Metastasis as supra-cellular selection? A reply to Lean and Plutynski

Springer Science and Business Media LLC - Tập 32 - Trang 281-287 - 2016
Pierre-Luc Germain1, Lucie Laplane2,3
1European Institute of Oncology, Milan, Italy
2CNRS UMR8590, IHPST, ENS, Université Paris 1 Panthéon-Sorbonne, Paris, France
3UMR1170, INSERM, Gustave Roussy, Paris Saclay, Villejuif, France

Tóm tắt

In response to Germain (Biol Philos 27:785–810, 2012. doi: 10.1007/s10539-012-9334-2 ) argument that evolution by natural selection has a limited explanatory power in cancer, Lean and Plutynski (Biol Philos 31:39–57, 2016. doi: 10.1007/s10539-015-9511-1 ) have recently argued that many adaptations in cancer only make sense at the tumor level, and that cancer progression mirrors the major evolutionary transitions. While we agree that selection could potentially act at various levels of organization in cancers, we argue that tumor-level selection (MLS2) is unlikely to actually play a relevant role in our understanding of the somatic evolution of human cancers.

Tài liệu tham khảo

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