clin. Genet. Sun, 2019, MiR-204 suppresses cell proliferation and promotes apoptosis in ovarian granulosa cells via targeting TPT1 in polycystic ovary syndrome, Biochem. Cell. Biol., 1 Lambert, 2011, The type III transforming growth factor-beta receptor inhibits proliferation, migration, and adhesion in human myeloma cells, Mol. Biol. Cell, 22, 1463, 10.1091/mbc.e10-11-0877 Han, 2018, Downregulation of microRNA-193-3p inhibits the progression of intrahepatic cholangiocarcinoma cells by upregulating TGFBR3, Exp. Ther. Med., 15, 4508 Du, 2019, MicroRNA-424-5p acts as a potential biomarker and inhibits proliferation and invasion in hepatocellular carcinoma by targeting TRIM29, Life Sci., 224, 1, 10.1016/j.lfs.2019.03.028 Jurisic, 2015, Soluble type III TGFbeta receptor in diagnosis and follow-up of patients with breast cancer, Growth Factors, 33, 200 Wang, 2017, Tumour cell-derived WNT5B modulates in vitro lymphangiogenesis via induction of partial endothelial-mesenchymal transition of lymphatic endothelial cells, Oncogene, 36, 1503, 10.1038/onc.2016.317 Wen, 2018, miR-424 coordinates multilayered regulation of cell cycle progression to promote esophageal squamous cell carcinoma cell proliferation, EBioMedicine, 37, 110, 10.1016/j.ebiom.2018.10.043 Liu, 2018, Upregulated lncRNA ADAMTS9-AS2 suppresses progression of lung cancer through inhibition of miR-223-3p and promotion of TGFBR3, IUBMB Life, 70, 536, 10.1002/iub.1752 Huang, 2019, Cancer cell-derived exosomes promote cell proliferation and inhibit cell apoptosis of both normal lung fibroblasts and non-small cell lung cancer cell through delivering alpha-smooth muscle actin, Am. J. Transl. Res., 11, 1711 Wei, 2016, miR-424-5p promotes proliferation of gastric cancer by targeting Smad3 through TGF-beta signaling pathway, Oncotarget, 7, 75185, 10.18632/oncotarget.12092 Zheng, 2013, Transient overexpression of TGFBR3 induces apoptosis in human nasopharyngeal carcinoma CNE-2Z cells, Biosci. Rep., 33, 10.1042/BSR20120047 Hou, 2018, Tumor-derived exosomes enhance invasion and metastasis of salivary adenoid cystic carcinoma cells, J. Oral Pathol. Med., 47, 144, 10.1111/jop.12654 Zhang, 2017, Loss of MiR-424-3p, not miR-424-5p, confers chemoresistance through targeting YAP1 in non-small cell lung cancer, Mol. Carcinog., 56, 821, 10.1002/mc.22536 Xue, 2017, Hypoxic exosomes facilitate bladder tumor growth and development through transferring long non-coding RNA-UCA1, Mol. Canc., 16, 143, 10.1186/s12943-017-0714-8