Autonomic receptor systems in the failing and aging human heart: similarities and differences

Arnold, 1984, Vagal activity is increased during intravenous isoprenaline infusion in man, Br. J. Clin. Pharmacol., 18, 311, 10.1111/j.1365-2125.1984.tb02469.x Asano, 2002, Altered expression of endothelin receptors in failing human left ventricles, J. Mol. Cell. Cardiol., 34, 833, 10.1006/jmcc.2002.2022 Benfey, 1993, Functions of myocardial α-adrenoceptors, J. Auton. Pharmacol., 13, 351, 10.1111/j.1474-8673.1993.tb00283.x Böhm, 1988, α-Adrenoceptors and α-adrenoceptor-mediated positive inotropic effects in the failing human myocardium, J. Cardiovasc. Pharmacol., 12, 357, 10.1097/00005344-198809000-00015 Böhm, 1990, Increase of Giα in human hearts with dilated but not ischemic cardiomyopathy, Circulation, 82, 1249, 10.1161/01.CIR.82.4.1249 Böhm, 1990, Beta adrenoceptors and m-cholinoceptors in myocardium of hearts with coronary artery disease or idiopathic dilated cardiomyopathy removed at cardiac transplantation, Am. J. Cardiol., 66, 880, 10.1016/0002-9149(90)90376-C Böhm, 1995, Evidence for reduction of noradrenaline uptake sites in the failing human heart, J. Am. Coll. Cardiol., 25, 146, 10.1016/0735-1097(94)00353-R Bristow, 1993, Changes in myocardial and vascular receptors in heart failure, J. Am. Coll. Cardiol., 22, 61A, 10.1016/0735-1097(93)90465-D Bristow, 1982, Decreased catecholamine sensitivity and β-adrenergic-receptor density in failing human hearts, N. Engl. J. Med., 307, 205, 10.1056/NEJM198207223070401 Bristow, 1988, Alpha-1 adrenergic receptors in the nonfailing and failing human heart, J. Pharmacol. Exp. Ther., 247, 1039 Brodde, 1993, β-Adrenoceptors in cardiac disease, Pharmacol. Ther., 60, 405, 10.1016/0163-7258(93)90030-H Brodde, 1999, Adrenergic and muscarinic receptors in the human heart, Pharmacol. Rev., 51, 651 Brodde, 1995, Signal transduction mechanisms controlling cardiac contractility and their alterations in chronic heart failure, Cardiovasc. Res., 30, 570, 10.1016/0008-6363(95)00152-2 Brodde, 1995, Age dependent changes in the β-adrenoceptor–G-protein(s)–adenylyl cyclase system in human right atrium, J. Cardiovasc. Pharmacol., 26, 20, 10.1097/00005344-199507000-00004 Brodde, 1998, Cardiac muscarinic receptors decrease with age: in vitro and in vivo studies, J. Clin. Invest., 101, 471, 10.1172/JCI1113 Brodde, 1998, Diminished responsiveness of Gs-coupled receptors in severely failing human hearts: no difference in dilated versus ischemic cardiomyopathy, J. Cardiovasc. Pharmacol., 31, 585, 10.1097/00005344-199804000-00018 Brown, 1992, Spare receptors for β-adrenoceptor-mediated positive inotropic effects of catecholamines in the human heart, J. Cardiovasc. Pharmacol., 19, 222, 10.1097/00005344-199202000-00011 Bruck, 2003, Effects of atropine on human cardiac β1- and/or β2-adrenoceptor stimulation, Naunyn-Schmiedeberg's Arch. Pharmacol., 367, 572, 10.1007/s00210-003-0757-9 Calzada, 2001, Alpha-adrenoceptor subtypes, Pharmacol. Res., 44, 195, 10.1006/phrs.2001.0857 Caulfield, 1993, Muscarinic receptors: characterization, coupling and function, Pharmacol. Ther., 58, 319, 10.1016/0163-7258(93)90027-B Caulfield, 1998, International Union of Pharmacology XVII. Classification of muscarinic acetylcholine receptors, Pharmacol. Rev., 50, 279 Chesley, 2000, The β2-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3′-kinase, Circ. Res., 87, 1172, 10.1161/01.RES.87.12.1172 Chidsey, 1966, Sympathetic activity and neurotransmitter depletion in congestive heart failure, Pharmacol. Rev., 18, 685 Cohn, 1990, Abnormalities of peripheral sympathetic nervous system control in congestive heart failure, Circulation, 82, I-59 Cohn, 1984, Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure, N. Engl. J. Med., 305, 185 Communal, 1999, Opposing effects of beta(1)- and beta(2)-adrenergic receptors on cardiac myocyte apoptosis: