Striatal contributions to working memory: a functional magnetic resonance imaging study in humans

European Journal of Neuroscience - Tập 19 Số 3 - Trang 755-760 - 2004
Simon J.G. Lewis1,2, Anja Dove3, Trevor W. Robbins4, Roger A. Barker1,2, Adrian M. Owen3
1Cambridge Centre for Brain Repair, Forvie Site, Addenbrooke's Hospital, Cambridge, CB2 2PY, UK
2Department of Neurology, University of Cambridge, UK
3Medical Research Council, Cognition and Brain Sciences Unit, Cambridge, UK
4Department of Experimental Psychology, University of Cambridge, UK

Tóm tắt

AbstractAlthough the role of the frontal cortex in executive performance has been widely accepted, issues regarding the contribution of subcortical structures to these functions remain unresolved. In this study, the neural circuitry underlying selective subcomponents of working memory was investigated using event‐related functional magnetic resonance imaging (fMRI). Ten healthy volunteers performed a verbal memory task, which allowed different aspects of working memory function such as maintenance, retrieval and manipulation to be tested within the same general paradigm. During performance of this task as a whole, fMRI revealed increases in signal intensity throughout the frontostriatal network. However, when signal intensity during the manipulation of information within working memory was compared to that during periods requiring only simple maintenance and retrieval, significant changes were observed only in the caudate nuclei, bilaterally. These results suggest an essential and specific role for the caudate nucleus in executive function, which may underlie the cognitive disturbances observed in frontostriatal neurodegenerative disorders such as Parkinson's disease.

Từ khóa


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European Journal of Neuroscience

Tập 19 Số 3

755-760

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