Lipopolysaccharide differentially modulates expression of cytokines and cyclooxygenases in dorsal root ganglion cells via Toll-like receptor-4 dependent pathways

Acosta, 2008, Bacterial lipopolysaccharide regulates nociceptin expression in sensory neurons, J Neurosci Res, 86, 1077, 10.1002/jnr.21565 Akashi-Takamura, 2008, TLR accessory molecules, Curr Opin Immunol, 20, 420, 10.1016/j.coi.2008.07.001 Araldi, 2013, Peripheral inflammatory hyperalgesia depends on the COX increase in the dorsal root ganglion, Proc Natl Acad Sci U S A, 110, 3603, 10.1073/pnas.1220668110 Barajon, 2009, Toll-like receptors 3, 4, and 7 are expressed in the enteric nervous system and dorsal root ganglia, J Histochem Cytochem, 57, 1013, 10.1369/jhc.2009.953539 Biswas, 2007, Myeloid differentiation factor 88-independent Toll-like receptor pathway: sustaining inflammation or promoting tolerance?, Int J Biochem Cell Biol, 39, 1582, 10.1016/j.biocel.2007.04.021 Brenneis, 2006, Inhibition of prostaglandin E2 synthesis by SC-560 is independent of cyclooxygenase 1 inhibition, FASEB J, 20, 1352, 10.1096/fj.05-5346com Cao, 2009, The contributing role of CD14 in toll-like receptor 4 dependent neuropathic pain, Neuroscience, 158, 896, 10.1016/j.neuroscience.2008.10.004 Ceruti, 2008, Purinoceptor-mediated calcium signaling in primary neuron-glia trigeminal cultures, Cell Calcium, 43, 576, 10.1016/j.ceca.2007.10.003 Cho, 2011, Production of prostaglandin E2 and I2 is coupled with cyclooxygenase-2 in human follicular dendritic cells, Immune Network, 11, 364, 10.4110/in.2011.11.6.364 Davenpeck, 1998, Lipopolysaccharide-induced leukocyte rolling and adhesion in the rat mesenteric microcirculation: regulation by glucocorticoids and role of cytokines, J Immunol, 161, 6861, 10.4049/jimmunol.161.12.6861 Diogenes, 2011, LPS sensitizes TRPV1 via activation of TLR4 in trigeminal sensory neurons, J Dent Res, 90, 759, 10.1177/0022034511400225 Dubový, 2006, Intra- and extraneuronal changes of immunofluorescence staining for TNF-α and TNFR1 in the dorsal root ganglia of rat peripheral neuropathic pain models, Cell Mol Neurobiol, 26, 1203, 10.1007/s10571-006-9006-3 Due, 2012, Neuroexcitatory effects of morphine-3-glucuronide are dependent on Toll-like receptor 4 signaling, J Neuroinflammation, 9, 200, 10.1186/1742-2094-9-200 Eberhardt, 2009, Glyceroltrinitrate facilitates stimulated CGRP release but not gene expression of CGRP or its receptor components in rat trigeminal ganglia, Neuropeptides, 43, 483, 10.1016/j.npep.2009.09.002 Fernyhough, 2005, Activation of nuclear factor-κB via endogenous tumor necrosis factor α regulates survival of axotomized adult sensory neurons, J Neurosci, 25, 1682, 10.1523/JNEUROSCI.3127-04.2005 Ferraz, 2011, Lipopolysaccharide from Porphyromonas gingivalis sensitizes capsaicin-sensitive nociceptors, J Endodontics, 37, 45, 10.1016/j.joen.2007.07.001 Font-Nieves, 2012, Induction of COX-2 enzyme and down-regulation of COX-1 expression by lipopolysaccharide (LPS) control prostaglandin E2 production in astrocytes, J Biol Chem, 287, 6454, 10.1074/jbc.M111.327874 Goethals, 2010, Toll-like receptor expression in the peripheral nerve, Glia, 58, 1701, 10.1002/glia.21041 Hanani, 2005, Satellite glial cells in sensory ganglia: from form to function, Brain Res Rev, 48, 457, 10.1016/j.brainresrev.2004.09.001 Hou, 2001, PKC and PKA, but not PKG mediate LPS-induced CGRP release and [Ca2+]i elevation in DRG neurons of neonatal rats, J Neurosci Res, 66, 592, 10.1002/jnr.1249 Hutchinson, 2013, Low-dose endotoxin potentiates capsaicin-induced pain in man: Evidence for a pain neuroimmune connection, Brain, Behav Immun, 30, 3, 10.1016/j.bbi.2013.03.002 Ichitani, 2001, Cyclooxygenase-1 and cyclooxygenase-2 expression in rat kidney and adrenal gland after stimulation with systemic lipopolysaccharide, Cell Tissue Res, 303, 235, 10.1007/s004410000296 Kawamoto, 2008, TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain, Eur J Pharmacol, 584, 40, 10.1016/j.ejphar.2008.01.026 Kersten, 2013, Epithelial growth factor receptor (EGFR)-inhibition for relief of neuropathic pain - A case series, Scand J Pain, 4, 3, 10.1016/j.sjpain.2012.11.011 Küper, 2012, Toll-like receptor 4 activates NF-κB and MAP kinase pathways to regulate expression of proinflammatory COX-2 in renal medullary collecting duct cells, Am J Physiol Renal Physiol, 302, F38, 10.1152/ajprenal.00590.2010 Lehnardt, 2003, Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway, Proc Natl Acad Sci U S A, 100, 8514, 10.1073/pnas.1432609100 Li, 2004, Cell-specific expression and