Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial
Iacopo Olivotto1,2, Artur Oreziak3, Roberto Barriales-Villa4,5,6,7,8, Theodore P Abraham9, Ahmad Masri10, Pablo Garcia-Pavia8,11,12, Sara Saberi13, Neal K Lakdawala14, Matthew T Wheeler15, Anjali Owens16, Milos Kubanek17, Wojciech Wojakowski18, Morten K Jensen19, Juan Gimeno-Blanes20, Kia Afshar21, Jonathan Myers22,23, Sheila M Hegde14, Scott D Solomon14, Amy J Sehnert24, David Zhang24
1Cardiomyopathy Unit, Azienda Ospedaliera Universitaria Careggi, Florence, Italy
2University of Florence, Florence, Italy
31st Department of Arrhythmia, National Institute of Cardiology, Warsaw, Poland
4Unidad de Cardiopatías Familiares, Instituto de Investigación Biomédica de A Coruña, A Coruña, Spain
5Complexo Hospitalario Universitario de A Coruña, A Coruña, Spain
6Servizo Galego de Saúde, A Coruña, Spain
7Universidade da Coruña, A Coruña, Spain
8Centro de Investigación Biomédica en Red, Madrid, Spain
9Division of Cardiology, University of California, San Francisco, San Francisco, CA, USA
10Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA
11Department of Cardiology, Hospital Universitario Puerta de Hierro, Madrid, Spain
12Universidad Francisco de Vitoria, Pozuelo de Alarcón, Madrid, Spain
13Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA
14Division of Cardiovascular Medicine, Brigham and Women’s Hospital, Boston, MA, USA
15Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA
16University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA
17Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
18Division of Cardiology and Structural Heart Diseases, Medical University of Silesia, Katowice, Poland
19Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
20Inherited Cardiac Disease Unit, University Hospital Virgen de la Arrixaca, Murcia, Spain
21Intermountain Medical Center Heart Institute, Intermountain Medical Center, Murray, UT, USA
22Division of Cardiology, Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA, USA
23Stanford University, Palo Alto, CA, USA
24MyoKardia, Brisbane, CA, USA