The thienopyridine ticlopidine selectively prevents the inhibitory effects of ADP but not of adrenaline on cAMP levels raised by stimulation of the adenylate cyclase of human platelets by PGE1

Biochemical Pharmacology - Tập 40 - Trang 2683-2687 - 1990
Christian Gachet1, Jean-Pierre Cazenave1, Philippe Ohlmann1, Cyrille Bouloux2, Ghyslain Defreyn2, Francis Driot2, Jean-Pierre Maffrand2
1INSERM U.311, Biologie et Pharmacologie des Interactions du Sang avec les Vaisseaux et les Biomatériaux, Centre Régional de Transfusion Sanguine, 10 rue Spielmann, 67085 Strasbourg Cedex, France
2Sanofi Recherche, Laboratoire d'Hémobiologie, 195, route d'Espagne, 31036 Toulouse Cédex, France

Tài liệu tham khảo

Panak, 1983, Ticlopidine: a promise for the prevention and treatment of thrombosis and its complications, Haemostasis, 13, 1 Maffrand, 1988, Reviewed pharmacology of ticlopidine, Angiologie, 77, 6 Saltiel, 1987, Ticlopidine, a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in platelet-dependent disease states, Drugs, 34, 222, 10.2165/00003495-198734020-00003 Feliste, 1987, Broad spectrum antiplatelet activity of ticlopidine and PCR 4099 involves the suppression of the effects of released ADP, Thromb Res, 48, 403, 10.1016/0049-3848(87)90398-7 Lee, 1981, The in vitro effect of ticlopidine on fibrinogen and factor VIII binding to human platelets, Thromb Haemost, 46, 590, 10.1055/s-0038-1653424 Dunn, 1984, In vivo effects of ticlopidine on fibrinogen platelet cofactor activity and binding of fibrinogen to platelets, Vol. 15, 97 Gachet, 1990, The thienopyridine PCR 4099 selectively inhibits ADP-induced platelet aggregation and fibronogen binding without modifying the membrane glycoprotein IIb-IIIa complex in rat and in man, Biochem Pharmacol, 40, 229, 10.1016/0006-2952(90)90683-C DiMinno, 1985, Functionally thrombasthenic state in normal platelets following the administration of ticlopidine, J Clin Invest, 75, 328, 10.1172/JCI111705 Ashida, 1979, Mode of action of ticlopidine in inhibition of platelet aggregation in the rat, Thromb Haemost, 41, 436, 10.1055/s-0038-1646792 Bonne, 1984, Ticlopidine and adenylate cyclase, Vol. 15, 88 Morikawa, 1986, Comparison of the inhibitory effects of aspirin and ticlopidine on platelet aggregation and Ca2+ mobilization in rat platelets, Res Commun Chem Pathol Pharmacol, 54, 275 Feliste, 1988, Effect of PCR 4099 on ADP-induced calcium movements and phosphatidic acid production in rat platelet, Biochem Pharmacol, 37, 2559, 10.1016/0006-2952(88)90246-8 Derian, 1988, Effect of ticlopidine ex vivo on platelet intracellular calcium mobilization, Thromb Res, 50, 65, 10.1016/0049-3848(88)90175-2 Lanza, 1988, Epinephrine potentiates human platelet activation but is not an aggregating agent, Am J Physiol, 225, 1276 Cazenave, 1983, L'agrégation plaquettaire: outil d'investigation clinique et d'étude phamacologique, Ann Biol Clin, 41, 167 Khym, 1975, An analytical system for rapid separation of tissue nucleotides at low pressures on conventional anion exchangers, Clin Chem, 21, 1245, 10.1093/clinchem/21.9.1245 Rink, 1982, Cytoplasmic free Ca2+ in human platelet: Ca2+ thresholds and Ca2+-independent activation for shape-change and secretion, FEBS Lett, 148, 21, 10.1016/0014-5793(82)81234-9 Aktories, 1985, Regulation of platelet cyclic AMP formation, 271 Aktories, 1984, Ni-mediated inhibition of human platelet adenylate cyclase by thrombin, Eur J Biochem, 145, 333, 10.1111/j.1432-1033.1984.tb08558.x