role of a pertussis toxin-sensitive G protein, Circulation, 100, 2210, 10.1161/01.CIR.100.22.2210 Davies, 1996, β-Adrenoceptor function changes with age of subject in myocytes from non-failing human ventricle, Cardiovasc. Res., 31, 152 Dhein, 2001, Muscarinic receptors in the mammalian heart, Pharmacol. Res., 44, 161, 10.1006/phrs.2001.0835 Docherty, 1990, Cardiovascular responses in ageing: a review, Pharmacol. Rev., 42, 104 Eckberg, 1971, Defective parasympathetic control in patients with heart disease, N. Engl. J. Med., 285, 877, 10.1056/NEJM197110142851602 Eisenhofer, 1996, Cardiac sympathetic nerve function in congestive heart failure, Circulation, 93, 1667, 10.1161/01.CIR.93.9.1667 El-Armouche, 2003, Inhibitory G-proteins and their role in desensitization of the adenylyl cyclase pathway in heart failure, Cardiovasc. Res., 60, 478, 10.1016/j.cardiores.2003.09.014 Erne, 1988, Impaired beta-adrenergic receptor and normal postreceptor responsiveness in congestive heart failure, Am. J. Cardiol., 61, 1132, 10.1016/0002-9149(88)90146-4 Eschenhagen, 1996, Chronic treatment with carbachol sensitizes the myocardium to cAMP-induced arrhythmia, Circulation, 93, 763, 10.1161/01.CIR.93.4.763 Esler, 1979, Determination of norepinephrine apparent release rate and clearance in humans, Life Sci., 25, 1461, 10.1016/0024-3205(79)90371-0 Esler, 1990, Overflow of catecholamine neurotransmitters to the circulation: source, fate, and functions, Physiol. Rev., 70, 963, 10.1152/physrev.1990.70.4.963 Esler, 1997, Adrenergic nervous system in heart failure, Am. J. Cardiol., 80, 7L, 10.1016/S0002-9149(97)00844-8 Ferrara, 1997, Alterations in β-adrenoceptor mechanisms in the aging heart. Relationship with heart failure, Aging Clin. Exp. Res., 9, 391, 10.1007/BF03339620 Folkow, 1993, Physiology of cardiovascular ageing, Physiol. Rev., 73, 725, 10.1152/physrev.1993.73.4.725 Folkow, 1983, Measurements of plasma norepinephrine concentrations in human primary hypertension, Hypertension, 5, 399, 10.1161/01.HYP.5.4.399 Fouad, 1984, Assessment of parasympathetic control of heart rate by a noninvasive method, Am. J. Physiol., 246, H838 Francis, 1986, The autonomic nervous system in congestive heart failure, Annu. Rev. Med., 37, 235, 10.1146/annurev.me.37.020186.001315 Fu, 1992, Increase in functional activity rather than in amount of Gi-α in failing human heart with dilated cardiomyopathy, Cardiovasc. Res., 26, 950, 10.1093/cvr/26.10.950 Gauthier, 2000, β3-Adrenoceptors in the cardiovascular system, Trends Pharmacol. Sci., 21, 426, 10.1016/S0165-6147(00)01562-5 Giessler, 1998, Age-dependent decrease in the negative inotropic effect of carbachol on isolated human right atrium, Eur. J. Pharmacol., 357, 199, 10.1016/S0014-2999(98)00568-8 Giessler, 1999, Muscarinic receptors in the failing human heart, Eur. J. Pharmacol., 375, 197, 10.1016/S0014-2999(99)00261-7 Goldstein, 1988, Plasma catecholamines and essential hypertension: an analytical review, Hypertension, 5, 86, 10.1161/01.HYP.5.1.86 Grimm, 1998, Inactivation of Giα proteins increases arrhythmogenic effects of β-adrenergic stimulation in the heart, J. Mol. Cell. Cardiol., 30, 1917, 10.1006/jmcc.1998.0769 Hellgren, 2000, Muscarinic M3 receptor subtype gene expression in the human heart, Cell. Mol. Life Sci., 57, 175, 10.1007/s000180050507 Hieble, 1995, International Union of Pharmacology X. Recommendation for nomenclature of α1-adrenoceptors: consensus update, Pharmacol. Rev., 47, 267 Hwang, 1996, α1-Adrenergic receptor coupling with Gh in the failing human heart, Circulation, 94, 718, 10.1161/01.CIR.94.4.718 Iaccarino, 1999, Beta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- and not alpha1-adrenergic stimulation, Hypertension, 33, 396, 10.1161/01.HYP.33.1.396 Jakubetz, 2000, Human cardiac β1- or β2-adrenergic receptor stimulation and the negative chronotropic effect of low-dose