Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-α secretion in vitro

Nature - Tập 429 Số 6987 - Trang 72-75 - 2004
Kouichi Ozaki1, Katsumi Inoue2, Hiroshi Sato3, Aritoshi Iida4, Yozo Ohnishi1, Akihiro Sekine4, Hideyuki Sato3, Keita Odashiro2, Masakiyo Nobuyoshi2, Masatsugu Hori3, Yusuke Nakamura4, Toshihiro Tanaka1
1Laboratory for Cardiovascular Diseases, SNP Research Center, The Institute of Physical and Chemical Research (RIKEN), 108-8639, Tokyo, Japan
2Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, 802-8555, Japan
3Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine, Suita, 565-0871, Japan
4Laboratory for Genotyping, SNP Research Center, The Institute of Physical and Chemical Research (RIKEN), 230-0045, Yokohama, Japan

Tóm tắt

Từ khóa


Tài liệu tham khảo

Ross, R. Atherosclerosis—an inflammatory disease. N. Engl. J. Med. 340, 115–126 (1999)

Ozaki, K. et al. Functional SNPs in the lymphotoxin-α gene that are associated with susceptibility to myocardial infarction. Nature Genet. 32, 650–654 (2002)

Gitt, M. A., Massa, S. M., Leffler, H. & Barondes, S. H. Isolation and expression of a gene encoding L-14-II, a new human soluble lactose-binding lectin. J. Biol. Chem. 267, 10601–10606 (1992)

Rigaut, G. et al. A generic protein purification method for protein complex characterization and proteome exploration. Nature Biotechnol. 17, 1030–1032 (1999)

Liu, L. B., Omata, W., Kojima, I. & Shibata, H. Insulin recruits GLUT4 from distinct compartments via distinct traffic pathways with differential microtubule dependence in rat adipocytes. J. Biol. Chem. 278, 30157–30169 (2003)

Subramanian, V. S., Marchant, J. S., Parker, I. & Said, H. M. Cell biology of the human thiamine transporter-1 (hTHTR1). Intracellular trafficking and membrane targeting mechanisms. J. Biol. Chem. 278, 3976–3984 (2003)

Schreyer, S. A., Vick, C. M. & LeBoeuf, R. C. L. Loss of lymphotoxin-α but not tumor necrosis factor-α reduces atherosclerosis in mice. J. Biol. Chem. 277, 12364–12368 (2002)

Iida, A. et al. Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH:ubiquinone oxidoreductase flavoproteins. J. Hum. Genet. 46, 668–683 (2001)

Ohnishi, Y. et al. A high-throughput SNP typing system for genome-wide association studies. J. Hum. Genet. 46, 471–477 (2001)

Yamada, R. et al. Association between a single-nucleotide polymorphism in the promoter of the human interleukin-3 gene and rheumatoid arthritis in Japanese patients, and maximum-likelihood estimation of combinatorial effect that two genetic loci have on susceptibility to the disease. Am. J. Hum. Genet. 68, 674–685 (2001)

Minami, M. et al. Expression of SR-PSOX, a novel cell-surface scavenger receptor for phosphatidylserine and oxidized LDL in human atherosclerotic lesions. Arterioscler. Thromb. Vasc. Biol. 21, 1796–1800 (2001)

Shi, S. R., Key, M. E. & Kalra, K. L. Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J. Histochem. Cytochem. 39, 741–748 (1991)

den Dunnen, J. T. & Antonarakis, S. E. Mutation nomenclature extensions and suggestions to describe complex mutations: a discussion. Hum. Mutat. 15, 7–12 (2000)