lipopolysaccharide-induced regulation of tumor necrosis factor α (TNFα) and TNF receptors in rat dorsal root ganglion, J Neurosci, 24, 9623, 10.1523/JNEUROSCI.2392-04.2004 Liu, 2012, Emerging role of toll-like receptors in the control of pain and itch, Neurosci Bull, 28, 131, 10.1007/s12264-012-1219-5 Livak, 2001, Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method, Methods, 25, 402, 10.1006/meth.2001.1262 Loram, 2012, Sex and estradiol influence glial pro-inflammatory responses to lipopolysaccharide in rats, Psychoneuroendocrinology, 37, 1688, 10.1016/j.psyneuen.2012.02.018 Ma, 2008, Does COX2-dependent PGE2 play a role in neuropathic pain?, Neurosci Lett, 437, 165, 10.1016/j.neulet.2008.02.072 McElroy, 2012, Transactivation of EGFR by LPS Induces COX-2 expression in enterocytes, PLoS ONE, 7, e38373, 10.1371/journal.pone.0038373 Miller, 2009, Cytokine and chemokine regulation of sensory neuron function, Handb Exp Pharmacol, 194, 417, 10.1007/978-3-540-79090-7_12 Miyake, 2007, Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors, Sem Immunol, 19, 3, 10.1016/j.smim.2006.12.002 Neeb, 2011, IL-1β stimulates COX-2 dependent PGE2 synthesis and CGRP release in rat trigeminal ganglia cells, PLoS ONE, 6, e17360, 10.1371/journal.pone.0017360 Ng, 2010, The role of glial cells in influencing neurite extension by dorsal root ganglion cells, Neuron Glia Biol, 6, 19, 10.1017/S1740925X09990433 Nicotra, 2012, Toll-like receptors in chronic pain, Exper Neurol, 234, 316, 10.1016/j.expneurol.2011.09.038 Nowicki, 2010, Oxidized low-density lipoprotein (oxLDL)-induced cell death in dorsal root ganglion cell cultures depends not on the lectin-like oxLDL receptor-1 but on the toll-like receptor-4, J Neurosci Res, 88, 403, 10.1002/jnr.22205 Ochoa-Cortes, 2010, Bacterial cell products signal to mouse colonic nociceptive dorsal root ganglia neurons, Am J Physiol Gastrointest Liver Physiol, 299, G723, 10.1152/ajpgi.00494.2009 Ohara, 2013, Toll-like receptor 4 signaling in trigeminal ganglion neurons contributes tongue-referred pain associated with tooth pulp inflammation, J Neuroinflamm, 10, 139, 10.1186/1742-2094-10-139 Ohtori, 2004, TNF-α and TNF-α receptor type 1 upregulation in glia and neurons after peripheral nerve injury, Spine, 29, 1082, 10.1097/00007632-200405150-00006 Okun, 2009, Toll-like receptors in neurodegeneration, Brain Res Rev, 59, 278, 10.1016/j.brainresrev.2008.09.001 Okun, 2011, Toll-like receptor signaling in neural plasticity and disease, Trends Neurosci, 34, 269, 10.1016/j.tins.2011.02.005 Qi, 2011, Painful pathways induced by TLR stimulation of dorsal root ganglion neurons, J Immunol, 186, 6417, 10.4049/jimmunol.1001241 Saito, 2010, Spinal glial TLR4-mediated nociception and production of prostaglandin E2 and TNF, Br J Pharmacol, 160, 1754, 10.1111/j.1476-5381.2010.00811.x Sorge, 2011, Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice, J Neurosci, 31, 15450, 10.1523/JNEUROSCI.3859-11.2011 Stokes, 2013, Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice, J. Neuroinflammation, 10, 148, 10.1186/1742-2094-10-148 Stokes, 2013, Spinal Toll-like receptor signaling and nociceptive processing: Regulatory balance between TIRAP and TRIF cascades mediated by TNF and IFNβ, Pain, 154, 733, 10.1016/j.pain.2013.01.012 Svensson, 2002, The spinal phospholipase-cyclooxygenase-prostanoid cascade in nociceptive processing, Annu Rev Pharmacol Toxicol, 42, 553, 10.1146/annurev.pharmtox.42.092401.143905 Tang, 2007, Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits, Proc Natl Acad Sci U S A, 104, 13798, 10.1073/pnas.0702553104 Tanga, 2005, The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy, Proc Natl Acad Sci U S A, 102, 5856, 10.1073/pnas.0501634102 Tegeder, 2004, Specific inhibition of IκB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats, J Neurosci, 24, 1637, 10.1523/JNEUROSCI.3118-03.2004 Wadachi, 2006, Trigeminal nociceptors express TLR-4 and CD14: a mechanism for pain due to infection, J Dental Res, 85, 49, 10.1177/154405910608500108 Zhang, 2007, Signal transduction pathways for epidermal growth factor stimulated cyclooxygenase-2 induction in astrocytes, Exper Eye Res, 85, 280, 10.1016/j.exer.2007.05.002 Zheng, 2007, Dissociation of dorsal root ganglion neurons induces hyperexcitability that is maintained by increased responsiveness to cAMP and cGMP, J Neurophysiol, 97, 15, 10.1152/jn.00559.2006 Zuo, 2001, Expression of lipopolysaccharide binding protein and its receptor CD14 in experimental alcoholic liver disease, World J Gastroenterol, 7, 836, 10.3748/wjg.v7.i6.836