High-Affinity Kainate Receptor Subunits Are Necessary for Ionotropic but Not Metabotropic Signaling

Armstrong, 2006, B-ephrin reverse signaling is required for NMDA-independent long-term potentiation of mossy fibers in the hippocampus, J. Neurosci., 26, 3474, 10.1523/JNEUROSCI.4338-05.2006 Bahn, 1994, Kainate receptor gene expression in the developing rat brain, J. Neurosci., 14, 5525, 10.1523/JNEUROSCI.14-09-05525.1994 Barberis, 2008, GluR6/KA2 kainate receptors mediate slow-deactivating currents, J. Neurosci., 28, 6402, 10.1523/JNEUROSCI.1204-08.2008 Bortolotto, 1999, Kainate receptors are involved in synaptic plasticity, Nature, 402, 297, 10.1038/46290 Breustedt, 2004, Assessing the role of GluK5 and GluK6 at hippocampal mossy fiber synapses, J. Neurosci., 24, 10093, 10.1523/JNEUROSCI.3078-04.2004 Castillo, 1997, Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons, Nature, 388, 182, 10.1038/40645 Chittajallu, 1996, Regulation of glutamate release by presynaptic kainate receptors in the hippocampus, Nature, 379, 78, 10.1038/379078a0 Contractor, 2000, Identification of the kainate receptor subunits underlying modulation of excitatory synaptic transmission in the CA3 region of the hippocampus, J. Neurosci., 20, 8269, 10.1523/JNEUROSCI.20-22-08269.2000 Contractor, 2001, Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampus, Neuron, 29, 209, 10.1016/S0896-6273(01)00191-X Contractor, 2002, Trans-synaptic Eph receptor-ephrin signaling in hippocampal mossy fiber LTP, Science, 296, 1864, 10.1126/science.1069081 Contractor, 2003, Loss of kainate receptor-mediated heterosynaptic facilitation of mossy-fiber synapses in KA2−/− mice, J. Neurosci., 23, 422, 10.1523/JNEUROSCI.23-02-00422.2003 Darstein, 2003, Distribution of kainate receptor subunits at hippocampal mossy fiber synapses, J. Neurosci., 23, 8013, 10.1523/JNEUROSCI.23-22-08013.2003 Fisahn, 2005, The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neurones, J. Physiol., 562, 199, 10.1113/jphysiol.2004.077412 Frerking, 2001, Kainate receptors depress excitatory synaptic transmission at CA3→CA1 synapses in the hippocampus via a direct presynaptic action, J. Neurosci., 21, 2958, 10.1523/JNEUROSCI.21-09-02958.2001 Grabauskas, 2007, Protein kinase signalling requirements for metabotropic action of kainate receptors in rat CA1 pyramidal neurones, J. Physiol., 579, 363, 10.1113/jphysiol.2006.122051 Greger, 2003, AMPA receptor tetramerization is mediated by Q/R editing, Neuron, 40, 763, 10.1016/S0896-6273(03)00668-8 Herb, 1992, The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits, Neuron, 8, 775, 10.1016/0896-6273(92)90098-X Ji, 2002, Presynaptic kainate receptors play different physiological roles in mossy fiber and associational-commissural synapses in CA3 of hippocampus from adult rats, Neurosci. Lett., 331, 71, 10.1016/S0304-3940(02)00865-0 Kamiya, 2002, Kainate receptor-dependent short-term plasticity of presynaptic Ca2+ influx at the hippocampal mossy fiber synapses, J. Neurosci., 22, 9237, 10.1523/JNEUROSCI.22-21-09237.2002 Kask, 2000, Developmental profile of kainate receptor subunit KA1 revealed by Cre expression in YAC transgenic mice, Brain Res., 876, 55, 10.1016/S0006-8993(00)02599-3 Kwon, 2008, Role of glutamate autoreceptors at hippocampal mossy fiber synapses, Neuron, 60, 1082, 10.1016/j.neuron.2008.10.045 