IL-1β and IFN-γ induce the expression of diverse chemokines and IL-15 in human and rat pancreatic islet cells, and in islets from pre-diabetic NOD mice

Kukreja A, Maclaren NK (1999) Autoimmunity and diabetes. J Clin Endocrinol Metab 84:4371–4378 Yoon JW, Jun HS, Santamaria P (1998) Cellular and molecular mechanisms for the initiation and progression of β-cell destruction resulting from the collaboration between macrophages and T cells. Autoimmunity 27:109–122 Thomas HE, Kay TW (2000) β-Cell destruction in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse. Diabetes Metab Res Rev 16:251–261 Casteels K, Waer M, Bouillon R et al. (1998) 1,25-Dihydroxyvitamin D3 restores sensitivity to cyclophosphamide-induced apoptosis in non-obese diabetic (NOD) mice and protects against diabetes. Clin Exp Immunol 112:181–187 Makino S, Kunimoto K, Muraoka Y, Mizushima Y, Katagiri K, Tochino Y (1980) Breeding of a non-obese, diabetic strain of mice. Jikken Dobutsu 29:1–13 Eizirik DL, Mandrup-Poulsen T (2001) A choice of death-the signal-transduction of immune-mediated β-cell apoptosis. Diabetologia 44:2115–2133 Chen MC, Schuit F, Eizirik DL (1999) Identification of IL-1β-induced messenger RNAs in rat pancreatic β-cells by differential display of messenger RNA. Diabetologia 42:1199–1203 Chen MC, Proost P, Gysemans C, Mathieu C, Eizirik DL (2001) Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 β-exposed human and rat islet cells. Diabetologia 44:325–332 Cardozo AK, Kruhoffer M, Leeman R, Orntoft T, Eizirik DL (2001) Identification of novel cytokine-induced genes in pancreatic β-cells by high-density oligonucleotide arrays. Diabetes 50:909–920 Cardozo AK, Heimberg H, Heremans Y et al. (2001) A comprehensive analysis of cytokine-induced and nuclear factor-κB-dependent genes in primary rat pancreatic β-cells. J Biol Chem 276:48879–48886 Luster AD (1998) Chemokines-chemotactic cytokines that mediate inflammation. N Engl J Med 338:436–445 Arimilli S, Ferlin W, Solvason N, Deshpande S, Howard M, Mocci S (2000) Chemokines in autoimmune diseases. Immunol Rev 177:43–51 Loetscher M, Loetscher P, Brass N, Meese E, Moser B (1998) Lymphocyte-specific chemokine receptor CXCR3: regulation, chemokine binding and gene localization. Eur J Immunol 28:3696–3705 Taub DD, Sayers TJ, Carter CR, Ortaldo JR (1995) Alpha and beta chemokines induce NK cell migration and enhance NK-mediated cytolysis. J Immunol 155:3877–3888 Garcia-Lopez MA, Sancho D, Sanchez-Madrid F, Marazuela M (2001) Thyrocytes from autoimmune thyroid disorders produce the chemokines IP-10 and Mig and attract CXCR3+ lymphocytes. J Clin Endocrinol Metab 86:5008–5016 Kieseier BC, Tani M, Mahad D et al. (2002) Chemokines and chemokine receptors in inflammatory demyelinating neuropathies: a central role for IP-10. Brain 125:823–834 Fife BT, Kennedy KJ, Paniagua MC et al. (2001) CXCL10 (IFN-γ-inducible protein-10) control of encephalitogenic CD4+ T cell accumulation in the central nervous system during experimental autoimmune encephalomyelitis. J Immunol 166:7617–7624 Shimada A, Morimoto J, Kodama K et al. (2001) Elevated serum IP-10 levels observed in type 1 diabetes. Diabetes Care 24:510–515 Hieshima K, Imai T, Opdenakker G et al. (1997) Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. J Biol Chem 272:5846–5853 Power CA, Church DJ, Meyer A et al. (1997) Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3α from lung dendritic cells. J Exp Med 186:825–835 Liao F, Rabin RL, Smith CS, Sharma G, Nutman TB, Farber JM (1999) CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3α. J Immunol 162:186–194 Homey B, Dieu-Nosjean MC, Wiesenborn A et al. (2000) Up-regulation of macrophage inflammatory protein-3α/CCL20 and CC chemokine receptor 6 in psoriasis. J Immunol 164:6621–6632 Nakayama T, Fujisawa R, Yamada H et al. (2001) Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3α/CCL20 by epidermal keratinocytes and its role in atopic dermatitis. Int Immunol 13:95–103 Matsui T, Akahoshi T, Namai R et al. (2001) Selective recruitment of CCR6-expressing cells