pirenzepine, Clin. Pharmacol. Ther., 67, 549, 10.1067/mcp.2000.105989 Lakatta, 1993, Cardiovascular regulatory mechanisms in advanced age, Physiol. Rev., 73, 413, 10.1152/physrev.1993.73.2.413 La Rovere, 1994, Scopolamine improves autonomic balance in advanced congestive heart failure, Circulation, 90, 838, 10.1161/01.CIR.90.2.838 Le Guludec, 1997, Increased myocardial muscarinic receptor density in idiopathic dilated cardiomyopathy. An in vivo PET study, Circulation, 96, 3416, 10.1161/01.CIR.96.10.3416 Leimbach, 1986, Direct evidence from intraneuronal recordings for increased central sympathetic outflow in patients with heart failure, Circulation, 73, 913, 10.1161/01.CIR.73.5.913 Leineweber, 2002, Age-dependent changes of cardiac neuronal noradrenaline reuptake transporter (uptake1) in the human heart, J. Am. Coll. Cardiol., 40, 1459, 10.1016/S0735-1097(02)02168-X Leineweber, 2003, Unchanged G-protein-coupled receptor kinase activity in the aging human heart, J. Am. Coll. Cardiol., 42, 1487, 10.1016/S0735-1097(03)01063-5 Leineweber, 2004, β-Adrenoceptor polymorphisms, Naunyn-Schmiedeberg's Arch. Pharmacol., 369, 1, 10.1007/s00210-003-0824-2 Li, 1997, Myocardial α1-adrenoceptor: inotropic effect and physiologic and pathologic implications, Life Sci., 60, 1305, 10.1016/S0024-3205(96)00650-9 Liu, 1999, Screening of serum autoantibodies to cardiac beta1-adrenoceptors and M2-muscarinic acetylcholine receptors in 408 subjects of varying ages, Autoimmunity, 29, 43, 10.3109/08916939908995971 Lohse, 2004, What is the role of β-adrenergic signaling in heart failure?, Circ. Res., 93, 896, 10.1161/01.RES.0000102042.83024.CA McDevitt, 1989, In vivo studies on the function of cardiac β-adrenoceptors in man, Eur. Heart J., 10, 22, 10.1093/eurheartj/10.suppl_B.22 Michel, 1995, Classification of α1-adrenoceptor subtypes, Naunyn-Schmiedeberg's Arch. Pharmacol., 352, 1, 10.1007/BF00169183 Näbauer, 1988, Positive inotropic effects in isolated ventricular myocardium from non-failing and terminally failing human hearts, Eur. J. Clin. Investig., 18, 600, 10.1111/j.1365-2362.1988.tb01274.x Ng, 1993, Age and gender influence muscle sympathetic nerve activity at rest in healthy humans, Hypertension, 21, 498, 10.1161/01.HYP.21.4.498 Oberhauser, 2001, Acetylcholine release in human heart atrium: influence of muscarinic autoreceptors, diabetes and age, Circulation, 103, 1638, 10.1161/01.CIR.103.12.1638 O'Brien, 1986, Heart rate variability in healthy subjects: effect of age and derivation of normal ranges for tests of autonomic function, Br. Heart J., 55, 348, 10.1136/hrt.55.4.348 Penn, 2000, Regulation of G-protein coupled receptor kinases, Trends Cardiovasc. Med., 10, 81, 10.1016/S1050-1738(00)00053-0 Petch, 1979, Uptake of catecholamines by human cardiac muscle in vitro, Br. Heart J., 41, 336, 10.1136/hrt.41.3.336 Pfeifer, 1983, Differential changes of autonomic nervous system function with age in man, Am. J. Med., 75, 249, 10.1016/0002-9343(83)91201-9 Pieske, 1999, Functional effects of endothelin and regulation of endothelin receptors in isolated human nonfailing and failing myocardium, Circulation, 99, 1802, 10.1161/01.CIR.99.14.1802 Pitschner, 1988, Dose–response curves of pirenzepine in man in relation to M1- and M2-cholinoceptor occupancy, Naunyn-Schmiedeberg's Arch. Pharmacol., 338, 207, 10.1007/BF00174872 Poller, 1997, Age-dependent changes in cardiac muscarinic receptor function in healthy volunteers, J. Am. Coll. Cardiol., 29, 187, 10.1016/S0735-1097(96)00437-8 Pönicke, 1998, Endothelin receptors in the failing and nonfailing human heart, Circulation, 97, 744, 10.1161/01.CIR.97.8.744 Pönicke, 2001, Noradrenaline-induced increase in protein synthesis in adult rat cardiomyocytes: involvement of α1A-adrenoceptors, Naunyn-Schmiedeberg's Arch. Pharmacol., 364, 444, 10.1007/s002100100469 Pönicke, 2003, Role of β1- and β2-adrenoceptors in hypertrophic and