Lauri, 2001, A critical role of a facilitatory presynaptic kainate receptor in mossy fiber LTP, Neuron, 32, 697, 10.1016/S0896-6273(01)00511-6 Melyan, 2002, Metabotropic-mediated kainate receptor regulation of IsAHP and excitability in pyramidal cells, Neuron, 34, 107, 10.1016/S0896-6273(02)00624-4 Melyan, 2004, Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors, J. Neurosci., 24, 4530, 10.1523/JNEUROSCI.5356-03.2004 Mulle, 1998, Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice, Nature, 392, 601, 10.1038/33408 Mulle, 2000, Subunit composition of kainate receptors in hippocampal interneurons, Neuron, 28, 475, 10.1016/S0896-6273(00)00126-4 O'Gorman, 1997, Protamine-Cre recombinase transgenes efficiently recombine target sequences in the male germ line of mice, but not in embryonic stem cells, Proc. Natl. Acad. Sci. USA, 94, 14602, 10.1073/pnas.94.26.14602 Petralia, 1999, Immunocytochemistry of NMDA receptors, Methods Mol. Biol., 128, 73 Pinheiro, 2006, Kainate receptors, Cell Tissue Res., 326, 457, 10.1007/s00441-006-0265-6 Pinheiro, 2008, Presynaptic glutamate receptors: physiological functions and mechanisms of action, Nat. Rev. Neurosci., 9, 423, 10.1038/nrn2379 Pinheiro, 2007, GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses, Proc. Natl. Acad. Sci. USA, 104, 12181, 10.1073/pnas.0608891104 Rodriguez-Moreno, 1998, Kainate receptor modulation of GABA release involves a metabotropic function, Neuron, 20, 1211, 10.1016/S0896-6273(00)80501-2 Rodriguez-Moreno, 2007, Kainate receptors with a metabotropic modus operandi, Trends Neurosci., 30, 630, 10.1016/j.tins.2007.10.001 Ruiz, 2005, Distinct subunits in heteromeric kainate receptors mediate ionotropic and metabotropic function at hippocampal mossy fiber synapses, J. Neurosci., 25, 11710, 10.1523/JNEUROSCI.4041-05.2005 Schmitz, 2000, Synaptic activation of presynaptic kainate receptors on hippocampal mossy fiber synapses, Neuron, 27, 327, 10.1016/S0896-6273(00)00040-4 Schmitz, 2001, Presynaptic kainate receptor mediation of frequency facilitation at hippocampal mossy fiber synapses, Science, 291, 1972, 10.1126/science.1057105 Scott, 2008, Target-cell specificity of kainate autoreceptor and Ca2+-store-dependent short-term plasticity at hippocampal mossy fiber synapses, J. Neurosci., 28, 13139, 10.1523/JNEUROSCI.2932-08.2008 Swanson, 1997, Identification of amino acid residues that control functional behavior in GluR5 and GluR6 kainate receptors, Neuron, 19, 913, 10.1016/S0896-6273(00)80972-1 Thomas-Crusells, 2003, A novel method for monitoring surface membrane trafficking on hippocampal acute slice preparation, J. Neurosci. Methods, 125, 159, 10.1016/S0165-0270(03)00050-5 Vignes, 1997, The synaptic activation of kainate receptors, Nature, 388, 179, 10.1038/40639 Werner, 1991, Cloning of a putative high-affinity kainate receptor expressed predominantly in hippocampal CA3 cells, Nature, 351, 742, 10.1038/351742a0 Westbrook, 1983, Cellular and synaptic basis of kainic acid-induced hippocampal epileptiform activity, Brain Res., 273, 97, 10.1016/0006-8993(83)91098-3 Wisden, 1993, A complex mosaic of high-affinity kainate receptors in rat brain, J. Neurosci., 13, 3582, 10.1523/JNEUROSCI.13-08-03582.1993 Xu, 2009, mGluR5 has a critical role in inhibitory learning, J. Neurosci., 29, 3676, 10.1523/JNEUROSCI.5716-08.2009