by increased production of MIP-3α in rheumatoid arthritis. Clin Exp Immunol 125:155–161 Shimizu Y, Murata H, Kashii Y et al. (2001) CC-chemokine receptor 6 and its ligand macrophage inflammatory protein 3α might be involved in the amplification of local necroinflammatory response in the liver. Hepatology 34:311–319 Bazan JF, Bacon KB, Hardiman G et al. (1997) A new class of membrane-bound chemokine with a CX3C motif. Nature 385:640–644 Yoneda O, Imai T, Goda S et al. (2000) Fractalkine-mediated endothelial cell injury by NK cells. J Immunol 164:4055–4062 Fong AM, Robinson LA, Steeber DA et al. (1998) Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow. J Exp Med 188:1413–1419 Robinson LA, Nataraj C, Thomas DW et al. (2000) A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejection. J Immunol 165:6067–6072 Haskell CA, Hancock WW, Salant DJ et al. (2001) Targeted deletion of CX(3)CR1 reveals a role for fractalkine in cardiac allograft rejection. J Clin Invest 108:679–688 Cockwell P, Chakravorty SJ, Girdlestone J, Savage CO (2002) Fractalkine expression in human renal inflammation. J Pathol 196:85–90 Kirman I, Vainer B, Nielsen OH (1998) Interleukin-15 and its role in chronic inflammatory diseases. Inflamm Res 47:285–289 Pipeleers DG, in't Veld PA, Van de Winkel M, Maes E, Schuit FC, Gepts W (1985) A new in vitro model for the study of pancreatic A and B cells. Endocrinology 117:806–816 Ling Z, Hannaert JC, Pipeleers D (1994) Effect of nutrients, hormones and serum on survival of rat islet β-cells in culture. Diabetologia 37:15–21 Keymeulen B, Ling Z, Gorus FK et al. (1998) Implantation of standardized β-cell grafts in a liver segment of IDDM patients: graft and recipients characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft. Diabetologia 41:452–459 Ling Z, Pipeleers DG (1996) Prolonged exposure of human β-cells to elevated glucose levels results in sustained cellular activation leading to a loss of glucose regulation. J Clin Invest 98:2805–2812 Pozzilli P, Signore A, Williams AJ, Beales PE (1993) NOD mouse colonies around the world-recent facts and figures. Immunol Today 14:193–196 Casteels K, Waer M, Laureys J et al. (1998) Prevention of autoimmune destruction of syngeneic islet grafts in spontaneously diabetic nonobese diabetic mice by a combination of a vitamin D3 analog and cyclosporine. Transplantation 65:1225–1232 Suarez-Pinzon W, Rajotte RV, Mosmann TR, Rabinovitch A (1996) Both CD4+ and CD8+ T-cells in syngeneic islet grafts in NOD mice produce interferon-γ during β-cell destruction. Diabetes 45:1350–1357 Liu D, Darville M, Eizirik DL (2001) Double-stranded ribonucleic acid (RNA) induces β-cell Fas messenger RNA expression and increases cytokine-induced β-cell apoptosis. Endocrinology 142:2593–2599 Overbergh L, Valckx D, Waer M, Mathieu C (1999) Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR. Cytokine 11:305–312 Giulietti A, Overbergh L, Valckx D, Decallonne B, Bouillon R, Mathieu C (2001) An overview of real-time quantitative PCR: applications to quantify cytokine gene expression. Methods 25:386–401 Eizirik DL, Flodstrom M, Karlsen AE, Welsh N (1996) The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic β-cells. Diabetologia 39:875–890 Eizirik DL, Pavlovic D (1997) Is there a role for nitric oxide in β-cell dysfunction and damage in IDDM? Diabetes Metab Rev 13:293–307 John NE, Andersen HU, Fey SJ et al. (2000) Cytokine- or chemically-derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans. Diabetes 49:1819–1829 Tensen CP, Flier J, Van Der Raaij-Helmer EM et al. (1999) Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). J Invest Dermatol 112:716–722 Liu D, Cardozo AK, Darville MI, Eizirik DL (2002) Double-stranded RNA cooperates with interferon-γ and IL-1β to induce both chemokine expression and nuclear factor-κB-dependent apoptosis in pancreatic β-cells: potential mechanisms for viral-induced insulitis and β-cell death in type 1 diabetes mellitus. Endocrinology 143:1225–1234 Grewal IS, Rutledge BJ, Fiorillo JA et al. (1997) Transgenic monocyte