apoptotic effects of noradrenaline and adrenaline in adult rat ventricular cardiomyocytes, Naunyn-Schmiedeberg's Arch. Pharmacol., 367, 592, 10.1007/s00210-003-0754-z Port, 2001, Altered beta-adrenergic receptor gene regulation and signaling in chronic heart failure, J. Mol. Cell. Cardiol., 33, 887, 10.1006/jmcc.2001.1358 Porter, 1990, Autonomic pathophysiology in heart failure patients. Sympathetic–cholinergic interrelations, J. Clin. Invest., 85, 1362, 10.1172/JCI114580 Rector, 1987, Predicting survival for an individual with congestive heart failure using the plasma norepinephrine concentration, Am. Heart J., 114, 148, 10.1016/0002-8703(87)90318-8 Schlüter, 1999, Regulation of growth in the adult cardiomyocytes, FASEB J., 13, S17, 10.1096/fasebj.13.9001.s17 Schwinger, 1990, Evidence against spare or uncoupled β-adrenoceptors in the human heart, Am. Heart J., 119, 899, 10.1016/S0002-8703(05)80329-1 Seals, 2000, Human ageing and sympathoadrenal system, J. Physiol., 528, 407, 10.1111/j.1469-7793.2000.00407.x Serneri, 2000, Selective upregulation of cardiac endothelin system in patients with ischemic but not idiopathic dilated cardiomyopathy: endothelin-1 system in the human failing heart, Circ. Res., 86, 377, 10.1161/01.RES.86.4.377 Simpson, 1983, Noradrenaline-stimulated hypertrophy of cultured rat myocardial cells is an alpha 1-adrenergic response, J. Clin. Invest., 72, 732, 10.1172/JCI111023 Steinberg, 1999, The molecular basis for distinct β-adrenergic receptor subtype action in cardiomyocytes, Circ. Res., 85, 1101, 10.1161/01.RES.85.11.1101 Steinfath, 1992, Reduced α1- and β2-adrenoceptor-mediated positive inotropic effects in human end-stage heart failure, Br. J. Pharmacol., 105, 463, 10.1111/j.1476-5381.1992.tb14276.x Sundlof, 1978, Human muscle nerve sympathetic activity at rest. Relationship to blood pressure and age, J. Physiol., 274, 621, 10.1113/jphysiol.1978.sp012170 Terzic, 1993, Cardiac α1-adrenoceptors: an overview, Pharmacol. Rev., 45, 147 Vago, 1989, Identification of α1-adrenergic receptors on sarcolemma from normal subjects and patients with idiopathic dilated cardiomyopathy: characteristics and linkage to GTP-binding protein, Circ. Res., 64, 474, 10.1161/01.RES.64.3.474 Walker, 2001, Beta-adrenergic and endothelin receptor interaction in dilated cardiomyopathic myocardium, J. Card. Fail., 7, 129, 10.1054/jcaf.2001.24125 Wangemann, 2003, The indirect negative inotropic effect of carbachol in β1-adrenoceptor antagonist-treated human right atria, Eur. J. Pharmacol., 458, 163, 10.1016/S0014-2999(02)02763-2 White, 1994, Aging and cardiovascular responsiveness to β-agonist in humans: role of changes in β responses versus baroreflex activity, Clin. Pharmacol. Ther., 56, 543, 10.1038/clpt.1994.176 White, 1994, Age-related changes in β-adrenergic neuroeffector systems in the human heart, Circulation, 90, 1225, 10.1161/01.CIR.90.3.1225 White, 1998, Age, hypertension, and cardiac responses to β-agonist in humans, Clin. Pharmacol. Ther., 63, 663, 10.1016/S0009-9236(98)90090-X Willmy-Matthes, 2003, Existence of functional M3-muscarinic receptors in the human heart, Naunyn-Schmiedeberg's Arch. Pharmacol., 368, 316, 10.1007/s00210-003-0796-2 Xiao, 1998, Age-associated reductions of cardiac β1- and β2-adrenergic responses without changes in inhibitory G proteins or receptor kinases, J. Clin. Invest., 101, 1273, 10.1172/JCI1335 Xiao, 1999, Recent advances in cardiac β2-adrenergic signal transduction, Circ. Res., 85, 1092, 10.1161/01.RES.85.11.1092 Yoshikawa, 1996, Cardiac adrenergic receptor effects of carvedilol, Eur. Heart J., 17, 8, 10.1093/eurheartj/17.suppl_B.8 Ziegler, 1976, Plasma noradrenaline increases with age, Nature, 261, 333, 10.1038/261333a0 Zolk, 1999, Expression of endothelin-1, endothelin-converting enzyme, and endothelin receptors in chronic heart failure, Circulation, 99, 2118, 10.1161/01.CIR.99.16.2118