Polygonumnolides A1–B3, minor dianthrone derivatives from the roots of Polygonum multiflorum Thunb

Jian‐Bo Yang1, Yan Zheng1, Jin Ren1, Zhong Dai2, Shuang‐Cheng Ma2, Aiguo Wang1, Ya‐Lun Su1
1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, People's Republic of China
2Research and Inspection Center of Traditional Chinese Medicine and Ethnomedicine, National Institutes for Food and Drug Control, State Food and Drug Administration, Beijing, 100050, People’s Republic of China

Tóm tắt

Abstract Seven new dianthrone glycosides, named polygonumnolides A1–B3 (17), were isolated from the 70 % EtOH extract of the dried roots of Polygonum multiflorum Thunb. using column chromatography and preparative high-performance liquid chromatography. Their structures were determined by 1D and 2D NMR and mass spectroscopy. The isolated compounds were evaluated for their cytotoxic effects against KB tumor cell lines and compounds 14 showed moderate cytotoxicity.

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