chemoattractant protein-1 (MCP-1) in pancreatic islets produces monocyte-rich insulitis without diabetes: abrogation by a second transgene expressing systemic MCP-1. J Immunol 159:401–408 Fehniger TA, Caligiuri MA (2001) Interleukin 15: biology and relevance to human disease. Blood 97:14–32 Bamford RN, Battiata AP, Burton JD, Sharma H, Waldmann TA (1996) Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region /IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation. Proc Natl Acad Sci USA 93:2897–2902 Musso T, Calosso L, Zucca M et al. (1999) Human monocytes constitutively express membrane-bound, biologically active, and interferon-γ-upregulated interleukin-15. Blood 93:3531–3539 Verma S, Hiby SE, Loke YW, King A (2000) Human decidual natural killer cells express the receptor for and respond to the cytokine interleukin 15. Biol Reprod 62:959–968 Proost P, Schutyser E, Menten P et al. (2001) Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties. Blood 98:3554–3561 Farber JM (1997) Mig and IP-10: CXC chemokines that target lymphocytes. J Leukoc Biol 61:246–257 Cole KE, Strick CA, Paradis TJ et al. (1998) Interferon-inducible T cell α chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J Exp Med 187:2009–2021 Schutyser E, Struyf S, Menten P et al. (2000) Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3α from normal and transformed cells. J Immunol 165:4470–4477 Hanenberg H, Kolb-Bachofen V, Kantwerk-Funke G, Kolb H (1989) Macrophage infiltration precedes and is a prerequisite for lymphocytic insulitis in pancreatic islets of pre-diabetic BB rats. Diabetologia 32:126–134 Schwizer RW, Leiter EH, Evans R (1984) Macrophage-mediated cytotoxicity against cultured pancreatic islet cells. Transplantation 37:539–544 Jun, HS, Santamaria, P, Lim, HW, Zhang, ML, Yoon, JW (1999) Absolute requirement of macrophages for the development and activation of β-cell cytotoxic CD8+ T-cells in T-cell receptor transgenic NOD mice. Diabetes 48:34–42 Oschilewski U, Kiesel U, Kolb H (1985) Administration of silica prevents diabetes in BB-rats. Diabetes 34:197–199 Matsushima K, Larsen CG, DuBois GC, Oppenheim JJ (1989) Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line. J Exp Med 169:1485–1490 Rothe H, Hausmann A, Kolb H (2002) Immunoregulation during disease progression in prediabetic NOD mice: inverse expression of arginase and prostaglandin H synthase 2 vs. interleukin-15. Horm Metab Res 34:7–12 Mathieu C, Waer M, Laureys J, Rutgeerts O, Bouillon R (1994) Prevention of autoimmune diabetes in NOD mice by 1,25 dihydroxyvitamin D3. Diabetologia 37:552–558 Gysemans CA, Waer M, Valckx D et al. (2000) Early graft failure of xenogeneic islets in NOD mice is accompanied by high levels of interleukin-1 and low levels of transforming growth factor-β mRNA in the grafts. Diabetes 49:1992–1997 Hancock WW, Gao W, Csizmadia V, Faia KL, Shemmeri N, Luster AD (2001) Donor-derived IP-10 initiates development of acute allograft rejection. J Exp Med 193:975–980 Strieter RM, Kunkel SL, Arenberg DA, Burdick MD, Polverini PJ (1995) Interferon γ-inducible protein 10 (IP-10), a member of the C-X-C chemokine family, is an inhibitor of angiogenesis. Biochem Biophys Res Commun 210:51–57 Jansson L, Carlsson P-O (2002) Graft vascular function after transplantation of pancreatic islets. Diabetologia 45:749–763 Mattsson G, Jansson L, Carlsson PO (2002) Decreased vascular density in mouse pancreatic islets after transplantation. Diabetes 51:1362–1366 Sandberg JO, Eizirik DL, Sandler S (1997) IL-1 receptor antagonist inhibits recurrence of disease after syngeneic pancreatic islet transplantation to spontaneously diabetic non-obese diabetic (NOD) mice. Clin Exp Immunol 108:314–317 Nadeau KC, Azuma H, Tilney NL (1995) Sequential cytokine dynamics in chronic rejection of rat renal allografts: roles for cytokines RANTES and MCP-1. Proc Natl Acad Sci USA 92:8729–8733 Piemonti L, Leone BE, Nano R et al. (2002) Human pancreatic islets produce and secrete MCP-1/CCL2: relevance in human islet transplantation. Diabetes 51:55–65