Phase 1 clinical trial of adoptive immunotherapy using “off-the-shelf” activated natural killer cells in patients with refractory and relapsed acute myeloid leukemia

Cytotherapy - Tập 19 - Trang 1225-1232 - 2017
Michael Boyiadzis1, Mounzer Agha1, Robert L. Redner1, Alison Sehgal1, Annie Im1, Jing-Zhou Hou1, Rafic Farah1, Kathleen A. Dorritie1, Anastasios Raptis1, Seah H. Lim1, Hong Wang1, Natalia Lapteva2, Zhuyong Mei2, Lisa H. Butterfield1, Cliona M. Rooney2, Theresa L. Whiteside1
1University of Pittsburgh, UPMC Hillman Cancer Center, Pittsburgh, PA, USA
2Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children’s Hospital and Houston Methodist Hospital, Houston, TX, USA

Tài liệu tham khảo

Childs, 2015, Therapeutic approaches to enhance natural killer cell cytotoxicity against cancer: the force awakens, Nat Rev Drug Discov, 14, 487, 10.1038/nrd4506 Bjorkstrom, 2016, Emerging insights into natural killer cells in human peripheral tissues, Nat Rev Immunol, 16, 310, 10.1038/nri.2016.34 Ruggeri, 2002, Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants, Science, 295, 2097, 10.1126/science.1068440 Ruggeri, 2007, Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value, Blood, 110, 433, 10.1182/blood-2006-07-038687 Costello, 2002, Defective expression and function of natural killer cell-triggering receptors in patients with acute myeloid leukemia, Blood, 99, 3661, 10.1182/blood.V99.10.3661 Szczepanski, 2010, Interleukin-15 enhances natural killer cell cytotoxicity in patients with acute myeloid leukemia by upregulating the activating NK cell receptors, Cancer Immunol Immunother, 59, 73, 10.1007/s00262-009-0724-5 Tajima, 1996, Natural killer cell activity and cytokine production as prognostic factors in adult acute leukemia, Leukemia, 10, 478 Gong, 1994, Characterization of a human cell line (NK-92) with phenotypical and functional characteristics of activated natural killer cells, Leukemia, 8, 652 Klingemann, 1996, A cytotoxic NK-cell line (NK-92) for ex vivo purging of leukemia from blood, Biol Blood Marrow Transplant, 2, 68 Yan, 1998, Antileukemia activity of a natural killer cell line against human leukemias, Clin Cancer Res, 4, 2859 Swerdlow, 2008 Arai, 2008, Infusion of the allogeneic cell line NK-92 in patients with advanced renal cell cancer or melanoma: a phase I trial, Cytotherapy, 10, 625, 10.1080/14653240802301872 Tonn, 2013, Treatment of patients with advanced cancer with the natural killer cell line NK-92, Cytotherapy, 15, 1563, 10.1016/j.jcyt.2013.06.017 Cheson, 2003, Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia, J Clin Oncol, 21, 4642, 10.1200/JCO.2003.04.036 Knorr, 2014, Clinical utility of natural killer cells in cancer therapy and transplantation, Semin Immunol, 26, 161, 10.1016/j.smim.2014.02.002 Miller, 2013, Therapeutic applications: natural killer cells in the clinic, Hematology, 2013, 247, 10.1182/asheducation-2013.1.247 Klingemann, 2016, Natural Killer cells for immunotherapy—advantages of the NK-92 cell line over blood NK cells, Front Immunol, 7, 91, 10.3389/fimmu.2016.00091 Suck, 2016, NK-92: an “off-the-shelf therapeutic” for adoptive natural killer cell-based cancer immunotherapy, Cancer Immunol Immunother, 65, 485, 10.1007/s00262-015-1761-x Bachanova, 2014, Clearance of acute myeloid leukemia by haploidentical natural killer cells is improved using IL-2 diphtheria toxin fusion protein, Blood, 123, 3855, 10.1182/blood-2013-10-532531 Curti, 2011, Successful transfer of alloreactive haploidentical KIR ligand-mismatched natural killer cells after infusion in elderly high risk acute myeloid leukemia patients, Blood, 118, 3273, 10.1182/blood-2011-01-329508 Miller, 2005, Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer, Blood, 105, 3051, 10.1182/blood-2004-07-2974 Rubnitz, 2010, NKAML: a pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia, J Clin Oncol, 28, 955, 10.1200/JCO.2009.24.4590 Nannmark, 2000, Tumor blood supply and tumor localization by adoptively transferred IL-2 activated natural killer cells, In Vivo, 14, 651 Pegram, 2010, Characterizing the anti-tumor function of adoptively transferred NK cells in vivo, Cancer Immunol Immunother, 59, 1235, 10.1007/s00262-010-0848-7 Boyiadzis, 2016, Circulating exosomes carrying an immunosuppressive cargo interfere with adoptive cell therapy in acute myeloid leukemia, Blood, 128, 1609, 10.1182/blood.V128.22.1609.1609 Boyiadzis, 2008, Up-regulation of NK cell activating receptors following allogeneic hematopoietic stem cell transplantation under a lymphodepleting reduced intensity regimen is associated with elevated IL-15 levels, Biol Blood Marrow Transplant, 14, 290, 10.1016/j.bbmt.2007.12.490 Chik, 2003, Elevated serum interleukin-15 level in acute graft-versus-host disease after hematopoietic cell transplantation, J Pediatr Hematol Oncol, 25, 960, 10.1097/00043426-200312000-00011